EP3259386A4 - Systeme und verfahren zur durchführung von immunoassays - Google Patents

Systeme und verfahren zur durchführung von immunoassays Download PDF

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Publication number
EP3259386A4
EP3259386A4 EP16752901.5A EP16752901A EP3259386A4 EP 3259386 A4 EP3259386 A4 EP 3259386A4 EP 16752901 A EP16752901 A EP 16752901A EP 3259386 A4 EP3259386 A4 EP 3259386A4
Authority
EP
European Patent Office
Prior art keywords
systems
methods
performing immunoassays
immunoassays
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP16752901.5A
Other languages
English (en)
French (fr)
Other versions
EP3259386A1 (de
EP3259386B1 (de
Inventor
Meng Ting CHUNG
Yujing SONG
Walker M. MCHUGH
Pengyu Chen
Katsuo Kurabayashi
Timothy T. CORNELL
Thomas P. Shanley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Michigan System
Original Assignee
University of Michigan System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Michigan System filed Critical University of Michigan System
Publication of EP3259386A1 publication Critical patent/EP3259386A1/de
Publication of EP3259386A4 publication Critical patent/EP3259386A4/de
Application granted granted Critical
Publication of EP3259386B1 publication Critical patent/EP3259386B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0645—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0442—Moving fluids with specific forces or mechanical means specific forces thermal energy, e.g. vaporisation, bubble jet
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
EP16752901.5A 2015-02-16 2016-02-16 Systeme und verfahren zur durchführung von immunoassays Active EP3259386B1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562116741P 2015-02-16 2015-02-16
US201562245066P 2015-10-22 2015-10-22
PCT/US2016/018060 WO2016133899A1 (en) 2015-02-16 2016-02-16 Systems and methods for performing immunoassays

Publications (3)

Publication Number Publication Date
EP3259386A1 EP3259386A1 (de) 2017-12-27
EP3259386A4 true EP3259386A4 (de) 2018-07-11
EP3259386B1 EP3259386B1 (de) 2019-09-04

Family

ID=56692696

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16752901.5A Active EP3259386B1 (de) 2015-02-16 2016-02-16 Systeme und verfahren zur durchführung von immunoassays

Country Status (8)

Country Link
US (2) US11137394B2 (de)
EP (1) EP3259386B1 (de)
CN (1) CN107849738B (de)
CA (1) CA2976678A1 (de)
DK (1) DK3259386T3 (de)
ES (1) ES2760501T3 (de)
PT (1) PT3259386T (de)
WO (1) WO2016133899A1 (de)

