EP3631444A4 - Biomarker und patientenauswahlstrategien - Google Patents

Biomarker und patientenauswahlstrategien Download PDF

Info

Publication number
EP3631444A4
EP3631444A4 EP18809063.3A EP18809063A EP3631444A4 EP 3631444 A4 EP3631444 A4 EP 3631444A4 EP 18809063 A EP18809063 A EP 18809063A EP 3631444 A4 EP3631444 A4 EP 3631444A4
Authority
EP
European Patent Office
Prior art keywords
biomarkers
patient selection
selection strategies
strategies
patient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP18809063.3A
Other languages
English (en)
French (fr)
Other versions
EP3631444A1 (de
Inventor
Christian Andrew HASSIG
Bryan William STROUSE
Ryan James HANSEN
Angie J. You
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sierra Oncology Inc
Original Assignee
Sierra Oncology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sierra Oncology Inc filed Critical Sierra Oncology Inc
Publication of EP3631444A1 publication Critical patent/EP3631444A1/de
Publication of EP3631444A4 publication Critical patent/EP3631444A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6872—Methods for sequencing involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2545/00—Reactions characterised by their quantitative nature
    • C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/01—DNA viruses
    • G01N2333/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP18809063.3A 2017-06-01 2018-06-01 Biomarker und patientenauswahlstrategien Withdrawn EP3631444A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762513954P 2017-06-01 2017-06-01
US201762597759P 2017-12-12 2017-12-12
US201862628900P 2018-02-09 2018-02-09
US201862650199P 2018-03-29 2018-03-29
PCT/US2018/035566 WO2018222970A1 (en) 2017-06-01 2018-06-01 Biomarkers and patient selection strategies

Publications (2)

Publication Number Publication Date
EP3631444A1 EP3631444A1 (de) 2020-04-08
EP3631444A4 true EP3631444A4 (de) 2021-06-09

Family

ID=64455400

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18809063.3A Withdrawn EP3631444A4 (de) 2017-06-01 2018-06-01 Biomarker und patientenauswahlstrategien

Country Status (5)

Country Link
US (1) US20200157638A1 (de)
EP (1) EP3631444A4 (de)
AU (1) AU2018278336A1 (de)
CA (1) CA3065803A1 (de)
WO (1) WO2018222970A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2019012176A (es) 2017-04-10 2020-02-19 Sierra Oncology Inc Metodos de combinacion de chk1(sra737)/parpi para inhibir el crecimiento tumoral.
US20200397796A1 (en) * 2018-02-26 2020-12-24 Sierra Oncology, Inc. Methods of treatment of cancer comprising chk1 inhibitors
JP2022532597A (ja) * 2019-05-14 2022-07-15 シエラ オンコロジー， インコーポレイテッド Ｃｈｋ１阻害剤を使用してがんを治療する方法
EP4196614A4 (de) 2020-08-12 2024-12-18 Boundless Bio, Inc. Zusammensetzungen aus replikationsstress-signalwegen und verfahren zur behandlung von krebs
WO2022155202A1 (en) 2021-01-13 2022-07-21 Schrödinger, Inc. Fused heterocycles and uses of same
KR20250060189A (ko) 2022-07-13 2025-05-07 아크리본 테라퓨틱스 인코포레이티드 Atr/chk1 신호전달 경로 저해제를 사용하여 질환을 치료하는 방법 및 시스템

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013096687A1 (en) * 2011-12-22 2013-06-27 Threshold Pharmaceuticals, Inc. Administration of hypoxia activated prodrugs in combination with chk1 inhibitors for treating cancer
WO2013103836A2 (en) * 2012-01-05 2013-07-11 Dana-Farber Cancer Institute, Inc. Methods of treating cancer
WO2013171470A1 (en) * 2012-05-15 2013-11-21 Cancer Research Technology Limited 5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile and therapeutic uses thereof
WO2018191299A1 (en) * 2017-04-10 2018-10-18 Sierra Oncology, Inc. Chk1(sra737)wee1 inhibitor combination methods of inhibiting tumor growth
WO2018191277A1 (en) * 2017-04-10 2018-10-18 Sierra Oncology, Inc. Chk1 (sra737)/parpi combination methods of inhibiting tumor growth

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9000027B2 (en) * 2008-02-04 2015-04-07 Dana-Farber Cancer Institute, Inc. Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, bcl-2 and caspase-3
US10676746B2 (en) * 2013-11-22 2020-06-09 Fred Hutchinson Cancer Research Center Methods for identifying therapeutic targets and treating monitoring cancers

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013096687A1 (en) * 2011-12-22 2013-06-27 Threshold Pharmaceuticals, Inc. Administration of hypoxia activated prodrugs in combination with chk1 inhibitors for treating cancer
WO2013103836A2 (en) * 2012-01-05 2013-07-11 Dana-Farber Cancer Institute, Inc. Methods of treating cancer
WO2013171470A1 (en) * 2012-05-15 2013-11-21 Cancer Research Technology Limited 5-[[4-[[morpholin-2-yl]methylamino]-5-(trifluoromethyl)-2-pyridyl]amino]pyrazine-2-carbonitrile and therapeutic uses thereof
WO2018191299A1 (en) * 2017-04-10 2018-10-18 Sierra Oncology, Inc. Chk1(sra737)wee1 inhibitor combination methods of inhibiting tumor growth
WO2018191277A1 (en) * 2017-04-10 2018-10-18 Sierra Oncology, Inc. Chk1 (sra737)/parpi combination methods of inhibiting tumor growth

