EP2879966B1 - Tropfenspenderausgabekopf - Google Patents

Tropfenspenderausgabekopf Download PDF

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Publication number
EP2879966B1
EP2879966B1 EP13773332.5A EP13773332A EP2879966B1 EP 2879966 B1 EP2879966 B1 EP 2879966B1 EP 13773332 A EP13773332 A EP 13773332A EP 2879966 B1 EP2879966 B1 EP 2879966B1
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EP
European Patent Office
Prior art keywords
liquid
bottle
tubular
membrane
filters
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Application number
EP13773332.5A
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English (en)
French (fr)
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EP2879966A1 (de
Inventor
Alain Defemme
Fabrice Mercier
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Laboratoires Thea SAS
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Laboratoires Thea SAS
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Publication of EP2879966A1 publication Critical patent/EP2879966A1/de
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/0094—Containers having an external wall formed as, or with, a diaphragm or the like which is deformed to expel the contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A61J1/065—Rigid ampoules, e.g. glass ampoules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1418—Threaded type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • A61J1/145—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using air filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1443—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters
    • A61J1/1456—Containers with means for dispensing liquid medicaments in a filtered or sterile way, e.g. with bacterial filters using liquid filters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1475—Inlet or outlet ports
    • A61J1/1481—Inlet or outlet ports with connection retaining means, e.g. thread or snap-fit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2068—Venting means
    • A61J1/2075—Venting means for external venting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2082—Filtering means for gas filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2079—Filtering means
    • A61J1/2086—Filtering means for fluid filtration

Definitions

  • the present invention relates to a liquid dispensing head from a bottle on which it is mounted. It relates more particularly to the design of drip dispensing bottles used in the pharmaceutical industry, but also the design of such bottles for cosmetics or parapharmacy, and more broadly for any industry with similar needs in the pharmaceutical industry. field of liquid distribution.
  • Liquid distribution heads comprise permselective membranes arranged inside a mounting body in the neck of a receiver bottle of a liquid to be dispensed, across the path of the expelled liquid and that of the air sucked in replacement.
  • these membranes can play several roles.
  • a membrane having properties equivalent to those with mesh sizes of less than 0.2 microns will function as a bacterial filtration membrane preserving the content remaining in the bottle of any bacterial contamination coming from the outside air called in. enter the bottle.
  • a membrane of hydrophilic material will tend to remain impregnated with an aqueous liquid having passed through it during the expulsion of a drop and thus become impervious to air, while hydrophobic material membrane will be passed through without difficulty by air until the pressure balance between the two faces of the membrane.
  • Flasks equipped with liquid distribution heads through a hydrophilic membrane filter are described in particular in the documents US 5,105,993 (The Hague) ) and EP 0 617 951 (Shimizu ).
  • the document WO2011 / 095877 A1 discloses a vial according to the preamble of claim 1.
  • the present invention differs as defined in claim.
  • flasks marketed by the Applicant it is also known to form the interface between the internal volume of the flask and the outside air by a membrane made to present partly hydrophilic properties and partly hydrophobic properties.
  • a membrane made to present partly hydrophilic properties and partly hydrophobic properties In practice, it is a membrane of bacterial filtration which is in hydrophilic material in certain areas (allowing itself to be impregnated and cross in particular by aqueous solutions) and hydrophobic material in other areas.
  • the aim of the invention is to provide an alternative to previous conventional designs by proposing dispensing heads in which it is intended to modify the design and arrangement of the semipermeable membrane so as to improve the conditions under which the management of the semipermeable membranes is ensured. exchange of fluids between the inside and the outside of the bottle according to a pressure differential between its two faces. It also aims to broaden the possibilities of application of the technique, and more specifically, in its preferred embodiments, to allow the dropwise distribution of viscous solutions preserved sterile.
  • the present invention consists in its principle in arranging the semi-permeable membrane in the longitudinal direction of the bottle rather than in the transverse direction as has been done hitherto.
  • the interface between liquid and air is maintained, at least at the level of the membrane with selective permeability to water (more generally to the liquid to be dispensed) in the presence of air, by configuring the membrane around one or more conduits in communication with the outside which dive into the bottle.
  • flexible tubes are used whose walls are made of the material of the membrane and whose ends open out of the bottle, through a perforated plate used to mount the assembly across the neck of the bottle of the liquid reservoir. distribute that surrounds their respective ends in a sealed manner by stiffening their walls so as to preserve the outlet of their internal conduits by individualized outlet ports.
  • the membrane which manages the alternation of the flows passing through the distribution head, is set up according to the pressures prevailing on both sides, in the form of tubular filters with permselective properties, which function either in liquid extraction out of of the bottle for its diffusion, or in return of outside air in the bottle in compensation of the liquid expelled.
