EP3241608B1 - Dispositif de melange et dispositif jetable pour un tel dispositif de melange - Google Patents

Dispositif de melange et dispositif jetable pour un tel dispositif de melange Download PDF

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Publication number
EP3241608B1
EP3241608B1 EP17154806.8A EP17154806A EP3241608B1 EP 3241608 B1 EP3241608 B1 EP 3241608B1 EP 17154806 A EP17154806 A EP 17154806A EP 3241608 B1 EP3241608 B1 EP 3241608B1
Authority
EP
European Patent Office
Prior art keywords
rotor
mixing
limiting element
rod
bearing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP17154806.8A
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German (de)
English (en)
Other versions
EP3241608A1 (fr
Inventor
Reto Dr. Schöb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Levitronix GmbH
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Levitronix GmbH
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Filing date
Publication date
Application filed by Levitronix GmbH filed Critical Levitronix GmbH
Priority to US15/581,880 priority Critical patent/US11819813B2/en
Publication of EP3241608A1 publication Critical patent/EP3241608A1/fr
Application granted granted Critical
Publication of EP3241608B1 publication Critical patent/EP3241608B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • B01F33/4531—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements using an axis supported in several points for mounting the stirring element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/452—Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
    • B01F33/453—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements
    • B01F33/4532—Magnetic mixers; Mixers with magnetically driven stirrers using supported or suspended stirring elements using a bearing, tube, opening or gap for internally supporting the stirring element
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50—Mixing receptacles
    • B01F35/513—Flexible receptacles, e.g. bags supported by rigid containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/50—Mixing receptacles
    • B01F35/53—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components
    • B01F35/531—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components with baffles, plates or bars on the wall or the bottom
    • B01F35/5312—Mixing receptacles characterised by the configuration of the interior, e.g. baffles for facilitating the mixing of components with baffles, plates or bars on the wall or the bottom with vertical baffles mounted on the walls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/60—Safety arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/30—Driving arrangements; Transmissions; Couplings; Brakes
    • B01F2035/35—Use of other general mechanical engineering elements in mixing devices
    • B01F2035/352—Bearings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/44—Mixing of ingredients for microbiology, enzymology, in vitro culture or genetic manipulation

Definitions

  • the invention relates to a mixing device for mixing or stirring substances and a disposable device for a mixing device according to the preamble of the independent claim of the respective category.
  • Mixing devices for mixing or stirring substances for example two liquids or one liquid with a powder or liquids or suspensions with gases, are used in many technical fields. In many applications, the purity of the mixing container in which the mixing takes place and the components contained therein are of great importance. Examples include the pharmaceutical industry and the biotechnology industry. Solutions and suspensions are often produced here that require thorough mixing of the substances.
  • the production of pharmaceutically active substances must meet the highest purity requirements, and the components that come into contact with the substances often have to be sterile. Similar requirements also arise in biotechnology, for example in the production, treatment or cultivation of biological substances, cells or microorganisms, where an extremely high degree of purity must be guaranteed in order not to endanger the usability of the product produced.
  • bioreactors in which, for example, biological substitutes for tissue or special cells or microorganisms are grown.
  • Mixing devices are also required here, for example in order to ensure continuous mixing of the nutrient liquid or its continuous circulation in the mixing container. A high level of purity must be guaranteed in order to protect the substances or the products produced from contamination.
  • Electromagnetically operated mixing devices are known for this purpose, in which a rotor, which usually comprises or drives an impeller, is arranged in the mixing container. Then is outside the mixing container A stator is provided which drives the rotor through the wall of the mixing container in a contactless manner by means of magnetic or electromagnetic fields and magnetically supports it in a desired position in a contactless manner.
  • This “non-contact” concept has the particular advantage that no mechanical bearings or feedthroughs are required in the mixing container that can form a cause of contamination or contamination.
  • a particularly efficient device of this type, with which substances are circulated or mixed in a bioreactor, is part of the EP-B-2 065 085 disclosed.
  • the stator and the rotor arranged in the mixing container form a bearingless motor.
  • bearingless motor means an electromagnetic rotary drive in which the rotor is mounted completely magnetically with respect to the stator, no separate magnetic bearings being provided.
  • the stator is designed as a bearing and drive stator, which is both the stator of the electric drive and the stator of the magnetic bearing.
  • a magnetic rotating field can be generated, which on the one hand exerts a torque on the rotor, which causes its rotation, and on the other hand exerts an arbitrarily adjustable lateral force on the rotor, so that its radial position can be actively controlled or regulated is.
  • the rotor of this mixing device is an integral rotor because it is both the rotor of the electromagnetic drive and the rotor of the mixer.
  • the bearingless motor also offers the advantage of a very compact and space-saving design.
  • Such a mixing device is then composed of a disposable device and a reusable device.
  • the disposable device comprises those components which are intended for single use, for example the mixing container with the rotor
  • the reusable device comprises those components which are permanently used repeatedly, for example the stator.
  • the mixing container When configured as a single-use part, the mixing container is often designed as a flexible plastic bag with a rotor contained therein. These bags are often sterilized during manufacture or after packaging and storage and delivered to the customer in sterile form in the packaging.
  • the mixing device for mixing or stirring substances, which comprises a magnetically mounted rotor, the rotor being better stabilized against tilting.
  • the mixing device should also be able to be designed in such a way that it comprises a single-use device for single use and a reusable device for multiple use.
  • the invention is intended to propose a disposable device for such a mixing device.
  • a mixing device for mixing or stirring substances with a mixing container for receiving the substances to be mixed or stirred, with a rotor arranged in the mixing container, with which at least one blade for mixing or stirring the substances for rotation about an axial Direction is drivable, as well as with a stator arranged outside the mixing container, with which the rotor can be driven magnetically for rotation around the axial direction in contactless manner in the operating state and can be magnetically supported with respect to the stator, an axially extending rod being provided which rotates with it is connected to the rotor, and a mechanical limiting element which is fixed with respect to the mixing container and which interacts with the rod, the limiting element being designed and is arranged that the rod can rotate with respect to the limiting element, and a tilting of the rotor is at least limited by physical contact between the rod and the limiting element.
  • the provision of the rod and the limiting element ensures that the magnetically mounted rotor is better and more reliably stabilized against tilting with respect to the axial direction, because its maximum possible tilting is at least limited mechanically.
  • the rod can be made in one piece and a fixed, i.e. have unchangeable length in the axial direction.
  • the rod can comprise a plurality of parts arranged concentrically one inside the other, for example pipes, which can be displaced in the axial direction relative to one another, so that the rod can be extended or lengthened in a known manner, similar to a telescopic antenna the individual pipes can be pushed together.
  • the stator is designed as a bearing and drive stator with which the rotor can be magnetically driven in a contactless manner in the operating state and can be magnetically supported at least radially with respect to the stator. This means that at least the position of the rotor in the radial plane can be controlled by an active magnetic bearing.
  • This configuration enables a particularly inexpensive and space-saving, compact configuration because the stator is not only designed as a drive stator, but at the same time is the stator for the magnetic mounting of the rotor.
  • Such an embodiment can, for example, be based on the principle of the bearingless motor, in which the rotor can be actively magnetically controlled with respect to three of its degrees of freedom, namely the rotation about the axial direction and its position in the radial plane perpendicular to the axial direction.
  • the rotor is passively magnetically stabilized with respect to the axial direction in the operating state and is preferably also passively magnetically stabilized with respect to tilting with respect to the axial direction.
  • Such an embodiment is also possible on the principle of the bearingless motor.
  • the three remaining degrees of freedom namely the position of the rotor in the axial direction and the two degrees of freedom of the tilt, are passively magnetically stabilized by reluctance forces, i.e. cannot be controlled.
