EP3355889A4 - Diaminopyrimidin-p2x3- und p2x2/3-rezeptor-modulatoren zur verwendung bei der behandlung von husten - Google Patents
Diaminopyrimidin-p2x3- und p2x2/3-rezeptor-modulatoren zur verwendung bei der behandlung von husten Download PDFInfo
- Publication number
- EP3355889A4 EP3355889A4 EP16852340.5A EP16852340A EP3355889A4 EP 3355889 A4 EP3355889 A4 EP 3355889A4 EP 16852340 A EP16852340 A EP 16852340A EP 3355889 A4 EP3355889 A4 EP 3355889A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- diaminopyrimidine
- cough
- modulators
- receptors
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Otolaryngology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP23155536.8A EP4215182A1 (de) | 2015-09-29 | 2016-09-23 | Diaminopyrimidin-p2x3- und p2x2/3-rezeptormodulatoren zur verwendung bei der behandlung von husten |
| HRP20230445TT HRP20230445T1 (hr) | 2015-09-29 | 2016-09-23 | Modulatori diaminopirimidin p2x3 i p2x2/3 receptora za primjenu u liječenju kašlja |
| SI201631686T SI3355889T1 (sl) | 2015-09-29 | 2016-09-23 | Modulatorji receptorja diaminopirimidina P2X3 in P2X2/3 za uporabo pri zdravljenju kašlja |
| RS20230321A RS64155B1 (sr) | 2015-09-29 | 2016-09-23 | Diaminopirimidinski modulatori p2x3 i p2x2/3 receptora, za upotrebu u lečenju kašlja |
| HUS2400004C HUS2400004I1 (hu) | 2015-09-29 | 2024-03-05 | Diaminopirimidin-P2X3 és P2X2/3 receptor modulátorok felhasználásra köhögés kezelésében |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562234584P | 2015-09-29 | 2015-09-29 | |
| US201662336381P | 2016-05-13 | 2016-05-13 | |
| PCT/US2016/053223 WO2017058645A1 (en) | 2015-09-29 | 2016-09-23 | Diaminopyrimidine p2x3 and p2x2/3 receptor modulators for use in the treatment of cough |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP23155536.8A Division EP4215182A1 (de) | 2015-09-29 | 2016-09-23 | Diaminopyrimidin-p2x3- und p2x2/3-rezeptormodulatoren zur verwendung bei der behandlung von husten |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| EP3355889A1 EP3355889A1 (de) | 2018-08-08 |
| EP3355889A4 true EP3355889A4 (de) | 2019-05-22 |
| EP3355889B1 EP3355889B1 (de) | 2023-02-15 |
Family
ID=58424436
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP16852340.5A Active EP3355889B1 (de) | 2015-09-29 | 2016-09-23 | Diaminopyrimidin-p2x3- und p2x2/3-rezeptor-modulatoren zur verwendung bei der behandlung von husten |
| EP23155536.8A Pending EP4215182A1 (de) | 2015-09-29 | 2016-09-23 | Diaminopyrimidin-p2x3- und p2x2/3-rezeptormodulatoren zur verwendung bei der behandlung von husten |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP23155536.8A Pending EP4215182A1 (de) | 2015-09-29 | 2016-09-23 | Diaminopyrimidin-p2x3- und p2x2/3-rezeptormodulatoren zur verwendung bei der behandlung von husten |
Country Status (23)
| Country | Link |
|---|---|
| US (3) | US11260056B2 (de) |
| EP (2) | EP3355889B1 (de) |
| JP (1) | JP6877441B2 (de) |
| KR (2) | KR20260022473A (de) |
| AU (1) | AU2016330466B2 (de) |
| CA (1) | CA2998742C (de) |
| CY (2) | CY1125963T1 (de) |
| DK (1) | DK3355889T3 (de) |
