EP3380012A1 - Oxymètre de pouls utilisant un bandage étirable jetable multi-matériaux - Google Patents

Oxymètre de pouls utilisant un bandage étirable jetable multi-matériaux

Info

Publication number
EP3380012A1
EP3380012A1 EP16801183.1A EP16801183A EP3380012A1 EP 3380012 A1 EP3380012 A1 EP 3380012A1 EP 16801183 A EP16801183 A EP 16801183A EP 3380012 A1 EP3380012 A1 EP 3380012A1
Authority
EP
European Patent Office
Prior art keywords
assembly
light
receptacle
light emitter
light sensor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP16801183.1A
Other languages
German (de)
English (en)
Inventor
John Cronin
Michael D'andrea
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke Philips NV
Original Assignee
Koninklijke Philips NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Koninklijke Philips NV filed Critical Koninklijke Philips NV
Publication of EP3380012A1 publication Critical patent/EP3380012A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14552—Details of sensors specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6825—Hand
    • A61B5/6826—Finger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813—Specially adapted to be attached to a specific body part
    • A61B5/6829—Foot or ankle

Definitions

  • the present invention generally relates to pulse oximetry assemblies. More specifically, the present invention concerns a pulse oximetry assembly having a flexible connector and receptacles for mounting a light emitter and a light sensor.
  • Pulse oximetry is an effective and non-invasive method of monitoring and acquiring oxygen saturation (Sp0 2 ) level and perfusion index of a patient. Pulse oximetry requires illumination of the patient blood-perfused tissue using a light source at one or more wavelengths. Spectroscopy is then employed to determine any changes in the oxygen saturation level, which can provide an indication of a patient condition. Because of the way pulse oximetry acquires light-based physiological data, it is critical to ensure the alignment of the light-emitting and sensing components to maximize the amount of desired detected signal and minimize detected signal contribution.
  • pulse oximeters typically use clip-on devices made of rigid materials. Although these afford secure placement on or attachment to a patient body part, clip-on devices cannot accommodate patient body parts with significantly varying sizes. Flexible oximeter devices offer an advantage over clip-on pulse oximeters in terms of adaptability for use with patient body parts of varying
  • the light-emitting and light-sensing components nevertheless remain difficult to align in flexible oximeter devices.
  • U.S. patent publication number discloses a flexible oximetry assembly for mitigating undesired effects of patient motion on oximeter readings.
  • the flexible oximeter includes an elastic sensor body with a stiffening member positioned between an emitter and a detector for stabilizing the distance between the emitter and the detector.
  • the stiffening member is adapted to bend to establish a fixed distance between the emitter and detector.
  • U.S. patent number 8,706,179 discloses a disposable bandage apparatus having a probe emitter receptacle and a probe detector receptacle for removably mounting an emitter and a detector, respectively.
  • the apparatus also includes a biasing member for ensuring the alignment between the emitter and the detector.
  • a first embodiment of the present invention concerns a customizable pulse oximetry assembly having a bandage with a first receptacle, a second receptacle, and a flexible connector connecting the first receptacle and the second receptacle.
  • the assembly includes a light emitter having a first probe housing for removably mounting the light emitter on the first receptacle and a light sensor comprising a second probe housing for removably mounting on the second receptacle.
  • the assembly further includes a cable connector for physically coupling the light emitter and the light sensor and for communicatively coupling the light emitter and the light sensor to a patient monitor.
  • the flexible connector, the first probe housing, and the second probe housing are adapted for adjusting a separation and an alignment between the light emitter and the light sensor according to a dimension of a patient body part.
  • a second embodiment of the present invention includes a method for attaching a light emitter having a first probe housing and a light sensor having a second probe housing to a bandage.
  • the bandage includes a first receptacle for the first probe housing, a second receptacle for the second probe housing, and a flexible connector connecting the first receptacle to a second receptacle.
  • the bandage is extended via the flexible connector to accommodate a dimension of a patient body part.
  • the bandage is attached to a patient body part.
  • the bandage may be adjusted such that the light emitter and the light sensor are aligned.
  • Light sensor data is then acquired using the light emitter and the light sensor. Data may then be transmitted to a patient monitor via a cable connector.
  • FIGURE 1A illustrates a customizable pulse oximetry assembly.
  • FIGURE IB illustrates the pulse oximetry assembly in a contracted state.
  • FIGURE 1C illustrates the pulse oximetry assembly in a stretched state to accommodate a physical dimension of a patient body part.
  • FIGURE 2 illustrates a method for measuring pulse oximeter data using the pulse oximetry assembly of the present invention.
