EP3796832A4 - Ethylenrezeptor-biosensor - Google Patents

Ethylenrezeptor-biosensor Download PDF

Info

Publication number
EP3796832A4
EP3796832A4 EP19806687.0A EP19806687A EP3796832A4 EP 3796832 A4 EP3796832 A4 EP 3796832A4 EP 19806687 A EP19806687 A EP 19806687A EP 3796832 A4 EP3796832 A4 EP 3796832A4
Authority
EP
European Patent Office
Prior art keywords
ethylene receptor
receptor biosensor
biosensor
ethylene
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP19806687.0A
Other languages
English (en)
French (fr)
Other versions
EP3796832A1 (de
EP3796832C0 (de
EP3796832B1 (de
Inventor
Katherine Konstantin SIZOV
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sizov Katherine Konstantin
Strella Biotechnology Inc
Original Assignee
Strella Biotechnology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Strella Biotechnology Inc filed Critical Strella Biotechnology Inc
Publication of EP3796832A1 publication Critical patent/EP3796832A1/de
Publication of EP3796832A4 publication Critical patent/EP3796832A4/de
Application granted granted Critical
Publication of EP3796832C0 publication Critical patent/EP3796832C0/de
Publication of EP3796832B1 publication Critical patent/EP3796832B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/04Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
    • G01N27/06Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
    • G01N27/07Construction of measuring vessels; Electrodes therefor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3276Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403Cells and electrode assemblies
    • G01N27/404Cells with anode, cathode and cell electrolyte on the same side of a permeable membrane which separates them from the sample fluid, e.g. Clark-type oxygen sensors
    • G01N27/4045Cells with anode, cathode and cell electrolyte on the same side of a permeable membrane which separates them from the sample fluid, e.g. Clark-type oxygen sensors for gases other than oxygen
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302Apparatus specially adapted for immunological test procedures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438Electrodes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/0004Gaseous mixtures, e.g. polluted air
    • G01N33/0009General constructional details of gas analysers, e.g. portable test equipment
    • G01N33/0027General constructional details of gas analysers, e.g. portable test equipment concerning the detector
    • G01N33/0036General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component
    • G01N33/0047Organic compounds
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/02Food
    • G01N33/025Fruits or vegetables

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Electrochemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biophysics (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP19806687.0A 2018-05-22 2019-05-16 Ethylenrezeptor-biosensor Active EP3796832B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862674639P 2018-05-22 2018-05-22
PCT/US2019/032731 WO2019226464A1 (en) 2018-05-22 2019-05-16 Ethylene receptor biosensor

Publications (4)

Publication Number Publication Date
EP3796832A1 EP3796832A1 (de) 2021-03-31
EP3796832A4 true EP3796832A4 (de) 2022-04-27
EP3796832C0 EP3796832C0 (de) 2024-01-03
EP3796832B1 EP3796832B1 (de) 2024-01-03

Family

ID=68617173

Family Applications (2)

Application Number Title Priority Date Filing Date
EP19806687.0A Active EP3796832B1 (de) 2018-05-22 2019-05-16 Ethylenrezeptor-biosensor
EP19928548.7A Pending EP3969902A4 (de) 2018-05-22 2019-11-19 Ethylenrezeptor-biosensor

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP19928548.7A Pending EP3969902A4 (de) 2018-05-22 2019-11-19 Ethylenrezeptor-biosensor

Country Status (7)

Country Link
US (4) US11662330B2 (de)
EP (2) EP3796832B1 (de)
CN (2) CN112188862A (de)
AU (2) AU2019272518B2 (de)
BR (2) BR112020023538A2 (de)
MX (2) MX2020012454A (de)
WO (2) WO2019226464A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019272518B2 (en) * 2018-05-22 2024-06-13 Katherine Konstantin SIZOV Ethylene receptor biosensor
KR102820491B1 (ko) 2020-03-25 2025-06-13 삼성디스플레이 주식회사 포토 마스크, 표시 장치 및 그 제조 방법
WO2023196371A1 (en) * 2022-04-05 2023-10-12 Trustees Of Dartmouth College Ethylene receptors and binding domains with modified binding kinetics for ethylene

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120247978A1 (en) * 2011-03-28 2012-10-04 Stichting Imec Nederland Electrochemical ethylene sensor and method for monitoring ethylene
KR20150134157A (ko) * 2014-05-21 2015-12-01 한국생명공학연구원 에틸렌 검출용 바이오센서 및 그 용도

