EP3277247B1 - Emballage pharmaceutique - Google Patents

Emballage pharmaceutique Download PDF

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Publication number
EP3277247B1
EP3277247B1 EP16710778.8A EP16710778A EP3277247B1 EP 3277247 B1 EP3277247 B1 EP 3277247B1 EP 16710778 A EP16710778 A EP 16710778A EP 3277247 B1 EP3277247 B1 EP 3277247B1
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EP
European Patent Office
Prior art keywords
hinged portion
packaging
unit
recess
hinged
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP16710778.8A
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German (de)
English (en)
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EP3277247A1 (fr
Inventor
Ad DEEBEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Nederland BV
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Teva Nederland BV
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Publication date
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Publication of EP3277247A1 publication Critical patent/EP3277247A1/fr
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
    • B65D75/367—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed and forming several compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D83/00—Containers or packages with special means for dispensing contents
    • B65D83/04—Containers or packages with special means for dispensing contents for dispensing annular, disc-shaped, spherical or like small articles, e.g. tablets or pills
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2205/00—General identification or selection means
    • A61J2205/10—Bar codes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2205/00—General identification or selection means
    • A61J2205/30—Printed labels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J2205/00—General identification or selection means
    • A61J2205/60—General identification or selection means using magnetic or electronic identifications, e.g. chips, RFID, electronic tags
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
    • B65D2075/363—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed the recess presenting a lateral or a frontal opening
    • B65D2075/365—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed the recess presenting a lateral or a frontal opening and being provided with a cover
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2203/00—Decoration means, markings, information elements, contents indicators