  • the limiting element is designed as a tilt limiter, such that the rod rotates contact-free with respect to the tilt limiter in the operating state when the rotor is not tilted, and that a tilting of the rotor is limited by physical contact between the rod and the tilt limiter.
  • the limiting element and the rod only touch in the operating state when the tilting of the rotor becomes too great or too large. If the rotor is not or only slightly tilted, then the rod and the limiting element do not touch, i. H. in this state, the magnetic bearing of the rotor is not supported by the tilt limiter because it does not exert any forces on the rod or the rotor which contribute to the bearing of the rotor. The rod rotates contactlessly with respect to the tilt limit and does not touch it. Only when the tilt of the rotor becomes too large does the rod contact the tilt limiter, as a result of which a further increase in the tilt of the rotor is efficiently avoided.
  • the tilt limit does not represent a full bearing for the rotor, but limits its maximum possible tilt.
  • the rod and the tilt limiter are preferably designed such that when the rotor is tilted, the rod comes into contact with the limiting element before the rotor comes into physical contact with a wall surrounding it. That is, the distance or the play between the rod and the limiting element designed as a tilting limitation is dimensioned such that the rod comes into contact with the limiting element and thus prevents further tilting of the rotor before the rotor can contact the wall surrounding it.
  • the limiting element is designed as a mechanical bearing for the rod, preferably as a mechanical radial bearing.
  • the limiting element is designed as a fully-fledged mechanical bearing which supports the rod which is connected to the rotor in a rotationally fixed manner.
  • This configuration of the limiting element as a mechanical bearing and in particular as a mechanical radial bearing can at least limit the tilting of the rotor in the operating state.
  • the rod is typically in contact with the limiting element in the operating state even when the rotor is not tilted, as is known from mechanical bearings.
  • all known embodiments of mechanical bearings are suitable for the configuration of the limiting element as a mechanical bearing, because it is preferred if the mechanical bearing is designed as a radial bearing and does not contribute to the axial bearing of the rotor .
  • the mechanical bearing is particularly preferably designed as a roller bearing, for example as a ball bearing, or as a sliding bearing or as a fluid-lubricated bearing or as a hydrodynamic bearing.
  • a fluid present in the mixing device is used for the lubrication of the bearing.
  • the mechanical bearing is designed as a self-aligning bearing, which can accommodate tilting of the rod.
  • Self-aligning bearings of this type are sufficiently known from the prior art. They have the property that, in addition to the radial bearing forces, they can also absorb tilting moments which are transferred to the mechanical bearing via the rod when the rotor is tilted.
  • the self-aligning bearing can be designed, for example, in a manner known per se as a self-aligning ball bearing — with or without a shaft between the bearing bodies — or as a self-aligning roller bearing or as a self-aligning plain bearing or as a spherical plain bearing or as an articulated plain bearing.
  • the following preferred measures or configurations generally relate to the limiting element, that is to say both to the first configuration as a tilt limiter and to the second configuration as a mechanical bearing.
  • the delimiting element is arranged on the inside on one of the two axial delimiting surfaces of the mixing container. This represents a particularly simple design.
  • the limiting element is arranged opposite the rotor, so that the rod extends essentially through the entire mixing container with respect to the axial direction.
  • the rotor is arranged in the stator in the region of the bottom of the mixing container, while the limiting element is therefore arranged on the opposite inner side or inner wall of the mixing container on its upper boundary surface.
  • the rod then extends from the center of the rotor in the axial direction through the entire mixing container and is then received by the limiting element.
  • a preferred measure is that the rod is secured against separation from the limiting element. After assembly of the mixing container, this prevents the rod from accidentally losing its operative connection with the limiting element, which increases the operational reliability of the mixing device.
  • the rod is for the rod to extend through the delimiting element in the axial direction.
  • the limiting element has, for example, a circular opening which is continuous in the axial direction and through which the rod is inserted when the mixing device is assembled, so that the limiting element then completely surrounds the rod.
  • the rod has at its end facing away from the rotor a closing element which is designed to be received by the limiting element.
  • the end element can be inserted into the limiting element via a snap connection.
  • the end element is provided, for example, with a diameter that is larger than the diameter of the rest of the rod.
  • the End element can then be inserted into the boundary element through an opening, the opening having a diameter which is smaller than the diameter of the end element and larger than the diameter of the rest of the rod. After the end element has snapped in, this ensures that the rod, if the limiting element is designed as a tilting limitation, can rotate freely in this opening, ie without contact, if the rotor is not tilted.
  • the snap-in prevents the rod from being able to separate from mechanical bearings during operation.
  • the end element is designed spherical or frustoconical, because then the rod can roll on the boundary element upon contact with it.
  • the delimiting element comprising a pin which extends in the axial direction and which can be inserted into the end of the rod.
  • the pin and the end of the rod receiving it can be designed such that the pin is inserted into the rod via a snap connection.
  • the limiting element is designed to be dimensionally stable and is made of a plastic. This enables a particularly simple and inexpensive production. For the same reason, it is also preferred if the rod and all wings are made of a plastic.
  • the mixing device comprises components which are designed as single-use parts for single use.
  • the mixing device has a disposable device, which is designed for single use, and a reusable device, which is designed for multiple use, the disposable device comprising the mixing container, the rotor, all vanes, the rod, and the limiting element, the mixing container as flexible mixing container is designed and made of a plastic, and wherein the reusable device comprises the stator, and a support container for receiving the mixing container.
  • the invention further proposes a disposable device for a mixing device according to the invention, which mixing device comprises the reusable device which is designed for multiple use, the disposable device being designed for single use, and comprises the flexible mixing container for holding the substances to be mixed or stirred , which is made of a plastic, and the rotor arranged in the mixing container, with which the at least one blade for mixing or stirring the substances for rotation is drivable around the axial direction, and the rod, which in the operating state extends in the axial direction and is connected in a rotationally fixed manner to the rotor, and the limiting element which is fixed with respect to the mixing container and which cooperates with the rod, the limiting element being designed and arranged in such a way that the rod can rotate in operation with respect to the delimiting element, and a tilting of the rotor is at least limited by physical contact between the rod and the delimiting element, the disposable device also being designed to interact with the reusable device, and into the support container of the reusable device
  • the rotor can be driven by the stator of
  • Fig. 1 shows a longitudinal sectional view of a first embodiment of a mixing device according to the invention, which is generally designated by the reference numeral 1.
  • Such mixing devices 1 can be used in particular in the pharmaceutical industry and are used in the biotechnological industry.
  • the mixing device according to the invention is also particularly suitable for those applications in which a very high degree of purity or sterility of those components which come into contact with the substances to be mixed is essential.
  • the mixing device 1 according to the invention can also be designed as a bioreactor or as a fermenter.
  • the invention is not limited to such configurations, but rather relates in general to mixing devices with which media or substances are mixed or stirred. In particular, these substances can be fluids or solids, preferably powders.
  • the mixing device 1 according to the invention is suitable for mixing or stirring liquids with one another and / or for mixing at least one liquid with a powder or other solid and / or for mixing gases with liquids and / or solids.
  • the mixing device 1 comprises a mixing container 2 for receiving the substances to be mixed or stirred, which is designed to be dimensionally stable and is preferably made of a plastic. Examples of suitable plastics are mentioned further below.
  • the mixing container 2 can have a plurality of inlets and outlets for liquid, gaseous or solid substances or for holding probes or measuring sensors which Fig. 1 are not shown for reasons of clarity.
  • the mixing container 2 has two axial boundary surfaces, namely a bottom 22 (as shown below in FIG Fig. 1 ) and a blanket 23 (as shown above in Fig. 1 ).
