EP3452500A4 - PROLIFERATION OF MESENCHYMAL STEM CELLS - Google Patents

PROLIFERATION OF MESENCHYMAL STEM CELLS Download PDF

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Publication number
EP3452500A4
EP3452500A4 EP17793552.5A EP17793552A EP3452500A4 EP 3452500 A4 EP3452500 A4 EP 3452500A4 EP 17793552 A EP17793552 A EP 17793552A EP 3452500 A4 EP3452500 A4 EP 3452500A4
Authority
EP
European Patent Office
Prior art keywords
proliferation
stem cells
mesenchymal stem
mesenchymal
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP17793552.5A
Other languages
German (de)
French (fr)
Other versions
EP3452500A1 (en
Inventor
Melinda SIMON
István HORNYÁK
Zsombor Lacza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lacerta Technologies Inc
Original Assignee
Lacerta Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacerta Technologies Inc filed Critical Lacerta Technologies Inc
Publication of EP3452500A1 publication Critical patent/EP3452500A1/en
Publication of EP3452500A4 publication Critical patent/EP3452500A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3616—Blood, e.g. platelet-rich plasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/115—Platelets, megakaryocytes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
EP17793552.5A 2016-05-06 2017-05-08 PROLIFERATION OF MESENCHYMAL STEM CELLS Pending EP3452500A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP1600306 2016-05-06
PCT/US2017/031585 WO2017193134A1 (en) 2016-05-06 2017-05-08 Mesenchymal stem cell proliferation

Publications (2)

Publication Number Publication Date
EP3452500A1 EP3452500A1 (en) 2019-03-13
EP3452500A4 true EP3452500A4 (en) 2019-12-11

Family

ID=89720150

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17793552.5A Pending EP3452500A4 (en) 2016-05-06 2017-05-08 PROLIFERATION OF MESENCHYMAL STEM CELLS

Country Status (2)

Country Link
EP (1) EP3452500A4 (en)
WO (1) WO2017193134A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109943471A (en) * 2017-12-21 2019-06-28 北京中原合聚经贸有限公司 A kind of mescenchymal stem cell filtering perfusion culture preparation facilities
CN110585243A (en) * 2019-08-12 2019-12-20 丰泽康生物医药（深圳）有限公司 Pluripotent cell active matter and platelet-rich plasma compound for treating glucocorticoid-dependent dermatitis as well as preparation method and application thereof
US12680923B2 (en) * 2019-12-31 2026-07-14 Sakura Finetek U.S.A., Inc. Automated staining system and reaction chamber
WO2022180193A1 (en) * 2021-02-25 2022-09-01 Swedish Stromabio Ab Compositions and methods for proliferation of mesenchymal stromal cells
CN113249332A (en) * 2021-07-15 2021-08-13 北京大学第三医院（北京大学第三临床医学院） Establishing method of ALPL gene-deleted mesenchymal stem cells
CN114869912A (en) * 2022-05-23 2022-08-09 西安中美弘康生物科技有限公司 A kind of preparation method of human mesenchymal stem cell composite nPRF preparation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090010896A1 (en) * 2007-07-05 2009-01-08 Centeno Christopher J Methods and compositions for optimized expansion and implantation of mesenchymal stem cells

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2956150T3 (en) * 2013-02-12 2022-01-03 Lacerta Technologies Inc. Serum fraction of platelet-rich fibrin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090010896A1 (en) * 2007-07-05 2009-01-08 Centeno Christopher J Methods and compositions for optimized expansion and implantation of mesenchymal stem cells

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHI-SHENG CHIEN ET AL: "Incorporation of exudates of human platelet-rich fibrin gel in biodegradable fibrin scaffolds for tissue engineering of cartilage", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B: APPLIED BIOMATERIALS, vol. 100B, no. 4, 25 May 2012 (2012-05-25), pages 948 - 955, XP055111158, ISSN: 1552-4973, DOI: 10.1002/jbm.b.32657 *
See also references of WO2017193134A1 *
SU C Y ET AL: "In vitro release of growth factors from platelet-rich fibrin (PRF): a proposal to optimize the clinical applications of PRF", ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY, ORAL RADIOLOGY AND ENDODONTICS, MOSBY-YEAR BOOK, ST. LOUIS, MO, US, vol. 108, no. 1, 1 July 2009 (2009-07-01), pages 56 - 61, XP026434162, ISSN: 1079-2104, [retrieved on 20090517] *
THIERRY BURNOUF ET AL: "Human blood-derived fibrin releasates: Composition and use for the culture of cell lines and human primary cells", BIOLOGICALS, vol. 40, no. 1, 1 January 2012 (2012-01-01), pages 21 - 30, XP055111162, ISSN: 1045-1056, DOI: 10.1016/j.biologicals.2011.09.017 *

Also Published As

Publication number Publication date
WO2017193134A1 (en) 2017-11-09
EP3452500A1 (en) 2019-03-13

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Inventor name: SIMON, MELINDA

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