  • FIGURE 3A illustrates the pulse oximetry assembly attached to a small finger.
  • FIGURE 3B illustrates the pulse oximetry assembly attached to a larger finger.
  • FIGURE 3C illustrates the pulse oximetry assembly 100 attached to an infant foot.
  • receptacle refers to a structural component for mounting a light emitter or a light sensor.
  • the receptacle may comprise rigid components (e.g., a metal, glass, or rigid polymer), flexible components (e.g., polymer or rubber), or any combination thereof.
  • the term "flexible connector” as used herein refers to a physical connector for connecting two receptacles and adjusting the separation and orientation between the two receptacles.
  • the flexible connector can be a wire, mesh, polymer, a series of pivotally connected segments, or any combination thereof, capable of being extended or contracted in length.
  • bandage refers to an assembly comprising two receptacles connected by the flexible connector.
  • probe housing refers to an enclosure for enclosing a light emitter or a light sensor.
  • the probe housing can be flexible and further usable for mounting the light emitter or the light sensor on the receptacles.
  • the probe housing may comprise a material such as a polymeric outer material and a flexible inner material comprising a metal or a polymer configured as wires, mesh, plate, or any configuration adapted to be flexible and structurally stable upon bending.
  • the term "cable connector” as used herein refers to a cable for physically connecting the light emitter and the light sensor and for communicatively coupling the light emitter and the light sensor to an external device, such as a patient monitor.
  • the cable connector can be a Y-cable wherein one end connects to an external system and the other end with the Y-branch connects to the light emitter and the light sensor.
  • the cable connector can be a USB cable capable of transmitting data packets and power from one end of the cable to another.
  • the cable connector can also be a fiber optic cable.
  • pulse oximetry is a method for measuring the oxygen saturation of patient blood.
  • Blood oxygen saturation is a measure of the amount of oxygen carried by hemoglobin in the blood stream. Saturation is usually expressed as a percentage rather than an absolute reading.
  • blood oxygen saturation levels measured immediately after birth can provide a good indicator of a general state of health. Levels below 75% could indicate that the newborn infant may be suffering from some abnormality.
  • the blood oxygen saturation should be expressed as a percentage of the total hemoglobin that is saturated with oxygen. Acceptable normal ranges for healthy patients range from 95 to 99 percent.
  • a pulse oximeter in accordance with the present invention includes an electronic processor and two or more small light-emitting diodes (LEDs) or a series of LEDs facing a photodiode at a translucent portion of a patient body. This is typically a fingertip or an earlobe.
  • LEDs small light-emitting diodes
  • One of the LEDs emits light in the red portion of the visible portion of the electromagnetic spectrum (red LED) while the other LED emits in the infrared portion.
  • the amount of light absorbed at these two wavelengths differs significantly between oxygen-rich blood and blood deficient in oxygen as oxygenated hemoglobin absorbs more infrared light and allows more red light to pass through.
  • Deoxygenated hemoglobin allows more infrared light to pass through and absorbs more red light. Oxy-hemoglobin and its deoxygenated form have significantly different absorption pattern.
  • the LEDs of the present invention alternately turn on and off and then both off for a predetermined period of time.
  • This alternation and termination allows the light sensor such as a photodiode to separately respond to the red and infrared light and to correct for the light detected due to ambient light, which is measured when both LEDs are off and used as baseline or reference signal.
  • the amount of light that is transmitted (that is, not absorbed) is measured and separate normalized signals are produced for each wavelength.
  • the light emitter of the presently disclosed invention can be a light emitting diode, photodiode, phototransistor, photo emitter, or any other type of light emitting component capable of emitting light at one or more wavelengths and varying the intensity and duration of the emitted light.
  • the light sensor may be a photodetector, photoelectric receiver, photodiode, or any other sensor capable of detecting light with one or more wavelengths or intensity.
  • the patient monitor transmits operational data to and receives operational data from the light emitter and the light sensor via the cable connector.
  • Operational data may include wavelength, light intensity, duration, and sampling rate.
  • the light emitter and the light sensor each include a probe housing for mounting the light emitter or light sensor on their respective receptacles.
  • the probe housings are configurable to establish sufficient contact with the patient body part.
  • the probe housings can also be physically manipulated to permit alignment of the light emitter and light sensor and to otherwise adapt to the shape of the surface of the patient body part to which they are attached.
  • One form of physical manipulation includes bending the probe housing to conform to the shape of the surface of the patient body part.
