EP3146077A4 - Signatures moléculaires de tissu de rejets de transplantation hépatique - Google Patents

Signatures moléculaires de tissu de rejets de transplantation hépatique Download PDF

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Publication number
EP3146077A4
EP3146077A4 EP15795618.6A EP15795618A EP3146077A4 EP 3146077 A4 EP3146077 A4 EP 3146077A4 EP 15795618 A EP15795618 A EP 15795618A EP 3146077 A4 EP3146077 A4 EP 3146077A4
Authority
EP
European Patent Office
Prior art keywords
kidney transplant
molecular signatures
transplant rejections
tissue molecular
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP15795618.6A
Other languages
German (de)
English (en)
Other versions
EP3146077A1 (fr
Inventor
Daniel Salomon
Sunil KURIAN
Michael Abecassis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Northwestern University
Original Assignee
Scripps Research Institute
Northwestern University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2014/054735 external-priority patent/WO2015035367A1/fr
Application filed by Scripps Research Institute, Northwestern University filed Critical Scripps Research Institute
Priority to EP20193121.9A priority Critical patent/EP3825417A3/fr
Publication of EP3146077A1 publication Critical patent/EP3146077A1/fr
Publication of EP3146077A4 publication Critical patent/EP3146077A4/fr
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G01N2800/245—Transplantation related diseases, e.g. graft versus host disease

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP15795618.6A 2014-05-22 2015-05-22 Signatures moléculaires de tissu de rejets de transplantation hépatique Ceased EP3146077A4 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20193121.9A EP3825417A3 (fr) 2014-05-22 2015-05-22 Signatures moléculaires de tissu de rejets de transplantation hépatique

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462001889P 2014-05-22 2014-05-22
US201462001909P 2014-05-22 2014-05-22
US201462001902P 2014-05-22 2014-05-22
US201462029038P 2014-07-25 2014-07-25
PCT/US2014/054735 WO2015035367A1 (fr) 2013-09-09 2014-09-09 Méthodes et systèmes permettant l'analyse d'une transplantation d'organes
US14/481,167 US20150167085A1 (en) 2013-09-09 2014-09-09 Methods and Systems for Analysis of Organ Transplantation
PCT/US2015/032195 WO2015179773A1 (fr) 2014-05-22 2015-05-22 Signatures moléculaires de tissu de rejets de transplantation hépatique

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP20193121.9A Division EP3825417A3 (fr) 2014-05-22 2015-05-22 Signatures moléculaires de tissu de rejets de transplantation hépatique

Publications (2)

Publication Number Publication Date
EP3146077A1 EP3146077A1 (fr) 2017-03-29
EP3146077A4 true EP3146077A4 (fr) 2018-05-02

Family

ID=63013167

Family Applications (2)

Application Number Title Priority Date Filing Date
EP20193121.9A Pending EP3825417A3 (fr) 2014-05-22 2015-05-22 Signatures moléculaires de tissu de rejets de transplantation hépatique
EP15795618.6A Ceased EP3146077A4 (fr) 2014-05-22 2015-05-22 Signatures moléculaires de tissu de rejets de transplantation hépatique

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP20193121.9A Pending EP3825417A3 (fr) 2014-05-22 2015-05-22 Signatures moléculaires de tissu de rejets de transplantation hépatique

Country Status (2)

Country Link
EP (2) EP3825417A3 (fr)
WO (1) WO2015179773A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014182330A1 (fr) 2013-05-06 2014-11-13 Hitachi Chemical Company Ltd Dispositifs et procédés de capture de molécules-cibles
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
JP6733968B2 (ja) * 2015-08-31 2020-08-05 日立化成株式会社 腎移植後合併症を評価するための分子法
DE112016003948T5 (de) 2015-08-31 2018-05-09 City Of Sapporo Molekulare verfahren zum beurteilen einer urothelialen erkrankung
US20200347455A1 (en) * 2017-09-05 2020-11-05 Agency For Science, Technology And Research Clear Cell Renal Cell Carcinoma Biomarkers
EP3911762A1 (fr) 2019-01-17 2021-11-24 Katholieke Universiteit Leuven Biomarqueurs à base d'arnm pour rejet de greffe à médiation par anticorps

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130040301A1 (en) * 1997-09-24 2013-02-14 Cornell Research Foundation, Inc. Methods of Evaluating Transplant Rejection

