EP3287139A4 - Nervenwachstumsfaktorzusammensetzung und pulverinjektion - Google Patents

Nervenwachstumsfaktorzusammensetzung und pulverinjektion Download PDF

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Publication number
EP3287139A4
EP3287139A4 EP16782600.7A EP16782600A EP3287139A4 EP 3287139 A4 EP3287139 A4 EP 3287139A4 EP 16782600 A EP16782600 A EP 16782600A EP 3287139 A4 EP3287139 A4 EP 3287139A4
Authority
EP
European Patent Office
Prior art keywords
growth factor
nerve growth
powder injection
factor composition
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP16782600.7A
Other languages
English (en)
French (fr)
Other versions
EP3287139A1 (de
EP3287139B1 (de
Inventor
Jianping Tan
Bingzhang WANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Staidson Medical Technology Co Ltd
Staidson Beijing Biopharmaceutical Co Ltd
Original Assignee
Beijing Staidson Medical Technology Co Ltd
Staidson Beijing Biopharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57143718&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP3287139(A4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Beijing Staidson Medical Technology Co Ltd, Staidson Beijing Biopharmaceutical Co Ltd filed Critical Beijing Staidson Medical Technology Co Ltd
Publication of EP3287139A1 publication Critical patent/EP3287139A1/de
Publication of EP3287139A4 publication Critical patent/EP3287139A4/de
Application granted granted Critical
Publication of EP3287139B1 publication Critical patent/EP3287139B1/de
Revoked legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP16782600.7A 2015-04-21 2016-04-18 Nervenwachstumsfaktorzusammensetzung und injektionspulver Revoked EP3287139B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510188969 2015-04-21
PCT/CN2016/079570 WO2016169453A1 (zh) 2015-04-21 2016-04-18 神经生长因子组合物及注射粉剂

Publications (3)

Publication Number Publication Date
EP3287139A1 EP3287139A1 (de) 2018-02-28
EP3287139A4 true EP3287139A4 (de) 2018-12-26
EP3287139B1 EP3287139B1 (de) 2021-08-11

Family

ID=57143718

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16782600.7A Revoked EP3287139B1 (de) 2015-04-21 2016-04-18 Nervenwachstumsfaktorzusammensetzung und injektionspulver

Country Status (6)

Country Link
US (1) US10576129B2 (de)
EP (1) EP3287139B1 (de)
CN (1) CN108348579B (de)
DK (1) DK3287139T3 (de)
ES (1) ES2893239T3 (de)
WO (1) WO2016169453A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119258198A (zh) * 2023-07-07 2025-01-07 重庆科润生物医药研发有限公司 一种含重组人神经生长因子的组合物及其应用和眼用制剂

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995005845A1 (en) * 1993-08-20 1995-03-02 Syntex (U.S.A.) Inc. Pharmaceutical formulations of nerve growth factor
CN1552440A (zh) * 2003-06-06 2004-12-08 北京三诺佳邑生物技术有限责任公司 去白蛋白神经生长因子制剂
CN101972470A (zh) * 2010-09-13 2011-02-16 舒泰神（北京）生物制药股份有限公司 一种眼用原位凝胶

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ226170A (en) 1987-09-18 1990-07-26 Ethicon Inc Stable freeze-dried pharmaceutical composition containing epidermal growth factor
ES2434840T3 (es) 1995-07-27 2013-12-17 Genentech, Inc. Formulación de proteína liofilizada isotónica estable
WO1997017087A1 (en) 1995-11-07 1997-05-15 Genentech, Inc. Stabilizing formulation for ngf
US6090781A (en) 1996-11-06 2000-07-18 Genentech, Inc. Stabilizing formulation for NGF
DK1820516T3 (da) 1999-02-22 2013-10-28 Univ Connecticut Nye albuminfrie faktor VIII-præparater
CZ20021186A3 (cs) * 1999-10-04 2002-11-13 Chiron Corporation Farmaceutické prostředky obsahující stabilizovaný kapalný polypeptid
MXPA04000747A (es) 2001-07-25 2004-07-08 Protein Desing Labs Inc Formulacion farmaceutica liofilizada estable de anticuerpos igg.
WO2006014965A2 (en) 2004-07-27 2006-02-09 Human Genome Sciences, Inc. Pharmaceutical formulation and process
JP2007131586A (ja) 2005-11-11 2007-05-31 Staidson (Beijing) Pharmaceutical Co Ltd 体重を減らすことができる有用な医薬品製剤における神経成長因子（ｎｇｆ）の使用
CN1843503A (zh) 2006-01-25 2006-10-11 安徽金大陆生物制药有限公司 一种滴眼剂
CN1857718A (zh) 2006-03-22 2006-11-08 安徽金大陆生物制药有限公司 一种神经生长因子注射剂
TW200831129A (en) 2006-10-06 2008-08-01 Amgen Inc Stable formulations
AU2008255016B2 (en) 2007-05-15 2013-05-09 Stryker Corporation Concentrated protein preparations of bone morphogenetic proteins and methods of use thereof
CN101613394B (zh) 2008-06-27 2012-07-18 厦门北大之路生物工程有限公司 鼠神经生长因子的制备方法和注射用鼠神经生长因子的制备方法
WO2010148321A1 (en) * 2009-06-18 2010-12-23 Wyeth Llc Slow dissolution method for reconstitution of lyophilized material

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995005845A1 (en) * 1993-08-20 1995-03-02 Syntex (U.S.A.) Inc. Pharmaceutical formulations of nerve growth factor
CN1552440A (zh) * 2003-06-06 2004-12-08 北京三诺佳邑生物技术有限责任公司 去白蛋白神经生长因子制剂
CN101972470A (zh) * 2010-09-13 2011-02-16 舒泰神（北京）生物制药股份有限公司 一种眼用原位凝胶

Also Published As

Publication number Publication date
US20180104310A1 (en) 2018-04-19
US10576129B2 (en) 2020-03-03
WO2016169453A1 (zh) 2016-10-27
CN108348579B (zh) 2021-04-27
ES2893239T3 (es) 2022-02-08
CN108348579A (zh) 2018-07-31
EP3287139A1 (de) 2018-02-28
EP3287139B1 (de) 2021-08-11
DK3287139T3 (da) 2021-09-13

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