  • a patient body part may have a relatively flat surface such that the probe housing is configured to also be also flat while another patient body part may be curved such that the probe housing is bent to conform to the curved surface.
  • the probe housing preferably incorporates one or more perforations to allow the transmission of light from the light emitter to the light sensor with minimal intensity loss.
  • the probe housing may fully enclose the light emitter or the light sensor.
  • the housing is preferably optically transparent at the wavelengths at which the light emitter and the light sensor operate.
  • the patient monitor of the presently disclosed invention includes a processor, display, user interface, and memory.
  • the patient monitor further includes a communication module for transmitting or receiving data with an external system wirelessly or via wired connections.
  • the patient monitor may also include a cable connector port for connecting a cable connector to the patient monitor.
  • the patient monitor is capable of performing functions such as transmitting data to and receiving data from the light emitter and light sensor via a cable connector.
  • the monitor may also receive input from a user via the user interface as well as process data, store data, and display data.
  • the monitor may also communicate with an external system, such as a cloud server, a hospital server, or a device such as mobile device, or a desktop computer.
  • FIGURE 1A illustrates a customizable pulse oximetry assembly 100.
  • the assembly includes a cable connector 102, a light emitter 104, a light sensor 106, and a bandage 108 having a flexible connector 110 connected to receptacles 112 and 114.
  • the light emitter 104 and light sensor 106 of FIGURE 1A are respectively mounted on receptacles 112 and 114.
  • the flexible connector 110 can be stretched, contracted, or distorted to accommodate the dimensions of a patient body part.
  • FIGURE IB illustrates the pulse oximetry assembly 100 in a contracted state.
  • FIGURE 1C illustrates the pulse oximetry assembly 100 in a stretched state to accommodate a physical dimension of a patient body part.
  • Bandage 108 includes two receptacles 112 and 114 and a flexible connector 110 connecting the two receptacles 112 and 114.
  • the receptacles 112 and 114 are usable for mounting the light emitter 104 and the light sensor 106.
  • the flexible connector 110 allows for the adjustment of the separation and alignment of the light emitter 104 and the light sensor 106.
  • the receptacles 112 and 114 further include attachments for fastening the light emitter 104 and the light sensor 106 to the receptacles 112 and 114.
  • a receptacle may incorporates any one or more of the following attachment means: Velcro, magnet, fastener, screw, clamp, clip, hook, pocket, strap, suction cup, pin, holes, and snaps. Other means for effectuating an attachment may also be used.
  • the aforementioned attachments are positioned on the underside of the receptacle. As a result, the light emitter and the light sensor are directly in contact with the patient body part. In another embodiment, the attachments are positioned on the external side of the receptacle. As a result, the light emitter and the light sensor are mounted on the external sides of the receptacles by way of said attachments. In an
  • a window is built through the receptacles to allow transmission of light from the light emitter through the patient body part and from the patient body part to the light sensor.
  • the flexible connector is preferably made of a material such that in a stretched state as illustrated in FIGURE 1C, the connector does not snap back into the original configuration as illustrated in FIGURE IB.
  • the flexible connector might include metallic wires or a wire mesh that can be bent to assume any variety of configurations.
  • the physical manipulations of the flexible connectors and probe housing such as bending, stretching, twisting, contraction, extension, or any combination thereof is reversible in a preferred embodiment.
  • the flexible connector may include a lightweight casing or sheath to protect the flexible connector.
  • the flexible connector is preferably made of one or more materials that are both sturdy and nontoxic.
  • the flexible connector may include metallic wires wrapped by a rubber casing.
  • the flexible connector includes a wire mesh enclosed in a plastic sheath.
  • the choice of casing may be based on aesthetics or form factor.
  • a medical facility or institution may design the casing to include labels or other useful information such as the name of manufacturer, hospital, or date of manufacture of the pulse oximetry assembly.
  • the flexible connector might also include a plurality of non-flexible sub- elements connected by hinges or similar connectors.
  • the plurality of non-flexible sub-elements are collectively flexible as might occur in the case of a series of rigid segments pivotally interconnected in a serial manner.
  • the series of rigid segments may be bent into a horseshoe shape with a variable curvature.
  • the pivots for the individual sub-elements might further provide a certain amount of rigidity to maintain a bent configuration set by a medical personnel.
  • the pivots afford sufficient rigidity to the interconnected plurality of sub-elements to allow them to retain their overall shape regardless of the physical distortions or manipulations at issue.
  • the number of rigid segments used for the flexible connector could be varied depending on the one or more dimensions of the patient body part.
