EP3500261A4 - Pulvérisation de naloxone liquide - Google Patents

Pulvérisation de naloxone liquide Download PDF

Info

Publication number: EP3500261A4
Authority: EP; European Patent Office
Prior art keywords: naloxone spray; liquid; liquid naloxone; spray; naloxone
Prior art date: 2016-08-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP17841883.6A

Other languages

German (de)

English (en)

Other versions

EP3500261A1 (fr

Inventor

Kiran AMANCHA

Shivani CHILAMPALLI

Thrimoorthy Potta

Ningxin YAN

Venkat R. Goskonda

Eshwaran Narayanan

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Hikma Pharmaceuticals USA Inc

Original Assignee

Hikma Pharmaceuticals USA Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2016-08-17

Filing date

2017-08-10

Publication date

2020-05-06

2016-08-17 Priority claimed from US15/238,909 external-priority patent/US10722510B2/en

2017-05-22 Priority claimed from US15/601,331 external-priority patent/US10617686B2/en

2017-08-10 Application filed by Hikma Pharmaceuticals USA Inc filed Critical Hikma Pharmaceuticals USA Inc

2019-06-26 Publication of EP3500261A1 publication Critical patent/EP3500261A1/fr

2020-05-06 Publication of EP3500261A4 publication Critical patent/EP3500261A4/fr

Status Pending legal-status Critical Current

Links

239000007788 liquid Substances 0.000 title 1
UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 title 1
229960004127 naloxone Drugs 0.000 title 1
239000007921 spray Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Otolaryngology (AREA)
Emergency Medicine (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EP17841883.6A 2016-08-17 2017-08-10 Pulvérisation de naloxone liquide Pending EP3500261A4 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US15/238,909 US10722510B2 (en)	2014-07-08	2016-08-17	Liquid naloxone spray
US15/601,331 US10617686B2 (en)	2014-07-08	2017-05-22	Liquid naloxone spray
PCT/US2017/046198 WO2018034920A1 (fr)	2016-08-17	2017-08-10	Pulvérisation de naloxone liquide

Publications (2)

Publication Number	Publication Date
EP3500261A1 EP3500261A1 (fr)	2019-06-26
EP3500261A4 true EP3500261A4 (fr)	2020-05-06

Family

ID=61197156

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP17841883.6A Pending EP3500261A4 (fr)	2016-08-17	2017-08-10	Pulvérisation de naloxone liquide

Country Status (7)

Country	Link
EP (1)	EP3500261A4 (fr)
JP (2)	JP7114570B2 (fr)
CN (1)	CN109922805A (fr)
AU (1)	AU2017312811B2 (fr)
CA (1)	CA3033897C (fr)
MA (1)	MA45995A (fr)
WO (1)	WO2018034920A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8580801B2 (en)	2008-07-23	2013-11-12	Robert I. Henkin	Phosphodiesterase inhibitor treatment
WO2015126944A1 (fr)	2014-02-18	2015-08-27	Henkin Robert I	Procédés et compositions permettant de diagnostiquer et de traiter une perte et/ou une distorsion du goût ou de l'odorat
WO2018034920A1 (fr) *	2016-08-17	2018-02-22	Insys Development Company, Inc.	Pulvérisation de naloxone liquide
US20180193332A1 (en) *	2017-10-09	2018-07-12	Adapt Pharma Operations Limited	Low-temperature stable opioid antagonist solutions
AU2019403903A1 (en) *	2018-12-19	2021-06-24	Acasti Pharma U.S., Inc.	Therapeutic composition of intranasal lidocaine
CA3130619C (fr)	2019-02-21	2022-08-23	Pharmaceutical Productions, Inc.	Preparations de naloxone a administrer par voie sublinguale et/ou buccale
CN116474218A (zh) *	2019-06-28	2023-07-25	四川普锐特药业有限公司	保持给药均一度的药物流体分配器及右美托咪定鼻喷器
CA3166250A1 (fr)	2020-02-05	2021-08-12	Gregory G. Plucinski	Produits medicamenteux destines a etre administres par voie intranasale et utilisations associees
CN115485027A (zh)	2020-03-24	2022-12-16	思瑞诺医疗有限公司	冠状病毒感染引起的化学感觉功能障碍的治疗
EP4460291A1 (fr) *	2022-01-06	2024-11-13	Cyrano Therapeutics, Inc.	Administration nasale améliorée d'agents thérapeutiques contre parkinson

