EP2881465A4 - An eine etikettabfolge angehängte zweidimensionale cdns-bibliothek sowie genexpressionsanalyseverfahren und genexpressionsanalysevorrichtung damit - Google Patents
An eine etikettabfolge angehängte zweidimensionale cdns-bibliothek sowie genexpressionsanalyseverfahren und genexpressionsanalysevorrichtung damitInfo
- Publication number
- EP2881465A4 EP2881465A4 EP12882489.3A EP12882489A EP2881465A4 EP 2881465 A4 EP2881465 A4 EP 2881465A4 EP 12882489 A EP12882489 A EP 12882489A EP 2881465 A4 EP2881465 A4 EP 2881465A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- gene expression
- expression analysis
- device connected
- same
- label sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1096—Processes for the isolation, preparation or purification of DNA or RNA cDNA Synthesis; Subtracted cDNA library construction, e.g. RT, RT-PCR
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Chemical Kinetics & Catalysis (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2012/069303 WO2014020657A1 (ja) | 2012-07-30 | 2012-07-30 | タグ配列付き2次元cDNAライブラリーデバイス、並びにこれを用いた遺伝子発現解析方法及び遺伝子発現解析装置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP2881465A1 EP2881465A1 (de) | 2015-06-10 |
| EP2881465A4 true EP2881465A4 (de) | 2016-04-20 |
| EP2881465B1 EP2881465B1 (de) | 2018-07-04 |
Family
ID=50027390
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP12882489.3A Active EP2881465B1 (de) | 2012-07-30 | 2012-07-30 | An eine etikettabfolge angehängte zweidimensionale cdns-bibliothek sowie genexpressionsanalyseverfahren und genexpressionsanalysevorrichtung damit |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11053536B2 (de) |
| EP (1) | EP2881465B1 (de) |
| JP (1) | JP5997278B2 (de) |
| CN (2) | CN110079585A (de) |
| WO (1) | WO2014020657A1 (de) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201106254D0 (en) | 2011-04-13 | 2011-05-25 | Frisen Jonas | Method and product |
| US9593365B2 (en) | 2012-10-17 | 2017-03-14 | Spatial Transcriptions Ab | Methods and product for optimising localised or spatial detection of gene expression in a tissue sample |
| DK3013983T3 (da) | 2013-06-25 | 2023-03-06 | Prognosys Biosciences Inc | Spatialt kodede biologiske assays ved brug af en mikrofluidisk anordning |
| WO2016001963A1 (ja) * | 2014-06-30 | 2016-01-07 | 株式会社日立製作所 | 核酸解析用アレイデバイス、核酸解析装置及び核酸解析方法 |
| WO2016038670A1 (ja) * | 2014-09-09 | 2016-03-17 | 株式会社日立製作所 | 細胞解析装置およびそれを用いた細胞解析方法 |
| JP6307179B2 (ja) | 2015-02-03 | 2018-04-04 | 株式会社日立製作所 | 単一細胞解析用フローセルデバイス及び単一細胞解析装置 |
| WO2016125254A1 (ja) * | 2015-02-03 | 2016-08-11 | 株式会社日立製作所 | 細胞処理デバイス、及び細胞処理システム |
| WO2016151719A1 (ja) * | 2015-03-23 | 2016-09-29 | 株式会社日立製作所 | 核酸反応デバイス |
| US10876106B2 (en) * | 2015-04-09 | 2020-12-29 | Hitachi, Ltd. | Gene analysis system |
| CN120425026A (zh) | 2015-04-10 | 2025-08-05 | 十程基因技术瑞典公司 | 生物样本的空间区别、多重核酸分析 |
| JP2018518157A (ja) * | 2015-05-11 | 2018-07-12 | イラミーナ インコーポレーテッド | 治療薬剤の発見および分析のためのプラットフォーム |
| JP6500119B2 (ja) * | 2015-09-30 | 2019-04-10 | 株式会社日立製作所 | 細胞解析装置およびそれを用いた細胞解析方法 |
