EP3235562C0 - Liposomherstellungsverfahren und liposomherstellungsvorrichtung - Google Patents

Liposomherstellungsverfahren und liposomherstellungsvorrichtung

Info

Publication number: EP3235562C0
Authority: EP; European Patent Office
Prior art keywords: liposome production; production method; liposome; production device; production
Prior art date: 2014-12-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

EP15870075.7A

Other languages

English (en)

French (fr)

Other versions

EP3235562B1 (de

EP3235562A4 (de

EP3235562A1 (de

Inventor

Susumu Sugiyama

Naoki Yamada

Shigehisa Sugiyama

Yohei Okubo

Takashi Sasaki

Tetsu Ishiguro

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Fujifilm Corp

Original Assignee

Fujifilm Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-12-19

Filing date

2015-12-18

Publication date

2023-10-18

2015-12-18 Application filed by Fujifilm Corp filed Critical Fujifilm Corp

2017-10-25 Publication of EP3235562A1 publication Critical patent/EP3235562A1/de

2017-12-13 Publication of EP3235562A4 publication Critical patent/EP3235562A4/de

2023-10-18 Application granted granted Critical

2023-10-18 Publication of EP3235562C0 publication Critical patent/EP3235562C0/de

2023-10-18 Publication of EP3235562B1 publication Critical patent/EP3235562B1/de

Status Active legal-status Critical Current

2035-12-18 Anticipated expiration legal-status Critical

Links

Classifications

- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D5/00—Condensation of vapours; Recovering volatile solvents by condensation
- B01D5/0057—Condensation of vapours; Recovering volatile solvents by condensation in combination with other processes
- B01D5/006—Condensation of vapours; Recovering volatile solvents by condensation in combination with other processes with evaporation or distillation
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/50—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/40—Mixing liquids with liquids; Emulsifying
- B01F23/41—Emulsifying
- B01F23/414—Emulsifying characterised by the internal structure of the emulsion
- B01F23/4145—Emulsions of oils, e.g. fuel, and water

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Dispersion Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Manufacturing Of Micro-Capsules (AREA)
Mixers Of The Rotary Stirring Type (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
Accessories For Mixers (AREA)

EP15870075.7A 2014-12-19 2015-12-18 Liposomherstellungsverfahren und liposomherstellungsvorrichtung Active EP3235562B1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2014257283A JP6316182B2 (ja)	2014-12-19	2014-12-19	リポソームの製造方法及びリポソーム製造装置
PCT/JP2015/085456 WO2016098876A1 (ja)	2014-12-19	2015-12-18	リポソームの製造方法及びリポソーム製造装置

Publications (4)

Publication Number	Publication Date
EP3235562A1 EP3235562A1 (de)	2017-10-25
EP3235562A4 EP3235562A4 (de)	2017-12-13
EP3235562C0 true EP3235562C0 (de)	2023-10-18
EP3235562B1 EP3235562B1 (de)	2023-10-18

Family

ID=56126756

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP15870075.7A Active EP3235562B1 (de)	2014-12-19	2015-12-18	Liposomherstellungsverfahren und liposomherstellungsvorrichtung

Country Status (5)

Country	Link
US (2)	US11325091B2 (de)
EP (1)	EP3235562B1 (de)
JP (1)	JP6316182B2 (de)
ES (1)	ES2963051T3 (de)
WO (1)	WO2016098876A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MA43184A (fr)	2015-11-02	2021-04-14	Fujifilm Corp	Composition liposomale et son procédé de production
RU2734900C1 (ru) *	2017-03-31	2020-10-26	Фуджифилм Корпорэйшн	Липосомальная композиция и фармацевтическая композиция
CN110546155B (zh)	2017-03-31	2023-06-23	浜理药品工业株式会社	肽的制备方法
JP6897353B2 (ja) *	2017-06-14	2021-06-30	ニプロ株式会社	調製装置及び調製方法
JP6964878B2 (ja) *	2017-12-22	2021-11-10	国立大学法人福井大学	脂質二重膜の特性の検査方法、薬剤のスクリーニング方法、および脂質二重膜の特性の解析システム
JP7036919B2 (ja)	2018-06-20	2022-03-15	富士フイルム株式会社	薬物を内包するリポソーム組成物および免疫チェックポイント阻害剤を含む組合せ医薬
EP3861987A4 (de)	2018-10-01	2021-09-15	FUJIFILM Corporation	Kombinationsarzneimittel mit wirkstoffverkapselnder liposomzusammensetzung und platinpräparat
DE102019218404A1 (de) *	2019-11-27	2021-05-27	Smartdyelivery Gmbh	Reaktor zur Herstellung einer Formulierung
TW202535424A (zh) *	2023-10-31	2025-09-16	日商富士軟片股份有限公司	脂質體組成物的製造方法及脂質體組成物