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US5939272A (en) 1989-01-10 1999-08-17 Biosite Diagnostics Incorporated Non-competitive threshold ligand-receptor assays
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5922615A (en) 1990-03-12 1999-07-13 Biosite Diagnostics Incorporated Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
CA2072758A1 (fr) 1990-09-14 1992-03-15 Kenneth Francis Buechler Anticorps liant aux complexes de recepteurs de ligands et de ligands et leur utilite dans les tests ligand-recepteur
CA2107894C (fr) 1991-04-10 2003-10-14 Kenneth F. Buechler Subtances inhibitrices
EP0579767B1 (fr) 1991-04-11 2000-08-23 Biosite Diagnostics Inc. Nouveaux conjugues et dosages destines a la detection simultanee de ligands multiples
US6143576A (en) 1992-05-21 2000-11-07 Biosite Diagnostics, Inc. Non-porous diagnostic devices for the controlled movement of reagents
US5458852A (en) 1992-05-21 1995-10-17 Biosite Diagnostics, Inc. Diagnostic devices for the controlled movement of reagents without membranes
US6019944A (en) 1992-05-21 2000-02-01 Biosite Diagnostics, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US5824799A (en) 1993-09-24 1998-10-20 Biosite Diagnostics Incorporated Hybrid phthalocyanine derivatives and their uses
US5538848A (en) 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5631734A (en) 1994-02-10 1997-05-20 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5578832A (en) 1994-09-02 1996-11-26 Affymetrix, Inc. Method and apparatus for imaging a sample on a device
WO1997027317A1 (fr) 1996-01-23 1997-07-31 Affymetrix, Inc. Evaluation rapide de difference d'abondance d'acides nucleiques, avec un systeme d'oligonucleotides haute densite
US6113855A (en) 1996-11-15 2000-09-05 Biosite Diagnostics, Inc. Devices comprising multiple capillarity inducing surfaces
US5947124A (en) 1997-03-11 1999-09-07 Biosite Diagnostics Incorporated Diagnostic for determining the time of a heart attack
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EP2070921A1 (fr) 2000-11-07 2009-06-17 Novartis Ag Dérivés d'indolylmaléimide comme inhibiteurs de la protéine kinase C
US20040126767A1 (en) 2002-12-27 2004-07-01 Biosite Incorporated Method and system for disease detection using marker combinations
TW200918046A (en) 2002-04-03 2009-05-01 Novartis Ag Indolylmaleimide derivatives
CA2506432A1 (fr) 2002-12-09 2004-06-24 Robert A. Kirken Procede d'inhibition selective de la janus tyrosine kinase 3 (jak3)
JP2006526140A (ja) 2002-12-24 2006-11-16 バイオサイト インコーポレイテッド 鑑別診断のためのマーカーおよびその使用方法
DK1704145T3 (da) 2004-01-12 2012-09-24 Ym Biosciences Australia Pty Selektive kinaseinhibitorer
GB0605217D0 (en) 2006-03-15 2006-04-26 Novartis Ag Method and compositions for assessing acute rejection
US20110143953A1 (en) 2006-10-16 2011-06-16 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Synthetic Antibodies
JP2011515068A (ja) 2007-11-08 2011-05-19 ノバルティス アーゲー 慢性／硬化性同種移植腎症に対する遺伝子発現シグネチャー
US20110003708A1 (en) * 2007-12-27 2011-01-06 Compugen Ltd. Biomarkers for the prediction of renal injury
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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130040301A1 (en) * 1997-09-24 2013-02-14 Cornell Research Foundation, Inc. Methods of Evaluating Transplant Rejection

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ANDREAS SCHERER ET AL: "Transcriptome changes in renal allograft protocol biopsies at 3 months precede the onset of interstitial fibrosis/tubular atrophy (IF/TA) at 6 months", NEPHROLOGY DIALYSIS TRANSPLANTATION., vol. 24, no. 8, August 2009 (2009-08-01), GB, pages 2567 - 2575, XP055432051, ISSN: 0931-0509, DOI: 10.1093/ndt/gfp183 *
FLECHNER S M ET AL: "Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes", AMERICAN JOURNAL OF TRANSPLANTATION, BLACKWELL MUNKSGAARD, DK, vol. 4, no. 9, September 2004 (2004-09-01), pages 1475 - 1489, XP008103279, ISSN: 1600-6135, [retrieved on 20040607], DOI: 10.1111/J.1600-6143.2004.00526.X *
J. L. GOULET ET AL: "Deficiency of 5-Lipoxygenase Accelerates Renal Allograft Rejection in Mice", THE JOURNAL OF IMMUNOLOGY, vol. 167, no. 11, December 2001 (2001-12-01), US, pages 6631 - 6636, XP055432046, ISSN: 0022-1767, DOI: 10.4049/jimmunol.167.11.6631 *
NILS HEYNE ET AL: "Urinary Neutrophil Gelatinase-Associated Lipocalin Accurately Detects Acute Allograft Rejection Among Other Causes of Acute Kidney Injury in Renal Allograft Recipients", TRANSPLANTATION, vol. 93, no. 12, June 2012 (2012-06-01), GB, pages 1252 - 1257, XP055357590, ISSN: 0041-1337, DOI: 10.1097/TP.0b013e31824fd892 *
S. M. KURIAN ET AL: "Molecular Classifiers for Acute Kidney Transplant Rejection in Peripheral Blood by Whole Genome Gene Expression Profiling", AMERICAN JOURNAL OF TRANSPLANTATION, vol. 14, no. 5, 11 April 2014 (2014-04-11), pages 1164 - 1172, XP055172952, ISSN: 1600-6135, DOI: 10.1111/ajt.12671 *
See also references of WO2015179773A1 *

Also Published As

Publication number Publication date
EP3146077A1 (fr) 2017-03-29
EP3825417A2 (fr) 2021-05-26
EP3825417A3 (fr) 2021-09-15
WO2015179773A1 (fr) 2015-11-26

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