EP3076949A4 - Analyse d'adn génomique, d'arn et de protéines dans des exosomes pour le diagnostic et la thérapie - Google Patents
Analyse d'adn génomique, d'arn et de protéines dans des exosomes pour le diagnostic et la thérapie Download PDFInfo
- Publication number
- EP3076949A4 EP3076949A4 EP14867768.5A EP14867768A EP3076949A4 EP 3076949 A4 EP3076949 A4 EP 3076949A4 EP 14867768 A EP14867768 A EP 14867768A EP 3076949 A4 EP3076949 A4 EP 3076949A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- theranosis
- exosomes
- rna
- diagnosis
- proteins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
- G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Food Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Hospice & Palliative Care (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HRP20192131TT HRP20192131T1 (hr) | 2013-12-04 | 2014-12-04 | Metoda za izolaciju egzosoma izvedenih iz stanica karcinoma |
| SI201431412T SI3076949T1 (sl) | 2013-12-04 | 2014-12-04 | Postopek za izoliranje eksosomov, ki izvirajo iz rakavih celic |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361911863P | 2013-12-04 | 2013-12-04 | |
| PCT/US2014/068630 WO2015085096A1 (fr) | 2013-12-04 | 2014-12-04 | Analyse d'adn génomique, d'arn et de protéines dans des exosomes pour le diagnostic et la thérapie |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP3076949A1 EP3076949A1 (fr) | 2016-10-12 |
| EP3076949A4 true EP3076949A4 (fr) | 2017-11-22 |
| EP3076949B1 EP3076949B1 (fr) | 2019-09-04 |
Family
ID=53274132
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP14867768.5A Active EP3076949B1 (fr) | 2013-12-04 | 2014-12-04 | Procédé pour isoler des exoxomes dérivés des cellules cancères |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9921223B2 (fr) |
| EP (1) | EP3076949B1 (fr) |
| JP (3) | JP2017501694A (fr) |
| AU (3) | AU2014360344B2 (fr) |
| CA (1) | CA2936100A1 (fr) |
| DK (1) | DK3076949T3 (fr) |
| HR (1) | HRP20192131T1 (fr) |
| HU (1) | HUE046489T2 (fr) |
| LT (1) | LT3076949T (fr) |
| NZ (1) | NZ721720A (fr) |
| SI (1) | SI3076949T1 (fr) |
| WO (1) | WO2015085096A1 (fr) |
| ZA (1) | ZA201604468B (fr) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11660317B2 (en) | 2004-11-08 | 2023-05-30 | The Johns Hopkins University | Compositions comprising cardiosphere-derived cells for use in cell therapy |
| US9599611B2 (en) | 2005-04-25 | 2017-03-21 | Trustees Of Boston University | Structured substrates for optical surface profiling |
| US11286463B2 (en) | 2012-03-08 | 2022-03-29 | Advanced ReGen Medical Technologies, LLC | Reprogramming of aged adult stem cells |
| AU2013302799B2 (en) | 2012-08-13 | 2018-03-01 | Cedars-Sinai Medical Center | Exosomes and micro-ribonucleic acids for tissue regeneration |
| WO2014028862A1 (fr) | 2012-08-17 | 2014-02-20 | Cornell University | Utilisation d'adn dans des exosomes circulants en tant que marqueur de diagnostic pour maladie métastasique |
| PT3527670T (pt) | 2013-03-15 | 2024-01-18 | Beth Israel Deaconess Medical Ct Inc | Biogénese de mirna em exossomas para diagnóstico e terapia |
| HUE046489T2 (hu) * | 2013-12-04 | 2020-03-30 | Univ Texas | Eljárás ráksejtekbõl származó exoszómák izolálására |
| US10772911B2 (en) | 2013-12-20 | 2020-09-15 | Advanced ReGen Medical Technologies, LLC | Cell free compositions for cellular restoration and methods of making and using same |
