EP3548135A4 - Dispositifs à micro-aiguilles coeur-enveloppe et leurs utilisations - Google Patents

Dispositifs à micro-aiguilles coeur-enveloppe et leurs utilisations Download PDF

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Publication number
EP3548135A4
EP3548135A4 EP17879565.4A EP17879565A EP3548135A4 EP 3548135 A4 EP3548135 A4 EP 3548135A4 EP 17879565 A EP17879565 A EP 17879565A EP 3548135 A4 EP3548135 A4 EP 3548135A4
Authority
EP
European Patent Office
Prior art keywords
core
micro needle
needle devices
shell micro
shell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP17879565.4A
Other languages
German (de)
English (en)
Other versions
EP3548135A1 (fr
EP3548135B1 (fr
Inventor
Zhen GU
Jinqiang Wang
Yanqi YE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
North Carolina State University
Original Assignee
North Carolina State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by North Carolina State University filed Critical North Carolina State University
Priority to EP20205415.1A priority Critical patent/EP3799865B1/fr
Publication of EP3548135A1 publication Critical patent/EP3548135A1/fr
Publication of EP3548135A4 publication Critical patent/EP3548135A4/fr
Application granted granted Critical
Publication of EP3548135B1 publication Critical patent/EP3548135B1/fr
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6955—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a plaster, a bandage, a dressing or a patch
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays or needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
    • C12Y101/03004—Glucose oxidase (1.1.3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y111/00—Oxidoreductases acting on a peroxide as acceptor (1.11)
    • C12Y111/01—Peroxidases (1.11.1)
    • C12Y111/01006—Catalase (1.11.1.6)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
EP17879565.4A 2016-12-05 2017-12-05 Dispositifs à micro-aiguilles coeur-enveloppe et leurs utilisations Not-in-force EP3548135B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20205415.1A EP3799865B1 (fr) 2016-12-05 2017-12-05 Dispositifs à micro-aiguilles coeur-enveloppe et leurs utilisations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662430260P 2016-12-05 2016-12-05
PCT/US2017/064723 WO2018106696A1 (fr) 2016-12-05 2017-12-05 Dispositifs à micro-aiguilles coeur-enveloppe et leurs utilisations

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP20205415.1A Division EP3799865B1 (fr) 2016-12-05 2017-12-05 Dispositifs à micro-aiguilles coeur-enveloppe et leurs utilisations
EP20205415.1A Division-Into EP3799865B1 (fr) 2016-12-05 2017-12-05 Dispositifs à micro-aiguilles coeur-enveloppe et leurs utilisations

Publications (3)

Publication Number Publication Date
EP3548135A1 EP3548135A1 (fr) 2019-10-09
EP3548135A4 true EP3548135A4 (fr) 2020-07-29
EP3548135B1 EP3548135B1 (fr) 2021-10-13

Family

ID=62491316

Family Applications (2)

Application Number Title Priority Date Filing Date
EP17879565.4A Not-in-force EP3548135B1 (fr) 2016-12-05 2017-12-05 Dispositifs à micro-aiguilles coeur-enveloppe et leurs utilisations
EP20205415.1A Not-in-force EP3799865B1 (fr) 2016-12-05 2017-12-05 Dispositifs à micro-aiguilles coeur-enveloppe et leurs utilisations

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP20205415.1A Not-in-force EP3799865B1 (fr) 2016-12-05 2017-12-05 Dispositifs à micro-aiguilles coeur-enveloppe et leurs utilisations

Country Status (7)

Country Link
US (2) US11697007B2 (fr)
EP (2) EP3548135B1 (fr)
JP (1) JP7232526B2 (fr)
CN (1) CN110167624B (fr)
CA (1) CA3045882A1 (fr)
DK (1) DK3548135T3 (fr)
WO (1) WO2018106696A1 (fr)