  • the dispensing head according to the invention with the longitudinal arrangement of the tubular filters that it comprises, makes it possible to have a large active surface in selective permeability, which no longer knows the dimensional limits which are linked, in the current bottles, to the diameter of the head of the bottle across of which the membrane is arranged. This feature is of importance especially for the liquid expulsion function, while the particle filtration capacity is especially sought from the active air suction membrane surface.
  • a bacterial filtration membrane will have a protective role for a liquid that is kept sterile in the vial. There is no need for the latter to contain a preservative agent.
  • a preservative agent it is known that the presence of a preservative in the composition of the product to be distributed entails risks of side effects, in terms of irritation of the mucous membranes, for example in the case of ophthalmic drops, or in the case of other zones. sensitive of the body, in dermatology in particular.
  • liquid-permeable activated filtering surface makes it possible to reduce the pressure that it is necessary to exert on the walls of the bottle in order to expel the liquid, since the functional surface is larger. Thus also, it facilitates the use in the flask of liquids consisting of viscous solutions.
  • Another advantage lies in the fact that one gains in freedom in the extent and the arrangement of the membrane areas which are functional hydrophilic or functional hydrophobic respectively. It is certainly conceivable to have hydrophilic areas and hydrophobic zones along the same tube, but it appears simpler in manufacture and more effective in operation to reserve the hydrophilic character to some of the tubular conduits (for operation in extraction of liquid) and reserve the hydrophobic character for other tubular ducts (for operation in air intake). In this way, no mixing between the liquid phase and the gas phase can occur there.
  • tubular duct in the broad sense is not necessarily folded back on itself, but that it may as well be tubes closed at the end and having a single end opening out of the reservoir bottle. liquid.
  • the filter assembly has antibacterial properties, and filter surfaces are hydrophilic and reserved for the extraction of the liquid while filter surfaces are hydrophobic and reserved for the entry of 'air. So that, when the flask is returned to deliver a drop, the air does not enter the bottle before the liquid outlet, it is generally desirable that the hydrophobic surfaces are arranged close to the mounting plate of the assembly which closes the axial passage of the annular body of the common distribution head to the liquid and to the air and that the hydrophilic surfaces extend longitudinally deeper into the liquid reservoir bottle. The hydrophobic surfaces thus bathe in liquid when the bottle is inverted, which prevents the passage of air.
  • the arrangements thus implemented according to the invention have the advantage of making it possible to regulate separately the extent of the areas reserved for the extraction of the liquid and the extent of the surfaces reserved for the entry of air, as well as that their respective provisions, more or less plunging deep into the bottle or more or less cantoned near the neck of the bottle.
  • the liquid extraction ducts are distinct from the air inlet ducts, any mixing between the liquid phase and the gas phase is avoided in the course of these operations, which is particularly useful when, for example, the nature of its active ingredient or the presence of a surfactant in its composition, the liquid to be diffused is likely to generate a foaming phenomenon in contact with the air.
  • the separation of the functions of the conduits and the freedom of their positioning in the bottle advantageously combine in such an application to the diffusion of foaming products.
  • the separation of physical order between the air passage and the passage of the liquid makes it possible to individually regulate the flows proper to the two fluids, this also makes it possible to dispense with the need for the porous flux regulating buffer.
  • the vials according to the invention become all the more advantageous for the distribution of foaming products, since the porous buffer is itself a foam producer in this case.
  • the quality of protection of the liquid against the penetration of bacterial contamination is excellent. Only the ends of the tubes are flush on the outside, where they are open for the exit of the liquid. The free surface of liquid exposed to the outside is extremely low. On the other hand, the liquid that has passed through the membrane and remains in the tubes is confined in thin columns, which allow neither the diffusion of contaminated plots of liquid nor the bacterial proliferation from them.
  • a secondary feature of the invention it is advantageous to group the various tubular elements of hydrophilic membrane into a bundle of parallel ducts in the axis of the bottle which is surrounded by a sheath having the effect of keeping them elongated in the direction longitudinal of the bottle, which is in favor of a good functional availability of the membrane.
  • the presence of such a sleeve, mechanically resistant, has the further advantage of facilitating assembly of the assembly in the plunging position in the bottle through the neck of the latter.
  • the sleeve surrounding the membrane tubes consists of a non-perforated tubular wall, it serves on the other hand to guide the circulation of the liquid which, during a distribution of drops, is pushed through it. in order to encourage the liquid to lick the walls of the membrane tubes while passing around them in a calm circulation mode.
  • the sheath an external configuration facilitating a sealed contact with the neck of the bottle.
  • this window is advantageously provided a window through the tubular wall of the sleeve just below the base of the terminal dropper tip. It allows the passage of the liquid inside the sleeve when there is only a little liquid in the bottle and this liquid meets outside the sleeve in the bottle turned upside down.
