EP2977195A1 - dispositif et procédé de fabrication de comprimés multi-couches - Google Patents

dispositif et procédé de fabrication de comprimés multi-couches Download PDF

Info

Publication number
EP2977195A1
EP2977195A1 EP14177771.4A EP14177771A EP2977195A1 EP 2977195 A1 EP2977195 A1 EP 2977195A1 EP 14177771 A EP14177771 A EP 14177771A EP 2977195 A1 EP2977195 A1 EP 2977195A1
Authority
EP
European Patent Office
Prior art keywords
station
starting material
geometrically limited
intermediate product
processing stations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP14177771.4A
Other languages
German (de)
English (en)
Inventor
Herbert Ritter
Christian Amon
Johannes Khinast
Thomas Klein
Stephan Sacher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
M & R Automation GmbH
Original Assignee
M & R Automation GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by M & R Automation GmbH filed Critical M & R Automation GmbH
Priority to EP14177771.4A priority Critical patent/EP2977195A1/fr
Priority to PCT/EP2015/066606 priority patent/WO2016012427A1/fr
Publication of EP2977195A1 publication Critical patent/EP2977195A1/fr
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
    • B30B11/085—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable for multi-layer articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/08—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable
    • B30B11/10—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds carried by a turntable intermittently rotated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B30—PRESSES
    • B30B—PRESSES IN GENERAL
    • B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
    • B30B11/02—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space
    • B30B11/14—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses using a ram exerting pressure on the material in a moulding space co-operating with moulds on a movable carrier other than a turntable or a rotating drum

