EP3146077A4 - Tissue molecular signatures of kidney transplant rejections - Google Patents

Tissue molecular signatures of kidney transplant rejections Download PDF

Info

Publication number
EP3146077A4
EP3146077A4 EP15795618.6A EP15795618A EP3146077A4 EP 3146077 A4 EP3146077 A4 EP 3146077A4 EP 15795618 A EP15795618 A EP 15795618A EP 3146077 A4 EP3146077 A4 EP 3146077A4
Authority
EP
European Patent Office
Prior art keywords
kidney transplant
molecular signatures
transplant rejections
tissue molecular
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP15795618.6A
Other languages
German (de)
French (fr)
Other versions
EP3146077A1 (en
Inventor
Daniel Salomon
Sunil KURIAN
Michael Abecassis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Northwestern University
Original Assignee
Scripps Research Institute
Northwestern University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/481,167 external-priority patent/US20150167085A1/en
Application filed by Scripps Research Institute, Northwestern University filed Critical Scripps Research Institute
Priority to EP20193121.9A priority Critical patent/EP3825417A3/en
Publication of EP3146077A1 publication Critical patent/EP3146077A1/en
Publication of EP3146077A4 publication Critical patent/EP3146077A4/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G01N2800/245—Transplantation related diseases, e.g. graft versus host disease

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP15795618.6A 2014-05-22 2015-05-22 Tissue molecular signatures of kidney transplant rejections Ceased EP3146077A4 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20193121.9A EP3825417A3 (en) 2014-05-22 2015-05-22 Tissue molecular signatures of kidney transplant rejections

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462001889P 2014-05-22 2014-05-22
US201462001902P 2014-05-22 2014-05-22
US201462001909P 2014-05-22 2014-05-22
US201462029038P 2014-07-25 2014-07-25
US14/481,167 US20150167085A1 (en) 2013-09-09 2014-09-09 Methods and Systems for Analysis of Organ Transplantation
PCT/US2014/054735 WO2015035367A1 (en) 2013-09-09 2014-09-09 Methods and systems for analysis of organ transplantation
PCT/US2015/032195 WO2015179773A1 (en) 2014-05-22 2015-05-22 Tissue molecular signatures of kidney transplant rejections

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP20193121.9A Division EP3825417A3 (en) 2014-05-22 2015-05-22 Tissue molecular signatures of kidney transplant rejections

Publications (2)

Publication Number Publication Date
EP3146077A1 EP3146077A1 (en) 2017-03-29
EP3146077A4 true EP3146077A4 (en) 2018-05-02

Family

ID=63013167

Family Applications (2)

Application Number Title Priority Date Filing Date
EP15795618.6A Ceased EP3146077A4 (en) 2014-05-22 2015-05-22 Tissue molecular signatures of kidney transplant rejections
EP20193121.9A Pending EP3825417A3 (en) 2014-05-22 2015-05-22 Tissue molecular signatures of kidney transplant rejections

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP20193121.9A Pending EP3825417A3 (en) 2014-05-22 2015-05-22 Tissue molecular signatures of kidney transplant rejections

Country Status (2)

Country Link
EP (2) EP3146077A4 (en)
WO (1) WO2015179773A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6297676B2 (en) 2013-05-06 2018-03-20 日立化成株式会社 Devices and methods for capturing target molecules
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
JP6733968B2 (en) * 2015-08-31 2020-08-05 日立化成株式会社 Molecular method for assessing post-renal transplant complications
DE112016003948T5 (en) 2015-08-31 2018-05-09 City Of Sapporo MOLECULAR METHODS FOR EVALUATING A UROTHIAL DISEASE
US20200347455A1 (en) 2017-09-05 2020-11-05 Agency For Science, Technology And Research Clear Cell Renal Cell Carcinoma Biomarkers
EP3911762A1 (en) 2019-01-17 2021-11-24 Katholieke Universiteit Leuven Mrna-based biomarkers for antibody-mediated transplant rejection