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA747937A (en) *		1966-12-06	Grunewald Helmut	Process for sulphonating and/or sulphating organic substances and an apparatus for carrying out the process
US431372A (en)		1890-07-01		Mash-tub
US444345A (en) *		1891-01-06		And harold
US1420210A (en)		1922-06-20		Apparatus for use ist effecting chemical reactions
US718227A (en) *	1901-10-03	1903-01-13	Myron J Stetson	Rotary churn-dasher.
US742712A (en) *	1903-08-21	1903-10-27	James Willard Morris	Dasher for churns.
US780260A (en) *	1904-02-16	1905-01-17	Miles W Beemer	Dasher.
US1156606A (en)	1914-08-10	1915-10-12	James Wright Lawrie	Process of treating aluminum screenings, dross, slags, or analogous aluminous materials.
US1645614A (en) *	1926-04-08	1927-10-18	Ormond B Monahan	Agitator
US1961903A (en) *	1928-11-20	1934-06-05	Sun Oil Co	Apparatus for making grease
US1963903A (en)	1933-06-22	1934-06-19	Hiss John Martin	Foot exerciser
US2703304A (en)	1949-06-07	1955-03-01	Fond Emanuele Paterno	Foamless stirring and/or homogenizing process and apparatus therefor
US3067988A (en) *	1958-04-30	1962-12-11	Penarroya Miniere Metall	Flotation with mechanical agitation
US3128084A (en) *	1961-11-15	1964-04-07	Wilbur W Castor	Stirrer
US3424733A (en)	1963-04-16	1969-01-28	Phillips Petroleum Co	Method and apparatus for handling of a fluid
CH522827A (de) *	1971-02-15	1972-05-15	Norm Amc Ag	Verfahren zur Verhinderung der Eisbildung und/oder Schmutzablagerung auf der Oberfläche eines Belüftungskreisels, Belüftungskreisel zur Ausführung des Verfahrens und Anwendung des Verfahrens
US3951386A (en)	1975-03-31	1976-04-20	Phillips Petroleum Company	Uniform mixing in vessels
CH624011A5 (de) *	1977-08-05	1981-07-15	Battelle Memorial Institute
US4235871A (en) *	1978-02-24	1980-11-25	Papahadjopoulos Demetrios P	Method of encapsulating biologically active materials in lipid vesicles
US4752425A (en) *	1986-09-18	1988-06-21	Liposome Technology, Inc.	High-encapsulation liposome processing method
US4781871A (en) *	1986-09-18	1988-11-01	Liposome Technology, Inc.	High-concentration liposome processing method
US5094785A (en) *	1986-12-10	1992-03-10	Ciba Corning Diagnostics Corp.	Process for stabilizing liposomes
JP2705175B2 (ja)	1987-03-05	1998-01-26	ザリポソームカンパニー，インコーポレイテッド	低毒性薬剤‐脂質系
JP2501336B2 (ja)	1987-07-02	1996-05-29	第一製薬株式会社	安定なリポソ−ム製剤
US4895452A (en) *	1988-03-03	1990-01-23	Micro-Pak, Inc.	Method and apparatus for producing lipid vesicles
US5013497A (en) *	1988-03-03	1991-05-07	Micro-Pak, Inc.	Method and apparatus for producing lipid vesicles
US5000887A (en) *	1988-05-17	1991-03-19	Liposome Technology, Inc.	Preparation of uniform-size liposomes
DE3827659A1 (de)	1988-08-16	1990-03-15	Gabor Klaus Dieter Dipl Ing	Verfahren zur physikalischen aufbereitung von medien - fluessiger bis duennbreiiger konsistenz - zur veraenderung physikalischer grundeigenschaften und aufbereitungsgeraet zur durchfuehrung des verfahrens
US5096629A (en) *	1988-08-29	1992-03-17	501 Nippon Fine Chemical Co., Ltd.	Method for preparing lipid powder for use in preparing liposomes and method for preparing liposomes