  • the flexible connector in an embodiment, may have corrugations such that extending or contracting the flexible connector causes the corrugated flexible connector to contract, expand, unfold, and fold.
  • corrugations such that extending or contracting the flexible connector causes the corrugated flexible connector to contract, expand, unfold, and fold.
  • at least some of the ridges and grooves of the corrugations overlap to more or less match the size of the patient body part.
  • At least some portions of the corrugations may have Velcro-type hooks and loops to prevent the folded corrugated flexible connector from unintentionally unfolding.
  • the flexible connector of the bandage and the two receptacles may be integrated such that the flexible connector is not detachable from the two receptacles.
  • the flexible connector and the receptacles may alternatively be detachable from each other.
  • a detachable or replaceable flexible connector may permit a higher degree of customizability as a user could then replace the flexible connector or the receptacles if necessary. For example, a user may replace a short flexible connector with a longer flexible connector or replace a long flexible connector with a shorter flexible connector.
  • the user may also replace a worn-out or contaminated flexible connector with a new or sterilized flexible connector. Conversely, the user may replace a worn-out or contaminated receptacle with a new or sterilized flexible connector.
  • FIGURE 2 illustrates a method for measuring pulse oximeter data using the pulse oximetry assembly of the present invention.
  • a light emitter and a light sensor are initially attached to a bandage comprising a flexible connector (step 202).
  • the assembly is extended via the flexible connector (step 204) and then attached to a patient body part to be used for the pulse oximetry measurement (step 206).
  • the assembly is adjusted such that the attachment is stable and the light emitter and light sensor are aligned and in contact with the patient body part (step 208).
  • the pulse oximetry data acquisition is then initiated by activating the light emitter and light sensor to acquire light sensor data (step 210). Afterwards, the acquired light sensor data are transmitted to a patient monitor via a cable connector for storage or further processing (step 212).
  • FIGURES 3A-3C illustrate various embodiments of the customizable pulse oximetry assembly as used on various patient body parts.
  • FIGURE 3A illustrates the pulse oximetry assembly 100 attached to a small finger 302.
  • FIGURE 3B illustrates the pulse oximetry assembly 100 attached to a larger finger 304.
  • FIGURE 3C illustrates the pulse oximetry assembly 100 attached to an infant foot 306.
  • the pulse oximetry assembly of the present invention may also be used in other patient body parts, such as the ear, forehead, nose, and toe.
  • three patients are admitted to an emergency room.
  • the first patient is a 10 year-old child, the second an adult male, and the third is an infant.
  • the medical personnel attends to the first patient and prepares a pulse oximeter assembly by first selecting a bandage and mounting the light emitter and light sensor on the bandage.
  • the bandage is then attached to the finger of the child; the bandage is adjusted to conform to the shape and size of the finger of the child.
  • the medical personnel measures the blood oxygen saturation level of the child.
  • the medical personnel then attends to the second patient.
  • the medical personnel uses the same pulse oximetry assembly for the adult patient.
  • the pulse oximetry assembly is first wiped with a disinfectant, then the flexible connector is stretched to accommodate the second patient body part—such as a finger that would be larger than that of the first patent— after which the pulse oximeter data is measured.
  • the medical personnel then takes a pulse oximetry measurement of the infant patient.
  • the medical personnel decides to use the same light emitter and light sensor after disinfecting them but uses a new bandage for the infant to minimize infections.
  • the medical personnel then stretches the flexible connector so it fits the foot of the infant then acquires the infant pulse oximetry data.
  • the medical personnel After acquiring each pulse oximeter data, the medical personnel transfers the acquired data to the emergency room desktop computer for displaying and processing the acquired data.
  • the medical personnel views the various data on the desktop computer, analyzes said data, arrive at a diagnosis, and enters findings and comments into the respective patient records.
  • the used pulse oximetry assembly components may either be disposed or sterilized for reuse on another patient.
  • the pulse oximetry assembly might include flexible electronic elements, such as flexible displays, flexible power sources, flexible light sources, and flexible sensors.
  • the light sensor and the light emitter are both flexible to allow easier adjustments when fitting the pulse oximetry assembly to the patient body part.
  • the receptacles may include a flexible display for providing visual indication such as a flexible OLED display to indicate the degree of alignment for the light emitter and light sensor.
  • the light emitter and the light sensor may also be powered by a flexible battery embedded in the bandage's receptacles.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Eye Examination Apparatus (AREA)