  • a disk-shaped or ring-shaped rotor 3 is arranged on its bottom 22, with which a plurality of blades 6 can be driven to rotate about an axial direction A, which mix or stir the substances in the mixing container 2.
  • a stator 4 is provided with a plurality of coil cores 41, which carry coils or windings 42, with which the rotor 3 can be magnetically driven in a contactless manner in the operating state.
  • the stator 4 is designed as a bearing and drive stator, with which the rotor 3 can be magnetically driven in a contactless manner in the operating state and magnetically supported in a contactless manner with respect to the stator 4.
  • the stator 4 and the rotor 3 thus form an electromagnetic rotary drive, which is preferably designed according to the principle of the bearingless motor.
  • the rotor 3 can be magnetically driven in a contactless manner and can be magnetically supported in a contactless manner with respect to the stator 4.
  • the stator 4 is designed as a bearing and drive stator, with which the rotor 3 can be magnetically driven in a contactless manner about a desired axis of rotation in the operating state - that is to say it can be rotated - and magnetically supported in a contactless manner with respect to the stator 4.
  • the target axis of rotation is the axis about which the rotor 3 rotates in the operating state when the rotor 3 is in a centered and untilted position with respect to the stator 4.
  • This nominal axis of rotation defines the axial direction A, ie the axial direction A is the direction of Target rotation axis.
  • the desired rotational axis defining the axial direction A coincides with the central axis of the stator 4.
  • a radial direction denotes a direction perpendicular to the axial direction.
  • bearingless motor is now well known to the person skilled in the art, so that a detailed description of its function is no longer necessary.
  • bearingless motor means that the rotor 3 is completely magnetically supported, with no separate magnetic bearings being provided.
  • the stator 4 is designed as a bearing and drive stator, so it is both the stator of the electric drive and the stator of the magnetic bearing.
  • the stator 4 comprises the windings 42, with which a rotating magnetic field can be generated, which on the one hand exerts a torque on the rotor 3, which causes its rotation, and on the other hand exerts an arbitrarily adjustable transverse force on the rotor 3, so that the latter radial position — thus its position in the radial plane perpendicular to the axial direction A — can be actively controlled or regulated.
  • At least three degrees of freedom of the rotor 3 can thus be actively regulated.
  • the rotor 3 is at least passively magnetic, that is to say cannot be controlled, stabilized by reluctance forces.
  • the rotor 3 - depending on the embodiment - can also be passively magnetically stabilized.
  • the magnetic bearing and the drive of the motor are realized via electromagnetic rotating fields, the sum of which, on the one hand, generates a drive torque on the rotor 3, and an arbitrarily adjustable transverse force with which the radial position of the rotor 3 can be regulated .
  • These rotating fields can either be generated separately - i.e. with different coils - or the rotating fields can be generated by superimposing the required currents or voltages and then using a single coil system.
  • the mixing container 2 For placing the rotor 3 in the mixing container 2, the mixing container 2 has at its bottom 22 an essentially cylindrical cup 21 which extends outward with respect to the mixing container 2 as a bulge and is arranged in the center of the bottom 22.
  • the cylindrical cup 21 is preferably dimensionally stable and made of a plastic.
  • the rotor 3 is arranged in the cup 21.
  • the stator 4 is arranged such that it completely surrounds the cup 21 in the circumferential direction, so that the rotor 3 is arranged centrally between the stator poles 43 formed by the coil cores 41.
  • the rotor 3 comprises a magnetically active core 31 which interacts with the stator 4 via magnetic fields in order to magnetically drive and support the rotor 3.
  • the magnetically active core 31 of the rotor 3 is an annular permanent magnet, the magnetization of which in Fig. 1 through the two arrows without Reference number is displayed.
  • the magnetically active core 31 is provided with a casing 32, which consists of plastic.
  • the magnetic rotor plane C denotes the magnetic center plane of the magnetically active core 31 of the rotor 3. This is the plane perpendicular to the axial direction A in which the rotor 3 or the magnetically active core 31 of the rotor 3 is mounted in the operating state when the rotor 3 is not tilted.
  • the magnetic rotor plane C is the geometric center plane of the magnetically active core 31 of the rotor 3, which lies perpendicular to the axial direction A.
  • the plane in which the rotor 3 is mounted in the operating state is also referred to as the radial plane.
  • the radial plane defines the x-y plane of a Cartesian coordinate system whose z-axis runs in the axial direction A. If the rotor 3 is not tilted, the radial plane coincides with the magnetic rotor plane C.
  • the cup 21 has a depth in the axial direction A, which is somewhat greater than the extent of the magnetically active core 31 of the rotor 3 in the axial direction A.
  • the stator 4 is arranged in an essentially cylindrical containment shell 5, which has a centrally arranged, likewise cylindrical recess 51 on its upper side, which is dimensioned such that it can accommodate the cup 21.
  • the cup 21 of the mixing container 2 is arranged coaxially with the containment shell 5 or the recess 51.
  • the dimensions of the can 5 and the cup 21 are matched to one another in such a way that the can 5 tightly encloses the cup 21 in the assembled state and lies with its outer surface on the outer surface of the cup 21.
  • the containment shell 5 is an integral part of a stator housing 52 or it is fixedly connected to the stator housing 52 which receives the stator 4.
  • the stator 4 is cast into the stator housing 52 by means of a thermally conductive casting compound and is thus fixed in the stator housing 52.
  • the rotary drive formed by the stator 4 and the rotor 3 is designed as a so-called temple motor.
  • the characteristic of a configuration as a temple motor is that the stator 4 comprises a plurality of separate coil cores 41, each of which comprises a rod-shaped longitudinal leg, which extends from a first end in the axial direction A to a second end, with all first ends - as shown in Fig. 1 these are the lower ends - are connected to one another by a yoke 44.
  • the inference 44 comprises several segments, each of which is the first end of one Coil core 41 connects to the first end of the adjacent coil core 41.
  • the individual coil cores 41 are preferably arranged such that they surround the rotor 3 in a circle and are arranged equidistantly on this circle.
  • the rotor 3 is magnetically supported contactlessly between the second ends of the coil cores 41, which have the radially inwardly directed stator poles 43.
  • the windings 42 of the stator 4 are each arranged around the longitudinal legs of the coil cores 41 and thus are arranged outside the magnetic rotor plane C, as shown below the magnetic rotor plane C.
  • the windings 42 are completely below the magnetic plane effective core 31 arranged.
  • the windings 42 are therefore not arranged in the plane in which the rotor 3 is driven and supported in the operating state.
  • the windings of the stator are arranged such that the coil axes are each in the magnetic rotor plane, i.e.
  • the windings 42 of the stator 2 are in the temple motor so arranged that the axes of the windings 42 are perpendicular to the magnetic rotor plane C and are thus aligned parallel to the axial direction A.
  • the invention is not restricted to such configurations as a temple motor. Numerous other configurations of the stator 4 are also possible. It is only essential that the rotor 3 can be driven magnetically for rotation about the axial direction in the operating state without contact.
  • the mixing device 1 has a rod 8 extending in the axial direction A, and a mechanical limiting element 9 which is fixed with respect to the mixing container 2 and which cooperates with the rod 8 in order to at least limit tilting of the rotor 3 in the operating state.
  • Tilting of the rotor 3 means that the magnetic rotor plane C of the rotor is no longer exactly perpendicular to the axial direction A, but instead includes an angle different from 90 °. This is equivalent to the fact that the magnetic rotor plane C and the radial plane in which the rotor 3 is mounted are no longer congruent and no longer parallel to one another, but instead form an angle different from zero.
