EP3377610A4 - Ratiometrische biosensoren und nichtgeometrisch modulierter fret - Google Patents

Ratiometrische biosensoren und nichtgeometrisch modulierter fret Download PDF

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Publication number
EP3377610A4
EP3377610A4 EP16867307.7A EP16867307A EP3377610A4 EP 3377610 A4 EP3377610 A4 EP 3377610A4 EP 16867307 A EP16867307 A EP 16867307A EP 3377610 A4 EP3377610 A4 EP 3377610A4
Authority
EP
European Patent Office
Prior art keywords
modulated
energy transfer
resonance energy
förster resonance
geometrically modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16867307.7A
Other languages
English (en)
French (fr)
Other versions
EP3377610A2 (de
Inventor
Homme W. Hellinga
Malin J. Allert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duke University
Original Assignee
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duke University filed Critical Duke University
Publication of EP3377610A2 publication Critical patent/EP3377610A2/de
Publication of EP3377610A4 publication Critical patent/EP3377610A4/de
Withdrawn legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Optical Transform (AREA)
EP16867307.7A 2015-11-20 2016-11-19 Ratiometrische biosensoren und nichtgeometrisch modulierter fret Withdrawn EP3377610A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562257863P 2015-11-20 2015-11-20
US201562257859P 2015-11-20 2015-11-20
US201562257850P 2015-11-20 2015-11-20
US201562257796P 2015-11-20 2015-11-20
PCT/US2016/062958 WO2017087912A2 (en) 2015-11-20 2016-11-19 Ratiometric biosensors and non-geometrically modulated fret

Publications (2)

Publication Number Publication Date
EP3377610A2 EP3377610A2 (de) 2018-09-26
EP3377610A4 true EP3377610A4 (de) 2019-10-16

Family

ID=58719234

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16867307.7A Withdrawn EP3377610A4 (de) 2015-11-20 2016-11-19 Ratiometrische biosensoren und nichtgeometrisch modulierter fret

Country Status (3)

Country Link
EP (1) EP3377610A4 (de)
CA (1) CA3005883A1 (de)
WO (1) WO2017087912A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013204332B2 (en) 2012-04-16 2015-07-16 Commonwealth Scientific And Industrial Research Organisation Methods and systems for detecting an analyte or classifying a sample
EP3377904B1 (de) 2015-11-20 2024-05-01 Duke University Harnstoffbiosensoren und verwendungen davon
EP3377897B1 (de) 2015-11-20 2024-05-01 Duke University Laktatbiosensoren und verwendungen davon
US11402384B2 (en) 2015-11-20 2022-08-02 Duke University Thermostable glucose biosensors and uses thereof
AU2017358067B2 (en) 2016-11-14 2024-04-18 PPB Technology Pty Ltd Protease sensor molecules
WO2019014419A1 (en) * 2017-07-14 2019-01-17 The Regents Of The University Of California COMPOSITIONS AND METHODS FOR ENHANCING ERADICATION OF CANCER CELLS OR MACROPHAGE-MEDIATED ANTIBODY TUMORS
CA3071994A1 (en) 2017-08-08 2019-02-14 Commonwealth Scientific And Industrial Research Organisation Carbohydrate sensors
CN110596072B (zh) * 2019-10-29 2022-05-13 陕西师范大学 基于聚酯纤维膜的比率型荧光纸芯片、制备方法和应用
EP4363826A1 (de) 2021-07-01 2024-05-08 NanoTemper Technologies GmbH Verfahren und vorrichtungen zur ratiometrischen charakterisierung von fluoreszierenden partikeln
CA3237959A1 (en) * 2021-12-07 2023-06-15 Megan PETTYGROVE Fluorescence detection of sulfite in water treatment applications
EP4524565A1 (de) 2023-09-12 2025-03-19 NanoTemper Technologies GmbH Verfahren zur messung von wechselwirkungen zwischen proteinen mit einem fc-teil und partikeln

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6900304B2 (en) * 1996-01-31 2005-05-31 The Regents Of The University Of California Emission ratiometric indicators of phosphorylation
EP1044374B1 (de) * 1997-12-31 2008-10-08 Duke University Glukosebiosensor
US6432723B1 (en) * 1999-01-22 2002-08-13 Clinical Micro Sensors, Inc. Biosensors utilizing ligand induced conformation changes
EP1335984A1 (de) * 2000-11-10 2003-08-20 Biosensor APS Bestimmung von hydrophoben coenzyme a estern und anderen lipiden mittels eines biosensors enthaltend ein modifiziertes coenzyme a- und acyl-coa bindungsprotein (acbp)
JP2008504881A (ja) * 2004-07-01 2008-02-21 ヴィヴォメディカル， インコーポレイテッド 非侵襲性グルコース測定
US8697388B2 (en) * 2007-02-08 2014-04-15 U.S. Department Of Energy Heavy metal biosensor
WO2009023153A1 (en) * 2007-08-10 2009-02-19 Carnegie Institution Of Washington Methods of using ret nanosensors
US8222047B2 (en) * 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KARLSTROEM A ET AL: "Dual labeling of a binding protein allows for specific fluorescence detection of native protein", ANALYTICAL BIOCHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 295, no. 1, 1 August 2001 (2001-08-01), pages 22 - 30, XP002224547, ISSN: 0003-2697, DOI: 10.1006/ABIO.2001.5186 *
KHAN F ET AL: "Fluorescence-based sensing of glucose using engineered glucose/galactose-binding protein: A comparison of fluorescence resonance energy transfer and environmentally sensitive dye labelling strategies", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 365, no. 1, 4 January 2008 (2008-01-04), pages 102 - 106, XP022680927, ISSN: 0006-291X, [retrieved on 20071030], DOI: 10.1016/J.BBRC.2007.10.129 *
SMITH J J ET AL: "ORTHOGONAL SITE-SPECIFIC PROTEIN MODIFICATION BY ENGINEERING REVERSIBLE THIOL PROTECTION MECHANISMS", PROTEIN SCI, WILEY, US, vol. 14, no. 1, 1 January 2005 (2005-01-01), pages 64 - 73, XP008047394, ISSN: 0961-8368, DOI: 10.1110/PS.04965405 *

Also Published As

Publication number Publication date
WO2017087912A3 (en) 2017-07-06
WO2017087912A2 (en) 2017-05-26
CA3005883A1 (en) 2017-05-26
EP3377610A2 (de) 2018-09-26

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