EP2863874A2 - Préparation cosmétique et dermatologique contenant une ou plusieurs substances modulant le gène / la protéine pour le récepteur endo180 - Google Patents

Préparation cosmétique et dermatologique contenant une ou plusieurs substances modulant le gène / la protéine pour le récepteur endo180

Info

Publication number
EP2863874A2
EP2863874A2 EP13725665.7A EP13725665A EP2863874A2 EP 2863874 A2 EP2863874 A2 EP 2863874A2 EP 13725665 A EP13725665 A EP 13725665A EP 2863874 A2 EP2863874 A2 EP 2863874A2
Authority
EP
European Patent Office
Prior art keywords
collagen
skin
weight
endo180
sulfonic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP13725665.7A
Other languages
German (de)
English (en)
Inventor
Julia WEISE
Stefanie TANG
Heiko Mielke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beiersdorf AG
Original Assignee
Beiersdorf AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beiersdorf AG filed Critical Beiersdorf AG
Publication of EP2863874A2 publication Critical patent/EP2863874A2/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Definitions

  • Cosmetic and dermatological preparation containing one or more substance (s) that modulate the gene / protein for the receptor Endo180
  • the invention encompasses cosmetic and dermatological preparations containing one or more substance (s) which modulate the gene / protein for the receptor Endo180, in particular those preparations for use on the skin of a human for the repair and regeneration of the human skin, in particular for improved skin contouring or against age-related skin folds.
  • the aim of skin care is also to compensate for the daily loss of fat and water loss of the skin. This is especially important when the natural regeneration capacity is insufficient.
  • skin care products to protect against environmental influences, especially from the sun and wind, and delay the aging of the skin.
  • Chronic skin aging is e.g. caused by endogenous, genetically determined factors.
  • age-related e. to the following structural damage and dysfunctions: a) dryness, roughness and formation of dryness wrinkles,
  • Exogenous factors such as UV light and chemical noxae can be cumulatively effective and e.g. accelerate or supplement intrinsic aging processes.
  • exogenous factors occur, e.g. to the following structural damage and dysfunction in the skin that go beyond the extent and quality of the damage caused by chronological aging: g) Visible vascular dilations (telangiectasia, cuperosis);
  • the present invention relates in particular to products for the care of naturally aged skin (intrinsic and extrinsic skin aging) and to the phenomena listed under a), c), e), h) and j).
  • Products for the care of relaxed, especially aged, skin are known per se. They contain e.g. Retinoids (vitamin A acid and / or derivatives thereof) or vitamin A and / or its derivatives.
  • Retinoids vitamin A acid and / or derivatives thereof
  • their effect on structural damage is limited in their scope.
  • the use of vitamin A acid-containing products often causes severe erythematous skin irritation. Retinoids can therefore only be used in low concentrations.
  • collagen The main connective tissue protein, collagen, which gives the skin resilience and tensile strength, also undergoes metabolism, from collagen synthesis via fibrillogenesis to degradation and endocytosis. Collagen turnover is a relatively slow process because half-lives are described for collagen 10-15 years (Verzijl et al, 2000).
  • Collagen is the most prominent protein in human skin and accounts for approximately 85% of the total protein. Thus, the collagen fibers have a decisive influence on the external appearance of the skin.
  • the collagen turnover in the skin depends on the balance between the new formation and the breakdown of the collagen.
  • the intrinsic and especially extrinsic aging of the skin leads to reduced collagen synthesis and increased degradation by collagen degrading enzymes such as matrix metalloproteases (MMPs).
  • MMPs matrix metalloproteases
  • the balance is disturbed, and there is a loss of dermal collagen, which contributes to the wrinkling and declining elasticity of aging skin.
  • MMPs matrix metalloproteases
  • the integrity of collagen and other components of the extracellular matrix (ECM) has a major impact on the interaction of collagen fibers with fibroblasts, which can synthesize the various components of ECM.
  • Fibroblasts possess various receptors for collagen, in particular integrins, discoidin domain receptors (DDRs) and members of the mannose receptor family such as Endo180 (Leitinger and Hohenester, 2007).
  • DDR2 and Endo180 receptors have been implicated in mouse skin fibroblasts Wound healing and remodeling processes have been demonstrated (Olaso et al, 2002, Madsen et al, 2007).
  • DDR2 is a receptor tyrosine kinase that is important for fibroblast proliferation as well as collagen fibrillogenesis.
  • Endo180 is important for the endocytotic removal of both intact collagen and collagen fragments. Following receptor-mediated collagen endocytosis, the resulting vesicles fuse with lysosomes, and the collagen fragments are subsequently degraded by cathepsins (Rünger et al, 2007). There is evidence that denatured collagens are better absorbed than native ones. For fibroblasts cultured on denatured collagen versus native collagen, the former show increased collagen uptake and COL1A1 expression (Abraham et al, 2007).
  • Endo180 and integrin a 2 ßi are receptors on the surface of mesenchymal cells such as dermal fibroblasts and responsible for the uptake of collagen. It has been shown that Endo180 and integrin a 2 are downregulated in photoaged skin or after acute UV stress in vivo (Fig. 1).
  • Fig. 1 Gene expression analysis of Endo180 and integrin a 2 in photoaged skin or after acute UV stress in vivo.
  • Fig. 2 Gene expression analysis of Endo180 and integrin a 2 as well as collagen endocytosis after acute UV stress in fibroblasts in vitro.
  • B) Analysis of collagen internalization by flow cytometry. One day after SSR After irradiation (135 mJ / cm 2 ), the cells were incubated with collagen fluorescein [25 ⁇ g / ml] for 24 h and the fraction of cells that had taken up collagen fluorescein was determined. The control was unirradiated cells. It was found that the collagen uptake after SSR irradiation was reduced by about 30%. n 6
  • Fig. 3 Collagen adhesion and endocytosis after Endo180 and / or integrin a 2 knockdown.
  • the fibroblast is surrounded pericellularly by degraded collagen
  • Fig. 4 Gene expression analysis of Endo180 in young vs. intrinsically aged skin in vivo.
  • the object of the present invention was therefore to find ways that avoid the disadvantages of the prior art.
  • Another object of the present invention was to provide skin care preparations and skin care preparations, which preparations should soothe and beautify the body exterior.
  • the receptor Endo180 is responsible for the uptake of collagen fragments by fibroblasts. Its expression decreases in photoaged skin. It would be desirable to stimulate the expression of Endo180 in the aging skin as an anti-aging approach.
  • Butyl methoxydibenzoylmethane (70356-09-1), ethylhexyl methoxycinnamate + BHT (5466-77-3 + 128-37-0), ethylhexyl salicylate (1 18-60-5), polysilicone-15 (207574-74-1), Phenylbenzimidazole sulfonic acid (27503-81 -7), benzophenone-4 (4065-45-6), drometrizol trisiloxane (155633-54-8) and terephthalylidene dicamphor sulfonic acid (92761-26-7) stimulate the expression of Endo180.
  • the active ingredients used in the invention are also referred to in the context of the disclosure of this invention with terms such as "the active ingredients used in the invention”.