  • An axial displacement of the rotor 3 means that the untilted rotor 3 is displaced in the axial direction A without being tilted in the process. In this case it is magnetic rotor plane C still parallel to the radial plane, but no longer congruent with this.
  • the rod 8 extending in the axial direction A is connected in a rotationally fixed manner to the rotor 3 and interacts with the limiting element 9 fixed with respect to the mixing container 2.
  • the rod 8 extending in the axial direction A is connected in a rotationally fixed manner to the rotor 3 and interacts with the limiting element 9 fixed with respect to the mixing container 2.
  • the limiting element 9 is designed as a tilt limiter 91. This means that the rod 8 rotates contact-free with respect to the tilt limiter 91 in the operating state with the rotor 3 not tilted - that is, when the magnetic rotor plane C of the rotor 3 is perpendicular to the axial direction A. Only when the rotor 3 is tilted does the rod 8 come into physical contact with the limiting element 9 designed as a tilting limiter 91, as a result of which the tilting of the rotor 3 is limited.
  • the limiting element 9 is designed as a mechanical bearing 92 for the rod 8, in particular as a radial bearing.
  • the limiting element 9 is thus a mechanical bearing 92 known per se, so that there is contact between the limiting element 9 and the rod 8 supported by it even when the rotor 3 is not tilted.
  • the rod 8 can be made in one piece and with a constant, non-changeable length in the axial direction A.
  • the rod 8 can comprise a plurality of parts or segments, for example pipes, arranged concentrically one inside the other, which can be displaced in the axial direction A relative to one another, so that the length of the rod is known, similar to a telescopic antenna is extendable or can be pushed together to the length of the individual parts or segments.
  • the rod 8 rotates in the operating state when the rotor 3 is not tilted with little play in a contact-free manner with respect to the limiting element 9 designed as a tilt limiter 91, and a tilting of the rotor 3 is limited by physical contact between the rod 8 and the limiting element 9.
  • the cylindrical rod 8 is arranged in the center of the rotor 3, so that the axis of the rod 8 coincides with the axial direction A when the rotor 3 is not tilted.
  • the rod 8 extends with respect to the axial direction A through the entire mixing container 2.
  • the limiting element 9 is arranged on the inside of the ceiling 23 of the mixing container, in such a way that the center of the limiting element 9 is aligned with the center of the rotor 3.
  • the limiting element 9 is designed here as a sleeve, the inner diameter ID of which is greater than the diameter D of the rod 8.
  • the rod 8 When the mixing device 1 is assembled, the rod 8 is inserted into the limiting element 9, the length of the rod 8 and its diameter D being so dimensioned are that between the inner wall of the Boundary element 9 and the rod 8 a game S exists. With regard to the axial direction A, the rod 8 is dimensioned such that it is also received by the limiting element 9 without contact in the axial direction A.
  • the rotor 3 is passively magnetic with respect to tilting, i. H. not controllable, stabilized in stator 4. This means that if the rotor 3 tilts in the operating state, this causes magnetic restoring forces, which bring about a torque with respect to the axial direction A on the rotor 3, which moves the rotor 3 back into its untilted position. These magnetic restoring forces are usually reluctance forces which are generated by the tilting of the rotor 3. This passive magnetic stabilization of the rotor 3 against tilting should not be influenced by the limiting element 9 either.
  • the rotor 3 rotates contactlessly in the stator 4 in the operating state, and the rod 8 also rotates contactlessly in the limiting element 9 designed as a tilt limiter 91 when the rotor 3 is free of tilt. If the rotor 3 is tilted during operation, this is initially caused by passive magnetic stabilization compensated for the rotor 3, which moves the rotor 3 back into its untilted position without physical contact between the rod 8 and the limiting element 9.
  • the rod 8 can rotate in the limiting element 9 without contact when the rotor 3 is not tilted and when the rotor 3 is tilted, which can be reversed by its passive magnetic mounting. Only when the tilt of the rotor 3 could become too great does physical contact between the rod 8 and the limiting element 9 prevent a further increase in the tilt of the rotor 3.
  • the tilt limiter 91 is therefore not a full-fledged bearing for the rotor 3, but merely a limitation for the tilting of the rotor 3.
  • the play S between the rod 8 and the tilt limiter 91 is preferably dimensioned such that the rod 8 comes into contact with the tilt limiter 91 before the rotor 3 comes into physical contact with the wall or the bottom of the cup 21. It can be determined in a simple manner how much the rotor 3 can be tilted before such contact with the cup 21 occurs. The game S is then selected so that contact between the rotor 3 and the cup 21 is reliably avoided.
  • the rod 8 is preferably also made of a plastic and can either be integrally formed on the casing 32 of the rotor 3 or - like this the representation in Fig. 1 shows - the rod 8 is produced as a separate component, which is then inserted into a central opening of the rotor 3, so that the rod 8 is connected to the rotor 3 in a rotationally fixed manner.
  • the rod 8 it is also possible to glue or weld the rod 8 to the rotor 3.
  • the rod 8 to consist of a metal, for example a stainless steel or aluminum.
  • the rod 8 can be designed in one piece with a length which cannot be changed in the axial direction A, or the rod 8 comprises a plurality of segments which are arranged concentrically one inside the other and can be moved relative to one another in the axial direction A, so that the rod 8 is telescopically pushed together or can be pulled apart.
  • the tilt limiter 91 which is preferably made of plastic, can be produced as a separate component and then fixed to the ceiling 23 of the mixing container 2, for example by welding or gluing. It is of course also possible for the tilt limiter 91 to be produced as an integral part of the ceiling 23. Of course, the tilt limiter 91 can also consist entirely or partially of a metallic material.
  • the first exemplary embodiment shown is provided in the mixing container 2 with a plurality of blades 6 for mixing or stirring the substances.
  • the wings 6 are preferably made of plastic and arranged and attached to the rod 8.
  • the wings 6 are arranged at different heights with respect to the axial direction A, so that the wings 6 are distributed in the axial direction A over the entire mixing container 2. This enables a particularly homogeneous mixing of the substances in the mixing container 2. Since the rod 8 with the wings 6 fastened thereon is connected to the rotor 3 in a rotationally fixed manner, the wings 6 can be driven to rotate about the axial direction A by the rotation of the rotor 3.
  • the wings 6 can be manufactured as separate components which are then connected to the rod 8, for example by welding or gluing, or the wings 6 can be an integral part of the rod 8.
  • the limiting element 9 can also be designed as a mechanical bearing 92, which forms a fully-fledged bearing, in particular a fully-fledged radial bearing for the rod 8.
  • a mechanical bearing 92 which forms a fully-fledged bearing, in particular a fully-fledged radial bearing for the rod 8.
  • Fig. 2 shows in a very schematic representation part of the ceiling 23 of the mixing container 2 with the attached limiting element 9, which is designed as a mechanical bearing 92, and the end of the rod 8, which is supported by the mechanical bearing 92. It is preferred if the bearing 92 is primarily designed as a radial bearing and not as an axial bearing for the rod 8.
  • the mechanical bearing 92 according to FIG Fig.
  • the rolling elements 923 can have all the configurations known per se from rolling bearings.
  • the rolling elements 923 can in particular be balls (ball bearings) or also cylindrical or conical or frustoconical rolling elements 923.
  • the mechanical bearing 92 supports the rod 8 in a manner known per se. In contrast to the first preferred embodiment, the rod 8 is constantly in physical contact with the mechanical bearing 92 during operation, even when the rotor 3 is not tilted.
  • the mechanical bearing 92 there are numerous variants with regard to the design of the mechanical bearing 92, and it is by no means necessary for the mechanical bearing 92 to be designed as a roller bearing.
  • the mechanical bearing 92 it is also possible to design the mechanical bearing 92 as a plain bearing or as a fluid-lubricated bearing or as a hydrodynamic bearing.