Definitions

  • the invention relates to a device for producing multilayer tablets from solid starting materials, in particular from powders, granules and / or from geometrically limited intermediates, comprising a plurality of processing stations and a conveyor unit with a plurality of conveyor containers. Furthermore, within the scope of the invention, multilayer tablets are also disclosed, which are produced using a device according to the invention, as well as process variants for the production of multilayer tablets.
  • multilayer tablet generally refers to solid bodies which have multiple layers of powders, granules and / or of geometrically limited intermediates, such as single-layered tablets, which are joined together in one unit.
  • cleaning rod as used for example for dishwashers or for cleaning dentures ("third teeth”), and various Dietary supplements in tablet form to understand.
  • two or more layers of different starting materials for example granules or powders
  • rotary presses are used with at least two filling and pressing stations.
  • the pressing process usually proceeds as follows: The granules or powder, which forms a first tablet layer, is thereby filled into a die and compacted by a press die under a relatively low pressure. Thereafter, this part is lowered in the die by moving the lower punch to a lower position and filling the powder or granules of the second layer above it. Finally, this layer and the two layers are compacted with the full pressing force.
  • the filling takes place from different Mountain Pont with appropriate storage containers.
  • the granules can also be successively filled into the matrix and pressed in a single step.
  • the currently known tableting machines are each set for a specific production process and assembled accordingly.
  • a simple retrofitting of existing tableting machines to produce if necessary new or changed products is usually not possible or requires at least a high conversion costs, including the associated conversion costs and uneconomically long downtime until a correspondingly upgraded tabletting machine can be put into operation again ,
  • the purchase of a tailor-made, new tableting machine was usually the only economic alternative to the production of new or modified multi-layer tablets.
  • the lack of flexibility or lack of opportunity for rapid and cost-effective conversion of existing tabletting machines is particularly disturbing.
  • the starting materials or intermediates to be pressed are each dry or at least have only a very low moisture content.
  • the use of problematic starting materials such as lubricants, which have a lubricating effect on the rotary plate of known rotary tableting machines must be avoided as far as possible in the currently known tabletting machines.
  • granules that break easily under a compressive load with conventional Tableting machines at the currently usual, high pressing pressures, which are usually between 5 kN and 20 kN, but also presses are used with a main pressure of up to 200 kN, are not processed.
  • a device according to the invention for producing multilayer tablets from solid starting materials in particular from powders, granules and / or from geometrically limited intermediates, comprising a plurality of processing stations and a conveyor unit with a plurality of conveyor containers
  • the individual processing stations are modularly variable in their arrangement.
  • a number and / or a sequence of the processing stations is or are modularly variable in a production device according to the invention.
  • one and the same inventive device quickly and with relatively little effort and in a short set-up time by modular variation of the correspondingly required processing stations, for example, from the production of two-layer tablets on the production of three or multi-layer tablets retrofit.
  • the sequence and the number of process steps can be variably set for the respective process steps in individual processing stations.
  • a manufacturing device according to the invention can be used particularly flexible for the production of a variety of multilayer tablets.
  • multilayer tablets with different contours in oval, circular and / or in square or square shape can be produced with the same device after appropriate adaptation.
  • various bonding agents may be used which, depending on the nature or property of the selected bonding agent, may also each have different processing methods for applying the bonding agents to powder, granules and / or geometrically limited intermediates, for example by spraying, dripping, etc., require.
  • the respectively required processing stations are selected and, if necessary, arranged in a corresponding sequence or individual processing stations are correspondingly replaced by other processing stations.
  • a device according to the invention can be used with the same basic structure for the production of various products from different industrial sectors.
  • a device of the same basic construction it is possible to produce both multilayer tablets for pharmaceutical applications and, for example, cleansing tablets which are used for cleaning purposes for dishwashers or for cleaning dentures, or else dietary supplements in tablet form.
  • the novel, modular variable arrangement of the individual processing stations in a device according to the invention has the advantage that individual processing stations, if necessary, can be maintained separately or renewed.
  • the costs for service and maintenance are advantageously lower than is the case in currently known from the prior art machines for tablet production.
  • the coupling of individual processing stations with other external units and devices within a process chain is facilitated by the modular arrangement of the device according to the invention.
  • individual processing stations or even the Integrate entire device according to the invention particularly simple and flexible in existing processes and facilities of a complex manufacturing process. For example, already existing packaging machines, loading stations and / or unloading stations can be flexibly coupled to the corresponding processing stations of the device according to the invention.
