EP3678830A1 - Monolithisches formteil mit mehreren matrizen für die diffusion von wirkstoffen und verfahren zu dessen herstellung - Google Patents

Monolithisches formteil mit mehreren matrizen für die diffusion von wirkstoffen und verfahren zu dessen herstellung

Info

Publication number
EP3678830A1
EP3678830A1 EP18772846.4A EP18772846A EP3678830A1 EP 3678830 A1 EP3678830 A1 EP 3678830A1 EP 18772846 A EP18772846 A EP 18772846A EP 3678830 A1 EP3678830 A1 EP 3678830A1
Authority
EP
European Patent Office
Prior art keywords
matrices
active ingredients
different
solvent
matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18772846.4A
Other languages
English (en)
French (fr)
Inventor
René Chelle
Arnaud Vilbert
Sophie LECLERC
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AB7 Sante SAS
Original Assignee
AB7 Innovation SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AB7 Innovation SAS filed Critical AB7 Innovation SAS
Publication of EP3678830A1 publication Critical patent/EP3678830A1/de
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
    • B29C45/16—Making multilayered or multicoloured articles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/24—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients to enhance the sticking of the active ingredients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/01—Deodorant compositions
    • A61L9/012—Deodorant compositions characterised by being in a special form, e.g. gels, emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/015—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
    • A61L9/04—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating
    • A61L9/042—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating with the help of a macromolecular compound as a carrier or diluent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/015—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
    • A61L9/04—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating
    • A61L9/12—Apparatus, e.g. holders, therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/015—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone
    • A61L9/04—Disinfection, sterilisation or deodorisation of air using gaseous or vaporous substances, e.g. ozone using substances evaporated in the air without heating
    • A61L9/12—Apparatus, e.g. holders, therefor
    • A61L9/125—Apparatus, e.g. holders, therefor emanating multiple odours
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2209/00—Aspects relating to disinfection, sterilisation or deodorisation of air
    • A61L2209/10—Apparatus features
    • A61L2209/13—Dispensing or storing means for active compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
    • B29K2105/0011—Biocides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
    • B29K2105/0029—Perfuming, odour masking or flavouring agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2105/00—Condition, form or state of moulded material or of the material to be shaped
    • B29K2105/0005—Condition, form or state of moulded material or of the material to be shaped containing compounding ingredients
    • B29K2105/0035—Medical or pharmaceutical agents