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EP3612813A4 (de) * 2017-04-18 2020-04-15 Okinawa Institute of Science and Technology School Corporation Nanoplasmonische instrumentierung, materialien, verfahren und systemintegration
WO2018200377A1 (en) 2017-04-25 2018-11-01 The Regents Of The University Of Michigan Plasmo photoelectronic immunosensor
US10566245B2 (en) * 2017-04-26 2020-02-18 Samsung Electronics Co., Ltd. Method of fabricating gate all around semiconductor device
CN108507678A (zh) * 2018-03-01 2018-09-07 东南大学 一种等离激元多谐振机制增强的可调超光谱探测芯片
CA3135743A1 (en) 2018-05-09 2019-11-14 Arizona Board Of Regents On Behalf Of Arizona State University Method for electronic detection and quantification of antibodies
SG11202011394WA (en) 2018-05-17 2020-12-30 Stuart Lindsay Device, system and method for direct electrical measurement of enzyme activity
CN108896363A (zh) * 2018-05-28 2018-11-27 杭州智微信息科技有限公司 一种骨髓涂片数字化的流程方法
WO2020160300A2 (en) 2019-01-30 2020-08-06 Stuart Lindsay Bioelectronic circuits, systems and methods for preparing and using them
CA3149567A1 (en) * 2019-09-10 2021-03-18 Scott Richard Castle Cryptoanchor reader
CN115023763A (zh) 2019-12-04 2022-09-06 威尔德康股份有限公司 数字疗法系统和方法
WO2021173639A1 (en) * 2020-02-24 2021-09-02 The Texas A&M University System Systems and methods for detection of analytes
KR20220147602A (ko) 2020-02-28 2022-11-03 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 생체고분자를 시퀀싱하는 방법
CN114317746B (zh) * 2020-03-30 2022-09-23 中国医学科学院肿瘤医院 外泌体arpc5、ypel2等在肺癌诊断中的应用
WO2021211950A1 (en) 2020-04-17 2021-10-21 Arizona Board Of Regents On Behalf Of Arizona State University Single-molecule electronic sequence detector and methods of use
KR20230005866A (ko) 2020-04-30 2023-01-10 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 바이오폴리머 시퀀싱 방법
EP4158063A4 (de) 2020-05-29 2024-05-29 Arizona Board of Regents on behalf of Arizona State University Bioelektronische vorrichtungen mit programmierbaren adaptern
CN111999784B (zh) * 2020-09-07 2024-03-22 科竟达生物科技有限公司 聚合物用作生物芯片的基底的用途
CN112033932B (zh) * 2020-09-07 2021-09-07 科竟达生物科技有限公司 一种局域表面等离子体激元共振生物芯片、其制造方法、包含其的生物传感系统及其应用
CN112033931B (zh) * 2020-09-07 2024-04-12 科竟达生物科技有限公司 一种光波导、其制造方法、包含其的生物传感系统及其应用
WO2022093745A1 (en) 2020-10-26 2022-05-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Single domain antibodies targeting sars coronavirus spike protein and uses thereof
US20220196646A1 (en) * 2020-12-18 2022-06-23 Arizona Board Of Regents On Behalf Of Arizona State University Method for manufacturing protein bioelectronic devices
CN112881312B (zh) * 2021-01-15 2022-04-05 中山大学 一种同时监测溶液变化和传感器固/液界面变化的检测装置
WO2022204258A1 (en) * 2021-03-24 2022-09-29 InnoTech Precision Medicine, Inc. Device and method for detecting inflammation
US20240218055A1 (en) 2021-04-29 2024-07-04 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Lassa virus-specific nanobodies and methods of their use
US20240270851A1 (en) 2021-06-09 2024-08-15 The U.S.A., As Represented By The Secretary, Department Of Health And Human Services Cross species single domain antibodies targeting pd-l1 for treating solid tumors
CA3232223A1 (en) 2021-09-17 2023-03-23 Ying Fu Synthetic humanized llama nanobody library and use thereof to identify sars-cov-2 neutralizing antibodies
WO2023076881A1 (en) 2021-10-26 2023-05-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Single domain antibodies targeting the s2 subunit of sars-cov-2 spike protein
CN115290605B (zh) * 2022-04-29 2024-01-02 科竟达生物科技有限公司 炽热表面等离子体共振生物芯片、其制造方法、包含其的生物传感系统及其应用
WO2024050399A1 (en) 2022-09-01 2024-03-07 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Single domain antibodies targeting hpv e6/e7 oncogenic peptide/mhc complexes
US12385818B2 (en) 2023-02-14 2025-08-12 Saudi Arabian Oil Company Modeling gas desorption in a subsurface reservoir
WO2024238346A1 (en) 2023-05-12 2024-11-21 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Single domain antibodies that specifically bind the s2 subunit of sars-cov-2 spike protein and compositions and uses thereof
CN116819065B (zh) * 2023-07-05 2026-03-27 上海精翰生物科技有限公司 一种用于检测血液样本中细胞因子的试剂盒
AU2024295016A1 (en) 2023-07-20 2026-02-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Fully human monoclonal antibodies and chimeric antigen receptors against cd276 for the treatment of solid tumors
WO2025171238A1 (en) 2024-02-07 2025-08-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Monoclonal antibodies that bind the juxta-membrane region of mesothelin and uses thereof
WO2025171448A1 (en) * 2024-02-15 2025-08-21 The University Of Sydney Microfluidic devices

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Also Published As

Publication number Publication date
PT3259386T (pt) 2019-12-18
DK3259386T3 (da) 2019-12-02
EP3259386A1 (de) 2017-12-27
EP3259386B1 (de) 2019-09-04
WO2016133899A1 (en) 2016-08-25
CN107849738A (zh) 2018-03-27
US11137394B2 (en) 2021-10-05
CA2976678A1 (en) 2016-08-25
ES2760501T3 (es) 2020-05-14
CN107849738B (zh) 2021-03-16
US20180031549A1 (en) 2018-02-01
US20220082559A1 (en) 2022-03-17

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