  • the multiple processing stations are particularly advantageously arranged serially along a substantially linear processing path.
  • the processing stations required in each case for producing an individual multilayer tablet are arranged in a particularly compact and clearly arranged linear manner.
  • the sequence of the individual manufacturing steps can also be monitored very easily. Due to the clear arrangement and easy accessibility monitoring of quality parameters of current production, for example, with external monitoring devices is particularly comfortable possible in a device according to the invention in addition to monitoring of incoming or outgoing materials.
  • monitoring devices for monitoring quality parameters of ongoing production in particular for monitoring flow, mass or weight, density, temperature and / or composition can be provided within the scope of the device according to the invention. If necessary, external monitoring devices, measuring devices, analyzers, sensors, etc. can be used and coupled with the corresponding processing stations or integrated into them.
  • the several processing stations are arranged serially along a curved processing path, preferably along a closed curved processing path.
  • This variant has the advantage of a particularly compact, space-saving arrangement of the processing stations. Furthermore, this arrangement is particularly advantageous for manufacturing processes in which an at least partially multiple passage of individual processing stations or a repetition of certain processing steps is required. If necessary, the delivery unit or the corresponding delivery containers can be moved several times in a circle along the curved processing path over an entire revolution in order to pass through individual processing stations several times.
  • the closed curved processing paths can have, for example, a circular or elliptical shape.
  • the processing stations are arranged in one plane, preferably in a substantially horizontal plane.
  • the arrangement of the processing stations in a plane also underlines advantages of the modular construction of the devices according to the invention.
  • an optionally required change of individual processing stations is particularly easy due to their arrangement in a common plane, preferably in a common horizontal plane.
  • a device according to the invention for the production of multilayer tablets at least one of the processing stations is repeatedly passable.
  • a multilayer tablet or its starting materials and / or their geometrically limited intermediates and / or their multilayer tablet body passes through or pass through at least one of the processing stations of the device according to the invention several times.
  • the device can be made compact in this embodiment and operated particularly economically.
  • multilayer tablets having more than two layers connected to one another can be produced by a plurality of circulations or runs, even with a device prepared for producing a two-layer tablet.
  • six-layered multilayer tablets can be produced by passing through the corresponding processing stations three times with a device which is in itself prepared for producing a two-layered tablet.
  • a plurality of solid starting materials and / or a plurality of geometrically limited intermediates can advantageously be processed simultaneously in a processing station.
  • Processing stations are also arranged parallel to each other and / or fed in parallel. This is particularly useful for processing stations for individual manufacturing steps with a comparatively long processing time.
  • the solid starting materials and / or the geometrically limited intermediates can be transferred from a previous processing station to a subsequent processing station in the transport direction.
  • the conveyor unit with the corresponding conveyor containers.
  • the solid starting materials and / or the geometrically limited intermediates at least between two adjacent processing stations within their respective delivery container.
  • a processing step in which a starting material is pressed and compacted as powder or granulate into a geometrically limited intermediate product is carried out within the corresponding delivery container, which for example has a female mold with the contours of the intermediate product.
  • a device it is particularly expedient to provide at least one application station for applying at least one bonding agent to a solid starting material and / or a geometrically limited intermediate product.
  • one or more connecting agents which are applied to a starting material or an intermediate product, for example a starting material already compacted into a tablet compact or a multilayer tablet body, the otherwise usually required high pressing pressures for pressing the tablets or their components can be significantly reduced become.
  • multilayer tablets with a greater number of interconnected layers or with layers having lower layer thicknesses can be produced by the use of connecting agents and the lower tablet pressures required for tablet production.
  • layer thicknesses of bonding agents that are applied between individual layers of powders, granules and / or geometrically limited intermediates may be a few nanometers or micrometers. It is likewise provided within the scope of the invention, depending on the requirement, to realize multilayer tablets having layer thicknesses - in the micrometer range or millimeter range, depending on the powders, granules and / or geometrically limited intermediates used.
  • a device in the at least one application station for applying bonding agent to a solid starting material and / or a geometrically limited intermediate, it is particularly advantageous to use female molds with receiving bores with an undersize within which female molds the geometrically limited intermediate products are inserted and glued together.
  • Matrizenformen By using appropriate Matrizenformen a particularly accurate, displacement-free positioning of the individual tablet layers is ensured during bonding.
  • Suitable binders are in themselves all known from the prior art binders in question, which improve the cohesion in the starting materials, for example in powders or granules or in the geometrically limited intermediates and thus increase the overall strength of the tablets.