| CR20160307A (es) | 2013-12-20 | 2016-11-08 | Advanced Regen Medical Tech Llc | Composiciones para la restauración de células y métodos para la preparación y utilización de las mismas |
| US10844436B2 (en) * | 2014-04-01 | 2020-11-24 | Cornell University | Use of double-stranded DNA in exosomes: a novel biomarker in cancer detection |
| WO2016054591A1 (fr) | 2014-10-03 | 2016-04-07 | Cedars-Sinai Medical Center | Cellules dérivées de la cardiosphère et exosomes sécrétés par ces cellules dans le traitement d'une dystrophie musculaire |
| WO2016057702A2 (fr) | 2014-10-07 | 2016-04-14 | Cornell University | Procédés de pronostic et de prévention du cancer métastatique du foie |
| WO2016172710A2 (fr) | 2015-04-24 | 2016-10-27 | Cornell University | Procédés et réactifs pour la détermination et le traitement de métastases organotropiques |
| US11339441B2 (en) * | 2015-05-12 | 2022-05-24 | The Research Foundation For The State University Of New York | Profiling chemically modified DNA/RNA units for disease and cancer diagnosis |
| AU2016276750A1 (en) | 2015-06-09 | 2018-01-18 | The Board Of Regents Of The University Of Texas System | Diagnostic test for early stage cancer |
| IL256175B2 (en) | 2015-06-10 | 2024-10-01 | Univ Texas | Using exosomes to treat the disease |
| EP3353528B1 (fr) | 2015-09-22 | 2023-11-29 | Trustees of Boston University | Phénotypage multiplexé de nanovésicules |
| GB201518466D0 (en) * | 2015-10-19 | 2015-12-02 | Cizzle Biotechnology Ltd | Use |
| US11253551B2 (en) | 2016-01-11 | 2022-02-22 | Cedars-Sinai Medical Center | Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction |
| EP3411713B1 (fr) | 2016-02-05 | 2021-06-30 | NanoView Biosciences, Inc. | Détection d'exosomes présentant des marqueurs de surface |
| SG10202008883SA (en) * | 2016-03-15 | 2020-10-29 | Codiak Biosciences Inc | Therapeutic membrane vesicles |
| WO2017190000A1 (fr) | 2016-04-29 | 2017-11-02 | Advanced ReGen Medical Technologies, LLC | Compositions de microarn, leurs procédés de préparation et d'utilisation |
| WO2017210652A1 (fr) | 2016-06-03 | 2017-12-07 | Cedars-Sinai Medical Center | Exosomes dérivés de cdc pour le traitement des tachyarythmies ventriculaires |
| US20190234955A1 (en) * | 2016-06-21 | 2019-08-01 | Nant Holdings Ip, Llc | Exosome-guided treatment of cancer |
| CN106124282B (zh) | 2016-07-26 | 2019-07-16 | 广州海力特生物科技有限公司 | 一种叠层离心过滤分离提取外泌体的方法 |
| US20180067121A1 (en) * | 2016-09-06 | 2018-03-08 | Nanoco Technologies Ltd. | Exosome-conjugated quantum dot nanoparticles and methods of detecting exosomes and cancer using same |
| EP3515459A4 (fr) | 2016-09-20 | 2020-08-05 | Cedars-Sinai Medical Center | Cellules dérivées de cardiosphères et leurs vésicules extracellulaires pour retarder ou inverser le vieillissement et des troubles liés à l'âge |
| WO2018173059A1 (fr) | 2017-03-21 | 2018-09-27 | Exoprother Medical Ltd. | Vésicules à visée thérapeutique dérivées de cellules natives et contenant des protéines suppressives de tumeur |
| GB2560897A (en) * | 2017-03-23 | 2018-10-03 | Lotvall Jan | Tissue-derived extracellular vesicles and their use as diagnostics |
| CA3059910A1 (fr) | 2017-04-19 | 2018-10-25 | Cedars-Sinai Medical Center | Methodes et compositions pour traiter une dystrophie musculaire squelettique |
