EP2885433A4 - Verfahren zum nachweis von non-sense-mutationen des hepatitis-b-virus-oberflächengens - Google Patents

Verfahren zum nachweis von non-sense-mutationen des hepatitis-b-virus-oberflächengens

Info

Publication number
EP2885433A4
EP2885433A4 EP13830315.1A EP13830315A EP2885433A4 EP 2885433 A4 EP2885433 A4 EP 2885433A4 EP 13830315 A EP13830315 A EP 13830315A EP 2885433 A4 EP2885433 A4 EP 2885433A4
Authority
EP
European Patent Office
Prior art keywords
hepatitis
methods
virus surface
detecting non
sense mutations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP13830315.1A
Other languages
English (en)
French (fr)
Other versions
EP2885433A2 (de
Inventor
Shiu-Feng Huang
Chau-Ting Yeh
Ya-Ting Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Health Research Institutes
Original Assignee
National Health Research Institutes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Health Research Institutes filed Critical National Health Research Institutes
Publication of EP2885433A2 publication Critical patent/EP2885433A2/de
Publication of EP2885433A4 publication Critical patent/EP2885433A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/103—Nucleic acid detection characterized by the use of physical, structural and functional properties luminescence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/08—Hepato-biliairy disorders other than hepatitis
    • G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP13830315.1A 2012-08-19 2013-06-06 Verfahren zum nachweis von non-sense-mutationen des hepatitis-b-virus-oberflächengens Withdrawn EP2885433A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261684766P 2012-08-19 2012-08-19
PCT/US2013/044619 WO2014031211A2 (en) 2012-08-19 2013-06-06 Methods for detecting hepatitis b virus surface gene non-sense mutations

Publications (2)

Publication Number Publication Date
EP2885433A2 EP2885433A2 (de) 2015-06-24
EP2885433A4 true EP2885433A4 (de) 2016-04-06

Family

ID=50100291

Family Applications (1)

Application Number Title Priority Date Filing Date
EP13830315.1A Withdrawn EP2885433A4 (de) 2012-08-19 2013-06-06 Verfahren zum nachweis von non-sense-mutationen des hepatitis-b-virus-oberflächengens

Country Status (6)

Country Link
US (1) US9163290B2 (de)
EP (1) EP2885433A4 (de)
KR (1) KR101918342B1 (de)
CN (2) CN111850163B (de)
TW (1) TWI565802B (de)
WO (1) WO2014031211A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113201051B (zh) * 2021-04-27 2022-08-02 复旦大学 一种乙肝病毒表面蛋白突变体及其在抗乙肝病毒中的应用
CN116732243A (zh) * 2023-04-04 2023-09-12 赛立安生物技术(广州)有限公司 一种用于检测hbv前s/s区基因突变的引物组、检测方法及其试剂盒

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100304378A1 (en) * 2007-09-17 2010-12-02 Universite De Strasbourg Method for Detecting or Quantifying a Truncating Mutation
JP2012090571A (ja) * 2010-10-27 2012-05-17 Sekisui Chem Co Ltd 動物の免疫方法、免疫用組成物、抗体の製造方法、並びに、ハイブリドーマの製造方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7312060B2 (en) 1999-08-25 2007-12-25 Ambergen, Inc. Methods for the detection, analysis and isolation of nascent proteins
US6969583B2 (en) * 2000-02-03 2005-11-29 Melbourne Health Method for detecting variant HBV
CA2351018A1 (en) * 2001-07-09 2003-01-09 Universite De Sherbrooke Dna vaccine against staphylococcus aureus
US20050053916A1 (en) 2002-10-01 2005-03-10 Korba Brent E. Diagnostic for long term response of HBV carrier to 3TC therapy
JPWO2005085436A1 (ja) 2004-03-05 2007-12-13 大塚製薬株式会社 Ｂ型肝炎ウィルスによる発癌の検出法
AU2006230802A1 (en) * 2005-04-08 2006-10-12 Austin Health Variants of hepatitis B virus with resistance to anti-viral nucleoside agents and applications thereof
WO2007109564A2 (en) * 2006-03-17 2007-09-27 University Of Massachusetts Yeast cell particles as oral delivery vehicles for antigens
WO2009042956A1 (en) * 2007-09-26 2009-04-02 The Trustees Of Columbia University In The City Of New York Control of spore germination
US20090264298A1 (en) * 2007-11-06 2009-10-22 Ambergen, Inc. Methods for enriching subpopulations
US20090280474A1 (en) * 2008-05-08 2009-11-12 Abbott Laboratories Method for detecting a virus

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100304378A1 (en) * 2007-09-17 2010-12-02 Universite De Strasbourg Method for Detecting or Quantifying a Truncating Mutation
JP2012090571A (ja) * 2010-10-27 2012-05-17 Sekisui Chem Co Ltd 動物の免疫方法、免疫用組成物、抗体の製造方法、並びに、ハイブリドーマの製造方法

