EP3453718A4 - Protéine dérivée de bactéries d'acide lactique et son procédé de préparation - Google Patents

Protéine dérivée de bactéries d'acide lactique et son procédé de préparation Download PDF

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Publication number
EP3453718A4
EP3453718A4 EP17874171.6A EP17874171A EP3453718A4 EP 3453718 A4 EP3453718 A4 EP 3453718A4 EP 17874171 A EP17874171 A EP 17874171A EP 3453718 A4 EP3453718 A4 EP 3453718A4
Authority
EP
European Patent Office
Prior art keywords
preparation
lactic acid
acid bacteria
protein derived
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP17874171.6A
Other languages
German (de)
English (en)
Other versions
EP3453718A1 (fr
EP3453718B1 (fr
Inventor
Myung Jun Chung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cell Biotech Co Ltd
Original Assignee
Cell Biotech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Biotech Co Ltd filed Critical Cell Biotech Co Ltd
Publication of EP3453718A1 publication Critical patent/EP3453718A1/fr
Publication of EP3453718A4 publication Critical patent/EP3453718A4/fr
Application granted granted Critical
Publication of EP3453718B1 publication Critical patent/EP3453718B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/335—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Lactobacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/308—Foods, ingredients or supplements having a functional effect on health having an effect on cancer prevention
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/41—Pediococcus
    • A23V2400/427—Pentosaceus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11—Medicinal preparations comprising living procariotic cells
    • A61K2035/115—Probiotics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP17874171.6A 2016-11-28 2017-02-15 Utilisation de la protéine p8 dérivée des bactéries lactiques comme agent anticancéreux Active EP3453718B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020160159479A KR101910808B1 (ko) 2016-11-28 2016-11-28 유산균 유래 p8 단백질 및 이의 항암 용도
PCT/KR2017/001625 WO2018097402A1 (fr) 2016-11-28 2017-02-15 Protéine dérivée de bactéries d'acide lactique et son procédé de préparation

Publications (3)

Publication Number Publication Date
EP3453718A1 EP3453718A1 (fr) 2019-03-13
EP3453718A4 true EP3453718A4 (fr) 2019-12-25
EP3453718B1 EP3453718B1 (fr) 2021-03-31

Family

ID=62195025

Family Applications (1)

Application Number Title Priority Date Filing Date
EP17874171.6A Active EP3453718B1 (fr) 2016-11-28 2017-02-15 Utilisation de la protéine p8 dérivée des bactéries lactiques comme agent anticancéreux

Country Status (7)

Country Link
US (1) US11213565B2 (fr)
EP (1) EP3453718B1 (fr)
JP (1) JP6586248B2 (fr)
KR (1) KR101910808B1 (fr)
CN (1) CN109153706B (fr)
DK (1) DK3453718T3 (fr)
WO (1) WO2018097402A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101915951B1 (ko) * 2018-01-09 2018-11-07 주식회사 쎌바이오텍 P8 단백질을 발현 및 분비하는 위장관 질환 치료 약물 전달용 미생물 및 그를 포함하는 위장관 질환 예방 또는 치료용 약제학적 조성물
KR102281858B1 (ko) 2019-09-11 2021-07-26 주식회사 쎌바이오텍 유산균 유래 p8 단백질의 발현 컨스트럭트를 포함하는 대장 질환의 치료 또는 예방용 조성물
CN110982745B (zh) * 2019-12-24 2021-06-25 扬州大学 一种戊糖片球菌z-1、戊糖片球菌细菌素z-1及戊糖片球菌细菌素z-1的生产方法
KR102719035B1 (ko) * 2020-04-20 2024-10-18 주식회사 리비옴 혈관 작동성 장 펩티드를 발현하는 미생물, 및 그의 용도

Family Cites Families (14)

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KR100232639B1 (ko) 1997-04-15 1999-12-01 김동현 장내 유해효소의 활성을 억제하는 새로운 한국형 유산균 및 그의 용도
WO2009093447A1 (fr) * 2008-01-22 2009-07-30 National University Corporation Asahikawa Medical College Agent antitumoral contre le cancer gastro-intestinal
GB0903016D0 (en) * 2009-02-23 2009-04-08 Univ Gent Method for alleviating intestinal problems and novel bacterial strains therefor
KR101178217B1 (ko) * 2009-10-28 2012-09-07 씨제이제일제당 (주) 신규한 락토바실러스 플란타룸 및 이를 포함하는 조성물
KR20110124516A (ko) * 2010-05-11 2011-11-17 포항공과대학교 산학협력단 유산균 배양액 추출물을 포함하는 염증관련질환 치료용 조성물
KR20120015644A (ko) * 2010-08-12 2012-02-22 박진형 항암 활성을 갖는 락토바실러스 균주 및 이를 활성성분으로 포함하는 항암 활성 조성물
KR101427363B1 (ko) 2011-11-23 2014-08-08 주식회사 쎌바이오텍 항암 약제학적 조성물
KR101377617B1 (ko) * 2011-11-23 2014-03-26 주식회사 쎌바이오텍 항알러지 활성을 갖는 피14 단백질 및 이들을 포함하는 항알러지 약제학적 조성물
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Title
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JUANITA ESCAMILLA ET AL: "Cell-Free Supernatants from Probiotic Lactobacillus casei and Lactobacillus rhamnosus GG Decrease Colon Cancer Cell Invasion In Vitro", NUTRITION AND CANCER, vol. 64, no. 6, 1 August 2012 (2012-08-01), US, pages 871 - 878, XP055641523, ISSN: 0163-5581, DOI: 10.1080/01635581.2012.700758 *
KIM ET AL: "Cancer chemopreventive effects of lactic acid bacteria", JOURNAL OF THE ALL-INDIA OPHTHALMOLOGICAL SOCIETY, MEDKNOW PUBLICATIONS AND MEDIA PVT. LTD, INDIA, vol. 17, no. 8, 1 January 2007 (2007-01-01), pages 1227 - 1235, XP008160403, ISSN: 0044-7307 *
LI ZHONG ET AL: "Emerging roles of lactic acid bacteria in protection against colorectal cancer", WORLD JOURNAL OF GASTROENTEROLOGY, vol. 20, no. 24, 1 January 2014 (2014-01-01), CN, pages 7878 - 7886, XP055531727, ISSN: 1007-9327, DOI: 10.3748/wjg.v20.i24.7878 *
UNIPROT DB: "UPI00019F7D40", UNIPROT, 16 June 2009 (2009-06-16), XP055641481, Retrieved from the Internet <URL:https://www.uniprot.org/uniparc/UPI00019F7D40> [retrieved on 20191112] *

Also Published As

Publication number Publication date
US11213565B2 (en) 2022-01-04
US20190201481A1 (en) 2019-07-04
JP2019521089A (ja) 2019-07-25
JP6586248B2 (ja) 2019-10-02
KR101910808B1 (ko) 2018-10-24
EP3453718A1 (fr) 2019-03-13
WO2018097402A1 (fr) 2018-05-31
DK3453718T3 (da) 2021-04-19
CN109153706A (zh) 2019-01-04
CN109153706B (zh) 2022-01-21
EP3453718B1 (fr) 2021-03-31
KR20180060228A (ko) 2018-06-07

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