Definitions

  • the present invention relates to a label arrangement.
  • the present invention is concerned with a blister pack including a label arrangement and its production.
  • Pharmaceuticals and drugs are typically provided in various liquid, semi-solid or solid dosage forms, for example in the form of a capsule or tablet.
  • a pharmaceutical dose is in the form of a capsule or tablet
  • the individual doses are often either provided in a jar or container or individually packaged in a particular type of pre-formed plastic packaging called a blister pack.
  • a blister pack (or press through pack) includes a blister or cavity made from a formable web. This cavity is typically backed with paperboard or a lidding seal of aluminium foil or plastic. Conventionally, the cavity is a semi-rigid formed cavity that is capable of collapsing upon the application of force such that when the cavity collapses it pushes the capsule or tablet through the seal thereby dispensing the individual doses of medicament.
  • Blister packs advantageously protect the product contained in the pack from contamination and provide a convenient means for dispensing individual doses. Blister packs are thus particularly useful in the pharmaceutical industry. An example of such a pharmaceutical packaging can be found in CA 2 776 111 A1 .
  • a pharmaceutical packaging including a plurality of recesses arranged to receive individual doses of medicament, a hermetically sealing layer sealing each of said recesses, and a plurality of hinged portions, each hinged portion associated with a recess. Each hinged portion is selectively movable between a first position adjacent said hermetically sealing layer and a second position in which the hermetically sealing layer is exposed.
  • a pharmaceutical packaging that conveniently provides additional space for providing the dose information required for regulatory approval whilst at the same time minimising the amount of alterations to current systems thereby reducing the burden of obtaining regulatory approval for the changes in the packaging.
  • a means of packaging the device that does not interfere with the dispensing of the dose from the packaging is also provided (for example in contrast to a label or cardboard adhering to the entire sealing layer).
  • the packaging arrangement optimises the available space for user and/or regulatory information whilst minimising the overall size of the packaging.
  • the packaging also provides flexibility should regulatory requirements change and/or differ in different jurisdictions.
  • this invention enables the production and provision of individualized medication from pre-packed blisters. In particular individualised medication can be provided from already existing blister packs without the need to re-pack the already blister-packed medication. Existing blister packs may remain in their primary packaging which has been approved by medical authorities during the entire chain of manufacturing, distribution and storage of the invention.
  • additional information relating to the contents of the packaging may be provided whilst at the same time allowing the additional material to be moved away from the recess such that the easy removal of the dose from the packaging is not compromised.
  • Each hinged portion may include an indicia supporting region on the user facing side of the hinged portion.
  • the indicia supporting region may include a machine readable region and a human readable region.
  • basic information to enable the user to identify the particular drug and dose may be provided in an easily readable format but more detailed information meeting the regulatory requirements relating to the manufacture of the dose is additionally provided on a machine readable region.
  • Information can be displayed or presented using multi-modes.
  • the machine readable region may include an RFID (radio-frequency identification) tag, a 2D or 3D matrix or bar code.
  • the RFID tag, 2D or 3D matrix or bar code may include alphanumeric data.
  • the RFID tag, 2D or 3D matrix or bar code may include data relating to the contents of the individual dose of medicament contained in the respective recess.
  • An RFID tag, 2D or 3D matrix or bar code is a convenient means for providing large amounts of information in a small area of space. In this manner detailed information relating to the particular dose can be provided on each individual dose.
  • the information contained in the bar code may be obtained by scanning the code with a machine and may be conveniently stored for a medical professional to review in due course.
  • each unit includes one recess and its associated hinged portion.
  • each individual unit provides detailed information relating to the particular dose contained therein thereby assisting in monitoring individual doses.
  • Each hinged portion may be sized such that it covers at least its respective recess when the hinged portion is in the first position. In this manner the packaging is a convenient shape for transportation and storage. Additionally, the hinged portion provides additional protection for the sealing layer thereby preventing the seal from being broken for example during storage or transport.
  • each hinged portion may be sized such that it covers its respective unit. In this manner the amount of space on which to provide the dose information is maximised whilst at the same time providing information on a per dose basis.
  • Each hinged portion is bonded to its respective unit along one edge of the unit. In this manner the hinged portion is bonded to its respective unit at a location as far from the recess as possible thereby minimising the amount of interference between the hinged portion and the recess.
  • the edge of the unit along which the hinged portion is bonded may be a straight edge.
  • Each hinged portion may include a bonding portion in the form of a strip arranged to adhere to one edge of the unit.
  • the strip may include an adhesive. In this manner a convenient means of bonding the hinged portion to the edge of the unit is provided that facilitates manufacture.
  • the packaging includes two rows of units and each hinged portion is bonded to its respective unit along an outer perimeter of the packaging.
  • each label portion may be attached to its respective unit along an inner edge of the blister pack.
  • Each unit may be joined to its adjacent units via frangible seams.
  • the packaging may be separated into individual dose units with each unit including relevant information relating to the dose. This can be particularly useful for example in nursing homes or hospitals where one packet of a drug may be needed for a number of patients.
  • Each recess may contain the same dose of medicament.
  • a packaging for a particular dose of a particular medicament is provided that can be divided into individual units for example for administration. This can be particularly useful where one packet of a drug is needed for a number of patients.
  • each recess may contain a different medicament and/or dose.
  • a flexible packaging is provided that can be used to provide a bespoke prescription for a single patient's use.
  • a method of manufacturing a pharmaceutical packaging including: providing a packaging comprising a plurality of recesses; providing a dose of a medicament in each of the recesses; sealing each of the recesses containing a dose with a hermetically sealing layer; and associating a hinged portion with each of the plurality of recesses.
  • Each hinged portion is selectively movable between a first position adjacent said hermetically sealing layer and a second position in which the hermetically sealing layer is exposed.
  • the packaging is divided into individual units wherein each unit comprises one recess and its associated hinged portion and wherein the associating step comprises bonding each hinged portion to its respective unit along one edge of the unit.
  • the bonding step may include applying adhesive to a bonding portion in the form of a strip along one edge of the respective unit.
  • Figure 1 illustrates a bottom view of a pharmaceutical packaging in the form of a blister pack (1).
