EP3976038A4 - Heterocyclische verbindungen als prmt5-inhibitoren - Google Patents

Heterocyclische verbindungen als prmt5-inhibitoren Download PDF

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Publication number
EP3976038A4
EP3976038A4 EP20814821.3A EP20814821A EP3976038A4 EP 3976038 A4 EP3976038 A4 EP 3976038A4 EP 20814821 A EP20814821 A EP 20814821A EP 3976038 A4 EP3976038 A4 EP 3976038A4
Authority
EP
European Patent Office
Prior art keywords
heterocyclic compounds
prmt5 inhibitors
prmt5
inhibitors
heterocyclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20814821.3A
Other languages
English (en)
French (fr)
Other versions
EP3976038A1 (de
Inventor
Wen-Lian Wu
Zhiqiang Yang
Francis Lee
John Qiang TAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Angex Pharmaceutical Inc
Original Assignee
Angex Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angex Pharmaceutical Inc filed Critical Angex Pharmaceutical Inc
Publication of EP3976038A1 publication Critical patent/EP3976038A1/de
Publication of EP3976038A4 publication Critical patent/EP3976038A4/de
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
EP20814821.3A 2019-05-30 2020-05-27 Heterocyclische verbindungen als prmt5-inhibitoren Withdrawn EP3976038A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962854435P 2019-05-30 2019-05-30
US202062966337P 2020-01-27 2020-01-27
PCT/US2020/034711 WO2020243178A1 (en) 2019-05-30 2020-05-27 Heterocyclic compounds as prmt5 inhibitors

Publications (2)

Publication Number Publication Date
EP3976038A1 EP3976038A1 (de) 2022-04-06
EP3976038A4 true EP3976038A4 (de) 2023-07-12

Family

ID=73553050

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20814821.3A Withdrawn EP3976038A4 (de) 2019-05-30 2020-05-27 Heterocyclische verbindungen als prmt5-inhibitoren

Country Status (7)

Country Link
EP (1) EP3976038A4 (de)
JP (1) JP2022534998A (de)
KR (1) KR20220016194A (de)
CN (1) CN114126614A (de)
AU (1) AU2020283505A1 (de)
CA (1) CA3141855A1 (de)
WO (1) WO2020243178A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024032572A1 (zh) * 2022-08-09 2024-02-15 上海湃隆生物科技有限公司 新型prmt5抑制剂及其应用
CN118103373A (zh) * 2023-01-18 2024-05-28 上海德琪医药科技有限公司 Prmt5抑制化合物和其用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017212385A1 (en) * 2016-06-06 2017-12-14 Pfizer Inc. Substituted carbonucleoside derivatives useful as anticancer agents
WO2019112719A1 (en) * 2017-12-05 2019-06-13 Angex Pharmaceutical, Inc. Heterocyclic compounds as prmt5 inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI870767B (zh) * 2015-08-26 2025-01-21 比利時商健生藥品公司 使用作為prmt5抑制劑之新穎經6-6雙環芳香環取代之核苷類似物
WO2018065365A1 (en) * 2016-10-03 2018-04-12 Janssen Pharmaceutica Nv Novel monocyclic and bicyclic ring system substituted carbanucleoside analogues for use as prmt5 inhibitors
US11220524B2 (en) * 2017-02-20 2022-01-11 Prelude Therapeutics Incorporated Selective inhibitors of protein arginine methyltransferase 5 (PRMT5)
EP3939986A1 (de) * 2017-08-09 2022-01-19 Prelude Therapeutics, Incorporated Selektive inhibitoren der protein-arginin-methyltransferase 5 (prmt5)
SMT202200396T1 (it) * 2017-12-13 2022-11-18 Lupin Ltd Composti eterociclici biciclici sostituiti come inibitori di prmt5
US12173026B2 (en) * 2018-08-07 2024-12-24 Merck Sharp & Dohme Llc PRMT5 inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017212385A1 (en) * 2016-06-06 2017-12-14 Pfizer Inc. Substituted carbonucleoside derivatives useful as anticancer agents
WO2019112719A1 (en) * 2017-12-05 2019-06-13 Angex Pharmaceutical, Inc. Heterocyclic compounds as prmt5 inhibitors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RUIFENG MAO ET AL: "Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 14, 26 June 2017 (2017-06-26), US, pages 6289 - 6304, XP055682728, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b00587 *
See also references of WO2020243178A1 *

Also Published As

Publication number Publication date
CN114126614A (zh) 2022-03-01
AU2020283505A1 (en) 2021-12-23
EP3976038A1 (de) 2022-04-06
JP2022534998A (ja) 2022-08-04
WO2020243178A1 (en) 2020-12-03
KR20220016194A (ko) 2022-02-08
CA3141855A1 (en) 2020-12-03

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