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1187512A (en) 1966-08-05 1970-04-08 Kyowa Hakko Kogyo Kk Process for Extracting Proteins from Micro-Organisms
US4366246A (en) 1977-11-08 1982-12-28 Genentech, Inc. Method for microbial polypeptide expression
EP0001929B1 (de) 1977-11-08 1989-04-19 Genentech, Inc. Plasmid zur Transformation eines bakteriellen Wirts um ihn zu Polypeptid Expression fähig zu machen
US4410632A (en) 1979-04-12 1983-10-18 Board Of Trustees Operating Michigan State University Gas sensing apparatus and method
US4414839A (en) 1979-04-12 1983-11-15 Board Of Trustees, A Constitutional Corporation Operating Michigan State University Gas sensing apparatus and method
US4431739A (en) 1979-11-05 1984-02-14 Genentech, Inc. Transformant bacterial culture capable of expressing heterologous protein
CA1219040A (en) 1983-05-05 1987-03-10 Elliot V. Plotkin Measurement of enzyme-catalysed reactions
US5063164A (en) 1990-06-29 1991-11-05 Quantum Group, Inc. Biomimetic sensor that simulates human response to airborne toxins
GB9218376D0 (en) * 1992-08-28 1992-10-14 Cranfield Inst Of Tech Media for biocatalytic electrochemical reactions in the gaseous phase
US5591321A (en) 1993-11-02 1997-01-07 Electric Power Research Institute Detection of fluids with metal-insulator-semiconductor sensors
RU2161653C2 (ru) * 1998-08-24 2001-01-10 ФАРМАКОВСКИЙ Дмитрий Александрович Способ количественного электрохимического анализа биомолекул
US6105416A (en) 1998-10-16 2000-08-22 Geo-Centers, Inc. Ethylene monitoring and control system
AU764491B2 (en) 1999-03-19 2003-08-21 Lee J. Jones Ripening gas delivery controller
KR100486441B1 (ko) 1999-06-29 2005-05-03 캐리어 코포레이션 공조 및 냉동 공정 감시용 바이오센서
US20110131679A2 (en) * 2000-04-19 2011-06-02 Thomas La Rosa Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
WO2002006456A1 (en) 2000-07-13 2002-01-24 Invitrogen Corporation Methods and compositions for rapid protein and peptide extraction and isolation using a lysis matrix
WO2002065125A1 (en) 2001-02-13 2002-08-22 Invitrogen Corporation Methods and compositions for isolation of biological macromolecules
JP3250197B1 (ja) 2001-03-08 2002-01-28 学校法人 慶應義塾 エチレンガス濃度制御方法及びその応用
CN1222347C (zh) 2001-03-08 2005-10-12 学校法人庆应义塾 乙烯气体吸附材料、乙烯气体浓度控制方法以及乙烯气体传感器
JP3218032B1 (ja) 2001-03-08 2001-10-15 学校法人 慶應義塾 エチレンガスセンサ、エチレンガス定量方法及び装置
WO2002099076A2 (en) 2001-06-04 2002-12-12 Basf Plant Science Gmbh Sugar and lipid metabolism regulators in plants ii
JP2003093047A (ja) * 2001-09-25 2003-04-02 Inst Of Physical & Chemical Res 環境因子の測定に用いる微生物
US8043868B2 (en) 2001-12-21 2011-10-25 Imec Method and apparatus for detecting an analyte
US7105654B1 (en) 2002-01-02 2006-09-12 Monsanto Technology Llc Ethylene receptor gene from Glycine max and its use
US20040128719A1 (en) 2002-06-21 2004-07-01 Klee Harry J. Materials and methods for tissue-specific targeting of ethylene insensitivity in transgenic plants
CN1232530C (zh) * 2002-09-04 2005-12-21 中国农业科学院原子能利用研究所 小麦乙烯受体蛋白及其编码序列
US20050272989A1 (en) * 2004-06-04 2005-12-08 Medtronic Minimed, Inc. Analyte sensors and methods for making and using them