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* Cited by examiner, † Cited by third party
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DK3548135T3 (da) * 2016-12-05 2021-11-22 Univ North Carolina State Kerne-skal-mikronålsindretninger og anvendelser deraf
US12109032B1 (en) 2017-03-11 2024-10-08 Biolinq Incorporated Methods for achieving an isolated electrical interface between an anterior surface of a microneedle structure and a posterior surface of a support structure
US12599337B1 (en) 2017-08-08 2026-04-14 Biolinq Incorporated Method and system for confirmation of microneedle-based analyte-selective sensor insertion into viable tissue via electrical interrogation
WO2019143293A1 (fr) * 2018-01-16 2019-07-25 Nanyang Technological University Micro-réservoirs de médicament auto-implantables pour une administration de médicament oculaire localisée et contrôlée
US11724941B2 (en) 2018-02-15 2023-08-15 North Carolina State University Synthesis of micron and nanoscale carbon spheres and structures using hydrothemal carbonization
US20210145984A1 (en) * 2018-04-13 2021-05-20 North Carolina State University Ros-responsive microneedle patch for acne vulgaris treatment
JP2021533934A (ja) 2018-08-24 2021-12-09 ノース カロライナ ステート ユニバーシティNorth Carolina State University 閉ループインスリン送達用のグルコース応答性マトリックスを備えたマイクロニードルアレイパッチ
WO2020041694A1 (fr) * 2018-08-24 2020-02-27 North Carolina State University Timbre à micro-aiguilles de cellules souches pour le traitement de maladies cardiaques
EP3852721A4 (fr) * 2018-09-20 2022-06-29 Singapore Health Services Pte Ltd Timbre à micro-aiguilles conductrices pour l'administration d'un agent actif
CN109675185A (zh) * 2019-01-02 2019-04-26 浙江大学 一种苯硼酸水凝胶基糖敏微针贴及其制备方法
JP2021153914A (ja) * 2020-03-27 2021-10-07 国立大学法人 東京医科歯科大学 薬剤送達デバイスおよびその製造方法
JP2023523952A (ja) 2020-04-28 2023-06-08 ティコナ・エルエルシー マイクロニードルアセンブリ
KR102740788B1 (ko) * 2020-07-02 2024-12-09 연세대학교 산학협력단 멀티 레이어 마이크로니들 구조체 및 이의 제조 방법
GB2631618B (en) 2020-07-29 2025-05-14 Biolinq Incorporated Continuous analyte monitoring system with microneedle array
CN118001218B (zh) * 2022-11-08 2026-03-06 沈阳药科大学 一种血糖响应型释药可视化长效微针及其制备方法
CN115998850A (zh) * 2022-12-26 2023-04-25 中山大学 一种尿酸响应性水凝胶微针及其制备方法
CN120857905A (zh) 2023-02-02 2025-10-28 比奥林公司 用于改善基于微针的连续分析物监测系统的传感器灵敏度的方法
WO2024167986A2 (fr) * 2023-02-10 2024-08-15 Alj Creative Works, Llc Système de micro-aiguille de dispositif médicamenteux programmable pour le traitement du diabète, de l'obésité et d'affections associées
CN117088903B (zh) * 2023-08-15 2026-03-17 河南师范大学 苯硼酸基两性离子表面活性剂的制备方法及其合成pH响应二聚体分子的应用
CN117159443B (zh) * 2023-10-19 2024-04-19 暨南大学 原位超分子凝胶微针贴片及其制备方法和应用

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EP1453860A2 (fr) 2001-12-02 2004-09-08 Novo Nordisk A/S Nouvelles insulines gluco-dependantes
US9549746B2 (en) 2007-09-28 2017-01-24 The Queen's University Of Belfast Delivery device and method
EP2234644B1 (fr) 2008-01-04 2013-07-31 Biodel, Inc. Préparations d'insuline pour libération d'insuline en fonction de niveaux de glucose dans les tissus
WO2010050913A1 (fr) 2008-10-31 2010-05-06 The Brigham And Women's Hospital, Inc. Vaccination avec des vecteurs poxviraux via rupture épidermique mécanique
WO2013123492A2 (fr) 2012-02-17 2013-08-22 Massachusetts Institute Of Technology Microgels répondant au glucose pour administration d'insuline en boucle fermée
US20150352777A1 (en) * 2013-01-18 2015-12-10 The University Of North Carolina At Chapel Hill High-throughput manufacturing of microneedles
US20160067190A1 (en) 2013-04-30 2016-03-10 The Children's Medical Center Corporation Injectable nano-network gels for diabetes treatment
US10987039B2 (en) 2014-12-03 2021-04-27 Stmicroelectronics S.R.L. Microneedle array device and method of making
TN2017000439A1 (en) 2015-04-21 2019-04-12 Univ North Carolina State Glucose-responsive insulin delivery system using hyoxia-sensitive nanocomposites
WO2016172554A1 (fr) 2015-04-23 2016-10-27 Carnegie Mellon University Tatouages de biocapteur et leurs utilisations pour la surveillance de biomarqueurs
CN110167537A (zh) 2016-11-07 2019-08-23 北卡罗来纳州立大学 用于增强葡萄糖反应性胰岛素的递送的装有双敏感囊泡的贴剂
CN110198730B (zh) 2016-12-05 2023-10-03 北卡罗莱纳州立大学 H2o2响应性纳米粒子及其用途
DK3548135T3 (da) * 2016-12-05 2021-11-22 Univ North Carolina State Kerne-skal-mikronålsindretninger og anvendelser deraf

Non-Patent Citations (1)

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Also Published As

Publication number Publication date
EP3548135A1 (fr) 2019-10-09
DK3548135T3 (da) 2021-11-22
EP3799865A1 (fr) 2021-04-07
CN110167624B (zh) 2021-11-19
WO2018106696A1 (fr) 2018-06-14
EP3548135B1 (fr) 2021-10-13
CA3045882A1 (fr) 2018-06-14
US11697007B2 (en) 2023-07-11
JP2020512283A (ja) 2020-04-23
JP7232526B2 (ja) 2023-03-03
US20230364402A1 (en) 2023-11-16
EP3799865B1 (fr) 2022-06-15
US20190351206A1 (en) 2019-11-21
CN110167624A (zh) 2019-08-23

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