EP3452500A4 - Prolifération de cellules souches mésenchymateuses - Google Patents

Prolifération de cellules souches mésenchymateuses Download PDF

Info

Publication number
EP3452500A4
EP3452500A4 EP17793552.5A EP17793552A EP3452500A4 EP 3452500 A4 EP3452500 A4 EP 3452500A4 EP 17793552 A EP17793552 A EP 17793552A EP 3452500 A4 EP3452500 A4 EP 3452500A4
Authority
EP
European Patent Office
Prior art keywords
proliferation
stem cells
mesenchymal stem
mesenchymal
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP17793552.5A
Other languages
German (de)
English (en)
Other versions
EP3452500A1 (fr
Inventor
Melinda SIMON
István HORNYÁK
Zsombor Lacza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lacerta Technologies Inc
Original Assignee
Lacerta Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacerta Technologies Inc filed Critical Lacerta Technologies Inc
Publication of EP3452500A1 publication Critical patent/EP3452500A1/fr
Publication of EP3452500A4 publication Critical patent/EP3452500A4/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3616—Blood, e.g. platelet-rich plasma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/115—Platelets, megakaryocytes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
EP17793552.5A 2016-05-06 2017-05-08 Prolifération de cellules souches mésenchymateuses Pending EP3452500A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP1600306 2016-05-06
PCT/US2017/031585 WO2017193134A1 (fr) 2016-05-06 2017-05-08 Prolifération de cellules souches mésenchymateuses

Publications (2)

Publication Number Publication Date
EP3452500A1 EP3452500A1 (fr) 2019-03-13
EP3452500A4 true EP3452500A4 (fr) 2019-12-11

Family

ID=89720150

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17793552.5A Pending EP3452500A4 (fr) 2016-05-06 2017-05-08 Prolifération de cellules souches mésenchymateuses

Country Status (2)

Country Link
EP (1) EP3452500A4 (fr)
WO (1) WO2017193134A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109943471A (zh) * 2017-12-21 2019-06-28 北京中原合聚经贸有限公司 一种间充质干细胞过滤灌流培养制备装置
CN110585243A (zh) * 2019-08-12 2019-12-20 丰泽康生物医药（深圳）有限公司 用于治疗糖皮质激素依赖性皮炎的多潜能细胞活性物与富血小板血浆复合物及制法和应用
JP7520981B2 (ja) * 2019-12-31 2024-07-23 サクラ ファインテック ユー．エス．エー．， インコーポレイテッド 自動化染色システム及び反応室
WO2022180193A1 (fr) * 2021-02-25 2022-09-01 Swedish Stromabio Ab Compositions et procédés de prolifération de cellules stromales mésenchymateuses
CN113249332A (zh) * 2021-07-15 2021-08-13 北京大学第三医院（北京大学第三临床医学院） 一种alpl基因缺失骨髓间充质干细胞的建立方法
CN114869912A (zh) * 2022-05-23 2022-08-09 西安中美弘康生物科技有限公司 一种人间充质干细胞复合nPRF制剂的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090010896A1 (en) * 2007-07-05 2009-01-08 Centeno Christopher J Methods and compositions for optimized expansion and implantation of mesenchymal stem cells

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9480716B2 (en) 2013-02-12 2016-11-01 Lacerta Technologies Inc. Serum fraction of platelet-rich fibrin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090010896A1 (en) * 2007-07-05 2009-01-08 Centeno Christopher J Methods and compositions for optimized expansion and implantation of mesenchymal stem cells