  • Diethylamino Hydroxybenzoyl Hexyl Benzoate (302776-68-7), Homosalates (1 18-56-9), Octocrylene (6197-30-4), Diethylhexyl Butamido Triazone (154702-15-5), Ethylhexyl Triazone (88122-99-0 ), Bis-ethylhexyloxyphenol methoxyphenyl triazine (187393-00-6), benzophenone-3 (131-57-7), disodium phenyl dibenzimidazole tetrasulfonate (180898-37-7) and isoamyl p-methoxycinnamate (71617-10-2) Inhibit expression of Endo180 or at best leave it unaffected.
  • Butyl methoxydibenzoylmethane (70356-09-1), ethylhexyl methoxycinnamate + BHT (5466-77-3 + 128-37-0), ethylhexyl salicylate (1 18-60-5), polysilicone-15 (207574-74-1), Phenylbenzimidazole sulfonic acid (27503-81 -7), benzophenone-4 (4065-45-6), drometrizol trisiloxane (155633-54-8), and terephthalylidene dicamphor sulfonic acid (92761-26-7) useful for stimulating the expression of Endo180.
  • UV filters selected from the group consisting of:
  • Butyl methoxydibenzoylmethane (70356-09-1), ethylhexyl methoxycinnamate + BHT (5466-77-3 + 128-37-0), ethylhexyl salicylate (1 18-60-5), polysilicone-15 (207574-74-1), Phenylbenzimidazole sulfonic acid (27503-81 -7), benzophenone-4 (4065-45-6), drometrizol trisiloxane (155633-54-8) and terephthalylidene dicamphor sulfonic acid (92761-26-7) for smoothing the skin and / or the contours of the skin an advantageous embodiment of the present invention.
  • Particularly advantageous active ingredients used according to the invention are ethylhexyl methoxycinnamate + BHT (5466-77-3 + 128-37-0), ethylhexyl salicylate (1 18-60-5), polysilicone-15 (207574-74-1), phenylbenzimidazole sulfonic acid (27503 -81-7) and drometrizol trisiloxane (155633-54-8).
  • preparations according to the invention having a cosmetically effective content of one or more active ingredients used according to the invention - eg. B. in the form of the examples mentioned - leads to a surprising improvement in the appearance of the aged skin.
  • Cosmetic or dermatological preparations according to the invention preferably contain from 0.00001 to 50% by weight, preferably from 0.001 to 20% by weight, of one or more active ingredients used according to the invention, based on the total weight of the preparation.
  • the cosmetic or dermatological preparations according to the invention may be composed as usual and serve for the treatment, care and cleansing of the skin. They preferably contain 0.002-10.0% by weight, more preferably 0.002-5.0% by weight, very preferably 0.005-3.0% by weight, based on the total weight of the preparations, of one or more according to the invention used active ingredients.
  • Emulsions are advantageous dosage forms in the sense of the present invention, e.g. in the form of a cream, a lotion, a cosmetic milk are advantageous and contain e.g. Fats, oils, waxes and / or other fatty substances, as well as water and one or more emulsifiers, as they are commonly used for such a type of formulation.
  • Medicinal topical compositions according to the present invention usually contain one or more drugs in effective concentration.
  • drugs for the sake of simplicity, reference is made to the clear distinction between cosmetic and medical use and corresponding products to the statutory provisions of the Federal Republic of Germany (eg Cosmetics Regulation, Food and Medicines Act). It is also advantageous to add the active ingredient used according to the invention as an additive to preparations which already contain other active ingredients for other purposes.
  • the cosmetic or dermatological preparation in the sense of the present invention is a solution or emulsion or dispersion, it is possible to use as solvent:
  • Oils such as triglycerides of capric or caprylic acid, but preferably castor oil;
  • Fats, waxes and other natural and synthetic fats preferably esters of fatty acids with lower C-number alcohols, e.g. with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with alkanoic acids of low C number or with fatty acids;
  • Alcohols, diols or polyols of low C number, and their ethers preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products ,
  • mixtures of the abovementioned solvents are used.
  • alcoholic solvents water can be another ingredient.
  • the oil phase of the emulsions, oleogels or hydrodispersions or lipodispersions in the context of the present invention is advantageously selected from the group of esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids having a chain length of 3 to 30 carbon atoms and saturated and / or unsaturated, branched and / or unbranched alcohols having a chain length of from 3 to 30 carbon atoms, from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols having a chain length of from 3 to 30 carbon atoms. atoms.
  • ester oils can then advantageously be chosen from the group isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyl tyldodecyl palmitate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate and synthetic, semi-synthetic and natural mixtures of such esters, eg jojoba oil.
  • the oil phase can be advantageously selected from the group of branched and unbranched hydrocarbons and waxes, the silicone oils, the dialkyl ethers, the group of saturated or unsaturated, branched or unbranched alcohols, and the fatty acid triglycerides, namely the triglycerol esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length of 8 to 24, in particular 12 to 18 carbon atoms.
  • the fatty acid triglycerides can be advantageously selected from the group of synthetic, semi-synthetic and natural oils, e.g. Olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil, and the like.
  • Alcohols, diols or polyols of low C number, and their ethers preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether, diethylene glycol monomethyl or monoethyl ether and analogous products, furthermore low C-number alcohols, eg Ethanol, isopropanol, 1, 2-propanediol, glycerol and in particular one or more thickening agents, which or which can be advantageously selected from the group of silica, aluminum silicates, polysaccharides or their derivatives, e.g.
  • Hyaluronic acid, xanthan gum, hydroxypropylmethylcellulose particularly advantageously from the group of polyacrylates, preferably a polyacrylate from the group of so-called carbopols, for example Carbopols types 980, 981, 1382, 2984, 5984, each individually or in combination.
  • carbopols for example Carbopols types 980, 981, 1382, 2984, 5984, each individually or in combination.
  • Gels used according to the invention usually contain alcohols of low carbon number, for example ethanol, isopropanol, 1, 2-propanediol, glycerol and water or an above-mentioned oil in the presence of a thickening agent which in oily-alcoholic gels preferably silica or an aluminum silicate, in aqueous Alcoholic or alcoholic gels is preferably a polyacrylate.
  • Solid pens contain, for example, natural or synthetic waxes, fatty alcohols or fatty acid esters.
  • liquid oils eg paraffin oils, castor oil, isopropyl myristate
  • semi-solid constituents eg petrolatum, lanolin
  • solid constituents eg beeswax, ceresin and microcrystalline Waxes or ozokerite
  • high-melting waxes eg carnauba wax, candelilla wax
  • Suitable propellants for sprayable from aerosol containers cosmetic and / or dermatological preparations in the context of the present invention the usual known volatile, liquefied propellants, such as hydrocarbons (propane, butane, isobutane) are suitable, which can be used alone or in mixture with each other. Also, compressed air is advantageous to use.
  • hydrocarbons propane, butane, isobutane
  • PEG-40 Stearate 0.80 1, 00 1, 00 1, 00
  • Methyl Methacrylate Crosspolymer 1 0 1, 0
  • Nylon 12 1.0 1.0 1.0 1.0 1.0
  • Glyceryl stearates self-emulsifying 2 2 1, 5 1, 5
  • Phenoxyethanol 0.35 0.25 0.3 0.3
  • Carrageenan 0, 1 0.1 - -
  • Glyceryl stearate self-emulsifying 1.0 1.0 1.0 1.0
  • Phenylbenzimidazole sulfonic acid 1.0 1.0 - 1.0
  • Cetylstearyl alcohol 5.0 3.5 4.0 3.0
  • Carbomer 0, 1 0.15 0.1 0.1
  • Caprylic acid / capric acid triglycerides 2.0 2.5 1, 0 2.0
  • Methylisothiazolinone 0.05 - -