  • lubricants in multi-layer tablets is also made possible by the use of appropriate connecting means, since adequate bonding between the individual layers, despite the lubricants used, is ensured by the connecting means used.
  • metallic stearates which are usually problematic as a lubricant in tablet production, can also be used in multi-layer tablets consolidated with bonding agents.
  • One or more connecting means can also be applied in the production of a multilayer tablet such that the connecting medium layer acts as a separating layer between two adjacent layers and different active substances in the respective adjacent tablet layers can not influence one another.
  • the at least one bonding agent in a device for producing multilayer tablets, has a formulation that is liquid or solid at ambient temperature.
  • Connecting agents may be used as so-called dry binders - examples being microcrystalline cellulose or starch - or as moisture binders or adhesives. Examples of possible representatives of moisture binders or adhesives known from the prior art are starch pastes, cellulose ethers, collidone and gelatin.
  • the application station comprises a tempering device for setting a temperature of the connection means.
  • a tempering device for setting a temperature of the connection means.
  • the bonding agent contains at least one active substance, preferably a pharmaceutical active substance.
  • the bonding agent contains at least one active substance, preferably a pharmaceutical active substance.
  • a cleaning station By means of a cleaning station a cyclic cleaning of the entire conveyor unit or at least of individual conveyor containers is particularly easy. Regular cleaning of the wetted parts of the device is essential in particular when connecting means are used in order to ensure a consistent quality of the products and to avoid cross-contamination by deposits of connecting agents and / or intermediates in the conveying containers.
  • the at least one cleaning station may comprise a separate drying station to ensure that the cleaned device parts are also dried again before being used again in a subsequent production cycle.
  • one or more cleaning stations and one or more drying stations are each arranged at suitable locations in the course of the processing stations.
  • a device it is possible in a device according to the invention to arrange at least one cleaning station and / or at least one drying station next to the conveyor unit or - depending on the embodiment of the device according to the invention - next to a rotary indexing table or next to a clock belt.
  • processing stations that serve for cleaning of conveyor containers or the conveyor unit also be positioned laterally next to, above or below the conveyor unit.
  • the modular arrangement of the processing stations further allows regular complete cleaning of individual or, if necessary, all in use processing stations of the device or a complete system for the production of multilayer tablets.
  • the individual processing stations are designed such that they can be cleaned and / or sterilized in an autoclave.
  • a multilayer tablet which is produced with a device according to the invention at least one bonding agent is applied to a solid starting material and / or a geometrically limited intermediate product.
  • one or more connecting means used in order to use the advantages of the use of connecting means described above can be beneficial in the Production of multilayer tablets with the device according to the invention.
  • a device 10 according to the invention with a curved machining path 20 is illustrated in a plan view.
  • the device 10 has a delivery unit 50 with a plurality of delivery containers 51 and is embodied here by way of example as a rotary transfer table 52.
  • the delivery containers 51 are moved in a transport direction 55, which is here identified by an arrow 55, along the substantially circular processing path 20.
  • a plurality of processing stations 100 are arranged serially along the processing path 20, and a sequence of a plurality of successive process steps for the production of multilayer tablets can thus be processed in succession at individual, serially arranged processing stations 100.
  • the number and / or the sequence of processing stations 100 are modularly variable.
  • monitoring devices 57 such as devices for automatic visual inspection, arranged.
  • Monitoring devices 57 may also be provided for monitoring quality parameters of current production, in particular for monitoring flow, mass or weight, density, temperature and / or composition in the context of device 10 according to the invention.
  • external monitoring devices, measuring devices, analyzers, sensors, etc. may be used and coupled to the corresponding processing stations 100 or integrated into them.
  • Starting materials are fed either as powdered starting materials or as granules 210, or as geometrically limited intermediates 220, for example as already pressed powder or powder mixtures in the direction of arrow 70, wherein an arrow 70 symbolizes a feed direction, a loading station 110. Furthermore, the Starting materials in the direction of arrow 75, which indicates a transfer direction 75 from the loading station 110 to the conveyor unit 50, are transferred to the conveyor unit 50 or to one or more delivery containers 51 of this conveyor unit 50.
  • the conveyor containers 51 are conveyed further by the conveyor unit 50 in the transport direction 55 and reach the next processing station 100, which serves as an applicator station 120 here.
  • a connection means 230 is applied to the solid starting material 210 or to the powder already pressed, for example, already to a geometrically limited intermediate product 220.
  • An application or application of the connecting means 230 is symbolized as arrow 80.
  • transfer methods can be used.
  • the connecting means 230 can be applied by spraying, dropping or by means of a screen printing process.
  • the applicator station 120 is here in Fig.