  • this window can be used for the penetration of the air to enter the bottle when releasing the pressure on the walls of the bottle by returning it to the normal upright position after the expulsion of a drop of liquid.
  • a dispensing head according to the invention adapted to be mounted on a liquid reservoir bottle and comprising a filtering device arranged across the neck of the bottle to interface between the inside and the outside of the bottle, on the path common to the liquid to the expulsion and to the external air sucked alternately .
  • a dispensing head 1 according to a first embodiment of the invention is illustrated on the figure 1 , mounted in a liquid conditioning bottle 2.
  • the elements that constitute the bottle, and in particular the dispensing head are generally made of a plastic material compatible with the application for the preservation of an ophthalmic solution. They are each made of polymer of the family of polyolefins, especially polyethylene.
  • the bottle comprises a liquid storage tank 4 whose cylindrical peripheral wall 6 is elastically reversible deformation, so as to allow a distribution of the liquid from a manual compression exerted on this wall by the user and a return spontaneous to its original shape by admission of air in compensation for the liquid released when this manual compression is released.
  • the return air in compensation is performed in the reverse path of the outlet of each drop of liquid, through the dispensing head, here through the cylindrical bore 8 internal to the body of the dispensing head, which is annular shape.
  • the cylindrical wall of the bottle has at its free end a throttling portion which is extended axially by a neck 10, wherein the dispensing head is fixed in sealed connection.
  • a removable cap 12 for closing the dispensing head is screwed in a conventional manner around the neck of the bottle.
  • the cap is formed of a hollow cylinder closed at one end and having inside the cylinder a concentric chimney 14.
  • the dispensing head forms a dropper tip 16, terminating its cylindrical annular body 17 outside the bottle.
  • the body 17 has a flange 18 which extends radially outwardly the cylindrical wall.
  • a throat is formed by a shoulder 20 so as to form an outlet port 22. of smaller diameter and a shoulder inside the tip.
  • a porous pad 24 is disposed at the end of the tip against this shoulder by filling the entire passage opening.
  • the pad is made of a porous thermoplastic material based on polyethylene conferring a hydrophobic character which avoids the stagnation of liquid and which promotes the entry of air when the pad dries. It is obtained by sintering, that is to say by heat treatment of particles of thermoplastic material, and it may contain a bactericidal agent, consisting for example of silver ions known to be effective on many bacterial strains present on the skin and the ocular mucous membranes.
  • the porous buffer has porosity characteristics capable of achieving a splitter effect with respect to the liquid exiting the bottle without substantially curbing its circulation, so as to form a droplet in expulsion. We can play on the diameter of the terminal orifice to define the size of the drop.
  • a filter device with semi-permeable membranes 26 is disposed inside the dispensing head. It comprises, on the one hand, a set of tubular filters, one with a hydrophobic semi-permeable wall and the other with a hydrophilic semi-permeable wall, and on the other hand an organic resin plate overmolded around the open ends of the tubular filters used for mounting the assembly across the nozzle 17 forming the body of the liquid dispensing head.
  • This plate 28 is arranged transversely in the tip, in sealing contact with the inner wall of the latter on all its around, while the various tubular filters are adapted to dip from it into the liquid reservoir bottle.
  • the set of tubular filters comprises filters 30 folded on themselves so as to have a shape of U, and an additional filter 32 wound in a spiral around the U-shaped filters.
  • the bent filters extend longitudinally in the bottle at a distance farther from the plate than the additional spiral filter, while the latter remains closer to the plate, away from the liquid when the bottle is placed vertical at rest.
  • Each tubular filter has a wall in the form of a semi-permeable membrane.
  • the spirally wound tubular filter 32 is formed of a semipermeable membrane tube of hydrophobic material, thus selectively permeable to air and not to liquid, while the tubular filters extending longitudinally in the bottle are respectively formed of a membrane of hydrophilic material, so that they are selectively permeable to the liquid in the presence of air.
  • each of these filters is a semi-permeable membrane tube open at its ends 31, said ends being open through the plate 28 on the side of the upper face of the plate which is covered by the distribution buffer 24, opposite the tank 4. It can thus be seen that all the open ends 31 of the tubular filters 30, 32 of the filtering device are disposed on the same side of the plate 28, that is to say on the of the outlet channel, and that these tubular filters do not have an open end on the side of the tank.
  • the porosity or mesh size of the membrane constituting the wall of the tubular filters which determines the particulate filtration capacity, may be different depending on whether it is wall pipes.
  • Hydrophobic membrane reserved for the aspiration of air or hydrophilic wall tubes reserved for the expulsion of liquid. So, while now a 0.2 micron bacterial filtration capacity for the air inlet membrane, in order to maintain a sterile medium inside the flask, we can settle for a coarser particle size filtration for the membrane of the tubes serving as liquid outlet.