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne l'utilisation d'un ou de plusieurs filtres à UV choisis dans le groupe comprenant butyl-méthoxydibenzoylméthane (70356-09-1), éthylhexyl-méthoxycinnamate + BHT (5466-77-3 + 128-37-0), éthylhexyl-salicylate (1 18-60-5), polysilicone-15 (207574-74-1), acide phénylbenzimidazol-sulfonique (27503-81-7), benzophénone-4 (4065-45-6), drométrizol-trisiloxane (155633-54-8) et acide téréphthalylidéno-dicamphro-sulfonique (92761-26-7) pour stimuler l'expression d'Endo180 pour activer le métabolisme du collagène dans la peau mature et pour amener la peau mature à éliminer du collagène défectueux.
EP13725665.7A 2012-06-20 2013-05-28 Préparation cosmétique et dermatologique contenant une ou plusieurs substances modulant le gène / la protéine pour le récepteur endo180 Ceased EP2863874A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102012210379A DE102012210379A1 (de) 2012-06-20 2012-06-20 Kosmetische und dermatologische Zubereitung enthaltend eine oder mehrere Substanz(en), die das Gen / Protein für den Rezeptor Endo180 modulieren
PCT/EP2013/060984 WO2013189702A2 (fr) 2012-06-20 2013-05-28 Préparation cosmétique et dermatologique contenant une ou plusieurs substances modulant le gène / la protéine pour le récepteur endo180