Definitions

  • the present invention relates to diffusion devices comprising at least two different active ingredients and their method of manufacture.
  • the present invention relates to a monolithic molded part in a polymer matrix comprising at least two different active ingredients, each of which has a specific kinetics of release, and it is desired to control each of the kinetics to obtain a desired effect. to a targeted target.
  • the active ingredients are incorporated in a single support, which can be solid in the form of a polymer matrix (necklaces, bracelets, patches, etc.), semi-solid (gels, creams, etc.) or liquid (spray lotions, etc.).
  • a polymer matrix necklaces, bracelets, patches, etc.
  • semi-solid gels, creams, etc.
  • liquid spray lotions, etc.
  • patent EP0178908 describes an animal pest control collar consisting of a first matrix comprising at least one insecticide capable of irritating the skin, said first matrix being co-extruded with a second plastic matrix also containing an insecticide and at least a portion of the second matrix is between the skin of the animal and the first matrix. It is sought in this patent the provision of a pest control collar, non-irritating to the skin of animals.
  • Plastic includes polyvinyl chloride (PVC), copolymers of ethylene and vinyl acetate (EVA), copolymers of vinyl acetals, copolymers of vinyl alcohols, copolymers of vinylbenzene and chlorides of vinyldiene .
  • Insecticides are pyrethroids, carbamates and organophosphorus compounds.
  • US5248700 discloses a polymer matrix system in which can be incorporated simultaneously different active ingredients at different concentrations. To do this, the active ingredient is first incorporated in a microporous polymer powder to constitute the active agent, then, said active agent is then dispersed in a biodegradable polymer.
  • the system is a strip made of a core of thermoplastic polymer material (polyethylenes, polypropylenes, polyamides, polycarbonates) loaded with high concentration insecticide wrapped in a textile material serving as a physical barrier between the insecticide and the skin.
  • thermoplastic polymer material polyethylenes, polypropylenes, polyamides, polycarbonates
  • EP0539295 discloses molded systems for the distribution of antiparasitic active agents in which, firstly, a considerable amount of these assets is not released and is unavailable for use against the targeted pests; this factor reduces the profitability and useful life of these products, and the release of assets is not achieved at a uniform speed.
  • This patent therefore proposes a solid PVC matrix loaded with antiparasitic active agent comprising a very large quantity of liquid plasticizer and miscible with PVC so that the PVC / plasticizer / active mixture remains fluid and dry in order to facilitate the release of the active ingredient from said solid matrix.
  • EP2064046 describes an injected piece diffusing odors, this part being made by at least two different polymers. obtained by simultaneous or sequential injection; the first polymer constitutes a skin enveloping a heart which contains a perfume while said heart is formed by the second polymer. To regulate the diffusion of the perfume, it is planned to incorporate in the skin, filtering charges of a mineral nature.
  • the patent EP2858687 discloses a deodorant article consisting of a core of a first thermoplastic polymer overmolded by injection of a sleeve into another perfumed polymer.
  • EPI 620060 discloses a ring comprising unit segments wherein each segment, obtained by simultaneous injection, is a thermoplastic polymer containing a drug; the ends of the unit segments being bonded together by means of an adhesive.
  • EPI 064935 discloses an ingestible pharmaceutical composition obtained in particular by (e) securing a mixture of polymethacrylates and drugs; the mass ratio of the polyacrylates within the mixture influences the modularity of the release of the drug.
  • Said composition is of concentric structure in that it consists of a core and an envelope.
  • the patent application US2011 / 0108632 discloses a perfume diffuser clip obtained by bi-injection, consisting of a molded central portion of an envelope.
  • Patent JP3240088 discloses a box, in two parts, of concentric structure in thermoplastic resin. Each of the parts comprises a core wrapped, by overmolding, with a rigid resin devoid of active substance. The release control of the active substances is carried out by means of particular notches made on the envelope.
  • the injected parts described above may have drawbacks in particular in terms of regulating the diffusion of the active ingredient when it is incorporated in the core, but also in terms of continuity of the structure. of the final device due to overmolding.
  • the molded part according to the present invention comprises at least two simple matrices, each being loaded with different active material, the simple matrices being welded laterally or facially so that the lateral or facial junctions of two adjacent matrices interpenetrate each other , by partial melting of the polymer which constitutes them, which authorizes the displacement of the solvent of the active ingredient of a. simple matrix to another.
  • Such a migration can only be obtained when, on the one hand, the polymers are compatible with each other, in particular because they belong to the same chemical family and, on the other hand, the single matrices are molded simultaneously by multiple injection.