FR2649335B1 (fr) *	1989-07-05	1991-09-20	Texinfine Sa	Procede et dispositif de production directe de liposomes
US5234636A (en)	1989-09-29	1993-08-10	3D Systems, Inc.	Methods of coating stereolithographic parts
FR2653015B1 (fr) *	1989-10-12	1993-10-29	Oreal	Composition cosmetique ou pharmaceutique pour application topique contenant au moins un derive retinouide et au moins un derive de pyrimidine, son utilisation comme medicament et procede de traitement correspondant.
DE59406065D1 (de) *	1993-03-24	1998-07-02	Ciba Geigy Ag	Verfahren zur Herstellung einer Liposomendispersion im Hochdruckbereich
WO1994022430A1 (en) *	1993-04-02	1994-10-13	The Liposome Company, Inc.	Method of producing liposomes
JPH08512056A (ja) *	1993-06-30	1996-12-17	ジェネンテク・インコーポレイテッド	リポソームの製造法
GB9320668D0 (en)	1993-10-07	1993-11-24	Secr Defence	Liposomes containing particulare materials
US7083572B2 (en) *	1993-11-30	2006-08-01	Bristol-Myers Squibb Medical Imaging, Inc.	Therapeutic delivery systems
US5993850A (en) *	1994-09-13	1999-11-30	Skyepharma Inc.	Preparation of multivesicular liposomes for controlled release of encapsulated biologically active substances
US5702722A (en) *	1994-09-30	1997-12-30	Bracco Research S.A.	Liposomes with enhanced entrapment capacity, method and use
US5582484A (en)	1995-07-10	1996-12-10	Tokushu Kika Kogyo Kabushiki Kaisha	Method of, and apparatus for, agitating treatment liquid
US5891467A (en)	1997-01-31	1999-04-06	Depotech Corporation	Method for utilizing neutral lipids to modify in vivo release from multivesicular liposomes
US6599005B2 (en)	1997-06-13	2003-07-29	Hosokawa Micron Bv	Intensive mixer
JP4575592B2 (ja)	1997-11-14	2010-11-04	パシラファーマシューティカルズインコーポレーテッド	多小胞リポソームの製造
US5932562A (en)	1998-05-26	1999-08-03	Washington University	Sitostanol formulation to reduce cholesterol absorption and method for preparing and use of same
US20020119188A1 (en) *	2000-02-08	2002-08-29	Susan Niemiec	Method of manufacturing liposomes
AUPQ695000A0 (en) *	2000-04-17	2000-05-11	Technological Resources Pty Limited	A direct smelting process and apparatus
AU2001252588A1 (en)	2000-04-28	2001-11-12	Tanabe Seiyaku Co., Ltd.	Method for preparing microsphere
CA2458313C (en)	2001-09-13	2011-06-28	Dsm Ip Assets B.V.	Zeacarotene colorant for food and pharmaceuticals
AU2003262048A1 (en) *	2002-09-11	2004-04-30	Tanabe Seiyaku Co., Ltd.	Process for the production of microspheres and unit therefor
EP1920765A1 (de) *	2006-11-07	2008-05-14	Medigene AG	Single-Pass Verfahren zur Liposomherstellung
JP5322476B2 (ja) *	2008-03-31	2013-10-23	テルモ株式会社	リポソームの製造装置およびリポソームの製造方法
US8931948B2 (en)	2008-10-01	2015-01-13	Bp Corporation North America Inc.	Process and apparatus for mixing a fluid within a vessel
JP4418019B1 (ja) *	2009-06-23	2010-02-17	和久村田	攪拌用回転体および攪拌装置
WO2010150656A1 (ja) *	2009-06-23	2010-12-29	株式会社エディプラス	攪拌用回転体および攪拌装置
JP5771366B2 (ja) *	2009-09-02	2015-08-26	株式会社バイオメッドコア	リポソーム製造装置及び方法
WO2011127456A2 (en) *	2010-04-09	2011-10-13	Pacira Pharmaceuticals, Inc.	Method for formulating large diameter synthetic membrane vesicles
JP2013529677A (ja)	2010-06-29	2013-07-22	コーニンクレッカフィリップスエレクトロニクスエヌヴィ	磁気粒子イメージング（ｍｐｉ）のための高性能鉄酸化物粒子トレーサーの合成
JP5794564B2 (ja) *	2011-05-23	2015-10-14	株式会社エディプラス	攪拌装置