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DU ET AL: "Rapid screen for truncating ATM mutations by PTT-ELISA", MUTATION RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 640, no. 1-2, 31 January 2008 (2008-01-31), pages 139 - 144, XP022527908, ISSN: 0027-5107, DOI: 10.1016/J.MRFMMM.2008.01.002 *
GARVIN A M ET AL: "MALDI-TOF based mutation detection using tagged in vitro synthesized peptides", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, US, vol. 18, no. 1, 1 January 2000 (2000-01-01), pages 95 - 97, XP002308554, ISSN: 1087-0156, DOI: 10.1038/72013 *
KAHMANN S ET AL: "A NON-RADIOACTIVE PROTEIN TRUNCATION TEST FOR THE SENSITIVE DETECTION OF ALL STOP AND FRAMESHIFT MUTATIONS", HUMAN MUTATION, JOHN WILEY & SONS, INC, US, vol. 19, no. 2, 1 January 2002 (2002-01-01), pages 165 - 172, XP009005892, ISSN: 1059-7794, DOI: 10.1002/HUMU.10024 *
MING-WEI LAI ET AL: "Identification of nonsense mutations in hepatitis B virus S gene in patients with hepatocellular carcinoma developed after lamivudine therapy", ANTIVIRAL THERAPY- AN OFFICIAL PUBLICATION OF THE INTERNATIONAL SOCIETY FOR ANTIVIRAL RESEARCH, vol. 14, no. 2, 1 January 2009 (2009-01-01), GB, pages 249 - 261, XP055253048, ISSN: 1359-6535 *
ROWAN A J ET AL: "INTRODUCTION OF A MYC REPORTER TAG TO IMPROVE THE QUALITY OF MUTATION DETECTION USING THE PROTEIN TRUNCATION TEST", HUMAN MUTATION, JOHN WILEY & SONS, INC, US, vol. 9, no. 2, 1 January 1997 (1997-01-01), pages 172 - 176, XP009006084, ISSN: 1059-7794 *
TRAVERSO G ET AL: "DETECTION OF APC MUTATIONS IN FECAL DNA FROM PATIENTS WITH COLORECTAL TUMORS", NEW ENGLAND JOURNAL OF MEDICINE, THE - NEJM, MASSACHUSETTS MEDICAL SOCIETY, US, vol. 346, no. 5, 31 January 2002 (2002-01-31), pages 311 - 320, XP009031611, ISSN: 1533-4406, DOI: 10.1056/NEJMOA012294 *

Also Published As

Publication number Publication date
EP2885433A2 (de) 2015-06-24
CN111850163A (zh) 2020-10-30
TW201416455A (zh) 2014-05-01
KR101918342B1 (ko) 2019-01-29
KR20150041637A (ko) 2015-04-16
CN111850163B (zh) 2024-08-06
WO2014031211A3 (en) 2014-10-16
WO2014031211A2 (en) 2014-02-27
TWI565802B (zh) 2017-01-11
CN104937114A (zh) 2015-09-23
US9163290B2 (en) 2015-10-20
US20140051065A1 (en) 2014-02-20

Similar Documents

Publication Publication Date Title
IL293362B1 (en) Broadly-neutralizing anti-hiv antibodies
EP2854832A4 (de) Modulation der hepatitis-b-virus-cccdns-transkription
IL252446A0 (en) Inhibitors of hepatitis c virus
EP2855680A4 (de) Zusammensetzungen und verfahren zur ausschaltung einer genexpression
DK3553174T3 (da) Rna-guided modificering af humant genom
ZA201404061B (en) Compositions and methods for treating the hepatitis c virus
EP2900595A4 (de) Kohlenstoffnanostrukturen und verfahren zur herstellung davon
EP2951319A4 (de) Verfahren zur genomanordnung und haplotypen-phasierung
EP2814983A4 (de) Verfahren zur erzeugung von doppelschichten zur verwendung mit nanoporensensoren
DK2828386T3 (da) RNA-STYRET DNA-SPALTNING VED HJÆLP AF Cas9-crRNA-KOMPLEKSET
EP2812040A4 (de) Erzeugnisse mit tantalbeschichteten nanostrukturen sowie verfahren zu ihrer herstellung und verwendung
GB2505104B (en) Malware detection
EP2890403A4 (de) Verfahren zur behandlung von hepatitis-b-und hepatitis-d-infektionen
EP2838535A4 (de) Zusammensetzungen und verfahren zur hemmung der viralen polymerase
IL227789A0 (en) Hepatitis c virus inhibitors
IL229270A0 (en) Hepatitis c virus inhibitors
EP2768517A4 (de) Hemmer des hepatitis-c-virus
EP2929973A4 (de) Verfahren für lichtbogenschweissen in schutzgas mit kleinem bandabstand
EP2885074A4 (de) Oberflächenoxidentfernungsverfahren
ZA201503458B (en) Hepatitis c virus inhibitors
EP2847130A4 (de) Zusammensetzungen, verfahren und systeme zur trennung von nanostrukturen auf kohlenstoffbasis
EP2904119A4 (de) Verfahren für mit dem dna-erfassungspfad assoziierten leiden
EP2663328A4 (de) Rekombinanten des infektiösen hepatitis e-virus vom genotyp 3
ZA201401400B (en) Assay for detection of jc virus dna
DK2555872T3 (da) Anordning til påvisning af nukleinsyrer

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 20150216

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20160308

RIC1 Information provided on ipc code assigned before grant

Ipc: C12Q 1/70 20060101AFI20160302BHEP

Ipc: C12Q 1/68 20060101ALI20160302BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20161011