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CHRISTOPHER BRYANT ET AL: "Inhibition of the checkpoint kinase Chk1 induces DNA damage and cell death in human Leukemia and Lymphoma cells", MOLECULAR CANCER, BIOMED CENTRAL, LONDON, GB, vol. 13, no. 1, 10 June 2014 (2014-06-10), pages 147, XP021190663, ISSN: 1476-4598, DOI: 10.1186/1476-4598-13-147 *
HANSEN R J ET AL: "The Chk1 inhibitor, SRA737, demonstrates chemical synthetic lethality with replication stress-inducing agents, including low-dose gemcitabine, in preclinical models of cancer", MOLECULAR CANCER THERAPEUTICS 20180101 AMERICAN ASSOCIATION FOR CANCER RESEARCH INC. NLD, vol. 17, no. 1, Supplement 1, 1 January 2018 (2018-01-01), XP009525194, ISSN: 1538-8514 *
INGER BRANDSMA ET AL: "Directing the use of DDR kinase inhibitors in cancer treatment", EXPERT OPINION ON INVESTIGATIONAL DRUGS, vol. 26, no. 12, 14 October 2017 (2017-10-14), UK, pages 1341 - 1355, XP055769191, ISSN: 1354-3784, DOI: 10.1080/13543784.2017.1389895 *
K BROOKS ET AL: "A potent Chk1 inhibitor is selectively cytotoxic in melanomas with high levels of replicative stress", ONCOGENE, vol. 32, no. 6, 5 March 2012 (2012-03-05), London, pages 788 - 796, XP055769157, ISSN: 0950-9232, DOI: 10.1038/onc.2012.72 *
MIKE I WALTON: "The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and E -MYC driven B-cell lymphoma", ONCOTARGET, 22 July 2015 (2015-07-22), United States, pages 2329 - 2342, XP055631783, Retrieved from the Internet <URL:https://epo.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Li5xAEG4y5JJLSEhIJg-oQPYQRKJt--jjrEx2IC_YNYc9iXYrkbjOMMsuzL_Jn8gfyC9LlW2rCWweh1xk6G4b9PumrCrLrxh7WZCIXRUrV4rSo9eM2iUZOFdwjf6Ch0FRL7FxnorsJD49oW4NtjHJNPZfkcYxxJq-nP0HtMdNcQB_I-Z4RNTx-Ne4j5876qkkiMq7dEPxvZOmGRdhHMTUzZxaU-yLtj30shrXOLt56zt> [retrieved on 20191014], DOI: 10.18632/oncotarget.4919 *
P T FERRAO ET AL: "Efficacy of CHK inhibitors as single agents in MYC-driven lymphoma cells", ONCOGENE, vol. 31, no. 13, 15 August 2011 (2011-08-15), London, pages 1661 - 1672, XP055768830, ISSN: 0950-9232, DOI: 10.1038/onc.2011.358 *
See also references of WO2018222970A1 *
STUART RUNDLE ET AL: "Targeting the ATR-CHK1 Axis in Cancer Therapy", CANCERS, vol. 9, no. 12, 27 April 2017 (2017-04-27), pages 41, XP055769168, DOI: 10.3390/cancers9050041 *
TRIPARNA SEN ET AL: "CHK1 Inhibition in Small-Cell Lung Cancer Produces Single-Agent Activity in Biomarker-Defined Disease Subsets and Combination Activity with Cisplatin or Olaparib", CANCER RESEARCH, vol. 77, no. 14, 10 May 2017 (2017-05-10), US, pages 3870 - 3884, XP055610613, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-16-3409 *

Also Published As

Publication number Publication date
WO2018222970A1 (en) 2018-12-06
US20200157638A1 (en) 2020-05-21
EP3631444A1 (de) 2020-04-08
CA3065803A1 (en) 2018-12-06
AU2018278336A1 (en) 2020-01-16

Similar Documents

Publication Publication Date Title
EP3866896A4 (de) Patientenschnittstelle
EP3773843A4 (de) Patientenschnittstelle
KR102199943B9 (ko) 의료용 자극 장치
EP3600509A4 (de) Patientenschnittstelle
EP3641644A4 (de) Medizinisches diagnosesystem und -verfahren
EP3840809A4 (de) Patientenschnittstelle
JP1662410S (ja) 患者インターフェース
EP3703551A4 (de) Sehschärfeuntersuchung
EP3631444A4 (de) Biomarker und patientenauswahlstrategien
PL3678714T3 (pl) Wyrób medyczny inżynierii tkankowej
EP4003475C0 (de) Patientenschnittstelle
EP3999156A4 (de) Patientenschnittstelle
EP4035608C0 (de) Medizinisches instrument
EP3834750C0 (de) Medizinisches instrument
EP3445431A4 (de) Patientenschnittstelle und aspekte davon
EP3603687A4 (de) Medizinisches gerät
EP3946535A4 (de) Patientenschnittstelle
EP3590482A4 (de) Pflegebett
EP3773844A4 (de) Patientenschnittstelle
EP3669791A4 (de) Medizinische zange
DK3728640T3 (da) Præoperativ risikostratificering baseret på pde4d7-ekspression og præoperative kliniske variabler
EP3747479A4 (de) Medizinisches instrument
EP3762079A4 (de) Patientenschnittstelle
EP4028096A4 (de) Patientenschnittstelle
EP4026572A4 (de) Medizinisches instrument

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20191217

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40027135

Country of ref document: HK

RIC1 Information provided on ipc code assigned before grant

Ipc: C12Q 1/37 20060101AFI20210201BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20210510

RIC1 Information provided on ipc code assigned before grant

Ipc: C12Q 1/37 20060101AFI20210503BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20211208