2014
- 2014-12-19 JP JP2014257283A patent/JP6316182B2/ja active Active
2015
- 2015-12-18 EP EP15870075.7A patent/EP3235562B1/de active Active
- 2015-12-18 WO PCT/JP2015/085456 patent/WO2016098876A1/ja not_active Ceased
- 2015-12-18 ES ES15870075T patent/ES2963051T3/es active Active
2017
- 2017-06-16 US US15/625,020 patent/US11325091B2/en active Active
2018
- 2018-01-11 US US15/868,092 patent/US11395999B2/en active Active

Also Published As

Publication number	Publication date
JP6316182B2 (ja)	2018-04-25
JP2016117005A (ja)	2016-06-30
US20170282144A1 (en)	2017-10-05
ES2963051T3 (es)	2024-03-25
US20180133676A1 (en)	2018-05-17
US11395999B2 (en)	2022-07-26
EP3235562B1 (de)	2023-10-18
EP3235562A4 (de)	2017-12-13
EP3235562A1 (de)	2017-10-25
WO2016098876A1 (ja)	2016-06-23
US11325091B2 (en)	2022-05-10

Legal Events

Date	Code	Title	Description
2017-06-20	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2017-09-22	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2017-09-22	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2017-10-25	17P	Request for examination filed	Effective date: 20170619
2017-10-25	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2017-10-25	AX	Request for extension of the european patent	Extension state: BA ME
2017-12-13	A4	Supplementary search report drawn up and despatched	Effective date: 20171115
2017-12-13	RIC1	Information provided on ipc code assigned before grant	Ipc: B01F 5/10 20060101ALI20171109BHEP Ipc: A61K 9/127 20060101ALI20171109BHEP Ipc: B01F 7/32 20060101ALI20171109BHEP Ipc: B01F 7/16 20060101ALI20171109BHEP Ipc: B01D 1/00 20060101ALI20171109BHEP Ipc: B01F 3/08 20060101ALI20171109BHEP Ipc: B01J 13/04 20060101AFI20171109BHEP Ipc: B01F 15/06 20060101ALI20171109BHEP Ipc: B01F 15/02 20060101ALI20171109BHEP Ipc: B01D 5/00 20060101ALI20171109BHEP Ipc: B01F 7/00 20060101ALI20171109BHEP
2018-03-28	DAV	Request for validation of the european patent (deleted)
2018-03-28	DAX	Request for extension of the european patent (deleted)
2020-02-08	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: EXAMINATION IS IN PROGRESS
2020-03-18	17Q	First examination report despatched	Effective date: 20200212
2021-04-14	RAP3	Party data changed (applicant data changed or rights of an application transferred)	Owner name: FUJIFILM CORPORATION
2023-04-20	REG	Reference to a national code	Ref country code: DE Ref legal event code: R079 Free format text: PREVIOUS MAIN CLASS: B01J0013040000 Ipc: A61K0009000000 Ref document number: 602015086167 Country of ref document: DE
2023-05-10	GRAP	Despatch of communication of intention to grant a patent	Free format text: ORIGINAL CODE: EPIDOSNIGR1
2023-05-10	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: GRANT OF PATENT IS INTENDED
2023-05-24	RIC1	Information provided on ipc code assigned before grant	Ipc: B01J 13/04 20060101ALI20230420BHEP Ipc: A61K 9/127 20060101ALI20230420BHEP Ipc: A61K 9/00 20060101AFI20230420BHEP
2023-06-07	INTG	Intention to grant announced	Effective date: 20230511
2023-09-08	GRAS	Grant fee paid	Free format text: ORIGINAL CODE: EPIDOSNIGR3
2023-09-15	GRAA	(expected) grant	Free format text: ORIGINAL CODE: 0009210
2023-09-15	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE PATENT HAS BEEN GRANTED
2023-10-18	AK	Designated contracting states	Kind code of ref document: B1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2023-10-18	REG	Reference to a national code	Ref country code: GB Ref legal event code: FG4D
2023-10-31	REG	Reference to a national code	Ref country code: CH Ref legal event code: EP
2023-11-08	REG	Reference to a national code	Ref country code: IE Ref legal event code: FG4D
2023-11-09	REG	Reference to a national code	Ref country code: DE Ref legal event code: R096 Ref document number: 602015086167 Country of ref document: DE
2023-12-13	U01	Request for unitary effect filed	Effective date: 20231106
2023-12-13	U07	Unitary effect registered	Designated state(s): AT BE BG DE DK EE FI FR IT LT LU LV MT NL PT SE SI Effective date: 20231110
2024-01-03	U20	Renewal fee for the european patent with unitary effect paid	Year of fee payment: 9 Effective date: 20231129
2024-03-25	REG	Reference to a national code	Ref country code: ES Ref legal event code: FG2A Ref document number: 2963051 Country of ref document: ES Kind code of ref document: T3 Effective date: 20240325
2024-04-08	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20240119
2024-04-09	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20240218
2024-04-30	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: IS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20240218 Ref country code: GR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20240119
2024-05-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: RS Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20231018 Ref country code: PL Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20231018 Ref country code: NO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20240118 Ref country code: HR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20231018
2024-07-19	REG	Reference to a national code	Ref country code: DE Ref legal event code: R097 Ref document number: 602015086167 Country of ref document: DE
2024-07-23	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20231018
2024-07-29	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20231018
2024-07-31	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: SM Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20231018 Ref country code: SK Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20231018 Ref country code: RO Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20231018 Ref country code: CZ Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20231018
2024-08-22	PLBE	No opposition filed within time limit	Free format text: ORIGINAL CODE: 0009261
2024-08-22	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT
2024-08-27	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: MC Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20231018
2024-08-30	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: MC Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20231018
2024-09-25	26N	No opposition filed	Effective date: 20240719
2024-12-11	U20	Renewal fee for the european patent with unitary effect paid	Year of fee payment: 10 Effective date: 20241107
2025-07-25	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: CY Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO Effective date: 20151218
2025-08-18	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: HU Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO Effective date: 20151218
2025-12-12	PG25	Lapsed in a contracting state [announced via postgrant information from national office to epo]	Ref country code: TR Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT Effective date: 20231018
2025-12-17	U20	Renewal fee for the european patent with unitary effect paid	Year of fee payment: 11 Effective date: 20251110
2026-01-01	REG	Reference to a national code	Ref country code: CH Ref legal event code: U11 Free format text: ST27 STATUS EVENT CODE: U-0-0-U10-U11 (AS PROVIDED BY THE NATIONAL OFFICE) Effective date: 20260101
2026-01-09	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: GB Payment date: 20251030 Year of fee payment: 11
2026-01-20	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: IE Payment date: 20251111 Year of fee payment: 11
2026-04-10	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: ES Payment date: 20260108 Year of fee payment: 11
2026-04-23	PGFP	Annual fee paid to national office [announced via postgrant information from national office to epo]	Ref country code: CH Payment date: 20260101 Year of fee payment: 11
2026-04-29	U1N	Appointed representative for the unitary patent procedure changed after the registration of the unitary effect	Representative=s name: MARKS & CLERK LLP; GB

