EP3143392A4 - Quantifizierung von tamoxifen und metaboliten davon durch massenspektrometrie - Google Patents

Quantifizierung von tamoxifen und metaboliten davon durch massenspektrometrie Download PDF

Info

Publication number: EP3143392A4
Authority: EP; European Patent Office
Prior art keywords: tamoxifen; quantitation; metabolites; mass spectrometry; spectrometry
Prior art date: 2014-05-12
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

EP15793289.8A

Other languages

English (en)

French (fr)

Other versions

EP3143392A1 (de

EP3143392B1 (de

Inventor

Nigel Clarke

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Quest Diagnostics Investments LLC

Original Assignee

Quest Diagnostics Investments LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-05-12

Filing date

2015-05-12

Publication date

2017-11-15

2015-05-12 Application filed by Quest Diagnostics Investments LLC filed Critical Quest Diagnostics Investments LLC

2015-05-12 Priority to EP23157017.7A priority Critical patent/EP4220178A3/de

2017-03-22 Publication of EP3143392A1 publication Critical patent/EP3143392A1/de

2017-11-15 Publication of EP3143392A4 publication Critical patent/EP3143392A4/de

2023-02-22 Application granted granted Critical

2023-02-22 Publication of EP3143392B1 publication Critical patent/EP3143392B1/de

Status Active legal-status Critical Current

2035-05-12 Anticipated expiration legal-status Critical

Links

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H01J49/0031—Step by step routines describing the use of the apparatus
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/17—Nitrogen containing
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25125—Digestion or removing interfering materials
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Biomedical Technology (AREA)
Physics & Mathematics (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Hematology (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Urology & Nephrology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Biophysics (AREA)
Bioinformatics & Cheminformatics (AREA)
Ecology (AREA)
Biotechnology (AREA)
Cell Biology (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Plasma & Fusion (AREA)
Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Investigating Or Analysing Biological Materials (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

EP15793289.8A 2014-05-12 2015-05-12 Quantifizierung von tamoxifenmetaboliten durch massenspektrometrie Active EP3143392B1 (de)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
EP23157017.7A EP4220178A3 (de)	2014-05-12	2015-05-12	Quantifizierung von tamoxifen und metaboliten davon durch massenspektrometrie

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201461992214P	2014-05-12	2014-05-12
PCT/US2015/030419 WO2015175561A1 (en)	2014-05-12	2015-05-12	Quantitation of tamoxifen and metabolites thereof by mass spectrometry

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
EP23157017.7A Division EP4220178A3 (de)	2014-05-12	2015-05-12	Quantifizierung von tamoxifen und metaboliten davon durch massenspektrometrie

Publications (3)

Publication Number	Publication Date
EP3143392A1 EP3143392A1 (de)	2017-03-22
EP3143392A4 true EP3143392A4 (de)	2017-11-15
EP3143392B1 EP3143392B1 (de)	2023-02-22

Family

ID=54367635

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
EP15793289.8A Active EP3143392B1 (de)	2014-05-12	2015-05-12	Quantifizierung von tamoxifenmetaboliten durch massenspektrometrie
EP23157017.7A Pending EP4220178A3 (de)	2014-05-12	2015-05-12	Quantifizierung von tamoxifen und metaboliten davon durch massenspektrometrie

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
EP23157017.7A Pending EP4220178A3 (de)	2014-05-12	2015-05-12	Quantifizierung von tamoxifen und metaboliten davon durch massenspektrometrie

Country Status (9)

Country	Link
US (7)	US9459267B2 (de)
EP (2)	EP3143392B1 (de)
JP (5)	JP6279104B2 (de)
CN (2)	CN106537139B (de)
AU (5)	AU2015259294A1 (de)
BR (1)	BR112016026459B1 (de)
CA (1)	CA2948823C (de)
SA (1)	SA516380291B1 (de)
WO (1)	WO2015175561A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8153962B2 (en) *	2008-12-24	2012-04-10	Quest Diagnostics Investments Incorporated	Mass spectrometry assay for congenital adrenal hyperplasia
EP3143392B1 (de)	2014-05-12	2023-02-22	Quest Diagnostics Investments Incorporated	Quantifizierung von tamoxifenmetaboliten durch massenspektrometrie
CN105159539B (zh) *	2015-09-10	2018-06-01	京东方科技集团股份有限公司	可穿戴设备的触控响应方法、装置及可穿戴设备
CN114585915B (zh)	2019-10-10	2024-02-23	瑞泽恩制药公司	用于分析两性电解质批次变化的液相色谱法-质谱法(lc-ms)方法
KR20220136376A (ko)	2020-01-31	2022-10-07	리제너론 파마슈티칼스 인코포레이티드	올리고뉴클레오티드의 특성을 분석하기 위한 액체 크로마토그래피 및 질량 분광분석의 용도
US12105102B2 (en)	2022-03-30	2024-10-01	University Of Utah Research Foundation	Methods for quantifying insulin-like growth factor-1 and insulin-like growth factor-2