  • target may be pests, a defined environment or the skin; in any case, the target is a function of the nature of the salted active ingredient.
  • antagonistic activities namely active ingredients to be released simultaneously but with different kinetics, or by the risk that they react with each other if they were pooled in a single matrix which distorts the desired effect, or in that at least one active ingredient inhibits the release of at least one other,
  • complementary activities namely by obtaining time-delayed release kinetics of the active ingredients (example active A is released before the active B, etc.), or with a different release time or nature of different active ingredients but complementary by their action, which allows, for example, obtaining a shock effect that precedes a treatment effect, or by obtaining the release of several active ingredients each of which induces a different effect for the benefit of the treatment of a human or animal subject.
  • a monolithic diffuser support polymer matrix loaded with at least two different active ingredients each having a specific kinetics of release, but that for to obtain the desired effect, it is necessary that the two active ingredients are released simultaneously, at substantially identical or different speeds over time.
  • a monolithic molded piece made of polymer matrix formed by the combination of at least two polymer matrices, excluding PVC, one of which comprises an insecticide of the pyrethroid family or its derivatives and the other an active ingredient excluding pyrethrinoids; the diffusion rate of the two active ingredients being close to produce effectively for a long time the anti-insect effect in a human or animal subject.
  • the beneficial effects referred to within the meaning of the invention include, in a non-exhaustive manner, the biocidal effects including insecticide, repellent and attractive, well-being perfuming, deodorant, cosmetic care, soothing, up to treatment with the delivery of pharmaceutical or phytosanitary substances.
  • the multi-injection polymer shaping technique makes it possible to obtain a complex molded part in its structure which makes it possible to combine the complementary properties of compatible or mutually compatible polymers.
  • the Applicant has diverted this technique, normally dedicated to the design of composite mechanical devices, to the development of monolithic multi-effect diffusion molds managed separately.
  • the present invention firstly relates to a monolithic molded piece consisting of cohesive multiple matrices, non-concentric continuous structure, formed by the combination of two to four simple matrices, welded together and are obtained through the technique of setting in multi-injection form, each of said single matrices being made of thermoplastic polymer and containing at least one active ingredient, each having a specific kinetics of release and that all of said active ingredients are salted simultaneously at substantially different or substantially similar speeds so that the sum of the quantities of released active ingredients makes it possible to synergistically achieve the intended beneficial effects, characterized in that the adjacent simple matrices are welded to each other laterally or face to face so that the solder ensures the structural continuity of the piece and, in that said udure, which constitutes the interface between the adjacent matrices, is constituted by the melt mixing of polymer (s) forming one and the other of said neighboring matrices.
  • the structural continuity is adapted to the migration of the solvent of at least one active ingredient from one simple matrix
  • the interface between the single matrices welded together which results in the creation of a connection having a good resistance to takeoff between two adjacent single matrices.
  • the multi-injection shaping makes it possible to obtain geometrically complex shapes of each of the single matrices, and consequently of that of the final molded part, which makes it possible to vary the thicknesses of each of the simple matrices. and, therefore, the reservoir capacity, the exchange surface and the asset release rate of a single matrix.
  • each of the single matrices contains an active ingredient different from that contained in the adjacent simple matrix.
  • all the simple matrices can be of different color.
  • a simple matrix of the molded part is devoid of any active ingredient, the latter being intended to be put in direct contact with the skin of man or of an animal, or in a layer of covering at least one active matrix to limit the atmospheric diffusion of a volatile asset, that is to say to channel the diffusion of the asset towards the target.
  • each of the single matrices may be from the same or different family of thermoplastic polymer, and the solvent in which the active ingredients are solubilized may be the same or different in each of the single matrices; the amount of said solvent may be the same or different from one simple matrix to another.
  • each of the single matrices is derived from the same family of thermoplastic polymer, and that the solvent (s) in which the active ingredients are solubilized is (are) identical. (s) in each of the simple matrices, but that the (or) amount (s) of the (said) solvent (s) which allowed the solubilization of the active ingredients is (are) different (s) of a matrix simple to another.