  • Fig. 3 shows a particularly simple variant in which the mechanical bearing 92 is designed as a plain bearing.
  • the bearing 92 is designed as a sleeve fixed to the cover 23 of the mixing container 2, which receives the end of the rod 8.
  • the inner diameter of the sleeve is essentially the same size as the diameter of the rod 8, so that the rod 8 slides along the inner wall of the sleeve during operation.
  • the axial end of the rod 8, more precisely its axial end surface, is not in contact with the sleeve, but only the outer surface of the rod 8 Fig. 3
  • the variant of the mechanical bearing 92 shown essentially corresponds to the structure in FIG Fig.
  • the sleeve of the bearing 92 can be made, for example, from the materials known under the brand name Teflon, polytetrafluoroethylene (PTFE) or perfluoroalkoxy polymers (PFA). be made that have good sliding or rubbing properties. However, other material combinations are also suitable, for example metal / polyethylene (PE) or other combinations of metal / plastic.
  • the rod 8 is then preferably made of a metal and the sleeve of the bearing 92 is made of a plastic.
  • Bearings, or sleeves and rods, which do not consist of fluoropolymers such as PTFE or PFA, or which do not comprise any parts made of these materials, are particularly suitable if the mixing device 1 or parts thereof are to be sterilized with gamma rays.
  • the mechanical bearing 92 is designed as a self-aligning bearing which can additionally accommodate tilting of the rod 8.
  • Self-aligning bearings are known in numerous embodiments. Illustrated as an example Fig. 4 the basic structure of an embodiment in which the mechanical bearing 92 is designed as a self-aligning ball bearing, that is, as a roller bearing.
  • the inner bearing body 921 which is non-rotatably connected to the rod 8 rotating in the operating state, is essentially cylindrical, while the inner boundary surface of the stationary outer bearing body 922, which faces the inner bearing body 921, is curved and, in particular, spherically curved.
  • the rolling elements 923 designed as balls can roll on the curved boundary surface of the outer bearing body 922, as indicated by the arrows with the reference symbol P in Fig. 4 is indicated.
  • the self-aligning ball bearing can also absorb or compensate for tilting moments which are introduced into the bearing 92 by a tilting of the rod 8.
  • the rolling elements 923 can alternatively be designed in the manner known per se in the form of rollers or cylinders.
  • the mechanical bearing 92 is designed as a self-aligning bearing.
  • all embodiments of self-aligning plain bearings known per se are suitable, such as e.g. spherical plain bearings or spherical plain bearings.
  • Fig. 5 a particularly simple configuration of the mechanical bearing 92 as a spherical plain bearing is shown in a schematic illustration. Additionally shows Fig. 6 another section along the section line VI-VI in Fig. 5 .
  • the limiting element 9 designed as a mechanical bearing 92 is arranged on the outside of the ceiling 23 of the mixing container 2, that is to say outside of the mixing container 2. It goes without saying that the delimiting element 9 or the bearing 92 can also be arranged on the inside of the ceiling 23 or on the bottom 22 of the mixing container 2 in a similar manner.
  • the outer bearing body 922 of the mechanical bearing 92 is designed as a disk 922 ', for example as a circular disk 922', which has an opening 925 in its center through which through which the rod 8 extends.
  • the rod 8 itself forms the inner bearing body in this embodiment.
  • the diameter of the opening 925 in the disk 922 ' is such that the rod 8 bears against the inner boundary of the opening 925, so that a plain bearing is thereby realized.
  • the boundary of the opening 925 is preferably rounded, as shown in FIG Fig. 5 is shown.
  • This in 5 and 6 Design shown represents a simple spherical plain bearing, because the rod 8 can perform 925 tilting movements in the opening.
  • the two counter-rotating partners can both be made of plastic, or one of the two counter-rotating partners can be made of metal and the other of plastic.
  • the disk 922 ' is here attached to the outside of the mixing container 2, namely on its ceiling 23, and can be fastened to the ceiling 23 of the mixing container 2, for example by gluing or welding. So that no liquid or gas can escape from the mixing container 2 along the rod 8 into the environment during operation, an end cap 926 is provided on the disk 922 ', which is preferably made of a plastic and which is the upper end of the rod as shown 8 completely surrounds.
  • the end cap 926 is connected to the disk 922 'in a fluid-tight manner, for example by gluing, welding or another suitable sealing connection, e.g. a snap connection.
  • the rod 8 preferably has a closing element 81 at its end facing away from the rotor 3, the diameter of which is larger than that Diameter of the opening 925.
  • this closure element 81 can be moved through the opening 925 due to elastic deformations.
  • Fig. 7 shows in a longitudinal section along the axial direction A a second embodiment of the mixing device 1 according to the invention.
  • the reference symbols have the same meaning as they already have in connection with the previously described first exemplary embodiment are explained. It goes without saying that all of the preceding explanations also apply in the same way or in the same way to the second exemplary embodiment.
  • the second exemplary embodiment shown here is designed as a bioreactor.
  • the rotor 3 and the stator 4 are arranged on the ceiling 23 of the mixing container 2 in the second exemplary embodiment.
  • the cup 21 is arranged in the center of the ceiling 23 and in turn - with respect to the mixing container 2 - configured as an outward protuberance.
  • the containment shell 5 with the stator 4 arranged therein is accordingly arranged on the outside on the cover 23, so that its recess 51 receives or encloses the cup 21 with the rotor 3 arranged therein in a manner corresponding to that described for the first exemplary embodiment.
  • the limiting element 9 is fixed opposite the center of the rotor 3 on the bottom 22 of the mixing container 2, so that the limiting element 9 can receive the end of the rod 8.
  • the mixing container 2 is arranged in a foot 10, which gives the mixing container 2 a safe stand.
  • a feed 26 is provided which extends through the wall of the mixing container 2 and through which substances can be introduced into the mixing container 2.
  • a gas feed 25 is provided which extends through the wall of the mixing container 2 and through which a gas, for example oxygen, can be introduced into the mixing container 2.
  • a gas outlet 24 is provided with a gas filter, which extends through the wall of the mixing container 2. About the gas discharge 24 gases, such as carbon dioxide, which, for. B. generated in biological processes in the mixing container 2, are discharged from this.
  • a further feedthrough 27 is also provided, which extends through the wall of the mixing container 2 and which can be used for receiving probes 271 or measuring sensors with which parameters can be monitored during the mixing process, e.g. B. pH, temperature, pressure, concentrations, etc.
  • a discharge 28 is provided which extends through the wall of the mixing container 2 and through which substances can be removed from the mixing container 2 or by means of which the mixing container 2 can be emptied.
  • Further bushings 29 can also be provided, which can be used for different purposes.
  • Fig. 8 shows in a longitudinal section along the axial direction A a third embodiment of the mixing device 1 according to the invention.
  • the reference symbols have the same meaning as they already have in Are explained in connection with the embodiments described above. It goes without saying that all of the preceding explanations also apply in the same way or in the same way to the third exemplary embodiment.
  • the third exemplary embodiment differs from the first two essentially in that the rod 8 does not extend through the entire mixing container 2 with respect to the axial direction A, but rather ends within the mixing container 2, that is to say at a considerable distance from its ceiling 23.
  • the limiting element 9 is provided and fixed on the bottom 22 of the mixing container 2.
  • Fig. 9 still a top view of the limiting element 9 of the in Fig. 8 shown mixing device 1.
  • the limiting element 9 comprises a central ring 93 for receiving the rod 8.
  • the inner diameter ID of the ring 93 is larger than the diameter D of the rod 8.
