EP3634450A4 - Verfahren und zusammensetzungen zur modifizierung der assembly-activating-protein (app)-abhängigkeit von viren - Google Patents

Verfahren und zusammensetzungen zur modifizierung der assembly-activating-protein (app)-abhängigkeit von viren Download PDF

Info

Publication number
EP3634450A4
EP3634450A4 EP18799088.2A EP18799088A EP3634450A4 EP 3634450 A4 EP3634450 A4 EP 3634450A4 EP 18799088 A EP18799088 A EP 18799088A EP 3634450 A4 EP3634450 A4 EP 3634450A4
Authority
EP
European Patent Office
Prior art keywords
app
dependence
modifying
compositions
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18799088.2A
Other languages
English (en)
French (fr)
Other versions
EP3634450A1 (de
Inventor
Luk H. VANDENBERGHE
Anna Claire MAURER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Schepens Eye Research Institute Inc
Massachusetts Eye and Ear
Original Assignee
Massachusetts Eye and Ear Infirmary
Schepens Eye Research Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Eye and Ear Infirmary, Schepens Eye Research Institute Inc filed Critical Massachusetts Eye and Ear Infirmary
Priority claimed from PCT/US2018/032166 external-priority patent/WO2018209154A1/en
Publication of EP3634450A1 publication Critical patent/EP3634450A1/de
Publication of EP3634450A4 publication Critical patent/EP3634450A4/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EP18799088.2A 2017-05-10 2018-05-10 Verfahren und zusammensetzungen zur modifizierung der assembly-activating-protein (app)-abhängigkeit von viren Pending EP3634450A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762504318P 2017-05-10 2017-05-10
PCT/US2018/032166 WO2018209154A1 (en) 2017-05-10 2018-05-10 Methods and compositions for modifying assembly-activating protein (app)-dependence of viruses

Publications (2)

Publication Number Publication Date
EP3634450A1 EP3634450A1 (de) 2020-04-15
EP3634450A4 true EP3634450A4 (de) 2021-03-31

Family

ID=69547516

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18799088.2A Pending EP3634450A4 (de) 2017-05-10 2018-05-10 Verfahren und zusammensetzungen zur modifizierung der assembly-activating-protein (app)-abhängigkeit von viren

Country Status (2)

Country Link
EP (1) EP3634450A4 (de)
CN (1) CN110831611A (de)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3003391B1 (de) * 2013-05-31 2021-09-22 The Regents of The University of California Adenoassoziierte virenvarianten und verfahren zur verwendung davon
ES2714535T3 (es) * 2013-10-11 2019-05-28 Massachusetts Eye & Ear Infirmary Métodos para predecir secuencias de virus ancestrales y usos de los mismos
GB201403684D0 (en) * 2014-03-03 2014-04-16 King S College London Vector
EP3872085B1 (de) 2015-07-30 2023-03-01 Massachusetts Eye & Ear Infirmary Anzestrale aav-sequenzen und verwendungen davon

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 23 June 2016 (2016-06-23), ZINN ERIC: "Adeno-associated virus capsid protein", XP055774598, Database accession no. AKU89600 *
ERIC ZINN ET AL: "In Silico Reconstruction of the Viral Evolutionary Lineage Yields a Potent Gene Therapy Vector", CELL REPORTS, 11 August 2015 (2015-08-11), United States, pages 1056 - 1068, XP055524240, Retrieved from the Internet <URL:https://ars.els-cdn.com/content/image/1-s2.0-S2211124715007597-mmc1.pdf> DOI: 10.1016/j.celrep.2015.07.019 *
ERIC ZINN ET AL: "In Silico Reconstruction of the Viral Evolutionary Lineage Yields a Potent Gene Therapy Vector", CELL REPORTS, vol. 12, no. 6, 1 August 2015 (2015-08-01), US, pages 1056 - 1068, XP055524241, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2015.07.019 *
M. NAUMER ET AL: "Properties of the Adeno-Associated Virus Assembly-Activating Protein", JOURNAL OF VIROLOGY, vol. 86, no. 23, 1 December 2012 (2012-12-01), US, pages 13038 - 13048, XP055372879, ISSN: 0022-538X, DOI: 10.1128/JVI.01675-12 *
MAURER ANNA C. ET AL: "The Assembly-Activating Protein Promotes Stability and Interactions between AAV's Viral Proteins to Nucleate Capsid Assembly", CELL REPORTS, vol. 23, no. 6, 8 May 2018 (2018-05-08), US, pages 1817 - 1830, XP055774488, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.04.026 *
See also references of WO2018209154A1 *

Also Published As

Publication number Publication date
CN110831611A (zh) 2020-02-21
EP3634450A1 (de) 2020-04-15

Similar Documents

Publication Publication Date Title
IL281930A (en) Rna particles comprising polysarcosin
IL282362A (en) Intein proteins and uses thereof
MA52746A (fr) Molécules à utilité pesticide, compositions et procédés associés
EP3468729A4 (de) Systeme und verfahren zur bogen- und -knotenkonstruktion und -herstellung
EP3641762A4 (de) N/o-gebundene degrone und degronimere zum proteinabbau
EP3953478A4 (de) Verfahren und zusammensetzungen zur verbesserung der anordnung von adeno-assoziierten viren (aavs)
IL279355A (en) Anti-steap1 antigen-binding protein
EP3362930A4 (de) Systeme, zusammensetzungen und verfahren zur entdeckung von msi und neoepitopen zur vorhersage der empfindlichkeit gegenüber checkpoint-inhibitoren
MA43019A (fr) Anticorps anti-humain cd19 à affinité élevée
EP3488069A4 (de) Siebanordnung
EP3294335A4 (de) Humanisierte affinitätsgereifte anti-fcrn-antikörper
EP3609568A4 (de) Systems zur eluierung von rubidium
EP3786415C0 (de) Schwellenwertgesteuerte tracer-teilchen
EP3806645A4 (de) Nährstoffzusammensetzung auf der basis von intaktem erbsenprotein
EP3645200A4 (de) Trennsäge
MA50404A (fr) Protéines immunomodulatrices à variants de ligand de icos variant, compositions et méthodes associées
EP3817741A4 (de) Aktivatoren der entfalteten proteinantwort
EP3456522A4 (de) Metall-harz-verbindungsvorrichtung
EP3452504A4 (de) Gegen influenzavirus gerichtete monoklonale dna-antikörper
EP3746926A4 (de) Kontextprofilerstellung für die erkennung von schadprogrammen
EP3858722A4 (de) Sattelfahrzeug
EP3679066A4 (de) Verfahren und zusammensetzungen zur herstellung von tensidprotein d (sp-d)
EP3632784A4 (de) Sattelfahrzeug
EP3867642A4 (de) Verfahren zum screening von ubiquitin-ligase-agonisten
MA48777A (fr) Nouvelles protéines de liaison à un antigène

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20191210

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40024595

Country of ref document: HK

A4 Supplementary search report drawn up and despatched

Effective date: 20210226

RIC1 Information provided on ipc code assigned before grant

Ipc: C07K 14/075 20060101ALI20210222BHEP

Ipc: C12N 15/86 20060101ALI20210222BHEP

Ipc: C07K 14/005 20060101ALI20210222BHEP

Ipc: A61K 35/761 20150101AFI20210222BHEP

Ipc: C12N 15/00 20060101ALI20210222BHEP

Ipc: C12N 15/09 20060101ALI20210222BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20220429