EP3449961A1 - Procédé de traitement de données de perfusion et système de pompe à perfusion - Google Patents

Procédé de traitement de données de perfusion et système de pompe à perfusion Download PDF

Info

Publication number
EP3449961A1
EP3449961A1 EP18195297.9A EP18195297A EP3449961A1 EP 3449961 A1 EP3449961 A1 EP 3449961A1 EP 18195297 A EP18195297 A EP 18195297A EP 3449961 A1 EP3449961 A1 EP 3449961A1
Authority
EP
European Patent Office
Prior art keywords
infusion
pump system
infusion pump
pressure
unit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP18195297.9A
Other languages
German (de)
English (en)
Other versions
EP3449961B1 (fr
Inventor
Achilleas Tsoukalis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micrel Medical Devices SA
Original Assignee
Micrel Medical Devices SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50151124&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP3449961(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Micrel Medical Devices SA filed Critical Micrel Medical Devices SA
Publication of EP3449961A1 publication Critical patent/EP3449961A1/fr
Application granted granted Critical
Publication of EP3449961B1 publication Critical patent/EP3449961B1/fr
Revoked legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M5/16854—Monitoring, detecting, signalling or eliminating infusion flow anomalies by monitoring line pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
    • G01L19/00—Details of, or accessories for, apparatus for measuring steady or quasi-steady pressure of a fluent medium insofar as such details or accessories are not special to particular types of pressure gauges
    • G01L19/08—Means for indicating or recording, e.g. for remote indication
    • G01L19/12—Alarms or signals
    • G—PHYSICS
    • G08—SIGNALLING
    • G08B—SIGNALLING SYSTEMS, e.g. PERSONAL CALLING SYSTEMS; ORDER TELEGRAPHS; ALARM SYSTEMS
    • G08B21/00—Alarms responsive to a single specified undesired or abnormal condition and not otherwise provided for
    • G08B21/18—Status alarms
    • G08B21/182—Level alarms, e.g. alarms responsive to variables exceeding a threshold
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M2005/14208—Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M2005/16863—Occlusion detection
    • A61M2005/16868—Downstream occlusion sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/50—General characteristics of the apparatus with microprocessors or computers
    • A61M2205/52—General characteristics of the apparatus with microprocessors or computers with memories providing a history of measured variating parameters of apparatus or patient

