EP3445359C0 - Verwendung von nicotinsäure-ribosid- oder nicotinamid-ribosit-derivaten und reduzierte derivate davon als nad+erhöhende vorläufer - Google Patents

Verwendung von nicotinsäure-ribosid- oder nicotinamid-ribosit-derivaten und reduzierte derivate davon als nad+erhöhende vorläufer

Info

Publication number: EP3445359C0
Authority: EP; European Patent Office
Prior art keywords: derivatives; ribosite; nad; nicotinamide; precursors
Prior art date: 2016-04-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

EP17786649.8A

Other languages

English (en)

French (fr)

Other versions

Inventor

Ryan Dellinger

Troy Rhonemus

Mark Morris

Aron Erickson

Hadi Casser

Marie E Migaud

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Chromadex Inc

Original Assignee

Chromadex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-04-20

Filing date

2017-04-20

Publication date

2023-06-07

2017-04-20 Application filed by Chromadex Inc filed Critical Chromadex Inc

2019-02-27 Publication of EP3445359A1 publication Critical patent/EP3445359A1/de

2019-12-25 Publication of EP3445359A4 publication Critical patent/EP3445359A4/de

2023-06-07 Application granted granted Critical

2023-06-07 Publication of EP3445359C0 publication Critical patent/EP3445359C0/de

2023-06-07 Publication of EP3445359B1 publication Critical patent/EP3445359B1/de

2023-09-06 Publication of EP3445359B8 publication Critical patent/EP3445359B8/de

Status Active legal-status Critical Current

2037-04-20 Anticipated expiration legal-status Critical

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Saccharide Compounds (AREA)

EP17786649.8A 2016-04-20 2017-04-20 Verwendung von nicotinsäure-ribosid- oder nicotinamid-ribosit-derivaten und reduzierte derivate davon als nad+ erhöhende vorläufer Active EP3445359B8 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201662325264P	2016-04-20	2016-04-20
PCT/US2017/028673 WO2017184885A1 (en)	2016-04-20	2017-04-20	Use of nicotinic acid riboside or nicotinamide ribosite derivatives, and reduced derivatives thereof, as nad+increasing precursors

Publications (5)

Publication Number	Publication Date
EP3445359A1 EP3445359A1 (de)	2019-02-27
EP3445359A4 EP3445359A4 (de)	2019-12-25
EP3445359C0 true EP3445359C0 (de)	2023-06-07
EP3445359B1 EP3445359B1 (de)	2023-06-07
EP3445359B8 EP3445359B8 (de)	2023-09-06

Family

ID=60088650

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP17786649.8A Active EP3445359B8 (de)	2016-04-20	2017-04-20	Verwendung von nicotinsäure-ribosid- oder nicotinamid-ribosit-derivaten und reduzierte derivate davon als nad+ erhöhende vorläufer

Country Status (13)

Country	Link
US (1)	US10183036B2 (de)
EP (1)	EP3445359B8 (de)
JP (3)	JP7089480B2 (de)
KR (1)	KR20190008246A (de)
CN (1)	CN109640984A (de)
AU (2)	AU2017254657A1 (de)
BR (1)	BR112018071573A2 (de)
CA (1)	CA3021571C (de)
ES (1)	ES2948968T3 (de)
MX (1)	MX393076B (de)
NZ (1)	NZ747693A (de)
WO (1)	WO2017184885A1 (de)
ZA (1)	ZA201807736B (de)

Families Citing this family (32)