US7364873B2 (en) * 2003-01-15 2008-04-29 Council Of Scientific And Industrial Research Method for manufacture of lactate biosensing strip
GB2394882C (en) 2003-04-05 2006-05-03 Greenvale Ap Ltd Method for controlling sprout growth in a root vegetable
US7105274B2 (en) 2003-06-02 2006-09-12 Wisconsin Alumni Research Foundation Photoluminescent ethylene sensors
US7491547B1 (en) 2003-11-07 2009-02-17 Piers Richard Warburton Filter for gas sensor
KR100568949B1 (ko) 2004-03-19 2006-04-07 코아텍주식회사 에틸렌 가스 분해촉매제를 내장한 필터와 오존발생기를 구비한 화훼, 채소 및 과일 냉장고 겸 저장고
AR051833A1 (es) * 2004-11-12 2007-02-14 Pioneer Hi Bred Int Histidina quinasas con actividad sensora de citoquinina y metodos de uso de las mismas en plantas y celulas vegetales
US20060127543A1 (en) 2004-11-12 2006-06-15 Arizona Board Of Regents On Behalf Of The University Of Arizona Non-invasive colorimetric ripeness indicator
JP2006242925A (ja) * 2005-03-07 2006-09-14 Seiko Epson Corp 電極基板、該基板を備える検出装置および該装置を含むキット、並びに該キットを用いた検出方法
KR20070117843A (ko) * 2006-06-09 2007-12-13 삼성전자주식회사 냄새 물질을 검출하기 위한 바이오센서 및 그를 이용하여기상의 냄새 물질을 검출하는 방법
US7560013B2 (en) 2006-06-20 2009-07-14 Fluid Analytics, Inc. Tree fruit postharvest chemical sensor
KR100775920B1 (ko) 2006-09-25 2007-11-15 주식회사 대우일렉트로닉스 과일 및 채소의 숙성 조절 장치
AU2008275876B2 (en) 2007-07-19 2013-10-24 The Regents Of The University Of California Increasing grain yield through targeted reduction in ethylene signaling
WO2010134506A1 (ja) * 2009-05-18 2010-11-25 日本電気株式会社 爆発物検出用の免疫センサおよびその製造方法
EP2622092B1 (de) * 2010-09-28 2015-08-12 Lifescan Scotland Limited Elektrochemische glukose messung verfahren mit fehler detektion
CN102095787B (zh) 2011-02-16 2013-05-22 西安交通大学 碳纳米管薄膜三电极乙烯传感器及其浓度测量方法
US8399262B2 (en) * 2011-03-23 2013-03-19 Darrel A. Mazzari Biosensor
CN202043580U (zh) 2011-04-06 2011-11-23 昆明天开农业设施有限公司 智能化柑橘退绿库控制系统
CN102288733A (zh) 2011-04-29 2011-12-21 山东省农业科学院农产品研究所 一种果蔬后熟情况检测装置
EP2696201A1 (de) * 2012-06-25 2014-02-12 Albert-Ludwigs-Universität Freiburg Sensoren für selektive elektrochemische Erkennung reaktiver Sauerstoffspezies und reaktiver Stickstoffspezies in Flüssigmedien
US20140250975A1 (en) * 2013-03-05 2014-09-11 Michael John Kane Handheld gas analyzer with sensor on chip
US20180252665A1 (en) * 2014-05-27 2018-09-06 Case Western Reserve University System and methods for the detection of biomarkers of neurodegenerative disorders
US9568456B2 (en) * 2014-10-08 2017-02-14 Korea Institute Of Science And Technology Peptide selectively binding to volatile organic compounds
WO2016187470A1 (en) * 2015-05-19 2016-11-24 Eatsafe Llc System and methods for dermining food spoilage
JP2019512825A (ja) * 2016-02-12 2019-05-16 デトコン, インコーポレイテッドDetcon, Inc. ワイヤレスガス検出センサ
US20190062809A1 (en) * 2017-08-24 2019-02-28 Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) Electrochemical detection of bacterial and/or fungal infections
AU2019272518B2 (en) * 2018-05-22 2024-06-13 Katherine Konstantin SIZOV Ethylene receptor biosensor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120247978A1 (en) * 2011-03-28 2012-10-04 Stichting Imec Nederland Electrochemical ethylene sensor and method for monitoring ethylene
KR20150134157A (ko) * 2014-05-21 2015-12-01 한국생명공학연구원 에틸렌 검출용 바이오센서 및 그 용도