Definitions

  • the present invention relates to a distributed infusion pump system.
  • downstream pressure is monitored to reveal downstream occlusion.
  • it is known to detect pressure levels of tissue type in subcutaneous infusions or leaks in the line or intravenous needle infiltration.
  • infusion pressure statistics both steady state and transient, below occlusion level, for new medical practice and decisions per therapy.
  • US 8,551,038 discloses an infusion system in which the treatment results and side-effects of infusion are monitored remotely through a server as pumps are online exchanging data through or after therapy.
  • US5609576 , US5803917 , US5087245 , US5609576 , US7022116 , US2755680 , US4898576 , US5087245 and US6158965 deal with the filtering or calculating of pressure downstream data in one or more flow levels due to a calculation of the line's flow resistance.
  • infusion pressure statistics considering both a steady state and a transient state, below occlusion level, for new medical practice and decisions per therapy.
  • Pressure measurements in clinical trials on several infusion sites show that pressure/time graphs define an exponential type like a built-up infusion set occlusion pressure. So, according to the present invention, the pressure is monitored only at steady state and the decay from a given pressure with the pump stopped/. This gives another great advantage that an infusion pump is not an ideal current source, as assumed in prior art models, so that the transient measuring when the pump is stopped for few seconds, gives accurate results.
  • the present invention makes use of downstream pressure monitoring not only for short-term deductions concerning leaks but recording an event/pressure profile useful for extraction of useful medical decisions, like ones needed for regional analgesia nerve blocks, but also for long-term conclusions like obstruction of the central venous catheter, venous-SVC stenosis, and catheter blockage in the Parkinson's disease intestinal catheter.
  • the intention of the present invention is to provide an infusion pump system with downstream pressure recording means, to be used within both a short term (one infusion) and a long term over several infusions, for detection of defined problems, as for example infusion catheter blockage, SVC stenosis in chronic patients and regional analgesia nerve blockage complications, and for short term detection of medically useful information, like perineural infusion or generally pain treatment, over one single infusion lasting a few days.
  • Prediction of blockage before the venous catheter actually blocks has significant advantages for the patient, since even at an advanced stage of blockage, if even a small quantity of liquid is able to pass through the catheter, it can be cleaned, thus preventing a surgical intervention for replacement.
  • the type of fluid used in each infusion is recorded, a sampling time interval per therapy having single or multiple infusions duration is defined, and then an average downstream pressure during this interval including maximum pressure and maximum pressure difference is obtained.
  • a pressure reading is always recorded at infusion rate transients even within an interval. Then, both rate and interval pressure statistics are recorded. Further, provided are means to display statistics graphs for one or more infusions, maybe over a day or many months, and for an algorithmic processing of said pressure/rate profiles for extracting medically useful information.
  • Said time interval is limited by data recording capacity of the system, it can be 10 seconds to one hour.
  • a knowledge data base is maintained for each therapy, with fluid/rate/pressure/transient pressure normal data being stored and processed wherein abnormal data can issue a warning.
  • a pressure threshold below occlusion defined per therapy and per site type (subcutaneous, intravenous etc.) and possibly user.
  • occlusion defined per therapy and per site type (subcutaneous, intravenous etc.) and possibly user.
  • special resistance of flow and time constants are measured and added to pressure statistics stored in the data base of the pump or the server (distributed pump system).
  • pressure statistic limits as defined by user are exceeded, an alarm or warning according to the therapy and risks identified is issued.
  • the knowledge is built over a long term, through experience by considering false alarms vs. correct alarms. The risk of percentage of false alarms is taken by user, who defines the amount of false alarms he can accept, just to prevent a higher risk of real alarms that need possibly surgical intervention.
  • warning and/or alarm limits or warning communication are also defined by a user group or the user and the therapy.
  • a user group or the user and the therapy For example, in a clinical study on parenteral nutrition pressure monitoring over hundreds of patients and almost a year of monitoring, only 2 patients showed pressure peaks being higher than 0,5 bar wherein one of them needed a medical intervention (venoplasty) and in the other case there was a false alarm.
  • the risk of false alarms defining 0,5 bar as pressure limit for a catheter vein problem warning is definitively small (1 false over hundreds no -alarm).
  • doctors report false and real alarms to the system stored in the data base per therapy and also user group. So, when a user or doctor selects some alarm and/or warning parameters for a therapy and patient type (fat /slim, race etc.), the system will warn him about the percentage of error these parameters can expect.
  • a telemedicine system described in US 8,551,038 in combination with the present invention, wherein a parametric definition of alarm and/or warning, communication type and urgency (text on mobile, email, alarm on pump), pressure level statistics, resistance of flow, transient time constant and sampling time are defined per therapy, gained experience and user risk acceptance so they are not fixed as in the prior art.
  • a parametric definition of alarm and/or warning, communication type and urgency text on mobile, email, alarm on pump
  • pressure level statistics resistance of flow
  • transient time constant and sampling time are defined per therapy, gained experience and user risk acceptance so they are not fixed as in the prior art.
  • an aspect of the present invention is the recording of pressure data below occlusion level and creating a graph of said data for deduction of medically useful information.
  • a further aspect of the present invention is the definition of a time interval per therapy for pressure data recording which time interval reduces the data to be sent.
  • a further aspect of the present invention is the measurement of the pressure data not only from one pump as in the prior art, but for many pumps and in many times so as to build up a group knowledge like an ongoing clinical trial.
  • downstream pressure statistics data are grouped in accordance with a) therapy, b) drug, c) way of introduction (intravenous, epidural, perineural, subcutaneous etc.), d) type of delivery (needle, central venous catheter, small perineural catheter, angled needle etc.), e) reported problem type, f) alarm and/or warning level, and g) user type so as to show results according to choices from some or all the aforementioned groups a to g. So, it can be asked e.g. for all reported cathether "type z", “obstructions” and “statistics" during the "last month of use for each catheter", so that a query is transferred to the database.
