EP3821230C0 - System zur analyse einer flüssigkeitsprobe - Google Patents

System zur analyse einer flüssigkeitsprobe

Info

Publication number
EP3821230C0
EP3821230C0 EP19742473.2A EP19742473A EP3821230C0 EP 3821230 C0 EP3821230 C0 EP 3821230C0 EP 19742473 A EP19742473 A EP 19742473A EP 3821230 C0 EP3821230 C0 EP 3821230C0
Authority
EP
European Patent Office
Prior art keywords
analysis
liquid sample
sample
liquid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP19742473.2A
Other languages
English (en)
French (fr)
Other versions
EP3821230A1 (de
EP3821230B1 (de
Inventor
Gregor Liebsch
Daniela Obermaier
Robert J Meier
Achim Stangelmayer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Presens Precision Sensing GmbH
Original Assignee
Presens Precision Sensing GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Presens Precision Sensing GmbH filed Critical Presens Precision Sensing GmbH
Publication of EP3821230A1 publication Critical patent/EP3821230A1/de
Application granted granted Critical
Publication of EP3821230B1 publication Critical patent/EP3821230B1/de
Publication of EP3821230C0 publication Critical patent/EP3821230C0/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14Process control and prevention of errors
    • B01L2200/141Preventing contamination, tampering
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14Process control and prevention of errors
    • B01L2200/148Specific details about calibrations
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/06Auxiliary integrated devices, integrated components
    • B01L2300/0627Sensor or part of a sensor is integrated
    • B01L2300/0654Lenses; Optical fibres
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6434Optrodes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N2021/6482Sample cells, cuvettes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N2021/6484Optical fibres
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6408Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6445Measuring fluorescence polarisation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
EP19742473.2A 2018-07-09 2019-05-31 System zur analyse einer flüssigkeitsprobe Active EP3821230B1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18182520 2018-07-09
PCT/IB2019/054521 WO2020012263A1 (en) 2018-07-09 2019-05-31 System for analysis of a fluid sample

Publications (3)

Publication Number Publication Date
EP3821230A1 EP3821230A1 (de) 2021-05-19
EP3821230B1 EP3821230B1 (de) 2024-03-27
EP3821230C0 true EP3821230C0 (de) 2024-03-27

Family

ID=67390105

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19742473.2A Active EP3821230B1 (de) 2018-07-09 2019-05-31 System zur analyse einer flüssigkeitsprobe

Country Status (3)

Country Link
US (1) US12005444B2 (de)
EP (1) EP3821230B1 (de)
WO (1) WO2020012263A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4187230A1 (de) * 2021-11-26 2023-05-31 ICHORtec GmbH Sensorgefäss zur optischen detektion von biomarkern
CN114527296A (zh) * 2022-03-02 2022-05-24 天津工业大学 原位监测微通道中流体状态的新型光纤光栅探头
DE102022002116B4 (de) 2022-06-13 2024-01-25 aquila biolabs GmbH Verfahren und Vorrichtung zur Überwachung des Inhalts durchmischter Reaktoren
US20240287435A1 (en) 2022-06-13 2024-08-29 aquila biolabs GmbH Method and device for monitoring the contents of mixed reactors
DE102023111143A1 (de) 2023-04-28 2024-10-31 aquila biolabs GmbH Verfahren und vorrichtung zur überwachung des inhalts durchmischter reaktoren

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005083423A2 (en) * 2004-02-27 2005-09-09 Board Of Regents, The University Of Texas System System and method for integrating fluids and reagents in self-contained cartridges containing particle and membrane sensor elements
EP2006020B1 (de) * 2007-06-15 2011-09-28 Hamilton Bonaduz AG Probenbehandlungsanordnung für eine Flüssigkeitsdosiervorrichtung
EP2486399A2 (de) * 2009-10-08 2012-08-15 GE Healthcare UK Limited Hochdruckflüssigchromatografiemodul mit mehreren strömen
WO2011120169A1 (en) 2010-03-31 2011-10-06 The Governing Council Of The University Of Toronto Microfluidic device and system with optical evanescent coupling element
CA2803632A1 (en) * 2010-06-30 2012-01-05 Anpac Bio-Medical Science Co., Ltd. Detection of a response to a signal applied to a biological subject
US8654323B2 (en) * 2010-09-27 2014-02-18 Arkray, Inc. Analyzing apparatus
DE102010061182B4 (de) 2010-12-13 2013-02-07 Presens Precision Sensing Gmbh Sensoranordnung, Verfahren und Messsystem zur Erfassung der Verteilung wenigstens einer Veränderlichen eines Objekts
DE102011050389B4 (de) * 2011-05-16 2021-09-02 Presens - Precision Sensing Gmbh Sensoreinheit und Messverfahren
DE102011055272B4 (de) 2011-11-11 2021-08-12 Presens Precision Sensing Gmbh Verfahren zur Bestimmung eines relaxationszeitabhängigen Parameters zu einem System
DE102013108659B3 (de) 2013-08-09 2014-07-03 Presens - Precision Sensing Gmbh Optischer Sensor und Messanordnung zum quantitativen Nachweis eines Analyten in einer Probe
DE102013109010B4 (de) 2013-08-21 2019-03-14 Presens - Precision Sensing Gmbh Verfahren zur Bestimmung einer Veränderlichen einer Probe
DE102014107837B4 (de) 2014-06-04 2021-09-02 Presens Precision Sensing Gmbh Optischer Sensor zum quantitativen Nachweis eines Analyten in einer Probe und Verfahren zur Herstellung des Sensors
US20160161705A1 (en) * 2014-12-04 2016-06-09 Marqmetrix, Inc. Removable optical assembly
EP3199240A1 (de) * 2016-01-26 2017-08-02 ThinXXS Microtechnology AG Mikrofluidische flusszelle mit integrierter elektrode und verfahren zu ihrer herstellung
EP3485249A4 (de) * 2016-08-03 2020-01-22 Ezmems Ltd. Fluidische mikroelektromechanische sensoren/vorrichtungen und herstellungsverfahren dafür
DE102018105174B4 (de) * 2018-03-07 2020-03-12 Presens Precision Sensing Gmbh Analyseeinheit

Also Published As

Publication number Publication date
US20210178391A1 (en) 2021-06-17
US12005444B2 (en) 2024-06-11
WO2020012263A1 (en) 2020-01-16
EP3821230A1 (de) 2021-05-19
EP3821230B1 (de) 2024-03-27

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