EP3493814A4 - Lipid-substituierte amino-1,2- und 1,3-diolverbindungen als modulatoren der tlr2-dimerisierung - Google Patents

Lipid-substituierte amino-1,2- und 1,3-diolverbindungen als modulatoren der tlr2-dimerisierung Download PDF

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Publication number
EP3493814A4
EP3493814A4 EP17837574.7A EP17837574A EP3493814A4 EP 3493814 A4 EP3493814 A4 EP 3493814A4 EP 17837574 A EP17837574 A EP 17837574A EP 3493814 A4 EP3493814 A4 EP 3493814A4
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Prior art keywords
modulators
lipid
substituted amino
diol compounds
tlr2
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EP17837574.7A
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English (en)
French (fr)
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EP3493814A1 (de
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Wolfgang Wrasidlo
Srinivasa Reddy Natala
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Neuropore Therapies Inc
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Neuropore Therapies Inc
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
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EP17837574.7A 2016-08-03 2017-08-01 Lipid-substituierte amino-1,2- und 1,3-diolverbindungen als modulatoren der tlr2-dimerisierung Withdrawn EP3493814A4 (de)

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US201662370637P 2016-08-03 2016-08-03
PCT/US2017/044984 WO2018026866A1 (en) 2016-08-03 2017-08-01 Lipid-substituted amino 1,2-and 1,3-diol compounds as modulators of tlr2 dimerization

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HK1257102A1 (zh) 2015-08-21 2019-10-11 Portola Pharmaceuticals, Inc. 苯基哌嗪前蛋白转化酶枯草杆菌蛋白酶/kexin9型(pcsk9)调节剂及其应用
US10865185B2 (en) 2015-08-21 2020-12-15 Srx Cardio, Llc Composition and methods of use of tetrahydroisoquinoline small molecules to bind and modulate PCSK9 protein activity
US10821106B2 (en) * 2015-08-21 2020-11-03 Srx Cardio, Llc Composition and methods of use of novel phenylalanine small organic compounds to directly modulate PCSK9 protein activity
US20190119236A1 (en) 2016-02-23 2019-04-25 Portola Pharmaceuticals, Inc. Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9)
JP2022527294A (ja) 2019-03-26 2022-06-01 ニューロポア セラピーズ インコーポレイテッド Ｔｌｒシグナル伝達の調節剤としての化合物及び組成物
PL3992177T3 (pl) * 2019-06-25 2024-08-26 Amtixbio Co., Ltd. Nowatorska pochodna kwasu aminoalkanowego, zawierająca w swojej strukturze ugrupowanie bifenylowe, oraz kompozycja farmaceutyczna o działaniu przeciwgrzybiczym, w skład której wchodzi ta pochodna
US12115154B2 (en) 2020-12-16 2024-10-15 Srx Cardio, Llc Compounds for the modulation of proprotein convertase subtilisin/kexin type 9 (PCSK9)
US12502416B1 (en) * 2025-04-08 2025-12-23 Dasman Diabetes Institute PAM3CSK4 injection for the prevention and management of MASLD

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EP0451763A2 (de) * 1990-04-09 1991-10-16 Fuji Photo Film Co., Ltd. Peptidderivate mit amphiphatischen Eigenschaften, ihre Zwischenprodukte und Liposome sowie Filme, die diese Derivate enthalten
WO2002072068A2 (en) * 2001-03-12 2002-09-19 Cancer Research Technology Limited Lipids, lipid compositions, liposomes, and lipoplexes
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