EP3698802A4 - Pluripotente stammzellen, die eine osteochondrale reparatur induzieren - Google Patents

Pluripotente stammzellen, die eine osteochondrale reparatur induzieren Download PDF

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Publication number
EP3698802A4
EP3698802A4 EP18867476.6A EP18867476A EP3698802A4 EP 3698802 A4 EP3698802 A4 EP 3698802A4 EP 18867476 A EP18867476 A EP 18867476A EP 3698802 A4 EP3698802 A4 EP 3698802A4
Authority
EP
European Patent Office
Prior art keywords
stem cells
pluripotent stem
cells inducing
osteochondral repair
osteochondral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP18867476.6A
Other languages
English (en)
French (fr)
Other versions
EP3698802A1 (de
Inventor
Naosuke KAMEI
Mari Dezawa
Mitsuo Ochi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tohoku University NUC
Hiroshima University NUC
Original Assignee
Tohoku University NUC
Hiroshima University NUC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tohoku University NUC, Hiroshima University NUC filed Critical Tohoku University NUC
Publication of EP3698802A1 publication Critical patent/EP3698802A1/de
Publication of EP3698802A4 publication Critical patent/EP3698802A4/de
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
    • A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C12N5/0695—Stem cells; Progenitor cells; Precursor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2509/00—Methods for the dissociation of cells, e.g. specific use of enzymes
    • C12N2509/10—Mechanical dissociation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP18867476.6A 2017-10-17 2018-10-17 Pluripotente stammzellen, die eine osteochondrale reparatur induzieren Pending EP3698802A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762573500P 2017-10-17 2017-10-17
PCT/JP2018/038687 WO2019078262A1 (ja) 2017-10-17 2018-10-17 骨軟骨修復を誘導する多能性幹細胞

Publications (2)

Publication Number Publication Date
EP3698802A1 EP3698802A1 (de) 2020-08-26
EP3698802A4 true EP3698802A4 (de) 2021-05-26

Family

ID=66174455

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18867476.6A Pending EP3698802A4 (de) 2017-10-17 2018-10-17 Pluripotente stammzellen, die eine osteochondrale reparatur induzieren

Country Status (9)

Country Link
US (2) US20200237828A1 (de)
EP (1) EP3698802A4 (de)
JP (1) JP7489016B2 (de)
KR (1) KR20200070247A (de)
CN (1) CN111225676A (de)
AU (1) AU2018352904A1 (de)
CA (1) CA3079500A1 (de)
SG (1) SG11202003507QA (de)
WO (1) WO2019078262A1 (de)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120244129A1 (en) * 2009-07-15 2012-09-27 Mari Dezawa Pluripotent stem cell that can be isolated from body tissue
EP3064577A1 (de) * 2013-11-01 2016-09-07 Kyoto University Neuartiges chondrozyteninduktionsverfahren
EP3189844A1 (de) * 2014-09-05 2017-07-12 The University of Tokyo Pluripotente stammzelle zur behandlung diabetischer hautgeschwüre

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5906934A (en) * 1995-03-14 1999-05-25 Morphogen Pharmaceuticals, Inc. Mesenchymal stem cells for cartilage repair
WO2004022120A1 (en) 2002-09-04 2004-03-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions comprising bone marrow cells, demineralized bone matrix and rtg polymers for use in the induction of bone and cartilage formation
US8048999B2 (en) 2005-12-13 2011-11-01 Kyoto University Nuclear reprogramming factor
US9550975B2 (en) 2009-07-15 2017-01-24 Mari Dezawa SSEA-3 pluripotent stem cell isolated from body tissue
JP2014133703A (ja) * 2011-03-30 2014-07-24 Clio Inc 生体組織から単離できるｓｓｅａ−３陽性の多能性幹細胞を含む他家移植用細胞治療用組成物
WO2014027474A1 (ja) * 2012-08-17 2014-02-20 株式会社Ｃｌｉｏ 心筋梗塞の修復再生を誘導する多能性幹細胞
JP2016524967A (ja) 2013-07-17 2016-08-22 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 組織再生のための微細組織を用いて機能化された三次元スキャフォールド
PT3083944T (pt) * 2013-12-19 2021-02-17 Univ Liege Células estaminais derivadas de músculo de mamífero
WO2016131430A1 (en) * 2015-02-20 2016-08-25 Shih-Chieh Hung Use of mesenchymal stem cells in treating osteoarthritis

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120244129A1 (en) * 2009-07-15 2012-09-27 Mari Dezawa Pluripotent stem cell that can be isolated from body tissue
EP3064577A1 (de) * 2013-11-01 2016-09-07 Kyoto University Neuartiges chondrozyteninduktionsverfahren
EP3064577B1 (de) * 2013-11-01 2020-09-09 Kyoto University Neuartiges chondrozyteninduktionsverfahren
EP3189844A1 (de) * 2014-09-05 2017-07-12 The University of Tokyo Pluripotente stammzelle zur behandlung diabetischer hautgeschwüre
EP3189844B1 (de) * 2014-09-05 2020-11-18 The University of Tokyo Pluripotente stammzelle zur behandlung diabetischer hautgeschwüre

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO2019078262A1 *
YOUNG H E ET AL: "ADULT RESERVE STEM CELLS AND THEIR POTENTIAL FOR TISSUE ENGINEERING", CELL BIOCHEMISTRY AND BIOPHYSICS, TOTOWA, NJ, US, vol. 40, no. 1, 1 January 2004 (2004-01-01), pages 1 - 80, XP009057187, ISSN: 1085-9195, DOI: 10.1385/CBB:40:1:1 *

Also Published As

Publication number Publication date
US20200237828A1 (en) 2020-07-30
US20220313741A1 (en) 2022-10-06
JPWO2019078262A1 (ja) 2020-11-05
EP3698802A1 (de) 2020-08-26
JP7489016B2 (ja) 2024-05-23
CN111225676A (zh) 2020-06-02
AU2018352904A1 (en) 2020-05-21
WO2019078262A1 (ja) 2019-04-25
KR20200070247A (ko) 2020-06-17
SG11202003507QA (en) 2020-05-28
CA3079500A1 (en) 2019-04-25

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