  • the diameter D of the rod is dimensioned such that the clearance S exists between the inner wall of the ring 93 and the rod 8, which is determined by the difference between the inner diameter ID of the ring 93 and the diameter D of the rod 8.
  • the rod 8 thus extends through the limiting element 9 in the axial direction A.
  • the inner diameter ID of the ring 93 is the same or almost the same size as the diameter of the rod 8, so that the play S is zero or approximately zero.
  • the ring 93 then forms a mechanical slide bearing 92 for the rod 8, preferably a fluid-lubricated slide bearing 92, which is lubricated by or by one of the process fluids which are in the operating state in the mixing container 2.
  • an annular insert (not shown) is provided in the ring 93, which is made of a material that is particularly suitable for sliding friction, for example a plastic such as the Teflon already mentioned.
  • the delimiting element 9 further comprises a plurality, here four arms 94, which each start equidistantly distributed on the radially outer edge of the ring 93, and from there initially in the radial direction and then extend in the axial direction A to the bottom 22 of the mixing container 2, where they are each fixed.
  • the arms 94 of the limiting element 9 can also be fixed to the ceiling 22 of the mixing container 2.
  • Fig. 10 shows in a longitudinal section along the axial direction A a fourth embodiment of the mixing device 1 according to the invention.
  • the reference symbols have the same meaning as already explained in connection with the exemplary embodiments described above. It goes without saying that all of the preceding explanations also apply in the same way or in the same way to the fourth exemplary embodiment.
  • the fourth exemplary embodiment of the mixing device 1 according to the invention is specially designed for single-use applications.
  • the fourth exemplary embodiment comprises a disposable device, which is designated in its entirety by reference numeral 20 and is designed for single use. as well as a reusable device, which is designated in its entirety by reference numeral 60 and which is designed for permanent use, that is to say multiple use.
  • the disposable device 20 comprises those components which come into contact with the substances to be mixed during the mixing process. These are, in particular, the mixing container 2, the rotor 3, all vanes 6, the rod 8 and the limiting element 9.
  • the disposable device 20 and other compositions with the component “disposable”, such as. B. one-time part, one-time component, etc. are components or parts that are designed for single use, which can only be used once as intended and then disposed of. A new, previously unused one-off part must then be used for a new application.
  • the disposable device 20 can be produced as simply and economically as possible, causes few costs and can be produced from materials that are available as inexpensively as possible.
  • the disposable device 20 can be combined with the reusable device 60 to form the mixing device 1 in the simplest possible manner.
  • the disposable device 20 should therefore be able to be replaced in a very simple manner without a high assembly effort being necessary for this.
  • the disposable device 20 should particularly preferably be able to be assembled or separated from the reusable device 60 without the use of tools.
  • the disposable device 20 is as easy to dispose of after use. For this reason, preference is given to materials that have the lowest possible environmental impact, particularly when it comes to disposal.
  • the mixing container 2 is designed as a flexible mixing container 2, which is made of a plastic.
  • the mixing container 2 is preferably a flexible bag, for example a plastic or a plastic bag, which can be folded up so that it has as little space as possible during storage claimed.
  • the mixing container 2 has a plurality of inlets or outlets 11 which, as described above, can be used, for example, for supplying and discharging substances and gases or for receiving probes or measuring sensors.
  • hoses or cunning-like extensions are provided on some of the inlets or outlets 11 in a manner known per se, which are made of plastic and are welded to the mixing container 2, so that substances can be added or removed through these hoses.
  • Other inlets or outlets 11 can also be designed in a manner known per se as self-sealing passages.
  • sampling ports 111 can be glued or welded to the mixing container 2. These are short tubular plastic structures, through which, for example, samples can be taken from the mixing container 2. Each sampling port 111 is usually secured in a manner known per se at its end protruding from the mixing container 2 with a clamp, so that no undesired substances can get into the interior of the mixing container 2 through these sampling ports 111.
  • the gas outlet 24 with the gas filter can also be provided on the mixing container 2, the gas filter also being designed for single use.
  • the cylindrical cup 21 for receiving the rotor 3 is preferably dimensionally stable and made of a plastic. However, it can also be designed, for example, in the form of a flexible tube or bag made of plastic film.
  • the limiting element 9, the rod 8 and all wings 6 are designed to be dimensionally stable and are preferably made of a plastic.
  • the dimensionally stable parts which are fixed to the mixing container 2, that is to say in particular the cup 21 and the limiting element 9, can be connected to the flexible mixing container 2 in a fluid-tight manner by means of gluing or welding. It is of course also possible in the configuration for single use to produce the rod 8 and or the limiting element 9 entirely or partially from a metallic material.
  • the limiting element 9 can be a metallic sleeve, e.g. B. be made of aluminum.
  • the rod 8 can also be made of a metallic material in the configuration for single use, for example to ensure greater stability. Since both the delimiting element 9 and the rod 8 are very simple components, particularly with regard to their geometry, they can also be produced very inexpensively.
  • the reusable device 60 comprises a dimensionally stable support container 61 for receiving the mixing container 2, as well as the stator 4.
  • the support container 61 has at its bottom a plurality of feet 62 on which the support container 61 stands. Furthermore, at least one opening 12 is provided in the bottom, so that substances can be removed from or introduced into the mixing container 2.
  • the essentially cylindrical support container 61 is open or, optionally, as in FIG Fig. 10 shown - provided with a removable cover 63 so that the mixing container 2 can be easily introduced into the support container 61.
  • windows 64 can be provided on the wall of the support container 61, through which windows optical access to the mixing container 2 is possible.
  • the essentially cylindrical containment shell 5 and the stator housing 52 with the stator 4 contained therein are arranged centrally on the bottom of the support container 61.
  • the can 5 is integrated in the stator housing 52 or fixed to it.
  • the containment shell 5 extends downward in the direction of its cylinder axis, so that it can coaxially accommodate the cup 21 in the assembled state.
  • the dimensions of the can 5 and the cup 21 are matched to one another in such a way that the recess 51 of the can 5 tightly encloses the cup 21 in the assembled state and lies with its outer surface on the outer surface of the cup 21.
  • the stator housing 52 with the containment shell 5 is preferably fixed to the bottom of the support container 61 by means of screws.
  • stator 4 Arranged in the stator housing 52 is the stator 4, which is designed as a bearing and drive stator, with which the rotor 3 can be driven in a contactless manner in the operating state and magnetically supported in a contactless manner with respect to the stator 3.
  • the assembly of the disposable device 20 and the reusable device 60 to form the mixing device 1 is extremely simple, and can be carried out quickly and in particular without tools.
  • the mixing container 2, usually folded for storage or wrapped around the rod 8, with the rotor 3 therein, the limiting element 9 and the wings 6 is removed from its packaging, inserted into the support container 61 and the cup 21 with the rotor 3 into the Can 5 inserted. If the rod 8 is not yet connected to the rotor 3, the rod 8 is inserted into the rotor 3 and then brought into operative connection with the limiting element 9.
  • the lid 63 is put on to close the support container 61. The mixing device 1 is then ready for use.
  • the mixing container 2 with the cup 21, the rod 8, the limiting element 9 and the rotor 3 is simply pulled out of the support container 61.
  • the cup 21 simply detaches from the containment shell 5.
  • the delimiting element 9 comprises a fixation 90 with which the delimiting element can be fixed with respect to the reusable device 60.
  • this fixation 90 comprises a pin or a threaded pin which reaches through a corresponding opening in the cover 63 of the reusable device 60 and is then fixed to the cover 63 by means of a nut or another suitable measure.
  • the rotor 3 can - as in Fig. 10 shown - be designed with a permanent magnet as a magnetically active core 31.
  • a permanent magnet as a magnetically active core 31.