| CN107338306A (zh) * | 2017-07-23 | 2017-11-10 | 嘉兴允英医学检验有限公司 | 一种用于GPC1mRNA表达检测的试剂盒 |
| WO2019028223A1 (fr) * | 2017-08-04 | 2019-02-07 | Cedars-Sinai Medical Center | Cellules dérivées de cardiosphère et leurs vésicules extracellulaires pour le traitement et la prévention du cancer |
| WO2019191444A1 (fr) * | 2018-03-28 | 2019-10-03 | Board Of Regents, The University Of Texas System | Utilisation d'exosomes pour l'administration ciblée d'agents thérapeutiques |
| GB2574785A (en) | 2017-09-15 | 2019-12-25 | Jan Loetvall | Method and system for identifying membrane proteins on extracellular vesicles |
| CN111566484A (zh) | 2017-11-09 | 2020-08-21 | 宾夕法尼亚大学董事会 | 细胞外囊泡蛋白及其在癌症诊断、预测对疗法的反应和治疗中的用途 |
| CN111971560B (zh) | 2017-12-01 | 2024-06-11 | 康奈尔大学 | 用于检测和治疗癌症的纳米颗粒和不同的外泌体子集 |
| WO2019118826A1 (fr) | 2017-12-15 | 2019-06-20 | Board Of Regents, The University Of Texas System | Méthodes et compositions pour le traitement du cancer utilisant des exosomes associés à l'édition génique |
| US11660355B2 (en) | 2017-12-20 | 2023-05-30 | Cedars-Sinai Medical Center | Engineered extracellular vesicles for enhanced tissue delivery |
| KR20200108275A (ko) * | 2017-12-28 | 2020-09-17 | 코디악 바이오사이언시즈, 인크. | 면역-종양학 및 항-염증 요법을 위한 엑소좀 |
| US10717981B2 (en) | 2018-01-18 | 2020-07-21 | Advanced ReGen Medical Technologies, LLC | Therapeutic compositions and methods of making and using the same |
| WO2019152549A1 (fr) | 2018-02-05 | 2019-08-08 | Cedars-Sinai Medical Center | Procédés d'utilisation thérapeutique d'exosomes et d'arn y |
| WO2019178317A1 (fr) | 2018-03-14 | 2019-09-19 | Children's Medical Center Corporation | Plate-forme d'évaluation de la transcytose de vésicules extracellulaires à travers des barrières endothéliales et ses utilisations |
| AU2019242912B2 (en) * | 2018-03-28 | 2025-07-17 | Board Of Regents, The University Of Texas System | Identification of epigenetic alterations in DNA isolated from exosomes |
| US20210024936A1 (en) * | 2018-04-09 | 2021-01-28 | Board Of Regents, The University Of Texas System | Therapeutic targeting of oncogenes using exosomes |
| CA3099385A1 (fr) * | 2018-05-04 | 2019-11-07 | Sigma-Aldrich Co. Llc | Production de proteines recombinees presentant des taux reduits de proteines de cellules hotes |
| US12510462B2 (en) | 2018-06-01 | 2025-12-30 | Unchained Labs | Compositions, systems, and methods for enhanced label-free and fluorescence-based detection of nanoparticles |
| IL269897B2 (en) | 2018-11-15 | 2023-08-01 | Sternum Ltd | Implementing control flow correctness verification in code intermediate files |
| US11766484B2 (en) | 2019-01-03 | 2023-09-26 | International Business Machines Corporation | Exosome vessels for delivery of molecular cargo |
| EP3908262A4 (fr) | 2019-01-09 | 2022-12-28 | Exocure Biosciences, Inc. | Vésicules dérivées de bactéries et leurs utilisations |
| US20220113313A1 (en) * | 2019-02-01 | 2022-04-14 | NanoView Biosciences, Inc. | Systems and methods for vesicle cargo labeling and detection |
| KR20210125532A (ko) * | 2019-02-08 | 2021-10-18 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 진단 및 치료 목적을 위한 엑소좀 관련 마이크로바이옴의 단리 및 검출 |
| US12502427B2 (en) * | 2019-03-21 | 2025-12-23 | Lonza Sales Ag | Extracellular vesicles for vaccine delivery |