  • the blister pack (1) includes eight individual units (2) each unit (2) containing a recess or blister (3) for storing a dose of medication for example in the form of a capsule or tablet.
  • the pharmaceutical packaging includes eight units (2) however the pharmaceutical packaging may be formed of any number of units (2).
  • the units (2) are arranged in two rows however in other examples the units (2) may be arranged in any suitable arrangement.
  • the units (2) are connected to each other via seams (4).
  • the seams (4) may be frangible such that the units (2) can be separated from one another.
  • the seams are perforated so that the entire blister can be easily broken up into individual units.
  • the seams may be permanent such that the individual units (2) might be separated e.g. by cutting the entire blister into individual units.
  • FIG 2 illustrates a top view of a pharmaceutical packaging according to the present invention.
  • Each of the units (2) is hermetically sealed by a sealing layer (5) extending over the recess (3) (shown in dotted line).
  • the sealing layer (5) may extend over the entire unit (2) or in alternative examples may extend only over the recess (3).
  • the sealing layer (5) thereby seals the individual dose of medicament (e.g. a capsule or tablet) in the recess (3) as illustrated in Figures 3A and 3B .
  • Suitable materials for the sealing layer (5) are well established for pharmaceutical packaging, for example hard and soft aluminium foil.
  • Each of the units also includes a label portion (6) in the form of a hinge.
  • Each hinged label portion (6) is arranged to cover the recess (3) of its respective unit (2) in a first position and to expose the recess (3) of its respective unit (2) in a second position.
  • Each label portion (6) is attached to the respective unit (2) along one edge.
  • the connection can be made via hot melt, an adhesive, a pressure sensitive tape or via a mechanical fastener, for example a paper staple.
  • connection is via a strip of adhesive or single line of glue.
  • Suitable adhesives include silicone adhesives, acrylate adhesives, gum, natural or synthetic rubber or resin. The expert is familiar with those materials used in e.g. pressure-sensitive adhesive tapes and stickers.
  • each label portion (6) is attached to its respective unit (2) along an outer perimeter edge of the blister pack (1). In other examples each label portion may be attached to its respective unit along an inner edge of the blister pack.
  • Each label portion (6) includes an indicia supporting region on its upper surface.
  • the upper surface is considered to be the surface facing the user when the label portion covers the recess (3).
  • the indicia supporting region provides information as to the contents of the pharmaceutical packaging in accordance with regulatory requirements.
  • the indicia supporting region includes a human-readable portion (7a) and a machine-readable portion (7b).
  • the human-readable portion (7a) provides information such as the title and dosage of the drug in a form readable to the human user.
  • the machine-readable portion (7b) includes an RFID tag, a 2D or 3D matrix or bar code (e.g.
  • this indicia supporting region includes only the machine-readable portion (7b) as described above.
  • Each hinged label portion (6) maybe made of any suitable material for example paper, cardboard, plastic (e.g. PE including PE-HD, PP, PVC, PET, polyolefine), or a laminate of plastic with other materials. In one embodiment the material might be thermo-sensitive for printing the required information.
  • each hinged label portion (6) may be made of paper or cardboard, more preferably of cardboard.
  • FIG 3A illustrates a side view of an individual unit (2) of the pharmaceutical packaging illustrated in Figures 1 and 2 in which the hinged label portion (6) is in its first position.
  • each unit is built up of a plurality of layers.
  • a base layer (8) typically formed of plastic includes a recess (3).
  • Suitable materials from which the base layer may be formed include thermo-formable and cold-formable materials known for use in pharmaceutical packaging, for example aluminium, polyamide, PVC, PVDC, PCTFE (ACLAR), PET, PE, PP, COC and various combinations thereof.
  • Preferred example materials are aluminium, PVC or PCTFE.
  • An individual dose of medicament e.g. capsule or tablet) (9) is provided in the recess.
  • a hermetically sealing layer (5) is provided on top of the base layer (8) such that it sealingly covers the recess (3) thereby retaining the capsule or tablet (9) in the recess and preventing contamination of the capsule or tablet (9).
  • This sealing layer may be for example made from aluminium.
  • a label portion (6) is provided on top of the hermetically sealing layer (5).
  • the label portion (6) includes a hinge (10) arranged along one edge of the unit (2) such that the hinge (10) lies outside of the area of the recess (3). In a first position illustrated in Figure 3A the hinge (10) is in a closed position such that the label portion (6) covers the hermetically sealing layer (5) and the recess (3).
  • each hinged region protrudes beyond the edge of the respective unit (e.g. by approximately 1 mm). Put another way, the hinged region extends slightly beyond one edge of the base layer. Preferably the hinged region extends slightly beyond the opposite edge to the attached edge. This makes it easier for the user to grasp and bend back the label portion thereby facilitating exposure of the hermetically sealing layer covering the recess.
  • each label is individually provided on each individual unit, in some examples the labels may be connected to one another in the same manner as the individual units.
  • the individual labels may be connected to one another via frangible seams that can be broken in the same manner as the frangible seams between individual units when an individual unit is to be separated from the rest of the packaging.
  • each individual blister may contain a number of different doses of different medications in which each individual blister contains a different dose or medicament. These may be for administration at different times of the day or on different days.
  • the present invention also relates to the production of a pharmaceutical packaging.
  • a packaging including a plurality of recesses is provided.
  • the packaging may be formed of a plurality of individual units, each unit having its own recess.
  • a dose of medicament is then provided in each of the recesses.
  • the dose may be in the form of a tablet, capsule or powder.
  • Each recess is subsequently sealed with a hermetically sealing layer.
  • a hinged portion is associated with each of the plurality of recesses. This may be achieved by bonding each hinged portion to its respective unit along one edge of the unit, for example by gluing.
  • Each hinged portion is selectively movable between a first position adjacent said hermetically sealing layer and a second position in which the hermetically sealing layer is exposed.
  • Each hinged portion may have an indicia supporting region on its upper surface as described above. This indicia supporting region may be printed on each hinged portion on-line during production shortly before it is associated with each of the plurality of recesses.
  • the production of a blister pack as defined above in which the packaging is divided into individual units wherein each recess is bonded along the edge of the individual unit to its associated hinged label portion as defined above is also contemplated.
  • a pharmaceutical packaging in which a blister pack may be bonded to a plurality of hinged label portions is provided. During production the packaging is divided into individual units wherein each unit includes one recess and its associated hinged portion.
  • the present invention also relates to the production of a pharmaceutical packaging as defined above which can be carried out using machines suitable for pharmaceutical mass production at high speed, preferably handling at least 100 blister packs per minute or at least 150 blister packs per minute.