Publication	Publication Date	Title
EP3205103C0 (de)	2024-08-14	Intrarundfunk und intervereinigung
IL249981A0 (en)	2017-03-30	Method
EP3836642C0 (de)	2024-02-14	Proximitätskommunikationsverfahren und vorrichtung
IL246992B (en)	2019-02-28	Purge device and purge method
PL3117909T3 (pl)	2026-02-16	Urządzenie aplikujące i sposób aplikacji
DK3134149T3 (da)	2026-02-02	Mikrokanyler og fremgangsmåder til fremstilling deraf
MA40933A (fr)	2017-09-19	Difluorométhyl-aminopyridines et difluorométhyl-aminopyrimidines
SG11201703021TA (en)	2017-05-30	Proximity monitoring devices and methods
EP3952592C0 (de)	2024-10-30	Kommunikationsvorrichtung und kommunikationsverfahren
BR112016027102A2 (pt)	2018-07-10	método e aparelho
EP3285237C0 (de)	2024-01-24	Benachrichtigungsvorrichtung und benachrichtigungsverfahren
SG11201702242PA (en)	2017-04-27	Gas-dissolved water production device and production method
IL249418B (en)	2020-07-30	Purge stocker and purging method
ZA201805436B (en)	2020-06-24	Nanofiber production device and nanofiber production method
PL3198460T3 (pl)	2022-11-14	Aparat i sposób konfiguracji zbiorów przerwań
PL3102503T3 (pl)	2017-12-29	Kartusz oraz sposób wytwarzania kartusza
IL246131A0 (en)	2016-07-31	Purge apparatus and purge method
EP3664570A4 (de)	2020-07-29	Sitzungsherstellungsverfahren und -vorrichtung
PL3235561T3 (pl)	2019-06-28	Sposób wytwarzania liposomów i urządzenie do wytwarzania liposomów
IL250589B (en)	2019-09-26	Electrode for electrochlorination processes and method of manufacturing thereof
EP3224983C0 (de)	2024-09-04	Authentifizierungsverfahren und -vorrichtung
IL252801A0 (en)	2017-08-31	Energy extraction system and methods
EP3235562A4 (de)	2017-12-13	Liposomherstellungsverfahren und liposomherstellungsvorrichtung
EP3910496C0 (de)	2025-12-24	Suchverfahren und vorrichtung
EP3178574C0 (de)	2025-12-17	Methangärungsverfahren und methangärungssystem