Abstract

Un ensemble d'oxymétrie de pouls personnalisable est décrit. Cet ensemble comprend un bandage comprenant un premier réceptacle, un second réceptacle, et un raccord flexible reliant le premier réceptacle et le second réceptacle. L'ensemble comprend également un émetteur de lumière ayant un premier logement de sonde pour monter amovible l'émetteur de lumière sur le premier réceptacle et un capteur de lumière comprenant un second logement de sonde pour monter amovible sur le second réceptacle. Un connecteur de câble destiné à coupler physiquement l'émetteur de lumière et le capteur de lumière, et pour coupler de façon communicative l'émetteur de lumière et le capteur de lumière à un moniteur de patient, est inclus en tant que partie de l'ensemble. Le connecteur souple, le premier logement de sonde, et le second logement de sonde peuvent être adaptés afin de s'ajuster pour une séparation et un alignement entre l'émetteur de lumière et le capteur de lumière selon une dimension d'une partie du corps du patient.
EP16801183.1A 2015-11-24 2016-11-23 Oxymètre de pouls utilisant un bandage étirable jetable multi-matériaux Withdrawn EP3380012A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562259062P 2015-11-24 2015-11-24
EP16161070 2016-03-18
PCT/EP2016/078519 WO2017089374A1 (fr) 2015-11-24 2016-11-23 Oxymètre de pouls utilisant un bandage étirable jetable multi-matériaux

Publications (1)

Publication Number Publication Date
EP3380012A1 true EP3380012A1 (fr) 2018-10-03

Family

ID=55640548

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16801183.1A Withdrawn EP3380012A1 (fr) 2015-11-24 2016-11-23 Oxymètre de pouls utilisant un bandage étirable jetable multi-matériaux

Country Status (5)

Country Link
EP (1) EP3380012A1 (fr)
JP (1) JP2019502422A (fr)
CN (1) CN108289645A (fr)
BR (1) BR112018010301A2 (fr)
WO (1) WO2017089374A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3934536B1 (fr) * 2019-03-07 2025-01-29 Koninklijke Philips N.V. Dispositif de surveillance de niveaux de saturation en oxygène dans des conditions cliniques
US11678822B2 (en) * 2020-06-18 2023-06-20 Covidien Lp Sensor joint wrapping in a medical sensor

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US4260951A (en) * 1979-01-29 1981-04-07 Hughes Aircraft Company Measurement system having pole zero cancellation
US4685464A (en) * 1985-07-05 1987-08-11 Nellcor Incorporated Durable sensor for detecting optical pulses
DE3809084C2 (de) * 1988-03-18 1999-01-28 Nicolay Gmbh Sensor zur nichtinvasiven Messung der Pulsfrequenz und/oder der Sauerstoffsättigung des Blutes und Verfahren zu seiner Herstellung
DE3810411A1 (de) * 1988-03-26 1989-10-12 Nicolay Gmbh Vorrichtung zum fixieren eines messaufnehmers, insbesondere eines messaufnehmers fuer oximetrische messungen
US5991648A (en) * 1998-03-30 1999-11-23 Palco Labs, Inc. Adjustable pulse oximetry sensor for pediatric use
US7245953B1 (en) 1999-04-12 2007-07-17 Masimo Corporation Reusable pulse oximeter probe and disposable bandage apparatii
ES2213472B1 (es) * 2002-12-26 2005-11-01 Carril Cables Y Sensores, S.L. Sensor de oximetria.
US7869850B2 (en) * 2005-09-29 2011-01-11 Nellcor Puritan Bennett Llc Medical sensor for reducing motion artifacts and technique for using the same
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US8577435B2 (en) * 2011-03-31 2013-11-05 Covidien Lp Flexible bandage ear sensor
CN102579053A (zh) * 2012-03-02 2012-07-18 天津大学 一种基于扩散理论的反射式脉搏血氧检测方法

Also Published As

Publication number Publication date
BR112018010301A2 (pt) 2018-12-04
JP2019502422A (ja) 2019-01-31
WO2017089374A1 (fr) 2017-06-01
CN108289645A (zh) 2018-07-17

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