Publications (1)

Publication Number Publication Date
EP2863874A2 true EP2863874A2 (fr) 2015-04-29

Family

ID=48536870

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13725665.7A Ceased EP2863874A2 (fr) 2012-06-20 2013-05-28 Préparation cosmétique et dermatologique contenant une ou plusieurs substances modulant le gène / la protéine pour le récepteur endo180

Country Status (3)

Country Link
EP (1) EP2863874A2 (fr)
DE (1) DE102012210379A1 (fr)
WO (1) WO2013189702A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107106462A (zh) 2014-12-15 2017-08-29 荷兰联合利华有限公司 用于提供改进的防晒保护的组合物
DE102015219008A1 (de) * 2015-10-01 2017-04-06 Beiersdorf Ag Sonnenschutzmittel mit reduzierter Textilverfleckung durch 4-(tert.-Butyl)-4'-methoxydibenzoylmethan
FR3091176B1 (fr) * 2018-12-26 2021-04-16 Oreal Composition cosmétique comprenant des filtres UV hydrosolubles
CN111840107A (zh) * 2020-08-13 2020-10-30 广州贝玛生物科技有限公司 一种孕产妇和敏感肌人群使用的防晒乳及其制备方法

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Publication number Priority date Publication date Assignee Title
US5492894A (en) * 1991-03-21 1996-02-20 The Procter & Gamble Company Compositions for treating wrinkles comprising a peptide
JP2001525353A (ja) * 1997-12-08 2001-12-11 アリゾナ ボード オブ リージェンツ 長時間作用する、化学的に耐性な皮膚エモリエント剤、モイスチャライザー、および強化剤
KR20050043781A (ko) * 2001-11-09 2005-05-11 바이어스도르프 악티엔게젤샤프트 옥타데센 디카르복실산 및 ｕｖ 필터링 물질을 함유하는화장품 및/또는 피부 질환용 제품
PL1625150T3 (pl) * 2003-05-08 2007-05-31 Dsm Ip Assets Bv Tripeptydy i ich pochodne do stosowania w kosmetyce w celu poprawy struktury skóry
GB0424891D0 (en) * 2004-11-11 2004-12-15 Boots Co Plc Topical compositions
EP2710996B1 (fr) * 2007-12-14 2022-08-17 Basf Se Compositions d'écran solaire comprenant des pigments de couleur

Non-Patent Citations (2)

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Title
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See also references of WO2013189702A2 *

Also Published As

Publication number Publication date
WO2013189702A2 (fr) 2013-12-27
DE102012210379A1 (de) 2013-12-24
WO2013189702A3 (fr) 2014-10-23

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