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WO2017011788A1 (en) *	2015-07-15	2017-01-19	Cornell University	Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives
JP6949002B6 (ja)	2015-08-05	2021-11-17	メトロインターナショナルバイオテック，エルエルシー	ニコチンアミドモノヌクレオチド誘導体及びそれらの使用
GB2542881B (en)	2015-10-02	2020-01-01	Carr Andrew	Crystal forms of ß-nicotinamide mononucleotide
CA3045876A1 (en)	2016-11-11	2018-05-17	The Queen's University Of Belfast	Scalable syntheses of nicotinoyl ribosides and reduced nic otinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof
MX2019006278A (es)	2016-11-29	2019-08-21	Univ Iowa Res Found	Uso de precursores de nad para mejorar la salud materna y/o salud de la descendencia.
US11071747B2 (en)	2016-11-29	2021-07-27	University Of Iowa Research Foundation	Use of NAD precursors for breast enhancement
WO2018191771A1 (en) *	2017-04-18	2018-10-25	Victor Chang Cardiac Research Institute	Detection and treatment of congenital malformations
EP3642214A2 (de)	2017-06-19	2020-04-29	Gangadhara Ganapati	Nicotinamid-ribosid-derivate und deren verwendungen
US11180521B2 (en)	2018-01-30	2021-11-23	Metro International Biotech, Llc	Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof
KR20260020496A (ko) *	2018-05-22	2026-02-11	점프스타트 퍼틸리티 피티와이 엘티디	노화방지제로서의 니코틴산 리보사이드의 아미노산 염
EP3897666A2 (de)	2018-12-17	2021-10-27	Mitopower LLC	Nicotinylribosidverbindungen und ihre verwendungen
KR20220013540A (ko)	2019-02-21	2022-02-04	크로마덱스 아이엔씨.	니코틴아미드 리보사이드, 니코틴산 리보사이드, 환원 니코티닐 리보사이드 화합물, 및 니코티닐 리보사이드 화합물 유도체의 제형에서의 용도
US11939348B2 (en)	2019-03-22	2024-03-26	Metro International Biotech, Llc	Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide
CA3139615A1 (en) *	2019-06-05	2020-12-10	Societe Des Produits Nestle S.A.	Reduced nicotinamideribosides for the treatment/prevention of liver disease
WO2020245187A1 (en) *	2019-06-05	2020-12-10	Société des Produits Nestlé S.A.	Reduced nicotinamideribosides for treating or preventing kidney disease
AU2020287733A1 (en) *	2019-06-05	2021-11-04	Société des Produits Nestlé S.A.	Reduced nicotinamideribosides for treating/preventing skeletal muscle disease
CN110973260A (zh) *	2019-12-11	2020-04-10	杨力	一种含有烟酰胺核糖苷的牛奶及其制备方法与应用
WO2021123245A1 (en)	2019-12-19	2021-06-24	Leibniz-Institut Für Alternsforschung - Fritz-Lipmann-Institut E.V. (Fli)	Nad-precursors and dietary restriction for treating age-related medical conditions
EP4117680A1 (de) *	2020-03-09	2023-01-18	Société des Produits Nestlé S.A.	Zusammensetzungen und verfahren mit reduziertem nicotinamidribosid zur prävention und behandlung von lungenerkrankungen und -leiden
US20230114280A1 (en) *	2020-03-09	2023-04-13	Societe Des Produits Nestle S.A.	Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of neurological diseases and conditions
US20230138327A1 (en) *	2020-03-09	2023-05-04	Societe Des Produits Nestle S.A.	Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of pancreatic diseases and conditions
WO2021180731A1 (en) *	2020-03-09	2021-09-16	Société des Produits Nestlé S.A.	Compositions and methods containing reduced nicotinamide riboside for prevention and treatment of cardiovascular diseases and conditions
CN114561342B (zh) *	2020-11-27	2024-12-20	西安交通大学医学院第一附属医院	Nad信号通路激动剂在体外胚胎培养中的应用
CN115669929A (zh) *	2021-01-15	2023-02-03	江苏恒正合生命科学有限公司	辅助改善记忆的功能性食品其制备方法
WO2022233625A2 (en) *	2021-05-05	2022-11-10	Société des Produits Nestlé S.A.	Composition and methods using combination of narh and nr to produce intracellular nicotinamide adenine dinucleotide (nad+)
WO2022251491A1 (en)	2021-05-27	2022-12-01	Metro International Biotech, Llc	Crystalline solids of nicotinic acid mononucleotide and esters thereof and methods of making and use
EP4313067A4 (de) *	2021-06-18	2024-12-18	Mitopower LLC	Behandlung von immunbedingten erkrankungen, nierenerkrankungen, lebererkrankungen, hämolytischen erkrankungen und oxidativen stressbedingten erkrankungen mit nrh, narh und reduzierten derivaten davon
JP7111878B1 (ja)	2021-10-27	2022-08-02	旭化成ファーマ株式会社	ニコチンアミドモノヌクレオチドの製造方法
CN118176006A (zh) *	2021-10-27	2024-06-11	益力舒健康公司	治疗更年期综合征的方法
WO2023150072A1 (en)	2022-02-01	2023-08-10	Sinclair David A	Compositions and methods for the preservation of plant matter
JP2025505177A (ja) *	2022-02-04	2025-02-21	エリジウムヘルスインコーポレーテッド	リボースリンカーおよびその複合体
WO2024118503A1 (en)	2022-11-28	2024-06-06	Hongene Biotech Corporation	Functionalized n-acetylgalactosamine analogs