  • connection means 230 which, for example, has a highly viscous, viscous formulation at ambient temperature and which, in the heated state at low viscosity, can be applied much more simply and uniformly to the solid starting material.
  • an active substance 240 is additionally sprayed onto the starting material 210, which is contained in the connecting means 230 or admixed thereto has been.
  • the transport containers 51 are further conveyed in the transport direction 55 and then pass through an intermediate station 130, in which here, for example, the applied connecting means 230 dried by blowing dried air and thus pre-cured.
  • an intermediate station 130 in which here, for example, the applied connecting means 230 dried by blowing dried air and thus pre-cured.
  • several intermediate stations 130, 131, 132, 133, etc. are passed through in series, which serve, for example, for cooling, heating, pressing, drying, irradiating and / or curing the media located in the conveyor containers 51 , These further intermediate stations are in Fig. 1 not explicitly shown.
  • a subsequent processing station 100 which serves here as a further or second loading station 111
  • the transfer 75 of a second solid starting material 211 or a second already pressed to a geometrically limited intermediate product 220 takes place Powder or granules to the conveyor unit 50 and to the respective delivery container 51.
  • the supply of the second solid starting material 211 and the second already to a geometrically limited intermediate 220 shaped powder or granules is symbolized by an arrow 70. It is likewise conceivable to supply a further active ingredient 241 to the device 10 at this point indicated by the arrow 70.
  • the further active compound 241 can optionally be added as an additive to the second solid starting material 211 or the second powder or granules already pressed to form a geometrically limited intermediate product 220.
  • the active ingredient 241 may already be present as a component in the starting material 211 or in the intermediate 220.
  • the delivery container 51 then passes to a composite station 140.
  • the composite station 140 the second starting material 211 and / or the second geometrically limited intermediate 221 with the first starting material 210 and / or the first geometrically limited intermediate product 220 are added if necessary another connecting means 231 connected to each other.
  • the interconnected starting materials 210, 211 and / or interconnected intermediates 220, 221 in the composite station 140 and / or in one or more other intermediate stations 131, 132, 133, etc. by cooling, heating, pressing, drying, irradiation and or hardening further treated and thus formulated into a multilayer tablet body 250.
  • the tablet bodies 250 may, if necessary, be further coated, dyed, dried, smoothed, polished and / or cured, thus obtaining a finished multilayer tablet 200.
  • the transport 55 of the multilayer tablets 200 takes place to an unloading station 160, where the multilayer tablets 200 are removed from the conveyor unit 50.
  • the multilayer tablets 200 are packaged in the unloading station 160 or in a subsequent packaging station 170.
  • the empty conveyor container 51 undergo an optional cleaning in a separate cleaning station 180 and - optionally also - a drying step in a drying station 190 before the corresponding of kauskarresten or of adhering solid cleaned conveying container 51 are available for a new production cycle.
  • one or more of the aforementioned method steps can also be repeated several times within a production cycle, or the corresponding processing stations 100 can be run through multiple times for this purpose.
  • Fig. 1 the position numbers of the respective processing stations are listed in ascending order in brackets, with the corresponding position numbers correspondingly increasing in the case of multiple, repeated passes.
  • the conveyor container 51 on the rotary table 52 in the transport direction 55 more than a complete revolution to move and thus at least individual processing stations 100 to pass through several times.
  • a pulverulent first starting material 210 together with a first active substance 240 is loaded into a delivery container 51.
  • This first starting material 210 together with the first active substance 240 is then sprayed in a dispensing station 120 with a first connecting means 230, for example, and then passes into a first intermediate station 130 in which the substances located in the corresponding conveyor 51 are pressed and cooled, wherein a first geometrically limited intermediate 220 - a single-layer tablet compact comprising the solid starting material 210, the active agent 240 and the connecting means 230 - is obtained.
  • the intermediate product 220 passes in the corresponding conveying container 51 to a second loading station 110, in which, for example, an already geometrically limited intermediate product 221, which contains a compacted granulate of a solid starting material 221 and a further active ingredient 241, is added to the intermediate product 220.
  • a second loading station 110 in which, for example, an already geometrically limited intermediate product 221, which contains a compacted granulate of a solid starting material 221 and a further active ingredient 241, is added to the intermediate product 220.
  • the two intermediates 220 and 221 are joined together by adding a bonding agent 231, which also contains an active substance 140, for example.
  • the rotary indexing table 52 is conveyed further in the transport direction 55 until the relevant conveyor container 51 again reaches the position of the original first loading station 110, which is now passed through as a loading station 112 a second time and in which another solid starting material 212 or another geometrically limited intermediate product 222 loaded become.
  • a further connecting means 232 is applied to the meanwhile three-layered tablet body 251.
  • the relevant delivery container 51 with the tablet body 251 therein optionally passes through further intermediate stations 132, 133, in which the tablet body 251 is pressed and hardened by means of UV light irradiation, for example, before the tablet body 251 is coated in the coating station 150, whereby a finished Multi-layer tablet 201 is obtained.
