EP3143379A4 - Ensembles de cuves à circulation microfluidique pour imagerie et procédé d'utilisation - Google Patents

Ensembles de cuves à circulation microfluidique pour imagerie et procédé d'utilisation Download PDF

Info

Publication number: EP3143379A4
Authority: EP; European Patent Office
Prior art keywords: imaging; flow cell; cell assemblies; microfluidic flow; microfluidic
Prior art date: 2014-05-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

EP15792752.6A

Other languages

German (de)

English (en)

Other versions

EP3143379A1 (fr

Inventor

Kashan Ali Shaikh

Mengli Wang

Adriana Ines Larriera Moreno

Jessica Godin Karp

Christine Lynne Pitner

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

General Electric Co

Original Assignee

General Electric Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-05-14

Filing date

2015-04-24

Publication date

2017-05-31

2014-05-14 Priority claimed from US14/277,503 external-priority patent/US9080941B2/en

2015-04-24 Application filed by General Electric Co filed Critical General Electric Co

2017-03-22 Publication of EP3143379A1 publication Critical patent/EP3143379A1/fr

2017-05-31 Publication of EP3143379A4 publication Critical patent/EP3143379A4/fr

Status Ceased legal-status Critical Current

Links

230000000712 assembly Effects 0.000 title 1
238000000429 assembly Methods 0.000 title 1
238000003384 imaging method Methods 0.000 title 1
238000000034 method Methods 0.000 title 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
- B01F31/30—Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted
- B01F31/31—Mixers with shaking, oscillating, or vibrating mechanisms comprising a receptacle to only a part of which the shaking, oscillating, or vibrating movement is imparted using receptacles with deformable parts, e.g. membranes, to which a motion is imparted
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/025—Align devices or objects to ensure defined positions relative to each other
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/028—Modular arrangements
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0874—Three dimensional network
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0887—Laminated structure
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/12—Specific details about materials
- B01L2300/123—Flexible; Elastomeric
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0346—Capillary cells; Microcells

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Analytical Chemistry (AREA)
Physics & Mathematics (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Physics & Mathematics (AREA)
Immunology (AREA)
Pathology (AREA)
Hematology (AREA)
Clinical Laboratory Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Dispersion Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Automatic Analysis And Handling Materials Therefor (AREA)

EP15792752.6A 2014-05-14 2015-04-24 Ensembles de cuves à circulation microfluidique pour imagerie et procédé d'utilisation Ceased EP3143379A4 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US14/277,503 US9080941B2 (en)	2012-04-27	2014-05-14	Microfluidic flow cell assemblies for imaging and method of use
PCT/US2015/027549 WO2015175188A1 (fr)	2014-05-14	2015-04-24	Ensembles de cuves à circulation microfluidique pour imagerie et procédé d'utilisation

Publications (2)

Publication Number	Publication Date
EP3143379A1 EP3143379A1 (fr)	2017-03-22
EP3143379A4 true EP3143379A4 (fr)	2017-05-31

Family

ID=54480428

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP15792752.6A Ceased EP3143379A4 (fr)	2014-05-14	2015-04-24	Ensembles de cuves à circulation microfluidique pour imagerie et procédé d'utilisation

Country Status (3)

Country	Link
EP (1)	EP3143379A4 (fr)
JP (1)	JP6723541B2 (fr)
WO (1)	WO2015175188A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20150166956A1 (en) *	2013-12-16	2015-06-18	General Electric Company	Devices for separation of particulates, associated methods and systems
FR3063990A1 (fr) *	2017-03-17	2018-09-21	Commissariat A L'energie Atomique Et Aux Energies Alternatives	Dispositif micro-fluidique
CA3061302A1 (fr)	2017-04-27	2019-10-23	Mochida Pharmaceutical Co., Ltd.	Nouveau derive de tetrahydronaphtyle uree
EP3700420B1 (fr) *	2017-10-26	2024-09-25	Essenlix Corporation	Dispositifs et procédés pour la coloration de tissus et de cellules
WO2020197993A1 (fr)	2019-03-26	2020-10-01	Siemens Healthcare Diagnostics Inc.	Procédés et et appareil pour effectuer des mesures d'échantillons en utilisant la lumière visible sur des échantillons manipulés avec des ondes acoustiques
GB2606852B (en) *	2019-09-23	2025-04-09	Element Biosciences Inc	Methods for cellularly addressable nucleic acid sequencing
WO2024040068A1 (fr)	2022-08-15	2024-02-22	Element Biosciences, Inc.	Capture sur surface à résolution spatiale d'acides nucléiques

Citations (9)