  • the above combinations result in different mechanical properties for each of the single matrices. It is also known to those skilled in the art that certain active ingredients, in particular essential oils or their components, can be incorporated directly into a polymer matrix without it being necessary to solubilize them in a solvent.
  • each of the single matrices is derived from a family of different thermoplastic polymers, but compatible with each other, and that the solvent (s) which allowed the solubilization of the active ingredients is (are) identical (s) or different) from one simple matrix to another, and that the amount of the solvent (s) is the same or different from one simple matrix to another.
  • thermoplastic polymers are biodegradable or non-biodegradable polymers chosen from the group formed by polyolefins and their derivatives chosen from polyethylenes (PE), polypropylenes (PP) and copolymers of ethylene and acetate.
  • vinyl ethers EVA
  • EBA amide block ethers
  • PVC polyvinyl chloride
  • SEBS polystyrene-polyisoprene-polystyrene
  • SIS polystyrene-polyisoprene-polystyrene copolymers
  • SBS polystyrene-polybutadiene-polystyrene copolymers
  • vulcanized thermoplastics agropolymers and their derivatives (polysaccharides, starch, cellulose, proteins) , polyesters and their derivatives as well as the mixture of all these polymers.
  • the active ingredients have biocidal, well-being and cosmetic, therapeutic, phytosanitary and biocontrol effects.
  • the active ingredients are chosen from insecticides, repellents, pheromones, hormones, attractants, perfumes, essential oils, plant extracts, active ingredients with cosmetic effect, pharmaceutical active ingredients and phytosanitary active agents.
  • the active agents with cosmetic effect, the pharmaceutical active agents as well as the phytosanitary active agents are known to those skilled in the art.
  • an active ingredient may consist of a mixture of essential oils or their compounds whose release profile of the assembly is compatible with the desired effect.
  • the insecticides according to the present invention may be in viscous liquid or solid form.
  • the insecticides are selected from the group consisting of pyrethroids (eg permethrin, deltamethrin, cypermethrin, tetramethrin), pyrethrins, carbamates, formamidines (eg amitraz), carboxylic esters (eg IR3535), phenylpyrazoles (eg fipronil), organophosphorus compounds, organohalogen compounds, neonicotinoids, avermectins and their derivatives, spinosyns, essential oils and their components.
  • the perfumes and hormones are of natural or synthetic origin.
  • the molded part comprises two simple diermoplastic polymer matrices, the first matrix containing 0.1 to 50% of its weight of an insecticide belonging to the pyrethroid family, whereas the second simple matrix containing 0 , 1 to 50% of its weight of active ingredient chosen from pyrethrins, carbamates, formamidines, organophosphorus compounds, organohalogen compounds, neonicotinoids, phenylpyrazoles, avermectins and their derivatives, spinosyns, perfumes, essential oils, pheromones, hormones, cosmetic effect active ingredients, pharmaceutical active ingredients, phytosanitary active ingredients or mixtures thereof.
  • active ingredient chosen from pyrethrins, carbamates, formamidines, organophosphorus compounds, organohalogen compounds, neonicotinoids, phenylpyrazoles, avermectins and their derivatives, spinosyns, perfumes, essential oils, pheromones, hormones, cosmetic effect active ingredients, pharmaceutical
  • one of the matrices contains 0.1 to 50% of its weight of insect repellents and the other matrix contains 0.1 to 50% of its weight of pheromone, hormone, d attractive, perfume, essential oil, plant extract, cosmetic active ingredient, pharmaceutical active ingredient, phytosanitary active agent or the mixture thereof.
  • Insect repellents may especially be monoterpene derivatives derived from essential oils, DEET, icaridine and its derivatives, dimethyl phthalate or mixtures thereof.
  • the solvent of the active ingredient is selected from the group of carbonates, esters, alkyls, amines, alcohols, phthalates, vegetable oils, mineral oils or the mixture thereof.
  • the molded piece is in the form of a necklace, a bracelet, a strap, a wafer, a patch, a medallion, etc.
  • the molded piece is in the form of a necklace whose total exchange surface is between 25 and 300 cm 2 or a medallion, to be fixed on a collar of the animal, of which the exchange surface is between 5 and 100 cm 2 .
  • the molded part according to the present invention incorporates active ingredients pest control effect on pets
  • this effect is the result of the combination of specialized insecticides to treat ectoparasites, said insecticides each having from their different physico-chemical property (powder, viscous liquid), opposite diffusion kinetics; the assembly of different simple matrices containing them allows the diffusion at the right dose of these insecticides during all the necessary period to reach a long-lasting efficiency in that the molded piece is able to repel the ectoparasites targeted during a period of in the nrinimum 6 months up to 12 months.
  • the simple matrices constituting the molded part according to the present invention may comprise other non-active agents, especially dyes, fillers, stabilizers and other agents known to those skilled in the art. .