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  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Composite Materials (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Packages (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Claims (12)

  1. Emballage pharmaceutique (1) comprenant :
    une pluralité d'évidements (3) agencés pour recevoir des doses individuelles de médicament ;
    une couche de scellement hermétique (5) scellant chacun desdits évidements ; et
    une pluralité de portions articulées (6), chaque portion articulée étant associée à un évidement ;
    chaque portion articulée étant sélectivement mobile entre une première position adjacente à ladite couche de scellement hermétique et une deuxième position dans laquelle la couche de scellement hermétique est exposée ;
    l'emballage comprenant une pluralité d'unités individuelles (2), chaque unité comprenant un évidement et sa portion articulée associée ; et
    l'emballage comprenant deux rangées d'unités et chaque portion articulée étant liée à son unité respective le long d'un périmètre externe de l'emballage.
  2. Emballage pharmaceutique selon la revendication 1 dans lequel chaque portion articulée comprend une région de support d'indices sur le côté faisant face à l'utilisateur de la portion articulée.
  3. Emballage pharmaceutique selon la revendication 2 dans lequel la région de support d'indices comprend une région lisible par machine (7b) et facultativement une région lisible par un humain (7a) et la région lisible par machine comprenant facultativement une étiquette RFID, une matrice 2D ou 3D ou un code à barres, et la matrice RFID, la matrice 2D ou 3D ou le code à barres comprenant facultativement des données alphanumériques et/ou l'étiquette RFID, la matrice 2D ou 3D ou le code à barres comprenant des données relatives au contenu de la dose individuelle de médicament contenue dans l'évidement respectif.
  4. Emballage pharmaceutique selon la revendication 1 dans lequel chaque portion articulée est dimensionnée de telle sorte qu'elle recouvre au moins son évidement respectif lorsque la portion articulée est dans la première position et/ou dans lequel la surface de chaque portion articulée est dimensionnée de telle sorte qu'elle recouvre son unité respective.
  5. Emballage pharmaceutique selon l'une quelconque des revendications précédentes, dans lequel chaque portion articulée est liée à son unité respective le long d'un bord de l'unité.
  6. Produit pharmaceutique selon la revendication 5 dans lequel le bord de l'unité le long duquel la portion articulée est liée est un bord droit et/ou dans lequel chaque portion articulée comprend une portion de liaison agencée pour adhérer à un bord de l'unité.
  7. Emballage pharmaceutique selon la revendication 5 ou la revendication 6 dans lequel chaque portion articulée comprend une portion de liaison sous la forme d'une bande agencée pour adhérer à un bord de l'unité et la bande comprenant facultativement un adhésif.
  8. Emballage pharmaceutique selon l'une quelconque des revendications précédentes dans lequel chaque unité est jointe à ses unités adjacentes par l'intermédiaire de coutures cassables.
  9. Emballage pharmaceutique selon l'une quelconque des revendications précédentes dans lequel chaque évidement contient la même dose de médicament.
  10. Emballage pharmaceutique selon la revendication 9 dans lequel le médicament est sous la forme d'une capsule ou d'un comprimé (9).
  11. Procédé de fabrication d'un emballage pharmaceutique comprenant :
    la fourniture d'un emballage comprenant : une pluralité d'évidements, une dose d'un médicament dans chacun des évidements et une couche de scellement hermétique scellant chacun des évidements ; et
    l'association d'une portion articulée à chaque évidement parmi la pluralité d'évidements, chaque portion articulée étant sélectivement mobile entre une première position adjacente à ladite couche de scellement hermétique et une deuxième position dans laquelle la couche de scellement hermétique est exposée, dans lequel :
    l'emballage est divisé en unités individuelles, chaque unité comprenant un évidement et sa portion articulée associée et l'étape d'association comprenant la liaison de chaque partie articulée à son unité respective le long d'un bord de l'unité ; et
    l'emballage comprend deux rangées d'unités et chaque portion articulée est liée à son unité respective le long d'un périmètre externe de l'emballage.
  12. Procédé selon la revendication 11 dans lequel l'étape de liaison comprend l'application d'un adhésif sur une portion de liaison sous la forme d'une bande le long d'un bord de l'unité respective.
EP16710778.8A 2015-04-02 2016-03-21 Emballage pharmaceutique Active EP3277247B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1505791.2A GB2536966A (en) 2015-04-02 2015-04-02 Pharmaceutical packaging
PCT/EP2016/056168 WO2016156093A1 (fr) 2015-04-02 2016-03-21 Emballage pharmaceutique