  • the magnetically active core 31 is then made, for example, from a soft magnetic material such as iron, nickel iron or silicon iron. This measure enables a cost-effective design of the rotor 3 as a single part, because in particular for the manufacture of the rotor 3 are no rare earths such as. B. neodymium or samarium, or compounds or alloys of these necessary, which are often used for the production of permanent magnets.
  • the rotor 3 is designed without permanent magnets
  • one or more permanent magnet (s) is / are provided in the stator 4 in order to generate a permanent magnetic bias flux, so that not all of the drive and the magnetic flux required for storage must be generated as an electromagnetic flux.
  • the parts made of plastic should be made from the most inexpensive, commercially available plastic.
  • the disposable device 20 or its components must be sterilizable for certain areas of application. It is particularly advantageous if the disposable device 20 can be gamma-sterilized. With this type of sterilization, the element to be sterilized is exposed to gamma radiation.
  • the advantage of gamma sterilization for example in comparison to steam sterilization, is in particular that the sterilization can also be carried out through the packaging.
  • the single-use device 20 offers the great advantage that it can only be used once, that the design does not have to value good cleanability of the single-use device 20 because the single-use device does not have to be cleaned when used as intended. Furthermore, it is generally not necessary that the disposable device 20 or its components have to be sterilizable more than once. This is a great advantage in particular with gamma sterilization, because exposure to gamma radiation in plastics can lead to degradation, so that multiple gamma sterilization can render the plastic unusable.
  • the disposable device 20 that can be gamma-sterilized at least once.
  • the materials should be gamma stable for a dose of at least 40 kGy in order to enable a single gamma sterilization.
  • no toxic substances should arise during gamma sterilization.
  • the following plastics are preferred for the production of the flexible mixing container 2: PolyEthylene (PE), Low Density PolyEthylene (LDPE), Ultra Low Density PolyEthylene (ULDPE), Ethylene Vinyl Acetate (EVA), PolyEthylene Terephthalate (PET), PolyVinylChlorid (PVC) , PolyPropylene (PP), PolyUrethan (PU), Silicones.
  • PE PolyEthylene
  • LDPE Low Density PolyEthylene
  • ULDPE Ultra Low Density PolyEthylene
  • EVA Ethylene Vinyl Acetate
  • PET PolyEthylene Terephthalate
  • PVC PolyVinylChlorid
  • PP PolyPropylene
  • PU PolyUrethan
  • the following plastics are preferred, for example: PolyEthylene (PE), PolyPropylene (PP), Low Density PolyEthylene (LDPE), Ultra Low Density PolyEthylene (ULDPE), Ethylene Vinyl Acetate (EVA), PolyEthylene Terephthalate (PET), PolyVinylChlorid (PVC), PolyVinyliDene Fluoride (PVDF), Acrylonitrile Butadiene Styrene (ABS), PolyAcryl, PolyCarbonate (PC).
  • PET PolyVinylChlorid
  • PVDF PolyVinyliDene Fluoride
  • ABS Acrylonitrile Butadiene Styrene
  • PC PolyAcryl
  • PC PolyCarbonate
  • Suitable or even unsuitable materials for the production of the plastic parts of the disposable device 20 are, for example, the materials known under the brand name Teflon, polytetrafluoroethylene (PTFE) and perfluoroalkoxy polymers (PFA).
  • Teflon polytetrafluoroethylene
  • PFA perfluoroalkoxy polymers
  • the mixing container 2 can of course also be made of PTFE or PFA or of a metal, for example stainless steel or glass.
  • the components consisting of plastic can be produced by means of an injection molding process, because this is a particularly cost-effective type of production.
  • the rod 8 and the delimiting element 9 preferably cooperate in such a way that the rod 8 is secured against separation from the delimiting element 9.
  • the rod 8 and the delimiting element 9 preferably cooperate in such a way that the rod 8 is secured against separation from the delimiting element 9.
  • the ring 93 of the limiting element 9 in which the rod 8 extends in the axial direction through the limiting element 9, show the Fig. 11-13 Embodiments in which the limiting element 9 cooperates with the end of the rod 8 facing away from the rotor 3.
  • the limiting element 9 is designed such that the end of the rod 8 facing away from the rotor 3 is received by the limiting element 9, while the end in FIG Fig. 11
  • the variant shown corresponds to an embodiment in which the end of the rod 8 facing away from the rotor 3 is designed in such a way that it encloses part of the limiting element 9.
  • the variant of the limiting element 9 shown comprises a pin 95 which protrudes from a base body 96 of the limiting element 9 in the axial direction A.
  • This pin 95 has at its end facing away from the base body 96 a spherical head 97 which is designed to cooperate with the rod 8.
  • the end of the rod 8 which cooperates with this pin 95 is hollow and comprises a tongue 82 at its end which delimits the opening of the rod 8 such that the passage formed by the tongue 82 is on the one hand larger than the diameter DS of the pin and on the other hand smaller than the diameter of the ball head 97.
  • the ball head 97 can be inserted into the end of the rod 8 in the form of a snap connection.
  • the diameter of the spherical head 97 is dimensioned such that the spherical head 97 is received in this end of the rod 8 without contact after it has been inserted into the end of the rod 8, as long as the rotor 3 is not tilted or in a tilt that can be compensated for by the passive magnetic bearing is oriented. Only when the tilt of the rotor 3 becomes too strong or too large does the ball head 97 put against the inner wall of the rod 8, roll on it and thus limit the maximum possible tilt of the rotor 3. The tilt of the rotor 3 is in Fig. 11 indicated by the double arrow without reference numerals.
  • the diameter of the spherical head 97 is dimensioned such that the spherical head 97 is constantly on the inner wall of the rod 8 after it has been inserted into the end of the rod 8, that is to say even when the rotor 3 is not tilted abuts and thus cooperates with this inner wall in the form of a plain bearing.
  • Variants shown for the limiting element 9 are variants in which the end of the rod 8 facing away from the rotor 3 is received by the limiting element 9.
  • the rod 8 is provided at its end facing away from the rotor 3 with the terminating element 81, which is designed to be received by the limiting element 9.
  • the operative connection between the end of the rod 8 and the limiting element 9 is preferably realized by a snap connection.
  • the end element 81 is frustoconical.
  • This embodiment is particularly suitable for the first preferred embodiment of the delimitation element 9 as a tilt limiter 91.
  • the delimitation element 9 then has an area designed as a claw 98 with a central entry opening 982 which is dimensioned such that the diameter of the entry opening 982 is larger than that Diameter D of the rod 8, but smaller than the maximum diameter of the frustoconical closing element 81.
  • the claw 98 forms a conical surface 981 around the inlet opening 982, through which the closing element 81 can be inserted into the limiting element 9.
  • a cavity 99 is provided below the claw 98, which is designed such that the closure element 81 can move contactlessly in the cavity 99, as long as the tilting of the rotor 3 does not exceed the predefinable limit value, which is due to the capacity of the passive magnetic stabilization of the rotor 3 is given. If this limit value is exceeded, the terminating element 81 comes into physical contact with the limiting element 9 and thus prevents a further increase in the tilting of the rotor 3. It is advantageous that the frustoconical terminating element 81 can roll on the inner surface of the limiting element 9.
  • the terminating element 81 is designed as a spherical head.
  • the diameter of the spherical head 81 is dimensioned such that the spherical head 81 is accommodated in the cavity 99 without contact after its insertion into the claw 98, as long as the rotor 3 is not tilted or in one by the passive magnetic bearing is oriented tiltable tilt. Only when the tilt of the rotor 3 becomes too strong or too large does the spherical head 81 contact the wall of the cavity 99, roll on it and thus limit the maximum possible tilt of the rotor 3.