  • the major advantage is to be able to use the vial for ophthalmic solutions of viscous consistency without having to excessively increase the pressure to be exerted to force the liquid to pass through the hydrophilic membrane, which is also a function of the semicircular surface area. permeable to the liquid available.
  • the acceptable viscosity can be set in compromise with the ability of the liquid impregnated membrane to become airtight so that, without going to the finesse necessary to filter the bacteria, the membrane does not let the contaminating microorganisms from outside air, assuming they reach it.
  • the porous buffer 24 contributes to the protection of a sterile content of the bottle by its filtering role with regard to the dust and equivalent particles present in the outside air, which it prevents from reaching at the entrance of ducts internal to the tubular filters, with the contaminating micro-organisms that they could convey.
  • the same buffer prevents any direct contact between the skin or mucous membranes of the user and the plate 28 on the surface of which these conduits open. In total we ensure a good air filtration that allows the vial to an ophthalmic solution without preservatives.
  • a sheath 34 extends perpendicular to the plate inside the liquid reservoir flask, where it has a hollow internal diameter shape adapted to receive the longitudinal filter tubes to serve as an extension guide. Moreover, the sleeve serves as a support for winding the spiral tube.
  • the sheath is open at both longitudinal ends. At one of its ends, it is secured to the perforated plate 28 serving as a support for all the tubular filters, for example during the manufacture by overmoulding of the resin plate on the tubes.
  • the sleeve has a liquid passage window 36 formed in its wall, close to the end adapted to be in contact with the transverse plate. It is made of a rigid plastic material, which provides protection for the tubes received inside and which guards the liquid penetrating the sheath by its open free end and the window.
  • the arrangement of the filters and the sleeve is such that the tubular filter with hydrophobic wall 32 is located between the plate and the window of the sleeve.
  • the advantage of such an arrangement is in particular to prevent too much liquid remains stuck in the bottle without being able to leave the end of use of the bottle.
  • the tampon 24 is first inserted inside the body of the nozzle, pushing it from the end of the larger diameter to the stop formed by the shoulder. 20 at the opposite end. Once in position, the convex shape of the pad is flush with the curved shape of the end of the body of the tip.
  • the assembly previously formed by the perforated plate for mounting the tubular filters, by the tubular filters and by the guide sleeve, is then forced into the endpiece until the plate comes into contact with the buffer.
  • the packaging bottle is then mounted by pressing the dispensing head into the neck of the bottle, after the reservoir of the bottle has been filled with liquid.
  • the dispensing head is mounted by first inserting the sleeve in the bottle and this until the end of the collar of the tip against the upper end of the neck of the bottle.
  • the dispensing head is then irreversibly snapped into the neck of the bottle by the cooperation of snap-fastening means at right angles which project from the circular wall of the nozzle and which cooperate with grooves of corresponding shapes formed in the inner wall of the neck of the bottle.
  • the mounting of the dispensing head as just described has a double advantage in that on the one hand the elements are mounted in a simple manner, mainly by fitting, and in that on the other hand there is no risk of damaging the longitudinal membrane tubes at the time of insertion since they are protected by the sheath that surrounds them.
  • the user returns the bottle and positions it above his eyes, and he exerts on the tank wall a manual pressure so as to deform the elastically reversible wall by compressing the interior space.
  • the liquid present in the reservoir is pressed against the membrane wall of the tubular filters, whether it is hydrophilic or hydrophobic, but only the hydrophilic membrane surfaces deliver a passage to the liquid which impregnates them because of the differential pressure on either side. membrane, closing at the same time any possibility of air penetration.
  • the liquid found inside the hydrophilic wall-type tubular filter is then led to the distribution pad through the perforated plate closing the internal space of the annular tip.
  • the pressure to be exerted on the walls of the flask to expel the liquid is less strong than it should be in the bottles of the prior art since the exchange surface proposed by the longitudinal arrangement of the membranes is greater than previously not in the case of a transverse membrane. It also ensures a sufficient liquid output flow through the diameter of the tubes and the number of these tubes defining a hydrophilic passage zone substantially in the center of the plate disposed transversely to the air passage and liquid. The liquid passes beyond the plate and passes through the terminal buffer which provides a splitter effect for the formation of a drop.
  • the user releases the pressure on the wall of the bottle and returns it to return it to the rest position. While the wall of the flask resumes its initial cylindrical shape, the liquid is sucked back into the flask by releasing the hydrophobic membrane and the air can freely penetrate therethrough into the flask until pressure equilibrium between the two faces of the flask is reached. filter device. All the time of this operation, the hydrophilic membrane remains impregnated with liquid and impervious to air, while the terminal buffer dries without difficulty.