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US5384260A (en) *	1990-09-05	1995-01-24	Board Of Regents, The University Of Texas System	Detection of onset of antiestrogen resistance in breast cancer
US20090186944A1 (en) *	2003-04-01	2009-07-23	Laboratoires Besins International Sa	Prevention and treatment of breast cancer with 4-hydroxy tamoxifen
WO2012167126A1 (en) *	2011-06-03	2012-12-06	Purdue Research Foundation	Ion generation using modified wetted porous materials

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US5605798A (en)	1993-01-07	1997-02-25	Sequenom, Inc.	DNA diagnostic based on mass spectrometry
WO1994028418A1 (en)	1993-05-28	1994-12-08	Baylor College Of Medicine	Method and apparatus for desorption and ionization of analytes
IES950928A2 (en) *	1995-12-08	1996-02-21	Bunskellig Limited	"A process for analysing a fluid"
GB9717926D0 (en)	1997-08-22	1997-10-29	Micromass Ltd	Methods and apparatus for tandem mass spectrometry
AU2463299A (en)	1998-01-23	1999-08-09	Analytica Of Branford, Inc.	Mass spectrometry from surfaces
CN1871517A (zh) *	2002-02-19	2006-11-29	免疫公司	快速有效分离循环癌细胞的方法和试剂
EP1952809B1 (de) *	2002-12-18	2017-08-02	Besins Healthcare Luxembourg SARL	Formulierungen für die Reduzierung der Brustdichte mit 4-Hydroxi-Tamoxifen
DE602004027839D1 (de) *	2003-12-26	2010-08-05	Takeda Pharmaceutical	Verfahren zur vorhersage von anomalien des lipidmetabolismus
MY145634A (en) *	2003-12-29	2012-03-15	Bristol Myers Squibb Co	Pyrrolotriazine compounds as kinase inhibitors
US20060105045A1 (en) *	2004-11-08	2006-05-18	Buchanan Charles M	Cyclodextrin solubilizers for liquid and semi-solid formulations
US20090291134A1 (en) *	2006-11-21	2009-11-26	Jina Pharmaceuticals, Inc.	Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases
US8017403B2 (en) *	2007-06-14	2011-09-13	Quest Diagnostics Investments Incorporated	Mass spectrometry method for measuring vitamin B6 in body fluid
US20090134325A1 (en) *	2007-11-27	2009-05-28	Goldman Mildred M	Methods for detecting estradiol by mass spectrometry
US8916385B2 (en) *	2007-12-13	2014-12-23	Quest Diagnostics Investments, Inc.	Methods for detecting estrone by mass spectrometry
US7834313B2 (en)	2008-08-08	2010-11-16	Quest Diagnostics Investments Incorporated	Mass spectrometry assay for plasma-renin
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CA2776383C (en) *	2009-10-06	2019-04-30	Wisconsin Alumni Research Foundation	Metabolic biomarkers of drug-induced cardiotoxicity
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EP3143392B1 (de) *	2014-05-12	2023-02-22	Quest Diagnostics Investments Incorporated	Quantifizierung von tamoxifenmetaboliten durch massenspektrometrie