| WO2017056251A1 (ja) * | 2015-09-30 | 2017-04-06 | 株式会社日立製作所 | 分析方法および分析用デバイス |
| WO2017094101A1 (ja) | 2015-12-01 | 2017-06-08 | 株式会社日立ハイテクノロジーズ | 細胞解析デバイス、装置およびそれを用いた細胞解析方法 |
| SG10202108763UA (en) | 2015-12-04 | 2021-09-29 | 10X Genomics Inc | Methods and compositions for nucleic acid analysis |
| JP6609530B2 (ja) * | 2016-09-05 | 2019-11-20 | 株式会社日立製作所 | 単一細胞解析用システム |
| EP3553158B1 (de) | 2016-12-07 | 2024-11-20 | Tokyo Ohka Kogyo Co., Ltd. | Partikelfangvorrichtung |
| WO2018134907A1 (ja) * | 2017-01-18 | 2018-07-26 | 株式会社日立ハイテクノロジーズ | 同一細胞複数生体分子抽出装置および方法 |
| US11519033B2 (en) | 2018-08-28 | 2022-12-06 | 10X Genomics, Inc. | Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample |
| US20220290217A1 (en) | 2018-12-10 | 2022-09-15 | 10X Genomics, Inc. | Resolving spatial arrays using deconvolution |
| US11649485B2 (en) | 2019-01-06 | 2023-05-16 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| US11926867B2 (en) | 2019-01-06 | 2024-03-12 | 10X Genomics, Inc. | Generating capture probes for spatial analysis |
| WO2020243564A1 (en) * | 2019-05-30 | 2020-12-03 | Beckman Coulter, Inc. | Methods and systems for immobilizing a biological specimen for microscopic imaging |
| EP3976820A1 (de) | 2019-05-30 | 2022-04-06 | 10X Genomics, Inc. | Verfahren zum nachweis der räumlichen heterogenität einer biologischen probe |
| US12157124B2 (en) | 2019-11-06 | 2024-12-03 | 10X Genomics, Inc. | Imaging system hardware |
| EP4055185A1 (de) | 2019-11-08 | 2022-09-14 | 10X Genomics, Inc. | Räumlich markierte analytfänger für analyt-multiplexing |
| WO2021092433A2 (en) | 2019-11-08 | 2021-05-14 | 10X Genomics, Inc. | Enhancing specificity of analyte binding |
| CN121022991A (zh) | 2019-12-23 | 2025-11-28 | 10X基因组学有限公司 | 使用rna模板化连接进行空间分析的方法 |
| EP4081777B1 (de) | 2019-12-23 | 2026-02-18 | 10X Genomics, Inc. | Reversible fixierreagenzien und verfahren zu deren verwendung |
| EP4081656A1 (de) | 2019-12-23 | 2022-11-02 | 10X Genomics, Inc. | Zusammensetzungen und verfahren zur verwendung von fixierten biologischen proben bei partitionsbasierten tests |
| US12365942B2 (en) | 2020-01-13 | 2025-07-22 | 10X Genomics, Inc. | Methods of decreasing background on a spatial array |
| US12405264B2 (en) | 2020-01-17 | 2025-09-02 | 10X Genomics, Inc. | Electrophoretic system and method for analyte capture |
| US11702693B2 (en) | 2020-01-21 | 2023-07-18 | 10X Genomics, Inc. | Methods for printing cells and generating arrays of barcoded cells |
| US11732299B2 (en) | 2020-01-21 | 2023-08-22 | 10X Genomics, Inc. | Spatial assays with perturbed cells |
| US20210230681A1 (en) | 2020-01-24 | 2021-07-29 | 10X Genomics, Inc. | Methods for spatial analysis using proximity ligation |
| US11821035B1 (en) | 2020-01-29 | 2023-11-21 | 10X Genomics, Inc. | Compositions and methods of making gene expression libraries |
| US12076701B2 (en) | 2020-01-31 | 2024-09-03 | 10X Genomics, Inc. | Capturing oligonucleotides in spatial transcriptomics |
| US12110541B2 (en) | 2020-02-03 | 2024-10-08 | 10X Genomics, Inc. | Methods for preparing high-resolution spatial arrays |