| ES (1) | ES2942711T3 (de) |
| FI (2) | FI3355889T3 (de) |
| FR (1) | FR24C1010I2 (de) |
| HR (1) | HRP20230445T1 (de) |
| HU (2) | HUE061764T2 (de) |
| LT (2) | LT3355889T (de) |
| LU (1) | LUC00332I2 (de) |
| MX (1) | MX390084B (de) |
| NL (1) | NL301260I2 (de) |
| NO (1) | NO2024009I1 (de) |
| PL (1) | PL3355889T3 (de) |
| PT (1) | PT3355889T (de) |
| RS (1) | RS64155B1 (de) |
| SI (1) | SI3355889T1 (de) |
| WO (1) | WO2017058645A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10676444B2 (en) * | 2016-12-20 | 2020-06-09 | Afferent Pharmaceuticals, Inc. | Crystalline salts and polymorphs of a P2X3 antagonist |
| US10111883B1 (en) * | 2017-09-18 | 2018-10-30 | Bellus Health Cough Inc. | Selective P2X3 modulators |
| KR20210009341A (ko) * | 2018-05-15 | 2021-01-26 | 바이엘 악티엔게젤샤프트 | 신경 섬유 감작과 연관된 질환의 치료를 위한 1,3-티아졸-2-일 치환된 벤즈아미드 |
| PL3862000T3 (pl) | 2018-10-05 | 2024-03-18 | Shionogi & Co., Ltd | Lek na przewlekły kaszel |
| WO2020174283A1 (en) | 2019-02-25 | 2020-09-03 | Bellus Health Cough Inc. | Treatment with p2x3 modulators |
| SG11202111877TA (en) * | 2019-04-30 | 2021-11-29 | Beijing Tide Pharmaceutical Co Ltd | Method for treating cough by using diaminopyrimidine compound |
| BR112021021738A2 (pt) | 2019-05-31 | 2021-12-28 | Chiesi Farm Spa | Derivados de amino quinazolina como inibidores de p2x3 |
| MX2021014116A (es) | 2019-05-31 | 2021-12-10 | Chiesi Farm Spa | Derivados de piridopirimidinas como inhibidores del purinoreceptor 3 de p2x (p2x3). |
| US12312327B2 (en) | 2019-09-19 | 2025-05-27 | Shionogi & Co., Ltd. | Crystal of 1,3,5-triazine derivative or solvate thereof and method for producing same |
| CN111635368B (zh) * | 2020-06-12 | 2021-06-29 | 东莞市东阳光仿制药研发有限公司 | 一种胺化合物的制备方法 |
| EP4251617B1 (de) | 2020-11-27 | 2025-03-12 | Chiesi Farmaceutici S.p.A. | (aza)chinolin-4-aminderivate als p2x3-inhibitoren |
| AU2021386405A1 (en) | 2020-11-27 | 2023-05-25 | Chiesi Farmaceutici S.P.A. | Phthalazine derivatives as p2x3 inhibitors |
| MX2023005803A (es) | 2020-11-27 | 2023-05-29 | Chiesi Farm Spa | Derivados de amino-quinazolina como inhibidores del purinorreceptor 3 p2x (p2x3). |
| CN116396285A (zh) * | 2022-01-04 | 2023-07-07 | 上海华汇拓医药科技有限公司 | 氘代四氢呋喃类化合物制备及其应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007025925A1 (en) * | 2005-09-01 | 2007-03-08 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| WO2008040652A1 (en) * | 2006-10-04 | 2008-04-10 | F. Hoffmann-La Roche Ag | Process for synthesis of phenoxy diaminopyrimidine derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2391636T3 (es) | 2004-03-05 | 2012-11-28 | F. Hoffmann-La Roche Ag | Diaminopirimidinas como antagonistas de P2X3 y P2X2/3 |
| EP1773405A4 (de) | 2004-07-22 | 2011-10-05 | Duska Scient Co | Verfahren zur diagnose, überwachung und behandlung von lungenerkrankungen |
| WO2007025901A1 (en) | 2005-09-01 | 2007-03-08 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| CN101253158B (zh) | 2005-09-01 | 2013-07-10 | 弗·哈夫曼-拉罗切有限公司 | 合成芳氧基二氨基嘧啶类化合物的方法 |
| ES2612890T3 (es) | 2005-09-01 | 2017-05-19 | F. Hoffmann-La Roche Ag | Diaminopirimidinas como moduladores de P2X3 y P2X2/3 |