  • Problems are preferably reported to the system by caregivers with reference to category (obstruction of catheter, obstruction of a vein, semi-obstruction etc) and part used (e.g. catheter brand or a model) so as to build up a knowledge on which group of data a problem arises.
  • a risk factor of statistical data and/or reported problems is evaluated by the user or by an automatic computerized process (e.g. comprising neural networks or other artificial intelligence or data filtering and/or algorithmic processing).
  • alarm and warning limits are chosen per user after his risk analysis or acceptance, and then applied to the system, i.e.
  • a distributed infusion pump system comprising
  • Fig. 3 schematically shows a typical drug delivery chain comprising an infusion set 1, a connector 2, a catheter 3 and a tissue or vein 4 wherein the connector 2 couples the infusion set 1 with the catheter 3 which is introduced into the tissue or vein 4.
  • parenteral nutrition there are different types of infusion, i.e. for main nutrition and for hydration or combination of both (dilutions).
  • the average flow speed for adults is 120 ml/hr, and for hydration it is the maximum pump flow, e.g. 400 ml/hr.
  • Typical parenteral nutrition pressure graphs are shown in Fig1 .
  • the pump initially records statistical information about downstream pressure of the infusion such as average pressure, maximum pressure and maximum pressure difference, together with how many peaks happened, and duration per peak, for the entire infusion.
  • pressure interval one hour
  • statistics and flow profile data are uploaded to a telemedicine server.
  • Pressure statistics include a calculated flow resistance A and a transient time constant ⁇ .
  • Average can be a real average or the result of digital filtering on the pressure data.
  • Pump system (pump screen or web server) can display graphs of statistical curves, or warn the user if abnormal peaks or trends are found.
  • the system makes time-stamped recordings of the pressure statistics and/or rates, so that a physician or an automated decision-making system evaluates the increase of pressure below occlusion and consequently informs the patient, who can also monitor the pressure statistic curves on the pump. Thanks to local and remote long term recording and the display of pressure statistics, surgical intervention can be avoided.
  • a clinical trial in a hospital has shown that the recording of the statistics on output pressure for each infusion rate in each patient demonstrates the catheter's tendency to block (several months recording).
  • pressure is usually between 0,1 and 0,5 bar. Pressure difference peaks of more than 0,5 bar and, hence, below occlusion level have showed Superior Vena Cava stenosis needing venoplasty.
  • said pressure statistics comprise such resistance of flow.
  • Fig.2 shows a transition from flow F1 and pressure P1 to flow F2 and pressure P2.
  • Fig. 1 which as an example shows graphs representing three different flows F1, F2 and F3 under different pressure P1, P2 and P3, respectively. Due to the differing viscosity of different fluids, the flow resistance calculated is not the real figure, but its trend over time reveals whether or not there is a verge of blockage and the catheter needs cleaning.
  • the pump can run a slow flow plus a fast flow and calculate the flow resistance, at the beginning or the end of the infusion wherein the end seems best because sugar intake has been completed and the adult patient is not at risk, i.e. flow resistance calculated within one single infusion.
  • the local display at the pump or the remote, mobile or internet application displays the pressure statistics and corresponding flow and also potentially the flow resistance in a diagram chronologically where the trend appears.
  • the derivative of the pressure curve over time i.e. the pressure's tendency to increase over time (days, weeks, months or years) is also displayed, for easy computation by an automated system, the patient or the physician, so as to create a figure or drawing of conclusions regarding the potential blockage of the catheter in the near future.
  • the derivative during and after a bolus gives useful information especially at subcutaneous infusions, where cavities (very slow change) or dead space and/or high change (inside a nerve) can be detected.
  • the system according to the present invention can also be used in cases other than central venous catheters, e.g. for Duodopa infusions in patients with Parkinson's disease, to prevent the blockage of duodenal stomach or peritoneal catheters, in infusions for peripheral analgesia where the involuntary relocation of the catheter near the nerve shows a sudden change in the output pressure, translated into alterations in the analgesia, so that changes to the anaesthetic dosage are required.
  • the resistance of flow is independent of flow.
  • Bolus time may not be generally enough to reach a pressure steady state for the flow rate, so that a measurement of transient fall times is taken for calculating a time constant ⁇ .
  • the flow resistance is not only measured in subcutaneous, epidural and intrathecal infusions, as pressure is built up relatively fast after a flow step, whereas a decay is relatively slow. So, according to the present invention, a transient response to flow and/or pressure only in the pressure decay after a high rate down to zero rate is measured.
  • This measurement is also used in intravenous infusions, stopping for some seconds a relatively high rate (above 100ml/hr) usual as in intravenous infusions.
  • the recording time interval can be 30 seconds, and the transient pressure after a maximum rate bolus is recorded followed by recording the decay of pressure at a generally low following basal rate, to show if the catheter is placed into a nerve which is potentially harmful to the patient.
  • the pressure rise and fall times are different depending on the placement of a peripheral nerve blocking catheter in surgery. This can give information regarding a reposition of the catheter and the avoidance of complications or a prediction for a based infusion and bolus needed, when the patient goes home.
  • Fig.5 shows a normal transient response during and after a loading dose and bolus
  • Fig. 4 shows an intraneural transient response i.e. with limited space and elasticity so that the pressure rises abruptly and decays slowly.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Primary Health Care (AREA)
  • Medical Informatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Business, Economics & Management (AREA)
  • Emergency Management (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
EP18195297.9A 2013-02-15 2014-02-17 Système de pompe à perfusion Revoked EP3449961B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GR20130100089 2013-02-15
EP14155405.5A EP2767919B1 (fr) 2013-02-15 2014-02-17 Procédé et dispositif pour le traitement de données de perfusion