  • the multilayer tablet 201 is transferred in the direction of arrow 85 from the conveyor unit 50 to the unloading station 160 and passes from the unloading station 160 on to the packaging station 170, in which the multilayer tablets 201 are packed in corresponding pack sizes.
  • processing stations 100 can be modularly varied in their arrangement and sequence along the processing path 20. Particularly when various connecting means are used, the cleaning station 180 and the drying station 190 are particularly advantageous for cleaning the rotary transfer table 52 or for cleaning the delivery containers 51.
  • Optional processing stations 100 for example one or more intermediate stations 130 (or 131, 132, 133, etc.), the packaging station 170 or the cleaning station 180 and drying station 190 are in Fig. 1 each drawn in dashed lines.
  • the device 10 can also be used, for example, for the preparation of soluble effervescent tablets, of nutritional supplements or of dishwasher tablets, dentures, or for comparable applications.
  • Fig. 2 shows a second embodiment of a device 11 according to the invention for the production of multilayer tablets in a plan view.
  • the individual processing stations 100 are arranged serially along a substantially linear processing path 21.
  • the device 11 has a delivery unit 60 with a plurality of delivery containers 61 and is embodied here by way of example as a timing belt 62.
  • the delivery containers 61 are moved in a transport direction 65, which is here identified by an arrow 65, along the substantially linear processing path 21.
  • a plurality of processing stations 100 are arranged serially along the processing path 21, and a sequence of a plurality of successive process steps for the production of multilayer tablets can thus be processed in succession at individual, serially arranged processing stations 100.
  • the number and / or the sequence of processing stations 100 are modularly variable. As in Fig.
  • the processing stations 100 are, for example, laterally next to the timing belt 62, which is why the starting materials 210 (or 211, 212, etc.) and / or the intermediates 220 (or 221, 222, etc.) respectively the respective processing stations 100th must be supplied.
  • the assignment of the individual processing stations 100 to the respective position of the conveying container 61 on the timing belt 62 is here in Fig. 2 indicated by dash-dotted lines.
  • processing stations 100 monitoring devices 57, for example, devices for automatic visual inspection, arranged. Further processing stations 100 can also be supplemented in a particularly flexible modular manner here with the device 11 with a linear processing path 21. Likewise, the sequence of processing stations 100 can be easily changed and varied in order to be able to fulfill with the device 11 the respective individual requirements for the production of different multilayer tablets.
  • FIG. 2 illustrates in an isometric view from the front a first embodiment of a multilayer tablet 200, which was produced with a device according to the invention or by means of a method according to the invention.
  • This multilayer tablet 200 consists of three layers of tablet pellets or powdery starting materials 210, 211, 212 connected to intermediates 220, 221, 222.
  • the intermediate product 220 further comprises a pharmaceutically active substance 240.
  • the intermediate product 221 comprises besides the powdery, solid starting material 211, a further active pharmaceutical ingredient 241.
  • the intermediate product 222 further includes in addition to the powdery, solid starting material 212, a third pharmaceutical agent 242.
  • the geometrically limited intermediates 220, 221 and 222 each have here a substantially cylindrical shape . Between the tablet pellets or between the intermediates 220, 221, 222 are each thin intermediate layers of a bonding agent 230.
  • the multilayer tablet 200 shown here was pressed after application of bonding agent 230, dried and cured by UV irradiation.
  • Fig. 4 relates in an isometric view from the front a second embodiment of a multilayer tablet 201, which was also produced with a device according to the invention or by means of a method according to the invention.
  • This multilayer tablet 201 likewise consists of three layers of tablet compacts or powdery starting materials 210, 211 and 213 connected to intermediates 220, 221, 223.
  • the intermediate product 220 comprises, in addition to the pulverulent, solid
  • the starting material 210 further comprises a first active pharmaceutical ingredient 240.
  • the intermediate product 221 arranged in the middle of the multi-layer tablet 201 comprises, in addition to the powdery, solid starting material 211, a further pharmaceutical active ingredient 242.
  • the intermediate product 223 further contains no additional active pharmaceutical ingredient apart from the powdered solid starting material 213 ,
  • the multilayer tablet 201 here has a substantially biconvex shape with a round cross section and is arched on its upper side and on its underside.
  • the multilayer tablet 201 shown here was pressed after the application of bonding agent 230 or 232, dried and cured by UV irradiation. Furthermore, a possible coating or printing and / or dyeing of the multilayer tablet 201 are not explicitly shown here.
  • multilayer tablets according to the invention may comprise all types of tablets in any desired shape or contour.
  • multilayer tablets made by the method of the invention may have, for example, a circular, oval or polygonal top view and / or may have rounded or sharp edges.
  • multilayer tablets made by the process of the present invention may include interfaces between adjacent tablet layers which are performed in complementary mating engagement structures to achieve a positive engagement.
  • individual or all layers or geometrically limited intermediates of a multilayer tablet may be positively connected to each other by one or more teeth in step shape, serrated shape, dovetail shape and / or waveform.
  • a multilayer tablet is produced in which an undesired separation ("lapping") of adjoining layers is reliably prevented.