| US11898205B2 (en) | 2020-02-03 | 2024-02-13 | 10X Genomics, Inc. | Increasing capture efficiency of spatial assays |
| US11732300B2 (en) | 2020-02-05 | 2023-08-22 | 10X Genomics, Inc. | Increasing efficiency of spatial analysis in a biological sample |
| WO2021158925A1 (en) | 2020-02-07 | 2021-08-12 | 10X Genomics, Inc. | Quantitative and automated permeabilization performance evaluation for spatial transcriptomics |
| US20230066282A1 (en) * | 2020-02-14 | 2023-03-02 | Sony Group Corporation | Analysis method, analysis system, and analysis surface |
| US12399123B1 (en) | 2020-02-14 | 2025-08-26 | 10X Genomics, Inc. | Spatial targeting of analytes |
| US12281357B1 (en) | 2020-02-14 | 2025-04-22 | 10X Genomics, Inc. | In situ spatial barcoding |
| US11891654B2 (en) | 2020-02-24 | 2024-02-06 | 10X Genomics, Inc. | Methods of making gene expression libraries |
| US11926863B1 (en) | 2020-02-27 | 2024-03-12 | 10X Genomics, Inc. | Solid state single cell method for analyzing fixed biological cells |
| US11768175B1 (en) | 2020-03-04 | 2023-09-26 | 10X Genomics, Inc. | Electrophoretic methods for spatial analysis |
| AU2021248806A1 (en) * | 2020-03-31 | 2022-10-13 | Personal Genome Diagnostics Inc. | Compositions and methods for nucleic acid quality determination |
| WO2021216708A1 (en) | 2020-04-22 | 2021-10-28 | 10X Genomics, Inc. | Methods for spatial analysis using targeted rna depletion |
| CN116134308B (zh) | 2020-05-19 | 2025-05-27 | 10X基因组学有限公司 | 电泳盒和仪器 |
| EP4414459B1 (de) | 2020-05-22 | 2025-09-03 | 10X Genomics, Inc. | Simultane räumlich-zeitliche messung der genexpression und der zellaktivität |
| WO2021237087A1 (en) | 2020-05-22 | 2021-11-25 | 10X Genomics, Inc. | Spatial analysis to detect sequence variants |
| WO2021242834A1 (en) | 2020-05-26 | 2021-12-02 | 10X Genomics, Inc. | Method for resetting an array |
| US12265079B1 (en) | 2020-06-02 | 2025-04-01 | 10X Genomics, Inc. | Systems and methods for detecting analytes from captured single biological particles |
| EP4158054B1 (de) | 2020-06-02 | 2025-04-16 | 10X Genomics, Inc. | Räumliche transkriptomik für antigenrezeptoren |
| WO2021247543A2 (en) | 2020-06-02 | 2021-12-09 | 10X Genomics, Inc. | Nucleic acid library methods |
| US12031177B1 (en) | 2020-06-04 | 2024-07-09 | 10X Genomics, Inc. | Methods of enhancing spatial resolution of transcripts |
| WO2021252499A1 (en) | 2020-06-08 | 2021-12-16 | 10X Genomics, Inc. | Methods of determining a surgical margin and methods of use thereof |
| US12435363B1 (en) | 2020-06-10 | 2025-10-07 | 10X Genomics, Inc. | Materials and methods for spatial transcriptomics |
| EP4446430A3 (de) | 2020-06-10 | 2024-12-18 | 10X Genomics, Inc. | Verfahren zur bestimmung einer position eines analyten in einer biologischen probe |
| WO2021252747A1 (en) | 2020-06-10 | 2021-12-16 | 1Ox Genomics, Inc. | Fluid delivery methods |
| WO2021263111A1 (en) | 2020-06-25 | 2021-12-30 | 10X Genomics, Inc. | Spatial analysis of dna methylation |
| US12209280B1 (en) | 2020-07-06 | 2025-01-28 | 10X Genomics, Inc. | Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis |
| US11981960B1 (en) | 2020-07-06 | 2024-05-14 | 10X Genomics, Inc. | Spatial analysis utilizing degradable hydrogels |
| US11761038B1 (en) | 2020-07-06 | 2023-09-19 | 10X Genomics, Inc. | Methods for identifying a location of an RNA in a biological sample |
| US12553898B1 (en) | 2020-08-10 | 2026-02-17 | 10X Genomics, Inc. | Fluorescent hybridization of antibody-oligonucleotide for multiplexing and signal amplification |
| US11981958B1 (en) | 2020-08-20 | 2024-05-14 | 10X Genomics, Inc. | Methods for spatial analysis using DNA capture |
| WO2022061150A2 (en) | 2020-09-18 | 2022-03-24 | 10X Geonomics, Inc. | Sample handling apparatus and image registration methods |
| US11926822B1 (en) | 2020-09-23 | 2024-03-12 | 10X Genomics, Inc. | Three-dimensional spatial analysis |
| US11827935B1 (en) | 2020-11-19 | 2023-11-28 | 10X Genomics, Inc. | Methods for spatial analysis using rolling circle amplification and detection probes |
| CN114574360B (zh) * | 2020-12-01 | 2025-02-11 | 中国科学院大连化学物理研究所 | 基于石英内衬管阵列的细胞操作装置及方法 |
| EP4121555B1 (de) | 2020-12-21 | 2026-02-25 | 10X Genomics, Inc. | Verfahren zur erfassung von sonden und/oder barcodes |
| EP4421491A3 (de) | 2021-02-19 | 2024-11-27 | 10X Genomics, Inc. | Verfahren zur verwendung einer modularen testträgervorrichtung |
| AU2022238446A1 (en) | 2021-03-18 | 2023-09-07 | 10X Genomics, Inc. | Multiplex capture of gene and protein expression from a biological sample |
| EP4428246B1 (de) | 2021-04-14 | 2025-12-24 | 10X Genomics, Inc. | Verfahren zur messung der fehllokalisierung eines analyten |
| EP4320271B1 (de) | 2021-05-06 | 2025-03-19 | 10X Genomics, Inc. | Verfahren zur erhöhung der auflösung von räumlicher analyse |
| WO2022256503A1 (en) | 2021-06-03 | 2022-12-08 | 10X Genomics, Inc. | Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis |
| US12553805B2 (en) | 2021-08-02 | 2026-02-17 | 10X Genomics, Inc. | Methods of preserving a biological sample |
| EP4196605B1 (de) | 2021-09-01 | 2024-12-04 | 10X Genomics, Inc. | Verfahren zur blockierung einer erfassungssonde auf einer räumlichen anordnung |
| USD1064308S1 (en) | 2021-09-17 | 2025-02-25 | 10X Genomics, Inc. | Sample handling device |
| WO2023086880A1 (en) | 2021-11-10 | 2023-05-19 | 10X Genomics, Inc. | Methods, compositions, and kits for determining the location of an analyte in a biological sample |
| WO2023102118A2 (en) | 2021-12-01 | 2023-06-08 | 10X Genomics, Inc. | Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis |
| EP4441711A1 (de) | 2021-12-20 | 2024-10-09 | 10X Genomics, Inc. | Selbsttest für eine pathologie-/histologie-objektträgerbildgebungsvorrichtung |
| JP2023183556A (ja) | 2022-06-16 | 2023-12-28 | 株式会社日立製作所 | 単一細胞解析用容器及びそれを用いた単一細胞解析方法 |
| WO2024102809A1 (en) | 2022-11-09 | 2024-05-16 | 10X Genomics, Inc. | Methods, compositions, and kits for determining the location of multiple analytes in a biological sample |
| KR102954407B1 (ko) | 2023-07-19 | 2026-04-20 | 서울대학교병원 | 폐암 stas 검출 장치 및 방법 |