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7022680B2 (en) *	2002-05-30	2006-04-04	Albert Einstein College Of Medicine Of Yeshiva University	Inhibitors of ADP-ribosyl transferases, cyclases, and hydrolases
US7977049B2 (en) *	2002-08-09	2011-07-12	President And Fellows Of Harvard College	Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
US7927859B2 (en) *	2003-08-22	2011-04-19	Rice University	High molar succinate yield bacteria by increasing the intracellular NADH availability
EP1723227A4 (de)	2004-02-10	2007-09-19	Dartmouth College	Nicotinamidribosid-kinase-zusammensetzungen und verfahren zu deren verwendung
CN1964627B (zh)	2004-06-04	2011-10-19	华盛顿大学	治疗神经病变的方法和组合物
CN101360421B (zh) *	2005-11-18	2014-06-18	康乃尔研究基金会有限公司	烟酰核苷组合物及其使用方法
GB201313465D0 (en)	2013-07-29	2013-09-11	Queens University Of The Belfast	Methods of preparing nicotinamide riboside and derivatives thereof
CA2928656C (en)	2013-10-30	2020-07-28	ChromaDex Inc.	Nicotinamide riboside compositions for topical use in treating skin conditions
CA2951287A1 (en) *	2014-06-06	2015-12-10	Glaxosmithkline Intellectual Property (No. 2) Limited	Nicotinamide riboside analogs and pharmaceutical compositions and uses thereof
CN107531738B (zh) *	2015-03-16	2021-02-19	可劳迈戴斯有限公司	烟酸核苷或烟酰胺核苷组合物、其还原衍生物及其用途
WO2017011788A1 (en)	2015-07-15	2017-01-19	Cornell University	Syntheses, activities, and methods of use of dihydronicotinamide riboside derivatives
JP6949002B6 (ja)	2015-08-05	2021-11-17	メトロインターナショナルバイオテック，エルエルシー	ニコチンアミドモノヌクレオチド誘導体及びそれらの使用
CN115176998A (zh) *	2016-04-14	2022-10-14	可劳迈戴斯有限公司	烟酰胺核苷、烟酸核苷、烟酰胺单核苷酸和烟碱基化合物衍生物在婴儿配方中的用途

2017
- 2017-04-20 US US15/492,952 patent/US10183036B2/en active Active
- 2017-04-20 EP EP17786649.8A patent/EP3445359B8/de active Active
- 2017-04-20 WO PCT/US2017/028673 patent/WO2017184885A1/en not_active Ceased
- 2017-04-20 MX MX2018012849A patent/MX393076B/es unknown
- 2017-04-20 KR KR1020187033413A patent/KR20190008246A/ko not_active Ceased
- 2017-04-20 BR BR112018071573-5A patent/BR112018071573A2/pt not_active Application Discontinuation
- 2017-04-20 AU AU2017254657A patent/AU2017254657A1/en not_active Abandoned
- 2017-04-20 ES ES17786649T patent/ES2948968T3/es active Active
- 2017-04-20 CA CA3021571A patent/CA3021571C/en active Active
- 2017-04-20 NZ NZ747693A patent/NZ747693A/en unknown
- 2017-04-20 CN CN201780038245.5A patent/CN109640984A/zh active Pending
- 2017-04-20 JP JP2018554765A patent/JP7089480B2/ja active Active
2018
- 2018-11-16 ZA ZA2018/07736A patent/ZA201807736B/en unknown
2021
- 2021-07-16 JP JP2021117648A patent/JP2021176871A/ja active Pending
2022
- 2022-08-22 AU AU2022221384A patent/AU2022221384C1/en active Active
- 2022-10-19 JP JP2022167877A patent/JP7493007B2/ja active Active

Also Published As

Publication number	Publication date
KR20190008246A (ko)	2019-01-23
ES2948968T3 (es)	2023-09-22
MX393076B (es)	2025-03-24
AU2017254657A1 (en)	2018-11-15
JP2021176871A (ja)	2021-11-11
BR112018071573A2 (pt)	2019-02-12
AU2022221384A1 (en)	2022-09-22
EP3445359A4 (de)	2019-12-25
MX2018012849A (es)	2019-08-29
EP3445359B8 (de)	2023-09-06
CN109640984A (zh)	2019-04-16
AU2022221384B2 (en)	2023-03-23
WO2017184885A8 (en)	2023-08-24
JP2023002685A (ja)	2023-01-10
WO2017184885A1 (en)	2017-10-26
EP3445359B1 (de)	2023-06-07
ZA201807736B (en)	2020-05-27
JP2019514874A (ja)	2019-06-06
CA3021571A1 (en)	2017-10-26
AU2022221384C1 (en)	2023-08-03
JP7493007B2 (ja)	2024-05-30
EP3445359A1 (de)	2019-02-27
US10183036B2 (en)	2019-01-22
NZ747693A (en)	2023-07-28
CA3021571C (en)	2023-01-03
US20170304338A1 (en)	2017-10-26
JP7089480B2 (ja)	2022-06-22

Legal Events

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2017-10-28	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
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2019-12-25	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 31/706 20060101ALI20191120BHEP Ipc: A61K 31/7052 20060101ALI20191120BHEP Ipc: C07H 19/00 20060101ALI20191120BHEP Ipc: A61K 31/44 20060101AFI20191120BHEP Ipc: A61P 43/00 20060101ALI20191120BHEP Ipc: C07H 19/048 20060101ALI20191120BHEP Ipc: C07H 19/04 20060101ALI20191120BHEP
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