Publications (2)

Publication Number Publication Date
EP3277247A1 EP3277247A1 (fr) 2018-02-07
EP3277247B1 true EP3277247B1 (fr) 2022-01-12

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EP16710778.8A Active EP3277247B1 (fr) 2015-04-02 2016-03-21 Emballage pharmaceutique

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EP (1) EP3277247B1 (fr)
GB (1) GB2536966A (fr)
WO (1) WO2016156093A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114728137B (zh) * 2019-11-18 2024-07-12 维克多瑞传送设备有限公司 具有依从性监视器的干粉吸入器
IL291998B2 (en) 2019-11-18 2025-02-01 Vectura Delivery Devices Ltd Inhaler for use with a compliance monitor
US11779518B2 (en) * 2021-08-09 2023-10-10 Express Scripts Strategic Development, Inc. Blister pack device and method
WO2024215297A1 (fr) * 2023-04-13 2024-10-17 Mili Healthcare Trade Dmcc, Limited Liability Company Plaquette alvéolaire de médicaments avec calendrier, son procédé d'utilisation et système électronique de gestion d'interaction avec une plaquette alvéolaire de médicaments avec calendrier

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070012592A1 (en) * 2005-07-14 2007-01-18 Bertsch Shane K Child-resistant blister package
US20070289893A1 (en) * 2004-08-20 2007-12-20 Perrigo Company Child-Resistant Medicament Package
US20130081968A1 (en) * 2009-12-22 2013-04-04 Boehringer Ingelheim International Gmbh Film container of a blister that cannot be extruded

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4988004A (en) * 1987-08-21 1991-01-29 Intini Thomas D Bend 'n peel child resistant/tamper evident blister package
CA2491007A1 (fr) * 2004-12-23 2006-06-23 Thomas D. Intini Conditionnement pour distribution de portions individuelles
US20120145585A1 (en) * 2010-12-08 2012-06-14 Id-Con, Llc Packaging systems and methods
CA2776111C (fr) * 2012-04-26 2019-02-05 Michel Bouthiette Feuille d'etancheite servant a fermer une feuille de definition de contenant

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070289893A1 (en) * 2004-08-20 2007-12-20 Perrigo Company Child-Resistant Medicament Package
US20070012592A1 (en) * 2005-07-14 2007-01-18 Bertsch Shane K Child-resistant blister package
US20130081968A1 (en) * 2009-12-22 2013-04-04 Boehringer Ingelheim International Gmbh Film container of a blister that cannot be extruded

Also Published As

Publication number Publication date
GB201505791D0 (en) 2015-05-20
WO2016156093A1 (fr) 2016-10-06
GB2536966A (en) 2016-10-05
EP3277247A1 (fr) 2018-02-07

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