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HUA JIAN ET AL: "Ethylene insensitivity conferred by Arabidopsis ERS gene", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 269, no. 5231, 22 September 1995 (1995-09-22), pages 1712 - 1714, XP002599344, ISSN: 0036-8075 *
MARCEL A. G. ZEVENBERGEN ET AL: "Electrochemical Sensing of Ethylene Employing a Thin Ionic-Liquid Layer", ANALYTICAL CHEMISTRY, vol. 83, no. 16, 15 August 2011 (2011-08-15), pages 6300 - 6307, XP055150406, ISSN: 0003-2700, DOI: 10.1021/ac2009756 *
See also references of WO2019226464A1 *
TAKALANI MULAUDZI ET AL: "Identification of a novel Arabidopsis thaliana nitric oxide-binding molecule with guanylate cyclase activity in vitro", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 585, no. 17, 31 July 2011 (2011-07-31), pages 2693 - 2697, XP071252848, ISSN: 0014-5793, DOI: 10.1016/J.FEBSLET.2011.07.023 *

Also Published As

Publication number Publication date
EP3796832A1 (de) 2021-03-31
AU2019445710A1 (en) 2021-11-25
US20240060929A1 (en) 2024-02-22
US11054379B2 (en) 2021-07-06
MX2021013848A (es) 2022-01-07
US11662330B2 (en) 2023-05-30
EP3796832C0 (de) 2024-01-03
EP3796832B1 (de) 2024-01-03
MX2020012454A (es) 2021-06-23
CN112188862A (zh) 2021-01-05
CN113826012A (zh) 2021-12-21
EP3969902A4 (de) 2023-01-25
US11360042B2 (en) 2022-06-14
WO2019226464A1 (en) 2019-11-28
BR112020023538A2 (pt) 2021-05-04
WO2020231466A1 (en) 2020-11-19
BR112021022741A2 (pt) 2022-01-11
AU2019272518B2 (en) 2024-06-13
US20210372963A1 (en) 2021-12-02
EP3969902A1 (de) 2022-03-23
US20200264125A1 (en) 2020-08-20
US20200292484A1 (en) 2020-09-17
US12146849B2 (en) 2024-11-19
AU2019272518A1 (en) 2020-12-10

Similar Documents

Publication Publication Date Title
EP3953327A4 (de) Melanocortin-4-rezeptor-agonisten
EP3636670A4 (de) Anti-igf-i-rezeptor-antikörper
EP3986936A4 (de) Anti-tigit-antikörper
EP3700925B8 (de) Neuartiger t-zell-rezeptor
EP3518944A4 (de) Adaptiver chimärer antigenrezeptor-t-zellenentwurf
EP4017510A4 (de) Chimärer inhibitorischer rezeptor
EP3769838A4 (de) Katalysator
EP3871816A4 (de) Flachbohrer
EP3986462A4 (de) Anti-tim-3-antikörper
AU2019361253A1 (en) Anti-synuclein antibodies
EP3796832A4 (de) Ethylenrezeptor-biosensor
EP3780207A4 (de) Neuartiger mediator
EP3808444A4 (de) Reaktionsvorrichtung
EP4064834A4 (de) Inkubator
EP3993793A4 (de) P2x7r-antagonisten
EP3779421A4 (de) Biosensor
HK40078505A (zh) 合成rig-i样受体激动剂
HK40081012A (zh) 基於lilrb1的嵌合抗原受体
HK40080571A (en) Anti-cd73 antibodies
HK40077792A (en) Anti-fucosyl-gm1 antibodies
HK40066819A (en) Anti-angpt2 antibodies
HK40060479A (zh) 抗btla抗体
HK40060202B (zh) 抗btla抗体
HK40060247A (en) Assay device
HK40054305A (en) Anti-klrg1 antibodies

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20201218

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

AX Request for extension of the european patent

Extension state: BA ME

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
A4 Supplementary search report drawn up and despatched

Effective date: 20220328

RIC1 Information provided on ipc code assigned before grant

Ipc: G01N 33/543 20060101ALI20220321BHEP

Ipc: C12M 1/40 20060101ALI20220321BHEP

Ipc: C07F 17/02 20060101ALI20220321BHEP

Ipc: A61B 5/1486 20060101ALI20220321BHEP

Ipc: A61B 5/145 20060101ALI20220321BHEP

Ipc: A61B 5/00 20060101AFI20220321BHEP

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: EXAMINATION IS IN PROGRESS

17Q First examination report despatched

Effective date: 20230112

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: GRANT OF PATENT IS INTENDED

INTG Intention to grant announced

Effective date: 20230718

RIN1 Information on inventor provided before grant (corrected)

Inventor name: SIZOV, KATHERINE, KONSTANTIN

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE PATENT HAS BEEN GRANTED

RAP3 Party data changed (applicant data changed or rights of an application transferred)

Owner name: SIZOV, KATHERINE KONSTANTIN

Owner name: STRELLA BIOTECHNOLOGY, INC.

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602019044545

Country of ref document: DE

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

U01 Request for unitary effect filed

Effective date: 20240130

U07 Unitary effect registered

Designated state(s): AT BE BG DE DK EE FI FR IT LT LU LV MT NL PT SE SI

Effective date: 20240205

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240103

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240103

U20 Renewal fee for the european patent with unitary effect paid

Year of fee payment: 6

Effective date: 20240509

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240503

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240404

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240403

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240103

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240103

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240403

Ref country code: NO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240403

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240503

Ref country code: HR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240103

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240404

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240103

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240103

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240103

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602019044545

Country of ref document: DE

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240103

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240103

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SM

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240103

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240103

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240103

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20241007

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240103

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20240516

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20240103

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20240531

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20240516

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20240516

U20 Renewal fee for the european patent with unitary effect paid

Year of fee payment: 7

Effective date: 20250522

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20190516

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20190516