| CA3137525A1 (fr) * | 2019-04-23 | 2020-10-29 | Children's Medical Center Corporation | Utilisation d'inhibiteurs de la gtpase rab7 (rab7) pour augmenter la permeabilite de la barriere hemato-encephalique (bhe) |
| US20230313147A1 (en) * | 2019-06-04 | 2023-10-05 | Jerome Canady Research Institute for Advanced Biological and Technological Sciences | Cold plasma treatment mediated mutant specific t cell immunity |
| US12564608B2 (en) | 2019-09-13 | 2026-03-03 | Exocure Sweden Ab | Use of ghost nanovesicles as therapeutics |
| JP7462452B2 (ja) * | 2020-03-27 | 2024-04-05 | 株式会社日立製作所 | 培養細胞の分化レベルを評価するための評価装置および評価方法、並びに自動細胞培養システム |
| CN112698033A (zh) * | 2020-12-09 | 2021-04-23 | 复旦大学附属中山医院 | 一种血源性外泌体her2的检测方法及其应用 |
| US20230340606A1 (en) * | 2021-09-09 | 2023-10-26 | The Regents Of The University Of California | Extracellular repetitive rna biomarkers of mutant kras cancers |
| US20250011876A1 (en) * | 2021-11-02 | 2025-01-09 | The Regents Of The University Of California | Extracellular rna signatures of mutant kras(g12c) cancers |
| WO2023210644A1 (fr) * | 2022-04-26 | 2023-11-02 | 国立大学法人東京大学 | Procédé d'isolement et de concentration d'un groupe de vésicules extracellulaires dérivé d'une cellule cancéreuse, procédé d'analyse, procédé de sélection de médicament, kit et agent anticancéreux |
| US20250290919A1 (en) * | 2022-05-06 | 2025-09-18 | The Trustees Of The University Of Pennsylvania | Ultrasensitive single extracellular vesicle detection using high throughput droplet digital enzyme-linked immunosorbent assay |
| WO2024047441A1 (fr) * | 2022-09-01 | 2024-03-07 | Fundação D. Anna De Sommer Champalimaud E Dr. Carlos Montez Champalimaud - Centro De Investigação Da Fundação Champalimaud | Méthode de surveillance de la charge tumorale chez des sujets au cours d'une intervention thérapeutique |
| US20260100247A1 (en) * | 2022-09-30 | 2026-04-09 | Foundation Medicine, Inc. | Systems and methods for processing clinico-genomic data |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100196426A1 (en) * | 2008-02-01 | 2010-08-05 | The General Hospital Corporation | Use of microvesicles in diagnosis and prognosis of medical diseases and conditions |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824311A (en) | 1987-11-30 | 1998-10-20 | Trustees Of The University Of Pennsylvania | Treatment of tumors with monoclonal antibodies against oncogene antigens |
| US4870287A (en) | 1988-03-03 | 1989-09-26 | Loma Linda University Medical Center | Multi-station proton beam therapy system |
| US5801029A (en) | 1993-02-16 | 1998-09-01 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
| US5801005A (en) | 1993-03-17 | 1998-09-01 | University Of Washington | Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated |
| GB9506466D0 (en) | 1994-08-26 | 1995-05-17 | Prolifix Ltd | Cell cycle regulated repressor and dna element |
| US5760395A (en) | 1996-04-18 | 1998-06-02 | Universities Research Assoc., Inc. | Method and apparatus for laser-controlled proton beam radiology |
| US5739169A (en) | 1996-05-31 | 1998-04-14 | Procept, Incorporated | Aromatic compounds for inhibiting immune response |
| US20030064949A1 (en) | 1998-02-17 | 2003-04-03 | Loretta Nielsen | Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms |
| FR2766205B1 (fr) | 1997-07-16 | 2002-08-30 | Inst Nat Sante Rech Med | Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede |
| KR100519384B1 (ko) * | 2002-08-13 | 2005-10-06 | (주)누백스 | 유전자 이입을 이용한 엑소좀의 제조방법 및 상기 엑소좀의 용도 |
| US20120196285A1 (en) * | 2011-01-31 | 2012-08-02 | Esoterix Genetic Laboratories, Llc | Methods for Enriching Microparticles or Nucleic Acids Using Binding Molecules |
| US9777042B2 (en) * | 2011-12-15 | 2017-10-03 | Morehouse School Of Medicine | Method of purifying HIV/SIV Nef from exosomal fusion proteins |
| US9309559B2 (en) * | 2013-04-15 | 2016-04-12 | Albert Einstein College Of Medicine, Inc. | Simultaneous extraction of DNA and RNA from FFPE tissues |
| HUE046489T2 (hu) * | 2013-12-04 | 2020-03-30 | Univ Texas | Eljárás ráksejtekbõl származó exoszómák izolálására |
-
2014
- 2014-12-04 HU HUE14867768A patent/HUE046489T2/hu unknown
- 2014-12-04 CA CA2936100A patent/CA2936100A1/fr active Pending
- 2014-12-04 DK DK14867768T patent/DK3076949T3/da active
- 2014-12-04 HR HRP20192131TT patent/HRP20192131T1/hr unknown
- 2014-12-04 EP EP14867768.5A patent/EP3076949B1/fr active Active
- 2014-12-04 WO PCT/US2014/068630 patent/WO2015085096A1/fr not_active Ceased
- 2014-12-04 JP JP2016536918A patent/JP2017501694A/ja not_active Ceased
- 2014-12-04 AU AU2014360344A patent/AU2014360344B2/en not_active Ceased
- 2014-12-04 SI SI201431412T patent/SI3076949T1/sl unknown
- 2014-12-04 NZ NZ721720A patent/NZ721720A/en not_active IP Right Cessation
- 2014-12-04 US US15/101,857 patent/US9921223B2/en active Active
- 2014-12-04 LT LT14867768T patent/LT3076949T/lt unknown
-
2016
- 2016-06-30 ZA ZA2016/04468A patent/ZA201604468B/en unknown
-
2017
- 2017-11-01 US US15/801,269 patent/US10598665B2/en active Active
-
2019
- 2019-01-30 AU AU2019200573A patent/AU2019200573A1/en not_active Abandoned
- 2019-02-25 AU AU2019201290A patent/AU2019201290A1/en not_active Withdrawn
- 2019-08-13 JP JP2019148579A patent/JP2019198327A/ja not_active Withdrawn
-
2020
- 2020-03-04 US US16/809,300 patent/US20200200755A1/en not_active Abandoned
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| US20100196426A1 (en) * | 2008-02-01 | 2010-08-05 | The General Hospital Corporation | Use of microvesicles in diagnosis and prognosis of medical diseases and conditions |
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| Publication number | Publication date |
|---|---|
| DK3076949T3 (da) | 2019-11-25 |
| JP7138372B2 (ja) | 2022-09-16 |
| EP3076949B1 (fr) | 2019-09-04 |
| HUE046489T2 (hu) | 2020-03-30 |
| US10598665B2 (en) | 2020-03-24 |
| AU2014360344A1 (en) | 2016-07-14 |
| EP3076949A1 (fr) | 2016-10-12 |
| AU2014360344B2 (en) | 2018-11-29 |
| HRP20192131T1 (hr) | 2020-02-21 |
| NZ721720A (en) | 2022-04-29 |
| WO2015085096A1 (fr) | 2015-06-11 |
| US20200200755A1 (en) | 2020-06-25 |
| US20180045728A1 (en) | 2018-02-15 |
| CA2936100A1 (fr) | 2015-06-11 |
| AU2019200573A1 (en) | 2019-02-21 |
| JP2021177760A (ja) | 2021-11-18 |
| LT3076949T (lt) | 2019-12-10 |
| US20170059572A1 (en) | 2017-03-02 |
| JP2019198327A (ja) | 2019-11-21 |
| AU2019201290A1 (en) | 2019-03-14 |
| SI3076949T1 (sl) | 2020-01-31 |
| JP2017501694A (ja) | 2017-01-19 |
| US9921223B2 (en) | 2018-03-20 |
| ZA201604468B (en) | 2024-01-31 |
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