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
EP14155405.5A Division EP2767919B1 (fr) 2013-02-15 2014-02-17 Procédé et dispositif pour le traitement de données de perfusion
EP14155405.5A Division-Into EP2767919B1 (fr) 2013-02-15 2014-02-17 Procédé et dispositif pour le traitement de données de perfusion

Publications (2)

Publication Number Publication Date
EP3449961A1 true EP3449961A1 (fr) 2019-03-06
EP3449961B1 EP3449961B1 (fr) 2021-03-31

Family

ID=50151124

Family Applications (2)

Application Number Title Priority Date Filing Date
EP14155405.5A Active EP2767919B1 (fr) 2013-02-15 2014-02-17 Procédé et dispositif pour le traitement de données de perfusion
EP18195297.9A Revoked EP3449961B1 (fr) 2013-02-15 2014-02-17 Système de pompe à perfusion

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP14155405.5A Active EP2767919B1 (fr) 2013-02-15 2014-02-17 Procédé et dispositif pour le traitement de données de perfusion

Country Status (2)

Country Link
US (3) US20140236119A1 (fr)
EP (2) EP2767919B1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2938371B1 (fr) * 2012-12-31 2019-08-28 Gambro Lundia AB Détection d'obstruction dans la délivrance de fluides
AU2016249994B2 (en) 2015-04-15 2020-04-02 Gambro Lundia Ab Treatment system with infusion apparatus pressure priming
US10881783B2 (en) 2015-11-20 2021-01-05 Fenwal, Inc. Processing infusion pump data for presentation on operator interface
US10485926B2 (en) 2016-10-07 2019-11-26 Carefusion 303, Inc. Systems and methods for controlling an infusion pump
US11429725B1 (en) * 2018-04-26 2022-08-30 Citicorp Credit Services, Inc. (Usa) Automated security risk assessment systems and methods
CN110841143B (zh) * 2019-10-22 2022-03-08 江苏爱朋医疗科技股份有限公司 一种用于预测输液管路状态的方法及系统
CN110841142B (zh) * 2019-10-22 2022-03-08 江苏爱朋医疗科技股份有限公司 一种用于预测输液管路堵塞的方法及系统
ES3030135T3 (en) * 2020-12-30 2025-06-26 Baxter Int Systems and methods for occlusion detection in infusion pumps
DE102022118179A1 (de) * 2022-07-20 2024-01-25 B. Braun Melsungen Aktiengesellschaft Verfahren zur Reduzierung eines Bolus, Prognoseverfahren, Sicherheitsvorrichtung und medizinische Pumpe
US11935389B2 (en) * 2022-08-10 2024-03-19 Honeywell International Inc. Methods and apparatuses for monitoring intravenous fluid bags
CN120204524B (zh) * 2025-05-29 2025-08-22 长治市人民医院(长治市职业病防治院) 结合cvp测量的静脉输液器监控系统

