EP2968407A4 - Individualisierte darmkrebsstammzellen von hoher reinheit, verfahren und verwendung davon - Google Patents

Individualisierte darmkrebsstammzellen von hoher reinheit, verfahren und verwendung davon Download PDF

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Publication number
EP2968407A4
EP2968407A4 EP14779579.3A EP14779579A EP2968407A4 EP 2968407 A4 EP2968407 A4 EP 2968407A4 EP 14779579 A EP14779579 A EP 14779579A EP 2968407 A4 EP2968407 A4 EP 2968407A4
Authority
EP
European Patent Office
Prior art keywords
methods
stem cells
same
high purity
colon carcinoma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP14779579.3A
Other languages
English (en)
French (fr)
Other versions
EP2968407A1 (de
Inventor
Candace Y. HSIEH
Andrew N. CORNFORTH
Gabriel Nistor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NeoStem Oncology LLC
Original Assignee
NeoStem Oncology LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2013/053850 external-priority patent/WO2014028274A1/en
Application filed by NeoStem Oncology LLC filed Critical NeoStem Oncology LLC
Publication of EP2968407A1 publication Critical patent/EP2968407A1/de
Publication of EP2968407A4 publication Critical patent/EP2968407A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/13—Tumour cells, irrespective of tissue of origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/193—Colony stimulating factors [CSF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/19—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/428—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C12N5/0695—Stem cells; Progenitor cells; Precursor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/50—Colon

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP14779579.3A 2013-03-13 2014-03-12 Individualisierte darmkrebsstammzellen von hoher reinheit, verfahren und verwendung davon Withdrawn EP2968407A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361778991P 2013-03-13 2013-03-13
PCT/US2013/053850 WO2014028274A1 (en) 2012-08-15 2013-08-06 Rapid method production high purity cancer stem cells and population of high purity cancer stem cells
PCT/US2014/024382 WO2014165101A1 (en) 2013-03-13 2014-03-12 Individualized high purity colon carcinoma stem cells, methods and use of the same

Publications (2)

Publication Number Publication Date
EP2968407A1 EP2968407A1 (de) 2016-01-20
EP2968407A4 true EP2968407A4 (de) 2017-01-04

Family

ID=51659063

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14779579.3A Withdrawn EP2968407A4 (de) 2013-03-13 2014-03-12 Individualisierte darmkrebsstammzellen von hoher reinheit, verfahren und verwendung davon

Country Status (3)

Country Link
EP (1) EP2968407A4 (de)
AU (1) AU2014248711A1 (de)
WO (1) WO2014165101A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3189133A4 (de) * 2014-09-04 2018-04-11 Agency for Science, Technology and Research Verfahren zur aufwärtsregelung von krebsstammzellenmarkern zur erzeugung von antigenspezifischen cytotoxischen effektor-t-zellen
US20180133327A1 (en) * 2015-03-16 2018-05-17 Amal Therapeutics Sa Cell Penetrating Peptides and Complexes Comprising the Same
EP3208331A1 (de) * 2016-02-17 2017-08-23 PromoCell bioscience alive GmbH Biomedizinische Produkte Chemisch definiertes medium für die kultur von krebsstammzellen (csc) enthaltende zellpopulationen
PL3429618T3 (pl) 2016-03-16 2024-07-01 Amal Therapeutics Sa Kombinacja modulatora immunologicznego punktu kontrolnego i kompleks zawierający peptyd penetrujący komórkę, cargo i agonistę peptydu tlr do zastosowania w medycynie
HUE067838T2 (hu) 2016-09-21 2024-11-28 Amal Therapeutics Sa Egy sejtpenetráló peptidet, egy multiepitópot és egy TLR peptidagonistát tartalmazó fúzió rák kezelésére

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2700573C (en) * 2006-09-26 2016-11-22 Cedars-Sinai Medical Center Cancer stem cell antigen vaccines and methods
CA2675521C (en) * 2007-01-22 2016-04-26 Raven Biotechnologies Human cancer stem cells
US20110313229A1 (en) * 2008-07-24 2011-12-22 Kiminobu Sugaya Therapy Targeting Cancer Stem Cells
JP6230789B2 (ja) * 2010-10-06 2017-11-15 中外製薬株式会社 癌幹細胞集団及びその作製方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEN WANGXUE ET AL: "Dendritic cell-based cancer immunotherapy: Potential for treatment of colorectal cancer?", JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, vol. 15, no. 7, July 2000 (2000-07-01), pages 698 - 705, XP002764333, ISSN: 0815-9319 *
PRASETYANTI PRAMUDITA R ET AL: "Isolation and Propagation of Colon Cancer Stem Cells", VIRAL GENE TRANSFER TECHNIQUES. GENE DELIVERY TO MAMMALIAN CELLS / VOL. 2; [METHODS MOL. BIOL.; ISSN 1064-3745, VOL. 246], TOTOWA, NJ : HUMANA PRESS, C2004, US, vol. 1035, 1 January 2013 (2013-01-01), pages 247 - 259, XP009192420, ISSN: 1064-3745, DOI: 10.1007/978-1-62703-508-8_21 *
See also references of WO2014165101A1 *

Also Published As

Publication number Publication date
EP2968407A1 (de) 2016-01-20
WO2014165101A1 (en) 2014-10-09
AU2014248711A1 (en) 2015-09-10

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