Landscapes

  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medicinal Preparation (AREA)
EP14177771.4A 2014-07-21 2014-07-21 dispositif et procédé de fabrication de comprimés multi-couches Withdrawn EP2977195A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP14177771.4A EP2977195A1 (fr) 2014-07-21 2014-07-21 dispositif et procédé de fabrication de comprimés multi-couches
PCT/EP2015/066606 WO2016012427A1 (fr) 2014-07-21 2015-07-21 Dispositif et procédé de fabrication de comprimés à plusieurs couches

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14177771.4A EP2977195A1 (fr) 2014-07-21 2014-07-21 dispositif et procédé de fabrication de comprimés multi-couches

Publications (1)

Publication Number Publication Date
EP2977195A1 true EP2977195A1 (fr) 2016-01-27

Family

ID=51224738

Family Applications (1)

Application Number Title Priority Date Filing Date
EP14177771.4A Withdrawn EP2977195A1 (fr) 2014-07-21 2014-07-21 dispositif et procédé de fabrication de comprimés multi-couches

Country Status (2)

Country Link
EP (1) EP2977195A1 (fr)
WO (1) WO2016012427A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108704998A (zh) * 2018-05-23 2018-10-26 芜湖华铸汽车部件有限公司 一种多执行机构同步加工的汽车零部件冲压设备
EP3650212A1 (fr) * 2018-11-12 2020-05-13 4K Global Holding UG (haftungsbeschränkt) Procédé de fabrication automatisée de comprimés individualisés et presse à comprimés destinée à la fabrication automatisée de comprimés individualisés

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE967423C (de) * 1951-08-24 1957-11-21 Friedrich Horn Maschinenfabrik Rundlaufpresse und Verfahren zur Herstellung von Presslingen mit einer Rundlaufpresse
JPS62178507A (ja) * 1986-01-30 1987-08-05 Shiseido Co Ltd 多色粉末化粧料の充填方法及び装置
EP1043149A2 (fr) * 1999-03-31 2000-10-11 Sumitomo Coal Mining Co., Ltd. Procédé et dispositif pour le chargement automatique de matériau en poudre dans un moule
EP1693182A2 (fr) * 2005-02-19 2006-08-23 Fette GmbH Procédé et dispositif pour le pressage d'essai de comprimés multi-couches ou de comprimés enrobés
DE102005030311B3 (de) * 2005-06-23 2006-11-23 Korsch Ag Verfahren zur Pressung von Tabletten und Rundläufer- Tablettiermaschine
DE102005030312A1 (de) * 2005-06-23 2006-12-28 Korsch Ag Rundläufer-Tablettiermaschine und Verfahren zur Herstellung einer Mehrschichttablette
EP2065176A2 (fr) * 2007-11-30 2009-06-03 Fette GmbH Presses rotatives
EP2110231A2 (fr) * 2008-04-18 2009-10-21 Korsch AG Presse rotative pour comprimés
WO2010127861A2 (fr) * 2009-05-07 2010-11-11 Korsch Ag Presse à table tournante, en particulier pour la fabrication de comprimés
WO2012004408A2 (fr) * 2010-07-09 2012-01-12 Research Center Pharmaceutical Engineering Formation de comprimés multicouches par collage ensemble de corps de comprimé

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE967423C (de) * 1951-08-24 1957-11-21 Friedrich Horn Maschinenfabrik Rundlaufpresse und Verfahren zur Herstellung von Presslingen mit einer Rundlaufpresse
JPS62178507A (ja) * 1986-01-30 1987-08-05 Shiseido Co Ltd 多色粉末化粧料の充填方法及び装置
EP1043149A2 (fr) * 1999-03-31 2000-10-11 Sumitomo Coal Mining Co., Ltd. Procédé et dispositif pour le chargement automatique de matériau en poudre dans un moule
EP1693182A2 (fr) * 2005-02-19 2006-08-23 Fette GmbH Procédé et dispositif pour le pressage d'essai de comprimés multi-couches ou de comprimés enrobés
DE102005030311B3 (de) * 2005-06-23 2006-11-23 Korsch Ag Verfahren zur Pressung von Tabletten und Rundläufer- Tablettiermaschine
DE102005030312A1 (de) * 2005-06-23 2006-12-28 Korsch Ag Rundläufer-Tablettiermaschine und Verfahren zur Herstellung einer Mehrschichttablette
EP2065176A2 (fr) * 2007-11-30 2009-06-03 Fette GmbH Presses rotatives
EP2110231A2 (fr) * 2008-04-18 2009-10-21 Korsch AG Presse rotative pour comprimés
WO2010127861A2 (fr) * 2009-05-07 2010-11-11 Korsch Ag Presse à table tournante, en particulier pour la fabrication de comprimés
WO2012004408A2 (fr) * 2010-07-09 2012-01-12 Research Center Pharmaceutical Engineering Formation de comprimés multicouches par collage ensemble de corps de comprimé