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2755680A (en) 1954-07-15 1956-07-24 Landis & Gyr Ag Instrument servomotor for torque amplification in measuring apparatus and the like
US4898576A (en) 1986-06-06 1990-02-06 Philip James H Intravenous fluid flow monitor
EP0431310A1 (fr) * 1989-11-08 1991-06-12 Ivac Corporation Méthode et système de détection des occlusions, côté réservoir
US5087245A (en) 1989-03-13 1992-02-11 Ivac Corporation System and method for detecting abnormalities in intravascular infusion
US5609576A (en) 1994-09-13 1997-03-11 Ivac Medical Systems, Inc. Fluid flow impedance monitoring system
US5803917A (en) 1994-09-13 1998-09-08 Alaris Medical Systems, Inc. Fluid flow resistance monitoring system
US6158965A (en) 1996-07-30 2000-12-12 Alaris Medical Systems, Inc. Fluid flow resistance monitoring system
US20050090799A1 (en) * 2003-10-23 2005-04-28 Medtronic, Inc. Method for monitoring bolus delivery
WO2009124134A2 (fr) * 2008-04-01 2009-10-08 Smiths Medical Md, Inc. Particularités logicielles pour pompe d’infusion médicale
US8551038B2 (en) 2010-07-19 2013-10-08 Micrel Medical Devices S.A. Pump infusion system

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5935099A (en) 1992-09-09 1999-08-10 Sims Deltec, Inc. Drug pump systems and methods
US4534756A (en) * 1983-04-11 1985-08-13 Ivac Corporation Fault detection apparatus and method for parenteral infusion system
US4530696A (en) * 1983-06-13 1985-07-23 Institute Of Critical Care Medicine Monitor for intravenous injection system for detecting occlusion and/or infiltration
US4690673A (en) * 1985-11-26 1987-09-01 Imed Corporation Dual mode I.V. infusion device with distal sensor
US4836752A (en) 1987-11-02 1989-06-06 Fisher Scientific Company Partial restriction detector
US4863425A (en) * 1987-12-04 1989-09-05 Pacesetter Infusion, Ltd. Patient-side occlusion detection system for a medication infusion system
US5116203A (en) 1990-03-15 1992-05-26 Abbott Laboratories Detecting occlusion of proximal or distal lines of an IV pump
DE69315450T2 (de) * 1992-01-22 1998-05-20 Alaris Medical Systems Inc N D Zustandbestimmung einer Flüssigkeitsschlauchleitung
JPH05277185A (ja) * 1992-04-03 1993-10-26 Sharp Corp 輸液装置
US5695473A (en) 1994-07-27 1997-12-09 Sims Deltec, Inc. Occlusion detection system for an infusion pump
US5445622A (en) * 1994-12-20 1995-08-29 Brown; Eric W. Flow switch device for medical applications
US5814015A (en) 1995-02-24 1998-09-29 Harvard Clinical Technology, Inc. Infusion pump for at least one syringe
US5827223A (en) * 1995-08-31 1998-10-27 Alaris Medical Systems, Inc. Upstream occulsion detection system
US6422057B1 (en) * 1998-09-29 2002-07-23 Deltec, Inc. Drug pump testing system and methods
US6551243B2 (en) * 2001-01-24 2003-04-22 Siemens Medical Solutions Health Services Corporation System and user interface for use in providing medical information and health care delivery support
US20050055242A1 (en) * 2002-04-30 2005-03-10 Bryan Bello System and method for medical data tracking, analysis and reporting for healthcare system
US20050038680A1 (en) 2002-12-19 2005-02-17 Mcmahon Kevin Lee System and method for glucose monitoring
US8065161B2 (en) * 2003-11-13 2011-11-22 Hospira, Inc. System for maintaining drug information and communicating with medication delivery devices
US8182461B2 (en) * 2003-11-04 2012-05-22 Smiths Medical Asd, Inc. Syringe pump rapid occlusion detection system
US20090093774A1 (en) * 2007-10-04 2009-04-09 Baxter International Inc. Ambulatory pump with intelligent flow control
WO2010102069A2 (fr) * 2009-03-04 2010-09-10 Masimo Corporation Système de surveillance médicale
EP2427841B1 (fr) 2009-05-05 2019-08-14 CareFusion 303, Inc. Dispositif de contrôle d'un site de perfusion basé sur un modèle
CA2785758A1 (fr) * 2009-12-28 2011-07-07 Gambro Lundia Ab Procede et dispositif de detection d'une configuration de dispositifs d'extraction et de renvoi
US8287486B2 (en) 2010-05-25 2012-10-16 Alcon Research, Ltd. Infusion pressure monitoring system
US9950112B2 (en) * 2010-08-17 2018-04-24 University Of Florida Research Foundation, Incorporated Intelligent drug and/or fluid delivery system to optimizing medical treatment or therapy using pharmacodynamic and/or pharamacokinetic data
US8690855B2 (en) * 2010-12-22 2014-04-08 Medtronic Minimed, Inc. Fluid reservoir seating procedure for a fluid infusion device
US9162023B2 (en) * 2011-05-05 2015-10-20 Carefusion 303, Inc. Automated pressure limit setting method and apparatus
CN105073159A (zh) * 2013-01-28 2015-11-18 史密斯医疗Asd公司 用药安全设备及方法