  • the hydrophobic surfaces are arranged close to the through plate at the top of the bottle. at rest, while the hydrophilic surfaces extend longitudinally deeper into the liquid reservoir than the hydrophobic surfaces.
  • the longitudinal component of the hydrophilic surfaces which dive deep into the tank, ensures a larger exchange surface to facilitate a larger volume of liquid leaving the tank, so that the pressure at exerting to expel a given volume of liquid can be reduced if the number of tubular filters and the diameter of their internal ducts to ensure the output flow of the liquid.
  • This dive in the hydrophilic filter tank also allows to soak the filters very quickly and block the passage of air via these filters. Even at the end of consumption of the vial, when the liquid is entirely against the transverse plate and the end of the tubular filters opposite the plate is no longer embedded by the liquid, the hydrophilic portion is moistened and therefore impervious to air .
  • the fact that over the length of the corresponding tubular filters the hydrophobic surfaces are arranged close to the transverse plate makes it possible to ensure that, when the bottle is inverted for use, there is liquid which covers and envelops the filter hydrophobic.
  • a bottle is thus provided with which the fraction of liquid remaining spoiled becomes extremely reduced. Indeed, when after a number of important uses, the fact of returning the bottle no longer allows to bathe the hydrophobic filter liquid since all the liquid is passed between the plate and the hydrophobic filter, the air in the tank can go out and the remaining liquid gets stuck in the bottle and is lost.
  • hydrophobic surfaces are arranged close to the plate closing the neck of the bottle, and so that they fit between this plate and the passage window made in the wall of the sheath.
  • This window allows the passage of the liquid inside the sheath when there is only a little liquid in the bottle and this liquid meets outside the sheath in the flask turned upside down.
  • the small amount of lost liquid that stagnates against the plate and is not drained by the hydrophilic filters is used to soak the hydrophobic filters to prevent the release of air and allow the proper operation of the bottle until the fluid level is insufficient to fully bathe the hydrophobic filters.
  • a second embodiment will now be described, schematically illustrated on the figure 3 .
  • the representation of the dispensing head has been voluntarily widened to clarify the arrangement of the elements relative to each other, so that the proportion may not be respected, for example between the width of the tubular filters and the thickness of the walls of the vial or between the height and width of the mouthpiece.
  • the hydrophobic membrane filters 132 selectively permeable to air, here have a U-shaped shape such as hydrophilic membrane tubular filters 130 dedicated to the liquid outlet. They are of similar diameter, of the order of a millimeter, but of much lesser length. In this way, the hydrophobic functional membrane surface is as previously grouped near the mounting plate of the filtering device, at the top of the bottle.
  • the second embodiment also differs in that the sleeve surrounding the tubes or its equivalent do not have a constant diameter.
  • a proximal portion 142 is at the tip 116 and a distal portion 144 is in the bottle.
  • the proximal portion is smaller in diameter and completely fills the inside diameter of the tip, while the distal portion is larger in diameter to reach the the wall of the neck of the bottle 110 before diving into the liquid reservoir.
  • the second embodiment also differs from the first in that the splitter buffer opens on an outlet channel 146 formed by the nozzle 116 which aims to facilitate the formation and good calibration of a drop.
  • the splitter buffer opens on an outlet channel 146 formed by the nozzle 116 which aims to facilitate the formation and good calibration of a drop.
  • the removable cap 112 has a shape adapted to close in its screwed position the end of the outlet channel.
  • the cap is formed of a hollow cylinder closed at one end and having inside the cylinder a central pin 148 projecting from the radial end wall.
  • the cap further comprises two concentric funnels 114 and 150 between the central pin and the peripheral side wall.
  • the central pin is intended to cooperate with the outlet channel of the nozzle to close it while the chimneys are intended to bear against the outer surfaces of the nozzle, one bearing radially on the periphery of the body, the other coming in axial support on the collar.
  • the foregoing description clearly explains how the invention achieves the objectives it has set.
  • it uses tubular filters permselective membrane that provide a large exchange surface for the liquid and air to pass through the interface between the liquid reservoir bottle and the outside air.
  • tubular filters permselective membrane that provide a large exchange surface for the liquid and air to pass through the interface between the liquid reservoir bottle and the outside air.
  • It also allows a simplified embodiment of two distinctly hydrophilic and hydrophobic zones to ensure the alternation of the passage of air and liquid which allows the proper operation of the bottle. It is found that one can thus increase the range of use of the dispensing head according to the invention by diversifying the type of more or less viscous liquid that can be inserted into the bottle associated with this dispensing head.