2015
- 2015-05-12 EP EP15793289.8A patent/EP3143392B1/de active Active
- 2015-05-12 BR BR112016026459-2A patent/BR112016026459B1/pt active IP Right Grant
- 2015-05-12 AU AU2015259294A patent/AU2015259294A1/en not_active Abandoned
- 2015-05-12 CA CA2948823A patent/CA2948823C/en active Active
- 2015-05-12 JP JP2016567654A patent/JP6279104B2/ja active Active
- 2015-05-12 CN CN201580037630.9A patent/CN106537139B/zh active Active
- 2015-05-12 WO PCT/US2015/030419 patent/WO2015175561A1/en not_active Ceased
- 2015-05-12 US US14/710,311 patent/US9459267B2/en active Active
- 2015-05-12 EP EP23157017.7A patent/EP4220178A3/de active Pending
- 2015-05-12 CN CN201910220665.6A patent/CN110044998B/zh active Active
2016
- 2016-10-03 US US15/284,248 patent/US9835606B2/en active Active
- 2016-11-13 SA SA516380291A patent/SA516380291B1/ar unknown
2017
- 2017-12-04 US US15/830,812 patent/US10830746B2/en active Active
2018
- 2018-01-16 JP JP2018004851A patent/JP6821610B2/ja active Active
- 2018-12-07 AU AU2018275011A patent/AU2018275011A1/en not_active Abandoned
2020
- 2020-09-23 AU AU2020239700A patent/AU2020239700B2/en active Active
- 2020-11-09 US US17/093,472 patent/US11428682B2/en active Active
2021
- 2021-01-06 JP JP2021000689A patent/JP2021073450A/ja active Pending
2022
- 2022-04-20 AU AU2022202628A patent/AU2022202628B2/en active Active
- 2022-08-23 US US17/893,950 patent/US11835505B2/en active Active
2023
- 2023-05-16 JP JP2023080724A patent/JP2023109874A/ja active Pending
- 2023-07-07 AU AU2023204389A patent/AU2023204389B2/en active Active
- 2023-10-25 US US18/494,030 patent/US12270803B2/en active Active
2025
- 2025-02-07 JP JP2025018885A patent/JP2025081382A/ja active Pending
- 2025-03-07 US US19/074,121 patent/US20260118337A1/en active Pending

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5384260A (en) *	1990-09-05	1995-01-24	Board Of Regents, The University Of Texas System	Detection of onset of antiestrogen resistance in breast cancer
US20090186944A1 (en) *	2003-04-01	2009-07-23	Laboratoires Besins International Sa	Prevention and treatment of breast cancer with 4-hydroxy tamoxifen
WO2012167126A1 (en) *	2011-06-03	2012-12-06	Purdue Research Foundation	Ion generation using modified wetted porous materials

Also Published As

Publication number	Publication date
US20230114103A1 (en)	2023-04-13
WO2015175561A1 (en)	2015-11-19
US20240060950A1 (en)	2024-02-22
JP2017516104A (ja)	2017-06-15
US20190212317A1 (en)	2019-07-11
BR112016026459B1 (pt)	2022-09-27
SA516380291B1 (ar)	2020-04-13
AU2023204389A1 (en)	2023-07-27
JP6821610B2 (ja)	2021-01-27
CA2948823C (en)	2020-09-22
US9459267B2 (en)	2016-10-04
US20210055277A1 (en)	2021-02-25
AU2023204389B2 (en)	2025-05-22
CN106537139A (zh)	2017-03-22
AU2024227191A1 (en)	2024-10-31
AU2020239700B2 (en)	2022-01-27
CN106537139B (zh)	2019-04-16
CN110044998B (zh)	2021-12-14
US20170023537A1 (en)	2017-01-26
AU2022202628A1 (en)	2022-05-12
US11835505B2 (en)	2023-12-05
EP4220178A2 (de)	2023-08-02
JP6279104B2 (ja)	2018-02-14
US11428682B2 (en)	2022-08-30
JP2023109874A (ja)	2023-08-08
US20150323513A1 (en)	2015-11-12
CA2948823A1 (en)	2015-11-19
CN110044998A (zh)	2019-07-23
BR112016026459A2 (de)	2017-08-15
US9835606B2 (en)	2017-12-05
US10830746B2 (en)	2020-11-10
JP2021073450A (ja)	2021-05-13
EP3143392A1 (de)	2017-03-22
AU2018275011A1 (en)	2019-01-03
AU2022202628B2 (en)	2023-06-08
AU2015259294A1 (en)	2016-12-01
AU2020239700A1 (en)	2020-10-15
EP3143392B1 (de)	2023-02-22
US12270803B2 (en)	2025-04-08
JP2025081382A (ja)	2025-05-27
JP2018077253A (ja)	2018-05-17
US20260118337A1 (en)	2026-04-30
EP4220178A3 (de)	2023-08-16

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