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2755680A (en) 1954-07-15 1956-07-24 Landis & Gyr Ag Instrument servomotor for torque amplification in measuring apparatus and the like
US4898576A (en) 1986-06-06 1990-02-06 Philip James H Intravenous fluid flow monitor
US5087245A (en) 1989-03-13 1992-02-11 Ivac Corporation System and method for detecting abnormalities in intravascular infusion
EP0431310A1 (fr) * 1989-11-08 1991-06-12 Ivac Corporation Méthode et système de détection des occlusions, côté réservoir
US5609576A (en) 1994-09-13 1997-03-11 Ivac Medical Systems, Inc. Fluid flow impedance monitoring system
US5803917A (en) 1994-09-13 1998-09-08 Alaris Medical Systems, Inc. Fluid flow resistance monitoring system
US6158965A (en) 1996-07-30 2000-12-12 Alaris Medical Systems, Inc. Fluid flow resistance monitoring system
US20050090799A1 (en) * 2003-10-23 2005-04-28 Medtronic, Inc. Method for monitoring bolus delivery
US7022116B2 (en) 2003-10-23 2006-04-04 Medtronic, Inc. Method for monitoring bolus delivery
WO2009124134A2 (fr) * 2008-04-01 2009-10-08 Smiths Medical Md, Inc. Particularités logicielles pour pompe d’infusion médicale
US8551038B2 (en) 2010-07-19 2013-10-08 Micrel Medical Devices S.A. Pump infusion system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GABE S M ET AL: "OP036 PUMP INFUSION PRESSURES IN PATIENTS ON LONG TERM PARENTERAL NUTRITION: A NOVEL APPROACH AND MONITORING TECHNIQUE TO ANTICIPATE CATHETER OCCLUSION", CLINICAL NUTRITION, vol. 32, 16 March 2015 (2015-03-16), XP028699194, ISSN: 0261-5614, DOI: 10.1016/S0261-5614(13)60038-2 *

Also Published As

Publication number Publication date
US11164667B2 (en) 2021-11-02
US12076529B2 (en) 2024-09-03
US20150306310A1 (en) 2015-10-29
EP2767919A1 (fr) 2014-08-20
EP2767919B1 (fr) 2019-01-30
US20140236119A1 (en) 2014-08-21
EP3449961B1 (fr) 2021-03-31
US20220008654A1 (en) 2022-01-13