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mechanical Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Closures For Containers (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Packages (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Claims (15)

  1. Flüssigkeitsaufbewahrungsflasche mit einer Wand mit reversibler elastischer Verformung, die mit einem Flüssigkeitsabgabekopf (1) ausgestattet ist, der in dichter Verbindung in einem Hals (10) der Flasche (2) befestigt ist und der eine Filtervorrichtung (26) mit einer Wand aus einer semipermeablen Membran mit zum Teil hydrophiler Natur und zum Teil hydrophober Natur aufweist, die an der Schnittstelle zwischen dem Inneren und dem Äußeren der Flüssigkeitsaufbewahrungsflasche angeordnet ist und den Flüssigkeitsausstoß durch eine äußere Öffnung (22) und den Lufteinlass durch die gleiche Öffnung in Abhängigkeit von einem Druckdifferenzial an beiden Seiten verwaltet, wobei die Membran an ihrer Oberfläche mit hydrophiler Natur selektiv in Gegenwart von Luft flüssigkeitsdurchlässig ist und wobei die Membran an ihrer Oberfläche mit hydrophober Natur in Gegenwart der Flüssigkeit selektiv luftdurchlässig ist, dadurch gekennzeichnet, dass die Membran an ihrer Oberfläche mit hydrophiler Natur in Form von rohrförmigen Flüssigkeitsausstoßfiltern (30; 130) ausgebildet ist, die sich in Längsrichtung im Inneren der Flasche ausgehend von einer perforierten Platte (28) zur Montage (28; 128) durch den Abgabekopf erstrecken, durch den die rohrförmigen Filter (30; 130) nach außen münden, und dass die Membran an ihrer Oberfläche mit hydrophober Natur in Form von einem oder mehreren rohrförmigen Filtern (32; 132) ausgebildet ist und in der Nähe der perforierten Platte (28; 128) angeordnet ist, um zum Einlass von Luft in die Flasche als Ausgleich für die ausgestoßene Flüssigkeit zu dienen.
  2. Flasche nach Anspruch 1, wobei die hydrophobe Membranoberfläche ausgebildet und angeordnet ist, um die Luft zu filtern, die ausgehend von der äußeren Öffnung (22) in die Flasche eingesaugt wird, wodurch der Innenraum der Flasche vor äußeren Verunreinigungen geschützt wird.
  3. Flasche nach Anspruch 1 oder 2, wobei die Filtervorrichtung (26) mehrere rohrförmige Flüssigkeitsausstoßfilter (30) aus einer hydrophilen Membran umfasst, die zu einem Bündel von Kanälen gruppiert sind, die sich in der Achse der Flasche erstrecken, und wobei der oder die hydrophoben rohrförmigen Filter (32, 132), die in Gegenwart der Flüssigkeit selektiv luftdurchlässig sind, getrennt von dem Bündel angeordnet sind, indem sie dieses in der Nähe der perforierten Montageplatte (28; 128) der Filtervorrichtung umgeben.
  4. Flasche nach einem der Ansprüche 1 bis 3, wobei der oder die rohrförmigen Lufteinlassfilter (32, 132) durch die perforierte Platte (28, 128) münden.
  5. Flasche nach einem der Ansprüche 1 bis 4, wobei die Oberfläche mit hydrophober Natur eine bestimmte Fähigkeit zur Filtration von Bakterien aufweist.
  6. Flasche nach den Ansprüchen 3 und 4 oder 5, wobei die Filtervorrichtung einen rohrförmigen Lufteinlassfilter (32) aus einer hydrophoben Membran umfasst und wobei der rohrförmige Lufteinlassfilter aus einer hydrophoben Membran in der Nähe der perforierten Montageplatte (28) der Filtervorrichtungs-Einheit (26) spiralförmig um das Bündel gewickelt ist.
  7. Flasche nach den Ansprüchen 3 und 4 oder 5, wobei die Filtervorrichtung (26) mehrere rohrförmige Lufteinlassfilter (32) aus einer hydrophoben Membran umfasst, die um das Bündel von rohrförmigen Filtern (30) aus einer hydrophilen Membran angeordnet sind und sich in Längsrichtung in der Nähe der perforierten Montageplatte (28) der Filtervorrichtungs-Einheit (26) erstrecken, während die hydrophilen rohrförmigen Luftausstoßfilter (30) derart ausgebildet sind, dass sie tief in der Flasche versenkt sind.
  8. Flasche nach Anspruch 3 und einem der Ansprüche 4 bis 7, wobei das Bündel von rohrförmigen Luftausstoßfiltern (30) von einer mechanisch widerstandsfähigen Führungshülse (34) umgeben ist, die bewirkt, dass sie in Längsrichtung der Flasche gestreckt gehalten werden, wobei die Hülse aus einer nicht perforierten rohrförmigen Wand gebildet ist, um die Zirkulation der Flüssigkeit zu führen, welche die Wand aus einer hydrophilen Membran der rohrförmigen Filter des Bündels entlangströmen soll.