  • the present invention also has as a second object, a method of manufacturing a cohesive multiple matrix monolithic molded part for the simultaneous diffusion of volatile active ingredients, contact or both, as described above, said complex matrix is formed by the combination of several single matrices welded together, characterized in that a first homogeneous mixture comprising a thermoplastic polymer incorporating a first active ingredient is introduced to form the first simple matrix in a first hopper of an injection molding machine and at the same time, introducing a second homogeneous mixture containing a second thermoplastic polymer incorporating a second active ingredient to constitute the second simple matrix in a second hopper of the same injection molding machine and shaping the two simple matrices. each of which contains a different active ingredient, by bi-injection of mani simultaneous re of two homogeneous mixtures.
  • the mold will have been provided to release cavities that are complementary to each injection cycle of different polymers.
  • each of the single matrices may be from the same or different family of thermoplastic polymer, and the solvent in which the active ingredients are solubilized may be the same or different in each of the single matrices; the amount of said solvent may be the same or different from one simple matrix to another.
  • thermoplastic polymers constituting the first and the second simple matrix are different.
  • the melting points of said polymers are close, the differential not exceeding 15 ° C.
  • thermoplastic polymers constituting the first and the second simple matrix are identical.
  • three to four independent homogeneous mixtures of polymers are constituted to form the corresponding single matrices, and which are placed in the form of three to four matrices by simultaneous or sequential multi-injection of said mixtures.
  • the total amount of all active ingredients is between 0.2 and 50% by weight of the total weight of the molded article as a whole.
  • EXAMPLE 1 Necklace Comprising Active Ingredients Which Are Incompatible With Each Other, Having Antagonistic Effects It is desired to manufacture a pest control collar (ticks, lice, fleas) and regenerating the skin intended for a pet. To do this, we have the following inputs: essential oils of lemongrass, eucalyptus and pennyroyal (volatile repellents)
  • geraniol which is a component of the essential oil of palmarosa for example (volatile repellent active)
  • vitamin F active contact, softening or even regenerating the skin during the friction of the collar during the port
  • coconut vegetable oil (emollient, solvent)
  • percentages by weight are based on the total weight of the final matrix.
  • the above compound is injected into a necklace 60 cm long and 1 cm wide and weighing 25 g.
  • the collars (C1) thus obtained were analyzed by GC assay of the assets contained in the matrix at time zero (T0) after injection, and then after 7 days of stability at 50 ° C. in a closed sealed package.
  • the assay results obtained for the different tracers of the repellent active agents are shown in Table 1.
  • the collar (Cl) has already lost 12%, 12%, 11%, 7% and 6% respectively for cineole, citronellal, citronellol and geraniol,
  • the collar (C2) kept all the tracers with the exception of citronellol which has a loss of 3%
  • Example 2 Bracelet containing volatile assets with complementary effect (expectoration), but with staggered release.
  • Litnonene a component of oils and essential oils of citrus fruits
  • eucalyptus radiata essential oil are available, both of which are known for their expectorant properties.
  • Figure 1 release profile at room temperature of limonene incorporated at 10% in different polymer matrices.
  • PEBA polyether block-amide bracelet
  • Figure 2 room temperature release profile of the eucalyptus radiata essential oil incorporated at 10% in an EVA matrix
  • the PEBA polymers loaded with 10% limonene and the EVA polymers loaded with 10% eucalyptus essential oil are banded by bi-injection as described in Example 1.
  • the PEBA matrix rapidly releases the limonene and the EVA matrix progressively releases the eucalyptus essential oil, which makes it possible to reach the aforementioned objective, namely the shock effect followed by a residual effect, the synergy of the two effects induces the expulsion of mucus by sputum or cough.
  • Example 3 Pest control collar for animals comprising two synergistic and complementary contact insecticides having different release profiles.
  • Synergistic insecticides are two pyrethroids, deltamethrin and permethrin.
  • Polyether thermoplastic polyurethane (TPU) polymer powder (EPAMOULD ® ) is also available, as well as a single solvent which is an ethylhexyldiphenyl phosphate (SANTICIZER 141 ® ).
  • Figure 3 In vitro release profile in the vegetable oil of the pest control collar containing 8% permethrin and 4% deltamethrin, both solubilized in 22% SANTICIZER 141 ®
  • FIG. 4 in vitro release profile in the vegetable oil of the collar antiparasitic obtained by bi-injection with a matrix containing 8% permethrin solubilized in 5% SANTICIZER ® 141 and the other matrix containing 4% deltamethrin dissolved in 22 % of SANTICIZER 141 ® .
  • Figure 4 shows that in order to obtain a substantially similar release profile of the two insecticides, it was necessary that one of the two single matrices EPAMOULD ® incorporates permethrin solubilized 5%, while the other incorporates deltamethrin solubilized at 22%.
  • the objective that we have set is thus achieved by the shaping of the two simple matrices by bi-injection.