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHI-SHENG CHIEN ET AL: "Incorporation of exudates of human platelet-rich fibrin gel in biodegradable fibrin scaffolds for tissue engineering of cartilage", JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B: APPLIED BIOMATERIALS, vol. 100B, no. 4, 25 May 2012 (2012-05-25), pages 948 - 955, XP055111158, ISSN: 1552-4973, DOI: 10.1002/jbm.b.32657 *
See also references of WO2017193134A1 *
SU C Y ET AL: "In vitro release of growth factors from platelet-rich fibrin (PRF): a proposal to optimize the clinical applications of PRF", ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY, ORAL RADIOLOGY AND ENDODONTICS, MOSBY-YEAR BOOK, ST. LOUIS, MO, US, vol. 108, no. 1, 1 July 2009 (2009-07-01), pages 56 - 61, XP026434162, ISSN: 1079-2104, [retrieved on 20090517] *
THIERRY BURNOUF ET AL: "Human blood-derived fibrin releasates: Composition and use for the culture of cell lines and human primary cells", BIOLOGICALS, vol. 40, no. 1, 1 January 2012 (2012-01-01), pages 21 - 30, XP055111162, ISSN: 1045-1056, DOI: 10.1016/j.biologicals.2011.09.017 *

Also Published As

Publication number Publication date
EP3452500A1 (fr) 2019-03-13
WO2017193134A1 (fr) 2017-11-09

Similar Documents

Publication Publication Date Title
EP3510145A4 (fr) Cellules immunitaires dérivées de cellules souches pluripotentes induites
IL250689A0 (en) Resetting pluripotent stem cells
EP3635132A4 (fr) Expression de nouvelles étiquettes de cellules
EP3371314A4 (fr) Ingénierie génomique de cellules pluripotentes
MA46959A (fr) Cellules b modifiées et compositions et méthodes associées
EP3541924A4 (fr) Dosage de cellules souches pluripotentes
MA45407A (fr) Compositions et méthodes de déplétion de cellules
EP3455344A4 (fr) Cellules souches/progénitrices hématopoïétiques
IL261710A (en) Production of antigen-specific t-cells
EP3654996A4 (fr) Réagrégation de cellules bêta pancréatiques dérivées de cellules souches
EP3538115A4 (fr) Cellules de schwann dérivées de cellules souches
PL3411473T3 (pl) Mezenchymalne komórki macierzyste nasilające aktywność antynowotworową immunoterapii
IL263265A (en) Use of mesenchymal stem cells and their parts
EP3359650A4 (fr) Activation et expansion de cellules t
EP3384006A4 (fr) Utilisations de populations étendues de cellules souches/progénitrices hématopoïétiques
EP3549590A4 (fr) Préparation de cellules
EP3384038A4 (fr) Méthodes et compositions pour la reprogrammation de cellules
DK3157504T3 (da) Stamcellestimulerende sammensætninger
IL260858B (en) Mesenchymal stem cells as vaccine adjuvants and methods for using the same
EP3340997A4 (fr) Procédés pour la transplantation de cellules souches
DK3702445T3 (da) Hidtil ukendt muskuloskeletal stamcelle
BR112016019822A2 (pt) Determinação enzimática de hba1c
DK3158057T3 (da) Stamcelleterapi ved endometriepatologier
EP3420075A4 (fr) Production de cellules souches cancéreuses et leur utilisation
FR3023067B1 (fr) Cellules tandem multifils

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20181206

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

RIN1 Information on inventor provided before grant (corrected)

Inventor name: SIMON, MELINDA

Inventor name: LACZA, ZSOMBOR

Inventor name: HORNYAK, ISTVAN

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20191113

RIC1 Information provided on ipc code assigned before grant

Ipc: A61L 27/36 20060101ALI20191107BHEP

Ipc: A61K 38/18 20060101ALI20191107BHEP

Ipc: A61K 35/28 20150101ALI20191107BHEP

Ipc: A61P 19/00 20060101ALI20191107BHEP

Ipc: C07K 14/75 20060101AFI20191107BHEP

Ipc: C12N 5/0775 20100101ALI20191107BHEP

Ipc: A61K 38/36 20060101ALI20191107BHEP

Ipc: A61L 27/54 20060101ALI20191107BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20210503