  9. Flasche nach Anspruch 8, wobei die Führungshülse (34) ein Fenster (36) zum Durchlass von Flüssigkeit durch die rohrförmige Wand der Führungshülse (34) aufweist, wenn der Abgabekopf zum Ausstoßen von Flüssigkeit mit dem Kopf nach unten gedreht ist, wobei das Fenster in der Nähe der perforierten Platte (28) angeordnet ist.
  10. Flasche nach Anspruch 9, wobei sich die hydrophobe Membranoberfläche in Form eines rohrförmigen Filters (32) zwischen der perforierten Platte (28) und dem Fenster (36) befindet, indem sie außerhalb der Führungshülse (34), welche die zum Austritt von Flüssigkeit reservierten rohrförmigen Filter (30) aus einer hydrophilen Membran umhüllt, Windungen um die Achse der Flasche bildet.
  11. Flasche nach Anspruch 8, wobei die Führungshülse (34), die das Bündel von rohrförmigen Filtern (30) aus einer hydrophilen Membran umgibt, dem Durchmesser des Halses der Flasche (10) entspricht, auf dem der Abgabekopf (1) montiert ist, wobei sich die hydrophobe rohrförmige Membran für den Lufteinlass nun im Inneren der Führungshülse befindet.
  12. Flasche nach einem der Ansprüche 4 bis 11, wobei sich die Fähigkeit der Wände der rohrförmigen Filter (30, 32) zur Partikelfiltration je nachdem unterscheidet, ob sie dem Flüssigkeitsauslass oder dem Lufteinlass zugeordnet sind, wobei sie bei der hydrophoben Wand, bei der es sich vorzugsweise um eine Membran zur Bakterienfiltration handelt, feiner ist und bei der hydrophilen Wand gröber ist, um die Verteilung von viskosen Lösungen zu erleichtern.
  13. Flasche nach einem der Ansprüche 4 bis 12, wobei die hydrophilen rohrförmigen Filter (130) zum Flüssigkeitsauslass und die hydrophoben rohrförmigen Filter (132) zum Lufteinlass zwischen zwei gegenüberliegenden Enden, wo ihre inneren Kanäle durch die Querplatte (128) münden, jeweils U-förmig auf sich selbst umgebogen sind, wobei die Höhe der hydrophoben rohrförmigen Filter (132) in Längsrichtung kleiner ist als jene der hydrophilen rohrförmigen Filter (130).
  14. Flasche nach einem der Ansprüche 1 bis 13, wobei die rohrförmigen Filter (30; 130; 132) auf sich selbst umgebogen sind, wobei die beiden mündenden Enden (31) von jedem von ihnen in die perforierte Platte (28) versenkt sind, so dass die inneren Kanäle der rohrförmigen Filter an der Oberseite (29) der perforierten Platte (28; 128) münden, um mit dem Äußeren zu kommunizieren.
  15. Flasche nach Anspruch 14, wobei über den mündenden Enden (31) der rohrförmigen Filter die Oberseite (29) der perforierten Platte (28; 128) mit einem schützenden porösen Puffer (24, 124) bedeckt ist, der eine verteilende Wirkung auf die aus der Flasche extrahierte Flüssigkeit aufweist, die sich gruppiert, um einen ausgestoßenen Flüssigkeitstropfen zu bilden.
EP13773332.5A 2012-08-06 2013-08-06 Tropfenspenderausgabekopf Active EP2879966B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1202192A FR2994162B1 (fr) 2012-08-06 2012-08-06 Tete de distribution de liquide, notamment pour flacon de conditionnement d'un liquide a distribuer goutte a goutte
PCT/IB2013/001728 WO2014024029A1 (fr) 2012-08-06 2013-08-06 Tete de distribution de liquide, notamment pour flacon de conditionnement d'un liquide a distribuer goutte a goutte

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EP2879966A1 EP2879966A1 (de) 2015-06-10
EP2879966B1 true EP2879966B1 (de) 2018-02-21

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EP (1) EP2879966B1 (de)
JP (1) JP6250049B2 (de)
KR (1) KR102126807B1 (de)
CN (1) CN104684815B (de)
AR (1) AR092864A1 (de)
AU (1) AU2013301315B2 (de)
BR (1) BR112015002196B8 (de)
CA (1) CA2880175C (de)
CL (1) CL2015000175A1 (de)
CO (1) CO7220325A2 (de)
EA (1) EA028504B1 (de)
ES (1) ES2670051T3 (de)
FR (1) FR2994162B1 (de)
IL (1) IL237022B (de)
MA (1) MA37843B1 (de)
MX (1) MX354026B (de)