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  • Pest Control & Pesticides (AREA)
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EP18772846.4A 2017-09-01 2018-08-24 Monolithisches formteil mit mehreren matrizen für die diffusion von wirkstoffen und verfahren zu dessen herstellung Pending EP3678830A1 (de)

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FR1770912A FR3070619B1 (fr) 2017-09-01 2017-09-01 Piece moulee monolithique en matrice multiple pour la diffusion d’actifs et son procede d’obtention
PCT/FR2018/000208 WO2019043303A1 (fr) 2017-09-01 2018-08-24 Pièce moulée monolithique en matrice multiple pour la diffusion d'actifs et son procédé d'obtention

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FR3107203B1 (fr) * 2020-02-14 2023-11-24 Ab7 Innovation Matrice solide composite pour la délivrance prolongée d’actifs

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FR2533412B2 (fr) * 1982-01-12 1986-05-09 Virbac Laboratoires Perfectionnements apportes aux colliers antiparasitaires pour animaux
US5248700A (en) 1982-05-14 1993-09-28 Akzo Nv Active agent containing solid structures for prolonged release of active agents
US4803956A (en) 1984-10-15 1989-02-14 A. H. Robins Company, Incorporated Co-extrustion of multi-component insecticidal pet collars
MX9206034A (es) 1991-10-24 1993-05-01 Roussel Uclaf Sistema para el control de plagas.
AU4048593A (en) 1992-04-10 1993-11-18 Daniel Gallucci Insect repelling carrier band
JP3240088B2 (ja) * 1993-12-28 2001-12-17 洋治 島崎 電気・電子機器用筐体及びその製造方法
DE69929055T2 (de) * 1998-05-01 2006-07-20 Duramed Pharmaceuticals Inc., Cincinnati Verfahren zur spritzgussherstellung von vorrichtungen mit kontrollierter wirkstofffreisetzung und damit hergestellte vorrichtung
FR2795326B1 (fr) * 1999-06-28 2001-08-31 Adir Composition pharmaceutique solide thermoformable a liberation controlee
EP1444082B1 (de) * 2001-10-18 2015-12-09 Community Enterprises, LLC Vorrichtung zum spritzgiessen von mehrschichtigen artikeln
DE602004026173D1 (de) * 2003-04-29 2010-05-06 Gen Hospital Corp Verfahren und vorrichtungen für die verzögerte freisetzung von mehreren arzneimitteln
DE102004015784A1 (de) * 2004-03-25 2005-10-20 Beiersdorf Ag Insektenrepellent-Pflaster
FR2905299A1 (fr) * 2006-08-29 2008-03-07 Plastigray Soc Par Actions Sim Procede de fabrication d'une piece injectee absorbant ou diffusant des odeurs et piece obtenue obtenue selon ce procede.
US20110108632A1 (en) * 2009-11-12 2011-05-12 Hayloft Enterprises, Inc. Air freshener vent clip and accessory
MX2014011384A (es) * 2012-03-23 2015-03-09 Celanese Eva Performance Polymers Inc Materiales repelentes de insectos de liberacion controlada.
US9107969B2 (en) 2012-06-08 2015-08-18 Brandywine Product Group International Inc. Air freshener
JP3240088U (ja) 2022-10-07 2022-12-06 謙一郎 林 交換可能な火袋を備えた提灯スタンド

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FR3070619A1 (fr) 2019-03-08
US12179400B2 (en) 2024-12-31
FR3070619B1 (fr) 2024-10-04
US20200206994A1 (en) 2020-07-02

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