Similar Documents

Publication Publication Date Title
US12076529B2 (en) Method for processing infusion data and an infusion pump system
EP2704766B1 (fr) Procédé et appareil de perfusion
US7509156B2 (en) System for managing glucose levels in patients with diabetes or hyperglycemia
EP2257217B1 (fr) Moniteurs hémodynamiques et alarmes
EP4708311A2 (fr) Procédés, systèmes et dispositifs d'administration d'insuline
CN113226402A (zh) 监护仪及其生理体征参数与用药信息结合显示的方法
US12364442B2 (en) Alarm system for intravenous pump or catheter based upon fuzzy logic
CN114761051A (zh) 包括针对管理患者参与度和诊治依从性的分析的医疗流体递送系统
Howsmon et al. Real-time detection of infusion site failures in a closed-loop artificial pancreas
EP4002379A1 (fr) Système comprenant un dispositif, procédé et programme informatique permettant de commander l'administration d'un médicament à un patient
Vitoux et al. Frequency and duration of infusion pump alarms: establishing national benchmarks
Snaith et al. Technologies in the management of type 1 diabetes.
US20200038587A1 (en) Systems and methods for monitoring and controlling a state of a subject during volume resuscitation
EP3171287A2 (fr) Traitement de données de pompe de perfusion pour une présentation sur une interface opérateur
JP6530013B2 (ja) 血液浄化システム
EP4306049B1 (fr) Dispositif de surveillance automatique de perfusion de médicament avec échantillons temporisés
WO2026084977A1 (fr) Prédiction de défaillance de perfusion par cathéter imminente à l'aide d'un apprentissage automatique
Sakuma et al. An adaptive scheme of controlling dosage and dosing interval in general anesthesia by model predictive control using anesthetic depth model
JP2025530927A (ja) 注入部位不具合検出
Sekmistrz Assessing the utilization of electronic infusion devices at a private community teaching facility

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN PUBLISHED

AC Divisional application: reference to earlier application

Ref document number: 2767919

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20190906

RBV Designated contracting states (corrected)

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: MICREL MEDICAL DEVICES S.A.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20200217

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20201002

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

AC Divisional application: reference to earlier application

Ref document number: 2767919

Country of ref document: EP

Kind code of ref document: P

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602014076287

Country of ref document: DE

Ref country code: AT

Ref legal event code: REF

Ref document number: 1376218

Country of ref document: AT

Kind code of ref document: T

Effective date: 20210415

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG9D

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210630

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210630

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

Ref country code: LV

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20210331

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 1376218

Country of ref document: AT

Kind code of ref document: T

Effective date: 20210331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210802

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210731

REG Reference to a national code

Ref country code: DE

Ref legal event code: R026

Ref document number: 602014076287

Country of ref document: DE

PLBI Opposition filed

Free format text: ORIGINAL CODE: 0009260

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: AL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

26 Opposition filed

Opponent name: HARDS, ANDREW

Effective date: 20211230

PLAX Notice of opposition and request to file observation + time limit sent

Free format text: ORIGINAL CODE: EPIDOSNOBS2

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210731

PLBB Reply of patent proprietor to notice(s) of opposition received

Free format text: ORIGINAL CODE: EPIDOSNOBS3

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

REG Reference to a national code

Ref country code: BE

Ref legal event code: MM

Effective date: 20220228

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220217

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220228

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220217

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220228

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20220228

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: FR

Payment date: 20230217

Year of fee payment: 10

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: GB

Payment date: 20230221

Year of fee payment: 10

Ref country code: DE

Payment date: 20230308

Year of fee payment: 10

REG Reference to a national code

Ref country code: DE

Ref legal event code: R103

Ref document number: 602014076287

Country of ref document: DE

Ref country code: DE

Ref legal event code: R064

Ref document number: 602014076287

Country of ref document: DE

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230526

RDAF Communication despatched that patent is revoked

Free format text: ORIGINAL CODE: EPIDOSNREV1

RDAG Patent revoked

Free format text: ORIGINAL CODE: 0009271

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: PATENT REVOKED

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

27W Patent revoked

Effective date: 20230629

GBPR Gb: patent revoked under art. 102 of the ep convention designating the uk as contracting state

Effective date: 20230629

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20140217

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20210331

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20210331