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130040301A1 (en) * 1997-09-24 2013-02-14 Cornell Research Foundation, Inc. Methods of Evaluating Transplant Rejection

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US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5922615A (en) 1990-03-12 1999-07-13 Biosite Diagnostics Incorporated Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
CA2072758A1 (en) 1990-09-14 1992-03-15 Kenneth Francis Buechler Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays
AU1772992A (en) 1991-04-10 1992-11-17 Biosite Diagnostics Incorporated Crosstalk inhibitors and their uses
JP3290988B2 (en) 1991-04-11 2002-06-10 バイオサイト・ダイアグノスティックス・インコーポレイテッド Novel conjugates and assays for simultaneous detection of multiple ligands
US6143576A (en) 1992-05-21 2000-11-07 Biosite Diagnostics, Inc. Non-porous diagnostic devices for the controlled movement of reagents
US5885527A (en) 1992-05-21 1999-03-23 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membrances
US5458852A (en) 1992-05-21 1995-10-17 Biosite Diagnostics, Inc. Diagnostic devices for the controlled movement of reagents without membranes
US5824799A (en) 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
JP2002515738A (en) 1996-01-23 2002-05-28 アフィメトリックス，インコーポレイティド Nucleic acid analysis
US6113855A (en) 1996-11-15 2000-09-05 Biosite Diagnostics, Inc. Devices comprising multiple capillarity inducing surfaces
US5947124A (en) 1997-03-11 1999-09-07 Biosite Diagnostics Incorporated Diagnostic for determining the time of a heart attack
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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130040301A1 (en) * 1997-09-24 2013-02-14 Cornell Research Foundation, Inc. Methods of Evaluating Transplant Rejection

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANDREAS SCHERER ET AL: "Transcriptome changes in renal allograft protocol biopsies at 3 months precede the onset of interstitial fibrosis/tubular atrophy (IF/TA) at 6 months", NEPHROLOGY DIALYSIS TRANSPLANTATION., vol. 24, no. 8, August 2009 (2009-08-01), GB, pages 2567 - 2575, XP055432051, ISSN: 0931-0509, DOI: 10.1093/ndt/gfp183 *
FLECHNER S M ET AL: "Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes", AMERICAN JOURNAL OF TRANSPLANTATION, BLACKWELL MUNKSGAARD, DK, vol. 4, no. 9, September 2004 (2004-09-01), pages 1475 - 1489, XP008103279, ISSN: 1600-6135, [retrieved on 20040607], DOI: 10.1111/J.1600-6143.2004.00526.X *
J. L. GOULET ET AL: "Deficiency of 5-Lipoxygenase Accelerates Renal Allograft Rejection in Mice", THE JOURNAL OF IMMUNOLOGY, vol. 167, no. 11, December 2001 (2001-12-01), US, pages 6631 - 6636, XP055432046, ISSN: 0022-1767, DOI: 10.4049/jimmunol.167.11.6631 *
NILS HEYNE ET AL: "Urinary Neutrophil Gelatinase-Associated Lipocalin Accurately Detects Acute Allograft Rejection Among Other Causes of Acute Kidney Injury in Renal Allograft Recipients", TRANSPLANTATION, vol. 93, no. 12, June 2012 (2012-06-01), GB, pages 1252 - 1257, XP055357590, ISSN: 0041-1337, DOI: 10.1097/TP.0b013e31824fd892 *
S. M. KURIAN ET AL: "Molecular Classifiers for Acute Kidney Transplant Rejection in Peripheral Blood by Whole Genome Gene Expression Profiling", AMERICAN JOURNAL OF TRANSPLANTATION, vol. 14, no. 5, 11 April 2014 (2014-04-11), pages 1164 - 1172, XP055172952, ISSN: 1600-6135, DOI: 10.1111/ajt.12671 *
See also references of WO2015179773A1 *

Also Published As

Publication number Publication date
EP3146077A1 (en) 2017-03-29
WO2015179773A1 (en) 2015-11-26
EP3825417A2 (en) 2021-05-26
EP3825417A3 (en) 2021-09-15

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