| JP2025187393A (ja) * | 2024-06-13 | 2025-12-25 | 株式会社日立製作所 | Ｔ細胞受容体（ｔｃｒ）またはｂ細胞受容体（ｂｃｒ）の遺伝子検査方法および遺伝子検査キット |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010046073A (ja) * | 2001-10-24 | 2010-03-04 | Sention Inc | 動的遺伝子発現プロファイリング方法及びシステム |
| WO2011068088A1 (ja) * | 2009-12-04 | 2011-06-09 | 株式会社日立製作所 | ２次元cDNAライブラリを用いた遺伝子発現解析方法 |
| WO2012140224A1 (en) * | 2011-04-13 | 2012-10-18 | Jonas Frisen | Method and product for localised or spatial detection of nucleic acid in a tissue sample |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1537954A (zh) * | 2003-04-18 | 2004-10-20 | ������������ʽ���� | 表达基因分析方法以及用于表达基因分析的探针试剂盒 |
| WO2005106035A2 (en) * | 2004-04-09 | 2005-11-10 | Cornell Research Foundation, Inc. | Modular design and construction of nucleic acid molecules, aptamer-derived nucleic acid constructs, rna scaffolds, their expression, and methods of use |
| US20100105104A1 (en) * | 2007-03-05 | 2010-04-29 | On-Chip Cellomics Consortium | Chip for sampling cell component, system for analyzing cell component and method of analyzing cell component using the same |
| US8314052B2 (en) * | 2009-03-23 | 2012-11-20 | Base Pair Biotechnologies, Inc. | Methods for simultaneous generation of functional ligands |
| WO2012129363A2 (en) * | 2011-03-24 | 2012-09-27 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
-
2012
- 2012-07-30 JP JP2014527831A patent/JP5997278B2/ja active Active
- 2012-07-30 CN CN201910366401.1A patent/CN110079585A/zh active Pending
- 2012-07-30 US US14/418,135 patent/US11053536B2/en active Active
- 2012-07-30 EP EP12882489.3A patent/EP2881465B1/de active Active
- 2012-07-30 CN CN201280074958.4A patent/CN104508128A/zh active Pending
- 2012-07-30 WO PCT/JP2012/069303 patent/WO2014020657A1/ja not_active Ceased
-
2021
- 2021-05-18 US US17/323,311 patent/US11680286B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010046073A (ja) * | 2001-10-24 | 2010-03-04 | Sention Inc | 動的遺伝子発現プロファイリング方法及びシステム |
| WO2011068088A1 (ja) * | 2009-12-04 | 2011-06-09 | 株式会社日立製作所 | ２次元cDNAライブラリを用いた遺伝子発現解析方法 |
| WO2012140224A1 (en) * | 2011-04-13 | 2012-10-18 | Jonas Frisen | Method and product for localised or spatial detection of nucleic acid in a tissue sample |
Non-Patent Citations (2)
| Title |
|---|
| EGUÃLUZ ET AL: "Multitissue array review: a chronological description of tissue array techniques, applications and procedures", PATHOLOGY, RESEARCH AND PRACTICE, vol. 202, no. 8, 1 January 2006 (2006-01-01), pages 561, XP055044030, ISSN: 0344-0338, DOI: 10.1016/j.prp.2006.04.003 * |
| See also references of WO2014020657A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| US11680286B2 (en) | 2023-06-20 |
| US11053536B2 (en) | 2021-07-06 |
| JPWO2014020657A1 (ja) | 2016-07-11 |
| WO2014020657A1 (ja) | 2014-02-06 |
| EP2881465A1 (de) | 2015-06-10 |
| JP5997278B2 (ja) | 2016-09-28 |
| US20150167063A1 (en) | 2015-06-18 |
| CN104508128A (zh) | 2015-04-08 |
| CN110079585A (zh) | 2019-08-02 |
| EP2881465B1 (de) | 2018-07-04 |
| US20210388422A1 (en) | 2021-12-16 |
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