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1575795A (zh) *	2003-06-25	2005-02-09	中国人民解放军军事医学科学院毒物药物研究所	盐酸纳洛酮鼻腔喷雾剂
US20160199294A1 (en) *	2014-07-08	2016-07-14	Insys Development Company, Inc.	Sublingual naloxone spray

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US585A (en)		1838-01-27		Apparatus for extinguishing sparks in the chimneys oe steam-boilers
US14730A (en)		1856-04-22		Improvement in corn-harvesters
US8627816B2 (en) *	2011-02-28	2014-01-14	Intelliject, Inc.	Medicament delivery device for administration of opioid antagonists including formulations for naloxone
HRP20180233T1 (hr)	2011-05-13	2018-06-01	Euro-Celtique S.A.	Intranazalni farmaceutski oblici doziranja koji sadrže nalokson
ME02153B (me) *	2011-09-19	2015-10-20	Orexo Ab	Nove farmaceutske kompozicije, otporne na zloupotrebu, za tretman zavisnosti od opioida
US8940052B2 (en)	2012-07-26	2015-01-27	DePuy Synthes Products, LLC	Expandable implant
CA2881144A1 (fr) *	2012-11-09	2014-05-09	Purdue Pharma	Compositions pharmaceutiques comprenant de l'hydromorphone et de la naloxone
DK3043777T3 (da)	2013-09-10	2020-07-20	Fresh Cut Dev Llc	Sublingual buprenorphinspray
CN103637987B (zh)	2013-12-09	2015-12-02	韩彬	羟考酮的液体药物组合物
US9192570B2 (en)	2013-12-20	2015-11-24	AntiOP, Inc.	Intranasal naloxone compositions and methods of making and using same
AU2015228541B2 (en) *	2014-03-14	2020-09-03	Opiant Pharmaceuticals, Inc.	Nasal drug products and methods of their use
US9480644B2 (en)	2014-03-14	2016-11-01	Opiant Pharmaceuticals, Inc.	Nasal drug products and methods of their use
EP3177146A4 (fr) *	2014-07-08	2018-01-03	Insys Pharma, Inc.	Aerosol sublingual de naloxone
WO2018034920A1 (fr)	2016-08-17	2018-02-22	Insys Development Company, Inc.	Pulvérisation de naloxone liquide

2017
- 2017-08-10 WO PCT/US2017/046198 patent/WO2018034920A1/fr not_active Ceased
- 2017-08-10 MA MA045995A patent/MA45995A/fr unknown
- 2017-08-10 AU AU2017312811A patent/AU2017312811B2/en active Active
- 2017-08-10 EP EP17841883.6A patent/EP3500261A4/fr active Pending
- 2017-08-10 JP JP2019508941A patent/JP7114570B2/ja active Active
- 2017-08-10 CA CA3033897A patent/CA3033897C/fr active Active
- 2017-08-10 CN CN201780063967.6A patent/CN109922805A/zh active Pending
2022
- 2022-05-18 JP JP2022081328A patent/JP7455157B2/ja active Active

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1575795A (zh) *	2003-06-25	2005-02-09	中国人民解放军军事医学科学院毒物药物研究所	盐酸纳洛酮鼻腔喷雾剂
US20160199294A1 (en) *	2014-07-08	2016-07-14	Insys Development Company, Inc.	Sublingual naloxone spray