MY (1) MY168490A (de)
SG (1) SG11201500894YA (de)
TN (1) TN2015000035A1 (de)
TW (1) TWI584803B (de)
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ES2986689T3 (es) * 2015-03-31 2024-11-12 Thea Lab Dispositivo dispensador de líquido desde un frasco de envasado estéril con membrana bifuncional
WO2016187230A1 (en) * 2015-05-18 2016-11-24 Cascade Designs, Inc. Water-treating bottle
PH12022551159A1 (en) 2016-01-22 2023-05-08 Baxter Healthcare Sa Method and machine for producing sterile solution product bags
RU2732111C2 (ru) 2016-01-22 2020-09-11 Бакстер Интернэшнл Инк. Мешок для стерильного раствора продукта
CN106389002B (zh) * 2016-09-28 2019-08-30 尹振图 一种滴液瓶嘴及眼药水瓶
KR101806524B1 (ko) * 2016-10-31 2017-12-07 (주)아모레퍼시픽 화장품 용기
JP6976469B1 (ja) * 2021-04-26 2021-12-08 さち子 松山 目薬容器

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Publication number Priority date Publication date Assignee Title
EP0617951A2 (de) * 1993-03-31 1994-10-05 Tomey Technology Corporation Tragbare Vorrichtung zum Reinigen von Flüssigkeiten
WO2011095877A1 (fr) * 2010-02-04 2011-08-11 Laboratoires Thea Flacon de conditionnement d'un liquide à tête de distribution goutte a goutte

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JPS62127063A (ja) * 1985-11-27 1987-06-09 ト−メ−産業株式会社 点眼容器
US5105993A (en) * 1989-12-29 1992-04-21 La Haye Laboratories, Inc. Disposable medical dispenser with a filtering dispenser nozzle
FR2770495B1 (fr) * 1997-11-04 1999-12-24 Transphyto Sa Dispositif de conditionnement pour liquide a distribuer goutte a goutte
EP1423334A4 (de) * 2001-08-10 2007-09-26 Innova Pure Water Inc Hohlfasermembranfilter in verschiedenen behältern
US20040074529A1 (en) * 2002-10-21 2004-04-22 Robert Levy Self-contained and ventilated temporary shelter
FR2872137B1 (fr) * 2004-06-24 2009-01-23 Thea Sa Lab Recipient pour le conditionnement d'un liquide a distributeur goutte a goutte, a deformation reversible par admission d'air
US7604737B2 (en) * 2007-01-25 2009-10-20 Acuity/Sparkle, Ltd. (Cayman) Water filter device for use with individual containers
FR2963326B1 (fr) * 2010-07-30 2012-09-07 Rexam Healthcare La Verpillier Embout et recipient de distribution de liquide
TW201225948A (en) * 2010-12-22 2012-07-01 Rexam Healthcare La Verpillier A liquid dispenser device

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0617951A2 (de) * 1993-03-31 1994-10-05 Tomey Technology Corporation Tragbare Vorrichtung zum Reinigen von Flüssigkeiten
WO2011095877A1 (fr) * 2010-02-04 2011-08-11 Laboratoires Thea Flacon de conditionnement d'un liquide à tête de distribution goutte a goutte

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EA028504B1 (ru) 2017-11-30
KR20150041108A (ko) 2015-04-15
ES2670051T3 (es) 2018-05-29
WO2014024029A1 (fr) 2014-02-13
MA20150155A1 (fr) 2015-05-29
UA114206C2 (uk) 2017-05-10
CO7220325A2 (es) 2015-03-20
AU2013301315B2 (en) 2016-11-03
TWI584803B (zh) 2017-06-01
MX2015001668A (es) 2015-04-10
US9487339B2 (en) 2016-11-08
HK1210449A1 (zh) 2016-04-22
MY168490A (en) 2018-11-09
JP2015532613A (ja) 2015-11-12
BR112015002196B1 (pt) 2021-07-13
AR092864A1 (es) 2015-05-06
SG11201500894YA (en) 2015-04-29
TN2015000035A1 (fr) 2016-06-29
CN104684815A (zh) 2015-06-03
FR2994162B1 (fr) 2014-09-05
TW201410234A (zh) 2014-03-16
CN104684815B (zh) 2016-08-31
MA37843B1 (fr) 2016-04-29
BR112015002196A2 (pt) 2017-07-04
CL2015000175A1 (es) 2015-07-10
US20150284173A1 (en) 2015-10-08
EA201590334A1 (ru) 2015-05-29
BR112015002196B8 (pt) 2021-09-14
FR2994162A1 (fr) 2014-02-07
AU2013301315A1 (en) 2015-02-26
CA2880175C (fr) 2021-07-20
MX354026B (es) 2018-02-07
IL237022B (en) 2019-02-28
CA2880175A1 (fr) 2014-02-13
JP6250049B2 (ja) 2017-12-20
EP2879966A1 (de) 2015-06-10
KR102126807B1 (ko) 2020-06-25

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