EP3773747A4 - Utilisation d'exosomes pour l'administration ciblée d'agents thérapeutiques - Google Patents

Utilisation d'exosomes pour l'administration ciblée d'agents thérapeutiques Download PDF

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Publication number
EP3773747A4
EP3773747A4 EP19776678.5A EP19776678A EP3773747A4 EP 3773747 A4 EP3773747 A4 EP 3773747A4 EP 19776678 A EP19776678 A EP 19776678A EP 3773747 A4 EP3773747 A4 EP 3773747A4
Authority
EP
European Patent Office
Prior art keywords
exosomes
therapeutic agents
targeted delivery
targeted
delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19776678.5A
Other languages
German (de)
English (en)
Other versions
EP3773747A1 (fr
Inventor
Raghu Kalluri
Valerie LEBLEU
Pedro CORREA DE SAMPAIO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
University of Texas at Austin
Original Assignee
University of Texas System
University of Texas at Austin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System, University of Texas at Austin filed Critical University of Texas System
Publication of EP3773747A1 publication Critical patent/EP3773747A1/fr
Publication of EP3773747A4 publication Critical patent/EP3773747A4/fr
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
EP19776678.5A 2018-03-28 2019-03-28 Utilisation d'exosomes pour l'administration ciblée d'agents thérapeutiques Pending EP3773747A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862649057P 2018-03-28 2018-03-28
PCT/US2019/024603 WO2019191444A1 (fr) 2018-03-28 2019-03-28 Utilisation d'exosomes pour l'administration ciblée d'agents thérapeutiques

Publications (2)

Publication Number Publication Date
EP3773747A1 EP3773747A1 (fr) 2021-02-17
EP3773747A4 true EP3773747A4 (fr) 2022-02-23

Family

ID=68060505

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19776678.5A Pending EP3773747A4 (fr) 2018-03-28 2019-03-28 Utilisation d'exosomes pour l'administration ciblée d'agents thérapeutiques

Country Status (7)

Country Link
EP (1) EP3773747A4 (fr)
JP (1) JP7813099B2 (fr)
KR (1) KR20200136978A (fr)
CN (1) CN112533643A (fr)
AU (1) AU2019243179B2 (fr)
CA (1) CA3095136A1 (fr)
WO (1) WO2019191444A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3775258A4 (fr) 2018-03-28 2022-01-26 Board of Regents, The University of Texas System Identification d'altérations épigénétiques dans de l'adn isolé à partir d'exosomes
IT201900007785A1 (it) * 2019-05-31 2020-12-01 Univ Degli Studi Milano Vescicole extracellulari per veicolare farmaci terapeutici o diagnostici
JP7674354B2 (ja) * 2019-12-05 2025-05-09 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 肝線維症および線維症に関連する他の疾患に対するエキソソームベースの療法
WO2021119552A1 (fr) * 2019-12-13 2021-06-17 Lawrence Livermore National Security, Llc Compositions de vésicule à nanotubes et utilisations associées
US12311053B2 (en) 2019-12-13 2025-05-27 Lawrence Livermore National Security, Llc Nanotube-vesicle compositions and uses thereof
CN117860902B (zh) * 2021-11-17 2024-07-16 中国人民解放军空军军医大学 一种前列腺癌分子靶向系统及其构建方法和应用
CN114774471A (zh) * 2022-05-10 2022-07-22 厦门星际诺康细胞科技有限公司 一种呈现il27稳转细胞及其构建方法、呈现il27工程化外泌体及其制备方法和应用
KR20250171535A (ko) * 2024-05-29 2025-12-09 사회복지법인 삼성생명공익재단 전기천공법을 이용한 상처치유용 세포외 소포체의 제조방법
WO2026002276A1 (fr) * 2024-06-28 2026-01-02 艾码生物科技(南京)有限公司 Procédé d'interférence d'arn ciblant tgfb, acide nucléique et application associée

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015085096A1 (fr) * 2013-12-04 2015-06-11 Board Of Regents, The University Of Texas System Analyse d'adn génomique, d'arn et de protéines dans des exosomes pour le diagnostic et la thérapie
WO2016201323A1 (fr) * 2015-06-10 2016-12-15 Board Of Regents, The University Of Texas System Utilisation d'exosomes pour le traitement de maladies

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7473678B2 (en) * 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US9085778B2 (en) * 2006-05-03 2015-07-21 VL27, Inc. Exosome transfer of nucleic acids to cells
GB201121069D0 (en) * 2011-12-07 2012-01-18 Isis Innovation Delivery system
ES2686129T3 (es) * 2012-11-13 2018-10-16 Codiak Biosciences, Inc. Administración de agentes terapéuticos
CN104822390A (zh) * 2012-11-29 2015-08-05 耶达研究及发展有限公司 预防肿瘤转移、癌症治疗和预后及鉴定为推定转移抑制剂的试剂的方法
JP2019501179A (ja) * 2015-12-30 2019-01-17 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 細胞由来ベシクルの向上された生成および単離のための方法
TWI601741B (zh) * 2016-07-11 2017-10-11 財團法人國家衛生研究院 利用前列腺素受體ｅｐ４－拮抗劑誘導幹細胞製造含有高囊泡含物之外泌體囊泡的方法及其應用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015085096A1 (fr) * 2013-12-04 2015-06-11 Board Of Regents, The University Of Texas System Analyse d'adn génomique, d'arn et de protéines dans des exosomes pour le diagnostic et la thérapie
WO2016201323A1 (fr) * 2015-06-10 2016-12-15 Board Of Regents, The University Of Texas System Utilisation d'exosomes pour le traitement de maladies

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO2019191444A1 *
SHIN-ICHIRO OHNO ET AL: "Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells", MOLECULAR THERAPY, vol. 21, no. 1, 1 January 2013 (2013-01-01), US, pages 185 - 191, XP055501314, ISSN: 1525-0016, DOI: 10.1038/mt.2012.180 *

Also Published As

Publication number Publication date
JP2021519296A (ja) 2021-08-10
WO2019191444A1 (fr) 2019-10-03
AU2019243179A1 (en) 2020-11-12
EP3773747A1 (fr) 2021-02-17
JP7813099B2 (ja) 2026-02-12
KR20200136978A (ko) 2020-12-08
CA3095136A1 (fr) 2019-10-03
AU2019243179B2 (en) 2025-09-18
CN112533643A (zh) 2021-03-19

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