EP3624839A4 - Schémas posologiques d'immunoconjugués anti-cd33 - Google Patents
Schémas posologiques d'immunoconjugués anti-cd33 Download PDFInfo
- Publication number
- EP3624839A4 EP3624839A4 EP18802489.7A EP18802489A EP3624839A4 EP 3624839 A4 EP3624839 A4 EP 3624839A4 EP 18802489 A EP18802489 A EP 18802489A EP 3624839 A4 EP3624839 A4 EP 3624839A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- dosage schedules
- immunoconjugate
- immunoconjugate dosage
- schedules
- dosage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762507636P | 2017-05-17 | 2017-05-17 | |
| US201762523112P | 2017-06-21 | 2017-06-21 | |
| US201762579779P | 2017-10-31 | 2017-10-31 | |
| US201762596377P | 2017-12-08 | 2017-12-08 | |
| US201862660096P | 2018-04-19 | 2018-04-19 | |
| PCT/US2018/032945 WO2018213430A1 (fr) | 2017-05-17 | 2018-05-16 | Schémas posologiques d'immunoconjugués anti-cd33 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP3624839A1 EP3624839A1 (fr) | 2020-03-25 |
| EP3624839A4 true EP3624839A4 (fr) | 2021-06-16 |
Family
ID=64274787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP18802489.7A Withdrawn EP3624839A4 (fr) | 2017-05-17 | 2018-05-16 | Schémas posologiques d'immunoconjugués anti-cd33 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP3624839A4 (fr) |
| JP (1) | JP2020519640A (fr) |
| MA (1) | MA49152A (fr) |
| WO (1) | WO2018213430A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12083192B2 (en) * | 2017-12-04 | 2024-09-10 | Actinium Pharmaceuticals, Inc. | Methods for treatment of patients with myelodysplastic syndromes |
| MA51629A (fr) | 2018-01-12 | 2020-11-18 | Immunogen Inc | Procédés de production, purification et formulation de conjugués anticorps-médicaments |
| TW202003048A (zh) | 2018-05-15 | 2020-01-16 | 美商伊繆諾金公司 | 用抗體-藥物偶聯物及flt3抑制劑之組合治療 |
| WO2019234694A2 (fr) * | 2018-06-07 | 2019-12-12 | Magenta Therapeutics, Inc. | Procédés thérapeutiques utilisant des conjugués anticorps-médicament (adc) |
| CN114401744B (zh) * | 2019-06-26 | 2024-11-05 | 纪念斯隆凯特琳癌症中心 | 用于治疗癌症的抗cd33抗体 |
| CN120843683A (zh) * | 2025-09-25 | 2025-10-28 | 细胞生态海河实验室 | 用于aml预后分型的生物标志物及其应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004043344A2 (fr) * | 2002-11-07 | 2004-05-27 | Immunogen, Inc. | Anticorps anti-cd33 et methode de traitement de la leucemie myeloide aigue a l'aide dudit anticorps |
| WO2015179400A2 (fr) * | 2014-05-20 | 2015-11-26 | Immunogen,Inc. | Procédés de caractérisation et de traitement de la leucémie myéloïde aiguë |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130309223A1 (en) * | 2012-05-18 | 2013-11-21 | Seattle Genetics, Inc. | CD33 Antibodies And Use Of Same To Treat Cancer |
-
2018
- 2018-05-16 JP JP2019562396A patent/JP2020519640A/ja active Pending
- 2018-05-16 MA MA049152A patent/MA49152A/fr unknown
- 2018-05-16 WO PCT/US2018/032945 patent/WO2018213430A1/fr not_active Ceased
- 2018-05-16 EP EP18802489.7A patent/EP3624839A4/fr not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004043344A2 (fr) * | 2002-11-07 | 2004-05-27 | Immunogen, Inc. | Anticorps anti-cd33 et methode de traitement de la leucemie myeloide aigue a l'aide dudit anticorps |
| WO2015179400A2 (fr) * | 2014-05-20 | 2015-11-26 | Immunogen,Inc. | Procédés de caractérisation et de traitement de la leucémie myéloïde aiguë |
Non-Patent Citations (1)
| Title |
|---|
| See also references of WO2018213430A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MA49152A (fr) | 2020-03-25 |
| EP3624839A1 (fr) | 2020-03-25 |
| JP2020519640A (ja) | 2020-07-02 |
| WO2018213430A1 (fr) | 2018-11-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3793613C0 (fr) | Immunoconjugués | |
| EP3607587A4 (fr) | Panneau d'affichage | |
| EP3430731A4 (fr) | Architecture d'iugw | |
| EP3426305A4 (fr) | Compositions d'immunoglobulines anti-cd45 radio-marquées stabilisées | |
| EP3624839A4 (fr) | Schémas posologiques d'immunoconjugués anti-cd33 | |
| EP3426242A4 (fr) | Icaritine et dérivés d'icaritine | |
| MA49006A (fr) | Inhibiteurs d'ip6k | |
| PL3672948T3 (pl) | Związki pirydynoamino-pirydonu i pirymidynoamino-pirydonu | |
| EP3506863A4 (fr) | Applicateurs d'implant | |
| EP3463259A4 (fr) | Compositions d'écran solaire | |
| EP3431808A4 (fr) | Butée d'arrêt | |
| MA43764A (fr) | Inhibiteur monovalent de l'interaction hutnfr1 | |
| EP3819231A4 (fr) | Récipient d'application | |
| EP3718414A4 (fr) | Composition d'émulsion | |
| MA50156A (fr) | Variants d'anticorps | |
| EP3616531A4 (fr) | Composition d'émulsion | |
| EP3458432A4 (fr) | Composition d'engrais | |
| EP3416672A4 (fr) | Formulations d'oritavancine | |
| EP3651199A4 (fr) | Panneau d'affichage | |
| IT201700035964A1 (it) | “divisorio per boiserie” | |
| IT201700090331A1 (it) | "lopemide" | |
| IT201700071679A1 (it) | Remembebe' | |
| EP3730143A4 (fr) | Association de l'omidénépag | |
| UA37095S (uk) | Перев'язувальна пов'язка-бандаж | |
| UA38250S (uk) | Ювелірна прикраса «сережки-вішалочки» |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
| 17P | Request for examination filed |
Effective date: 20191217 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
| AX | Request for extension of the european patent |
Extension state: BA ME |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20210519 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 39/00 20060101AFI20210512BHEP Ipc: C12Q 1/68 20180101ALI20210512BHEP Ipc: A61K 31/5517 20060101ALI20210512BHEP Ipc: G01N 33/574 20060101ALI20210512BHEP Ipc: A61P 35/00 20060101ALI20210512BHEP Ipc: A61P 35/02 20060101ALI20210512BHEP Ipc: C07K 16/28 20060101ALI20210512BHEP |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20211201 |