| WO2008104474A1 (en) * | 2007-02-28 | 2008-09-04 | F. Hoffmann-La Roche Ag | Diaminopyrimidines |
| CR20160093A (es) * | 2013-08-23 | 2016-08-26 | Afferent Pharmaceuticals Inc | Moduladores del receptor p2x3 y p2x2/3 de diaminopiridina para el tratamiento de la tos aguda, sub aguda o cronica |
-
2016
- 2016-09-23 PT PT168523405T patent/PT3355889T/pt unknown
- 2016-09-23 CA CA2998742A patent/CA2998742C/en active Active
- 2016-09-23 US US15/764,174 patent/US11260056B2/en active Active
- 2016-09-23 WO PCT/US2016/053223 patent/WO2017058645A1/en not_active Ceased
- 2016-09-23 ES ES16852340T patent/ES2942711T3/es active Active
- 2016-09-23 JP JP2018535821A patent/JP6877441B2/ja active Active
- 2016-09-23 LT LTEPPCT/US2016/053223T patent/LT3355889T/lt unknown
- 2016-09-23 RS RS20230321A patent/RS64155B1/sr unknown
- 2016-09-23 EP EP16852340.5A patent/EP3355889B1/de active Active
- 2016-09-23 MX MX2018003893A patent/MX390084B/es unknown
- 2016-09-23 HU HUE16852340A patent/HUE061764T2/hu unknown
- 2016-09-23 SI SI201631686T patent/SI3355889T1/sl unknown
- 2016-09-23 FI FIEP16852340.5T patent/FI3355889T3/fi active
- 2016-09-23 EP EP23155536.8A patent/EP4215182A1/de active Pending
- 2016-09-23 AU AU2016330466A patent/AU2016330466B2/en active Active
- 2016-09-23 KR KR1020267001658A patent/KR20260022473A/ko active Pending
- 2016-09-23 KR KR1020187011747A patent/KR20180054843A/ko not_active Ceased
- 2016-09-23 PL PL16852340.5T patent/PL3355889T3/pl unknown
- 2016-09-23 DK DK16852340.5T patent/DK3355889T3/da active
- 2016-09-23 HR HRP20230445TT patent/HRP20230445T1/hr unknown
-
2022
- 2022-01-24 US US17/582,485 patent/US20220143015A1/en not_active Abandoned
-
2023
- 2023-05-09 CY CY20231100217T patent/CY1125963T1/el unknown
-
2024
- 2024-03-04 NL NL301260C patent/NL301260I2/nl unknown
- 2024-03-05 HU HUS2400004C patent/HUS2400004I1/hu unknown
- 2024-03-06 NO NO2024009C patent/NO2024009I1/no unknown
- 2024-03-12 LT LTPA2024507C patent/LTPA2024507I1/lt unknown
- 2024-03-12 FR FR24C1010C patent/FR24C1010I2/fr active Active
- 2024-03-13 CY CY2024005C patent/CY2024005I1/el unknown
- 2024-03-13 FI FIC20240006C patent/FIC20240006I1/fi unknown
- 2024-03-14 LU LU00332C patent/LUC00332I2/fr unknown
- 2024-04-19 US US18/640,100 patent/US20240285620A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007025925A1 (en) * | 2005-09-01 | 2007-03-08 | F. Hoffmann-La Roche Ag | Diaminopyrimidines as p2x3 and p2x2/3 modulators |
| WO2008040652A1 (en) * | 2006-10-04 | 2008-04-10 | F. Hoffmann-La Roche Ag | Process for synthesis of phenoxy diaminopyrimidine derivatives |
Non-Patent Citations (1)
| Title |
|---|
| FORD ANTHONY P: "In pursuit of P2X3 antagonists: novel therapeutics for chronic pain and afferent sensitization", vol. 8, no. Suppl 1, 1 February 2012 (2012-02-01), pages S3 - S26, XP002699076, ISSN: 1573-9546, Retrieved from the Internet <URL:http://rd.springer.com/article/10.1007%2Fs11302-011-9271-6> DOI: 10.1007/S11302-011-9271-6 * |
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