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Publication number	Priority date	Publication date	Assignee	Title
US20020185184A1 (en) *	2001-06-07	2002-12-12	Nanostream, Inc.	Microfluidic synthesis devices and methods
WO2003015922A1 (fr) *	2001-08-20	2003-02-27	Biomicro Systems, Inc.	Dispositif d'interface a microreseaux stratifie
US20050019898A1 (en) *	2001-03-09	2005-01-27	Nils Adey	Fluid mixing in low aspect ratio chambers
US20090081464A1 (en) *	2005-12-06	2009-03-26	Philip Summersgill	Fine Line Bonding and/or Sealing System and Method
US20100179068A1 (en) *	2007-05-03	2010-07-15	Clondiag Gmbh	Assays
EP2388500A1 (fr) *	2010-05-18	2011-11-23	Samsung Electronics Co., Ltd.	Microvanne et procédé destiné à sa fabrication
US20120128548A1 (en) *	2007-08-14	2012-05-24	Arcxis Biotechnologies	Polymer microfluidic biochip fabrication
WO2013106458A2 (fr) *	2012-01-09	2013-07-18	Micronics, Inc.	Filière de réacteur microfluidique
US20130287645A1 (en) *	2012-04-27	2013-10-31	General Electric Company	Microfluidic chamber device and fabrication

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5147606A (en) *	1990-08-06	1992-09-15	Miles Inc.	Self-metering fluid analysis device
US5872582A (en) *	1996-07-02	1999-02-16	Hewlett-Packard Company	Microfluid valve for modulating fluid flow within an ink-jet printer
JP3777112B2 (ja) *	2001-11-02	2006-05-24	財団法人川村理化学研究所	マイクロ流体デバイス及びその製造方法
WO2004103563A2 (fr) *	2003-05-20	2004-12-02	Fluidigm Corporation	Procede et systeme pour dispositif microfluidique et son imagerie
JP2007322284A (ja) *	2006-06-01	2007-12-13	Konica Minolta Medical & Graphic Inc	マイクロチップおよびマイクロチップへの試薬の充填方法
US9494500B2 (en) *	2012-10-29	2016-11-15	Academia Sinica	Collection and concentration system for biologic substance of interest and use thereof

2015
- 2015-04-24 EP EP15792752.6A patent/EP3143379A4/fr not_active Ceased
- 2015-04-24 WO PCT/US2015/027549 patent/WO2015175188A1/fr not_active Ceased
- 2015-04-24 JP JP2016567401A patent/JP6723541B2/ja active Active

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050019898A1 (en) *	2001-03-09	2005-01-27	Nils Adey	Fluid mixing in low aspect ratio chambers
US20020185184A1 (en) *	2001-06-07	2002-12-12	Nanostream, Inc.	Microfluidic synthesis devices and methods
WO2003015922A1 (fr) *	2001-08-20	2003-02-27	Biomicro Systems, Inc.	Dispositif d'interface a microreseaux stratifie
US20090081464A1 (en) *	2005-12-06	2009-03-26	Philip Summersgill	Fine Line Bonding and/or Sealing System and Method
US20100179068A1 (en) *	2007-05-03	2010-07-15	Clondiag Gmbh	Assays
US20120128548A1 (en) *	2007-08-14	2012-05-24	Arcxis Biotechnologies	Polymer microfluidic biochip fabrication
EP2388500A1 (fr) *	2010-05-18	2011-11-23	Samsung Electronics Co., Ltd.	Microvanne et procédé destiné à sa fabrication
WO2013106458A2 (fr) *	2012-01-09	2013-07-18	Micronics, Inc.	Filière de réacteur microfluidique
US20130287645A1 (en) *	2012-04-27	2013-10-31	General Electric Company	Microfluidic chamber device and fabrication

Non-Patent Citations (1)

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Title
See also references of WO2015175188A1 *

Also Published As

Publication number	Publication date
JP2017516099A (ja)	2017-06-15
EP3143379A1 (fr)	2017-03-22
WO2015175188A1 (fr)	2015-11-19
JP6723541B2 (ja)	2020-07-15

Legal Events

Date	Code	Title	Description
2016-11-01	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2017-02-17	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2017-02-17	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2017-03-22	17P	Request for examination filed	Effective date: 20161028
2017-03-22	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2017-03-22	AX	Request for extension of the european patent	Extension state: BA ME
2017-05-31	A4	Supplementary search report drawn up and despatched	Effective date: 20170504
2017-05-31	RIC1	Information provided on ipc code assigned before grant	Ipc: G01N 21/64 20060101ALI20170426BHEP Ipc: B01F 11/00 20060101ALI20170426BHEP Ipc: B01J 19/00 20060101ALI20170426BHEP Ipc: G01N 21/03 20060101ALI20170426BHEP Ipc: G01N 21/05 20060101AFI20170426BHEP Ipc: F16K 99/00 20060101ALI20170426BHEP Ipc: B01L 3/00 20060101ALI20170426BHEP
2017-08-23	DAV	Request for validation of the european patent (deleted)
2017-08-23	DAX	Request for extension of the european patent (deleted)
2018-08-10	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: EXAMINATION IS IN PROGRESS
2018-09-12	17Q	First examination report despatched	Effective date: 20180809
2020-02-05	REG	Reference to a national code	Ref country code: DE Ref legal event code: R003
2020-07-10	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED
2020-08-12	18R	Application refused	Effective date: 20200205

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