  • the tilt of the rotor 3 is in Fig. 13 indicated by the double arrow without reference numerals.
  • the variant shown according to the second preferred embodiment of the limiting element 9 is designed as a mechanical bearing 92, the diameter of the spherical head 81 is dimensioned such that the spherical head 81 is constantly on the wall of the cavity after it has been introduced into the cavity 99, that is to say even when the rotor 3 is not tilted abuts and thus cooperates with this wall in the form of a plain bearing.
  • the preferably dimensionally stable limiting element 9 can - as in Fig. 13 shown - connected by welding or gluing to the mixing container 2 and fixed with respect to this.
  • Fig. 14 shows a variant that is particularly suitable for the second preferred embodiment of the limiting element 9 as a mechanical bearing 92.
  • This variant corresponds roughly to that in Fig. 13 shown, wherein in Fig. 14 Specifically shows an embodiment as a plain bearing made of plastic, in which the end element 81 designed as a spherical head snaps into the claw 98, so that the axial play of the rod 8 is also limited.

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Accessories For Mixers (AREA)

Claims (14)

  1. Un dispositif de mélange pour mélanger ou agiter des substances avec un réservoir de mélange (2) pour recevoir les substances à mélanger ou à agiter, avec un rotor (3) disposé dans le réservoir de mélange (2), avec lequel au moins une aube (6) pour mélanger ou agiter les substances peut être entraînée pour la rotation autour d'une direction axiale (A), et avec un stator (4) disposé à l'extérieur du réservoir de mélange (2), avec lequel le rotor (3), à l'état de fonctionnement, peut être entraînée magnétiquement sans contact pour la rotation autour de la direction axiale (A) et peut être supporté magnétiquement par rapport au stator (4), caractérisé en ce qu'une tige (8) est prévue s'étendant dans la direction axiale (A) qui est reliée de manière non rotative au rotor (3), et un élément de limitation mécanique (9) fixé par rapport au réservoir de mélange (2), qui interagit avec la tige (8), dans lequel l'élément de limitation (9) est conçu et disposé de telle sorte que la tige (8) peut tourner par rapport à l'élément de limitation (9) et qu'un basculement du rotor (3) par un contact physique entre la tige (8) et l'élément de limitation (9) est au moins limité, dans lequel le stator (4) est conçu comme un stator de palier et d'entraînement, avec lequel le rotor (3), à l'état de fonctionnement, peut être entraînée magnétiquement sans contact et peut être supporté magnétiquement au moins radialement par rapport au stator (4).
  2. Un dispositif de mélange selon la revendication 1, dans lequel le rotor (3), à l'état de fonctionnement, est stabilisé magnétiquement de manière passive par rapport à la direction axiale (A) et est de préférence en outre stabilisé magnétiquement de manière passive contre des basculements par rapport à la direction axiale (A).
  3. Un dispositif de mélange selon l'une des revendications précédentes, dans lequel l'élément de limitation (9) est conçu comme limitation du basculement (91) de telle sorte que la tige (8), à l'état de fonctionnement, tourne sans contact par rapport à la limitation du basculement (91) lorsque le rotor (3) est non basculé, et qu'un basculement du rotor (3) par un contact physique entre la tige (8) et la limitation du basculement (91) est limité.
  4. Un dispositif de mélange selon l'une des revendications 1 à 2, dans lequel l'élément de limitation (9) est conçu comme un palier mécanique (92) pour la tige (8), de préférence comme un palier radial mécanique.
  5. Un dispositif de mélange selon la revendication 4, dans lequel le palier mécanique (92) est conçu comme palier à rouleau ou comme palier lisse ou comme palier lubrifié par un fluide ou comme palier hydrodynamique.
  6. Un dispositif de mélange selon l'une des revendications 4 à 5, dans lequel le palier mécanique (92) est conçu comme palier auto-aligneur qui peut recevoir des basculements de la tige (8).
  7. Un dispositif de mélange selon l'une des revendications précédentes, dans lequel l'élément de limitation (9) est disposé intérieurement sur l'une des deux surfaces de limitation axiales (22, 23) du réservoir de mélange (2).
  8. Un dispositif de mélange selon l'une des revendications précédentes, dans lequel la tige (8) est sécurisée contre une séparation de l'élément de limitation (9).
  9. Un dispositif de mélange selon l'une des revendications précédentes, dans lequel la tige (8) s'étend dans la direction axiale (A) à travers l'élément de limitation (9).
  10. Un dispositif de mélange selon l'une des revendications précédentes, dans lequel la tige (8) présente à son extrémité opposée au rotor (3) un élément terminal (81), qui est conçu à être reçu par l'élément de limitation (9).
  11. Un dispositif de mélange selon la revendication 10, dans lequel l'élément terminal (81) peut être inséré dans l'élément de limitation (9) par l'intermédiaire d'une liaison par encliquetage.
  12. Un dispositif de mélange selon l'une des revendications précédentes, dans lequel une pluralité d'aubes (6) pour mélanger ou agiter les substances sont prévues sur la tige (8).
  13. Un dispositif de mélange selon l'une des revendications précédentes avec un dispositif jetable (20), qui est conçu à usage unique et avec un dispositif réutilisable (60), qui est conçu à usage multiple, dans lequel le dispositif jetable (20) comprend le réservoir de mélange (2), le rotor (3), toutes les aubes (6), la tige (8) et l'élément de limitation (9), le réservoir de mélange (2) étant conçu comme un réservoir de mélange flexible (2) et étant fabriqué d'une matière plastique, et dans lequel le dispositif réutilisable (60) comprend le stator (4) et un réservoir de support (61) pour recevoir le réservoir de mélange (2).
  14. Un dispositif jetable pour un dispositif de mélange selon la revendication 13, ledit dispositif de mélange comprend le dispositif réutilisable (60), qui est conçu à usage multiple, dans lequel le dispositif jetable (20) est conçu à usage unique et comprend le réservoir de mélange flexible (2) pour recevoir les substances à mélanger ou à agiter, qui est fabriqué d'une matière plastique, et le rotor (3) disposé dans le réservoir de mélange (2), avec lequel l'au moins une aube (6) pour mélanger ou agiter les substances peut être entraînée pour la rotation autour d'une direction axiale (A), et la tige (8) s'étendant dans la direction axiale (A) à l'état de fonctionnement, qui est reliée de manière non rotative au rotor (3), et l'élément de limitation (9) fixé par rapport au réservoir de mélange (2), qui interagit avec la tige (8), dans lequel l'élément de limitation (9) est conçu et disposé de telle sorte que la tige (8), à l'état de fonctionnement, peut tourner par rapport à l'élément de limitation (9), et un basculement du rotor (3) par un contact physique entre la tige (8) et l'élément de limitation (9) est au moins limité, dans lequel le dispositif jetable (20) est en outre conçu pour interagir avec le dispositif réutilisable (60) et peut être inséré dans le réservoir de support (61) du dispositif réutilisable (60), dans lequel le rotor (3) peut être entraîné sans contact autour de la direction axiale (A) par le stator (4) du dispositif réutilisable (60) à travers un champ magnétique rotatif et peut être supporté magnétiquement par rapport au stator (4).
EP17154806.8A 2016-05-02 2017-02-06 Dispositif de melange et dispositif jetable pour un tel dispositif de melange Active EP3241608B1 (fr)

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US15/581,880 US11819813B2 (en) 2016-05-02 2017-04-28 Mixing apparatus with a contactlessly magnetically drivable rotor

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US20170312713A1 (en) 2017-11-02
US20170312712A1 (en) 2017-11-02
US11819813B2 (en) 2023-11-21
EP3241609A1 (fr) 2017-11-08

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