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108704998A (zh) * 2018-05-23 2018-10-26 芜湖华铸汽车部件有限公司 一种多执行机构同步加工的汽车零部件冲压设备
CN108704998B (zh) * 2018-05-23 2019-11-22 宣城加特林机械有限公司 一种多执行机构同步加工的汽车零部件冲压设备
EP3650212A1 (fr) * 2018-11-12 2020-05-13 4K Global Holding UG (haftungsbeschränkt) Procédé de fabrication automatisée de comprimés individualisés et presse à comprimés destinée à la fabrication automatisée de comprimés individualisés
WO2020099387A1 (fr) * 2018-11-12 2020-05-22 4K Global Holding UG (haftungsbeschränkt) Procédé de fabrication automatisée de comprimés individualisés et presse à comprimés pour la fabrication automatisée de comprimés individualisés
US12274792B2 (en) 2018-11-12 2025-04-15 Privmed X Ab Method for automatically producing individualized tablets, and tablet press for automatically producing individualized tablets

Also Published As

Publication number Publication date
WO2016012427A1 (fr) 2016-01-28

Similar Documents

Publication Publication Date Title
DE69413425T2 (de) Gerät und Verfahren zur Beschichtung eines Produktes
DE69118815T2 (de) Vorrichtung zum Anbringen einer Gelatine-Beschichtigung
DE69109163T2 (de) Überzogene Arzneimittel und Einrichtung und Verfahren zu ihrer Herstellung.
DE69315169T2 (de) Verfahren und Einrichtung zur Herstellung von eine gepressten Tablette und so hergestellte Tablette
DE2201103C3 (de) Einrichtung zum Prüfen von Arzneikapseln u.dgl
DE3107627A1 (de) Verfahren und einrichtung zum abdichten von gelatinekapseln aus hartgelatine und zum aufbereiten einer dosis eines fluessigen produkts in der so abgedichteten gelatinekapsel
EP0803440A1 (fr) Procédé et dispositif pour remplir des alvéoles d'un film avec des produits
DE102013114693A1 (de) Stopfstempelstation und Verfahren zum Füllen von Kapseln in einer Stopfstempelstation
EP2081758B1 (fr) Procédé et dispositif de moulage d'ébauches à partir d'une matière malléable
DE69406697T2 (de) Apparat zur Beschichtung von Tabletten
DE102013109471B3 (de) Vorrichtung zum Befüllen und Verschließen von Kapseln
DE2504246B2 (de) Verfahren zum Gießen eines Fonnkörpers und Füllvorrichtung zu dessen Durchführung
DE60320289T2 (de) Kapselfüllmaschine
EP2977195A1 (fr) dispositif et procédé de fabrication de comprimés multi-couches
DE69718981T2 (de) Vorrichtung zum Formen einer Kunststoffdichtung in einer Verschlusskappe zum Verschliessen eines Behälters
DE69414013T2 (de) Apparat und Verfahren zum schrittweisen Vorschieben einer Mehrzahl von Produktaufnahmeplatten
DE3318810A1 (de) Vorrichtung zum dosierten abfuellen pharmazeutischer pasten
DE102005062715B4 (de) Vorrichtung zum Befüllen von Aufnahmebehältern mit den Produkten einer Rundläuferpresse
DE102011101286B4 (de) Rundläuferpresse und Verfahren zum Betreiben einer Rundläuferpresse
EP3908244B1 (fr) Dispositif et procédé de mise en comprimés d'une composition de principes actifs pulvérulente, liquide, pâteuse, encapsulée ou granulaire
EP3369409B1 (fr) Dispositif et procédé de dosage de matériaux de remplissage pulvérulents
EP0445106A2 (fr) Presse pour fabriquer des objets en matière pulvérulente
EP2161120A2 (fr) Procédé de contrôle de comprimés multicouches dans une presse rotative
EP2168874A1 (fr) Dispositif pour transférer des produits d'un conteneur de stockage dans des récipients d'emballage
EP2081759B1 (fr) Procédé et dispositif de moulage à cycles de rotation à haut rendement

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

17P Request for examination filed

Effective date: 20160429

RBV Designated contracting states (corrected)

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20180801

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20181212