EP3143162A4 - Mirna-expressionssignatur in der klassifizierung von schilddrüsentumoren - Google Patents

Mirna-expressionssignatur in der klassifizierung von schilddrüsentumoren Download PDF

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Publication number
EP3143162A4
EP3143162A4 EP15792258.4A EP15792258A EP3143162A4 EP 3143162 A4 EP3143162 A4 EP 3143162A4 EP 15792258 A EP15792258 A EP 15792258A EP 3143162 A4 EP3143162 A4 EP 3143162A4
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EP
European Patent Office
Prior art keywords
classification
mirna expression
expression signature
thyroid tumors
thyroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP15792258.4A
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English (en)
French (fr)
Other versions
EP3143162A1 (de
Inventor
Zohar BARNETT-ITZHAKI
Gila Lithwick Yanai
Eti Meiri
Yael Spector
Hila Benjamin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rosetta Genomics Ltd
Original Assignee
Rosetta Genomics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rosetta Genomics Ltd filed Critical Rosetta Genomics Ltd
Publication of EP3143162A1 publication Critical patent/EP3143162A1/de
Publication of EP3143162A4 publication Critical patent/EP3143162A4/de
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP15792258.4A 2014-05-13 2015-05-13 Mirna-expressionssignatur in der klassifizierung von schilddrüsentumoren Pending EP3143162A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461992531P 2014-05-13 2014-05-13
US201461992756P 2014-05-13 2014-05-13
US201462069353P 2014-10-28 2014-10-28
US201562139066P 2015-03-27 2015-03-27
PCT/US2015/030564 WO2015175660A1 (en) 2014-05-13 2015-05-13 Mirna expression signature in the classification of thyroid tumors

Publications (2)

Publication Number Publication Date
EP3143162A1 EP3143162A1 (de) 2017-03-22
EP3143162A4 true EP3143162A4 (de) 2017-04-26

Family

ID=54480610

Family Applications (1)

Application Number Title Priority Date Filing Date
EP15792258.4A Pending EP3143162A4 (de) 2014-05-13 2015-05-13 Mirna-expressionssignatur in der klassifizierung von schilddrüsentumoren

Country Status (7)

Country Link
EP (1) EP3143162A4 (de)
JP (1) JP6216470B2 (de)
CN (1) CN106460053A (de)
BR (1) BR112016026575A2 (de)
CA (1) CA2945531C (de)
IL (1) IL248639A0 (de)
WO (1) WO2015175660A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106434872A (zh) * 2016-08-11 2017-02-22 河南大学 一种诊断2型糖尿病的miRNA分子标志物hsa‑miR‑152‑3p及其应用
CN107385093A (zh) * 2017-09-07 2017-11-24 青岛大学 引物组合物及其应用和应用其的产品及产品的使用方法
CN107723365B (zh) * 2017-09-11 2019-10-01 朱伟 一种与肺鳞癌辅助诊断相关的血浆miRNA标志物及其应用
CN108038352B (zh) * 2017-12-15 2021-09-14 西安电子科技大学 结合差异化分析和关联规则挖掘全基因组关键基因的方法
CN120977377A (zh) 2018-01-05 2025-11-18 维森盖特有限公司 使用光学断层扫描对细胞进行形态计量学基因分型以检测肿瘤突变负荷
BR102018003587A2 (pt) * 2018-02-23 2020-07-07 Onkos Diagnósticos Moleculares Ltda Me método e kit para detecção de tipo de tumor de tireoide
CN108721318B (zh) * 2018-05-16 2021-06-25 广东药科大学 miR-125b和化疗剂在制备治疗甲状腺癌的药物中的应用
EP3835434A4 (de) * 2018-08-10 2022-06-08 Toray Industries, Inc. Kit, vorrichtung und verfahren für den nachweis von prostatakrebs
CN109700824A (zh) * 2019-01-08 2019-05-03 上海长海医院 miR-31及其类似物在制备预防或治疗血管内皮损伤的药物中的应用
CN110499367B (zh) * 2019-08-09 2022-11-22 深圳市第二人民医院 生物标志物及其应用
CN113025714B (zh) * 2021-03-23 2022-05-24 华中科技大学同济医学院附属同济医院 用于甲状腺乳头状癌颈侧方淋巴结转移诊断的miRNA生物标志物及检测试剂盒
CN116769922B (zh) * 2023-08-24 2023-11-24 四川大学华西医院 检测循环sEV RNA试剂的用途、试剂盒和诊断系统
WO2025063647A1 (ko) * 2023-09-18 2025-03-27 (주)에스엔이바이오 miRNA 억제제를 포함하는 혈액응고장애 치료용 조성물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013063544A1 (en) * 2011-10-27 2013-05-02 Asuragen, Inc. Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011154008A1 (en) * 2010-06-11 2011-12-15 Rigshospitalet Microrna classification of thyroid follicular neoplasia
JP2014511677A (ja) * 2011-03-22 2014-05-19 コーネル・ユニバーシティー 鑑別困難な良性甲状腺病変と悪性甲状腺病変との識別法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013063544A1 (en) * 2011-10-27 2013-05-02 Asuragen, Inc. Mirnas as diagnostic biomarkers to distinguish benign from malignant thyroid tumors

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
H. MAZEH: "MicroRNA as a Diagnostic Tool in Fine-Needle Aspiration Biopsy of Thyroid Nodules", THE ONCOLOGIST, vol. 17, no. 8, 15 June 2012 (2012-06-15), US, pages 1032 - 1038, XP055355012, ISSN: 1083-7159, DOI: 10.1634/theoncologist.2012-0013 *
NIKIFOROVA MARINA N ET AL: "MicroRNA expression profiling of thyroid tumors: Biological significance and diagnostic utility", JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, THE ENDOCRINE SOCIETY, US, vol. 93, no. 5, 1 May 2008 (2008-05-01), pages 1600 - 1608, XP002636292, ISSN: 0021-972X, [retrieved on 20080212], DOI: 10.1210/JC.2007-2696 *
PIERLORENZO PALLANTE ET AL: "Deregulation of microRNA expression in thyroid neoplasias", NATURE REVIEWS. ENDOCRINOLOGY, vol. 10, no. 2, 19 November 2013 (2013-11-19), US, pages 88 - 101, XP055355049, ISSN: 1759-5029, DOI: 10.1038/nrendo.2013.223 *
See also references of WO2015175660A1 *
ZI-MING YUAN ET AL: "Deregulation of microRNA expression in thyroid tumors", ZHEJIANG UNIVERSITY. JOURNAL. SCIENCE B: INTERNATIONAL BIOMEDICINE & BIOTECHNOLOGY JOURNAL, vol. 15, no. 3, 1 March 2014 (2014-03-01), CN, pages 212 - 224, XP055355031, ISSN: 1673-1581, DOI: 10.1631/jzus.B1300192 *

Also Published As

Publication number Publication date
CA2945531A1 (en) 2015-11-19
EP3143162A1 (de) 2017-03-22
WO2015175660A1 (en) 2015-11-19
CN106460053A (zh) 2017-02-22
CA2945531C (en) 2018-01-30
BR112016026575A2 (pt) 2017-12-12
JP2017521051A (ja) 2017-08-03
JP6216470B2 (ja) 2017-10-18
IL248639A0 (en) 2017-01-31

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