Also Published As

Publication number	Publication date
JP7114570B2 (ja)	2022-08-08
JP2022119843A (ja)	2022-08-17
JP2019528278A (ja)	2019-10-10
CA3033897C (fr)	2024-03-26
JP7455157B2 (ja)	2024-03-25
AU2017312811A8 (en)	2019-03-14
MA45995A (fr)	2019-06-26
AU2017312811A1 (en)	2019-03-07
AU2017312811B2 (en)	2023-03-16
CN109922805A (zh)	2019-06-21
CA3033897A1 (fr)	2018-02-22
EP3500261A1 (fr)	2019-06-26
WO2018034920A1 (fr)	2018-02-22

Legal Events

Date	Code	Title	Description
2018-02-24	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2019-05-27	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2019-05-27	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2019-06-26	17P	Request for examination filed	Effective date: 20190315
2019-06-26	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2019-06-26	AX	Request for extension of the european patent	Extension state: BA ME
2020-03-04	RAP1	Party data changed (applicant data changed or rights of an application transferred)	Owner name: HIKMA PHARMACEUTICALS USA INC.
2020-05-06	A4	Supplementary search report drawn up and despatched	Effective date: 20200402
2020-05-06	RIC1	Information provided on ipc code assigned before grant	Ipc: A61K 9/00 20060101ALI20200328BHEP Ipc: A61K 47/18 20170101ALI20200328BHEP Ipc: A61K 31/485 20060101AFI20200328BHEP
2020-07-10	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 40011159 Country of ref document: HK
2023-06-21	P01	Opt-out of the competence of the unified patent court (upc) registered	Effective date: 20230513
2024-03-20	RAP3	Party data changed (applicant data changed or rights of an application transferred)	Owner name: HIKMA PHARMACEUTICALS USA INC.

Publication	Publication Date	Title
EP3164221B8 (fr)	2019-12-18	Systèmes de nébulisation de liquide
AU2015242948A1 (en)	2016-05-12	Spray nozzle
GB201419803D0 (en)	2014-12-24	Spray booths
EP3239005A4 (fr)	2018-08-22	Gicleur de lave-glace
EP3105146A4 (fr)	2017-12-06	Dispositif de distribution par pulvérisation
EP3253684A4 (fr)	2018-09-26	Système de capuchon d'atomisation
EP3199189A4 (fr)	2018-07-11	Capuchon de buse
EP3213822A4 (fr)	2018-06-13	Pulvérisateur de liquide de type à gâchette
EP3150287A4 (fr)	2018-01-10	Pulvérisateur de liquide du type à gâchette
EP3177146A4 (fr)	2018-01-03	Aerosol sublingual de naloxone
EP3162451A4 (fr)	2018-02-28	Pulvérisateur de liquide de à gâchette
EP3225314A4 (fr)	2018-06-27	Pulvérisateur de liquide de type à gâchette
EP3476765A4 (fr)	2020-03-11	Pulvérisateur sous pression
ZA201805751B (en)	2019-11-27	Spray device
EP3157684A4 (fr)	2017-10-18	Pulvérisateur d'eau éclairé
MA45995A (fr)	2019-06-26	Pulvérisation de naloxone liquide
EP3266725A4 (fr)	2018-12-05	Buse
EP3162461A4 (fr)	2018-04-25	Buse de pulvérisation
EP3210671A4 (fr)	2018-05-30	Structure d'orifice de pulvérisation
EP3375529B8 (fr)	2020-12-16	Dispositif de pulvérisation électrostatique
EP3315036A4 (fr)	2019-01-23	Unité d'atomisation
EP3272702A4 (fr)	2018-11-14	Distributeur de liquide
EP3097983A4 (fr)	2018-01-17	Pulvérisateur de type à gâchette
EP3099428A4 (fr)	2017-10-18	Dispositif de nettoyage par pulvérisation d'un récipient
EP3384767A4 (fr)	2019-06-19	Pulvérisateur perfectionné