EP3980524A4 - CELL LINES FOR THE PRODUCTION OF HIGH-LEVEL PROTEIN-BASED PHARMACEUTICALS - Google Patents

CELL LINES FOR THE PRODUCTION OF HIGH-LEVEL PROTEIN-BASED PHARMACEUTICALS Download PDF

Info

Publication number
EP3980524A4
EP3980524A4 EP19933147.1A EP19933147A EP3980524A4 EP 3980524 A4 EP3980524 A4 EP 3980524A4 EP 19933147 A EP19933147 A EP 19933147A EP 3980524 A4 EP3980524 A4 EP 3980524A4
Authority
EP
European Patent Office
Prior art keywords
production
cell lines
level protein
based pharmaceuticals
pharmaceuticals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19933147.1A
Other languages
German (de)
French (fr)
Other versions
EP3980524A1 (en
Inventor
Lawrence Forman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHO Plus Inc
Original Assignee
CHO Plus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHO Plus Inc filed Critical CHO Plus Inc
Publication of EP3980524A1 publication Critical patent/EP3980524A1/en
Publication of EP3980524A4 publication Critical patent/EP3980524A4/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
EP19933147.1A 2019-06-10 2019-06-10 CELL LINES FOR THE PRODUCTION OF HIGH-LEVEL PROTEIN-BASED PHARMACEUTICALS Pending EP3980524A4 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2019/036379 WO2020251537A1 (en) 2019-06-10 2019-06-10 Cell lines for high level production of protein-based pharmaceuticals

Publications (2)

Publication Number Publication Date
EP3980524A1 EP3980524A1 (en) 2022-04-13
EP3980524A4 true EP3980524A4 (en) 2023-01-11

Family

ID=73780999

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19933147.1A Pending EP3980524A4 (en) 2019-06-10 2019-06-10 CELL LINES FOR THE PRODUCTION OF HIGH-LEVEL PROTEIN-BASED PHARMACEUTICALS

Country Status (9)

Country Link
EP (1) EP3980524A4 (en)
JP (2) JP2022543522A (en)
KR (1) KR102648479B1 (en)
CN (1) CN114096659A (en)
AU (1) AU2019450349B2 (en)
BR (1) BR112021024923A2 (en)
IL (1) IL288877B2 (en)
WO (1) WO2020251537A1 (en)
ZA (1) ZA202200397B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023239928A1 (en) 2022-06-09 2023-12-14 CHO Plus Inc. Cell hybrids as host cells for high efficiency production of gene therapy vectors and viral vaccines
WO2025128096A1 (en) * 2023-12-13 2025-06-19 CHO Plus Inc. High production of recombinant protein by making cell hybrids and enriching for a preferred mitochondrial phenotype

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120015841A1 (en) * 2009-02-02 2012-01-19 Chromocell Corporation Novel cell lines and methods

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912040A (en) * 1986-11-14 1990-03-27 Genetics Institute, Inc. Eucaryotic expression system
US6136599A (en) * 1998-12-10 2000-10-24 Bayer Corporation Human hybrid host cell for mammalian gene expression
DK1196566T3 (en) * 1999-07-12 2006-06-06 Genentech Inc Expression vectors and methods
US7033781B1 (en) * 1999-09-29 2006-04-25 Diversa Corporation Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
WO2006027202A1 (en) * 2004-09-06 2006-03-16 Unite De Recherche En Biotherapie Et Oncologie (Rubio) Generation of multiparent cell hybrids
US7351582B2 (en) * 2005-06-17 2008-04-01 Avigenics, Inc. Cell lines
WO2009103753A1 (en) * 2008-02-20 2009-08-27 Ablynx Nv Methods for identifying and/or sorting cells by secreted molecule and kits for performing such methods
SG176302A1 (en) * 2009-06-10 2012-01-30 Bts Res Internat Pty Ltd Methods of generating hybrid/chimeric cells, and uses thereof
BR112016017606A2 (en) * 2014-01-29 2017-10-10 Amgen Inc overexpression of n-glycosylation pathway regulators to modulate recombinant protein glycosylation
US10329594B1 (en) * 2015-09-03 2019-06-25 CHO Plus, Inc. Cell lines for high level production of protein-based pharmaceuticals
US12054733B2 (en) * 2017-06-16 2024-08-06 Lonza Ltd Universal self-regulating mammalian cell line platform for the production of biologics

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120015841A1 (en) * 2009-02-02 2012-01-19 Chromocell Corporation Novel cell lines and methods

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DORNER ANDREW J. ET AL: "The Levels of Endoplasmic Reticulum Proteins and ATP Affect Folding and Secretion of Selective Proteins", BIOLOGICALS, 1 January 1994 (1994-01-01), pages 103 - 112, XP093003660, Retrieved from the Internet <URL:https://reader.elsevier.com/reader/sd/pii/S1045105684710165?token=069F25DB2642E2D12088208A58559271B0E6DB7AA135D27F0D1CEB4132C546674B48627BE3FB27EA3E8A11B57B75D245&originRegion=eu-west-1&originCreation=20221130141652> [retrieved on 20221130] *
KRISTINE SCHAUER ET AL: "Probabilistic density maps to study global endomembrane organization", NATURE METHODS, vol. 7, no. 7, 1 July 2010 (2010-07-01), pages 560 - 566, XP055011171, ISSN: 1548-7091, DOI: 10.1038/nmeth.1462 *
See also references of WO2020251537A1 *

Also Published As

Publication number Publication date
ZA202200397B (en) 2025-06-25
IL288877A (en) 2022-07-01
JP2024091682A (en) 2024-07-05
KR102648479B1 (en) 2024-03-15
KR20220024478A (en) 2022-03-03
IL288877B1 (en) 2024-01-01
JP2022543522A (en) 2022-10-13
CA3143154A1 (en) 2020-12-17
CN114096659A (en) 2022-02-25
AU2019450349A1 (en) 2022-01-27
IL288877B2 (en) 2024-05-01
WO2020251537A1 (en) 2020-12-17
BR112021024923A2 (en) 2022-02-15
AU2019450349B2 (en) 2022-05-26
EP3980524A1 (en) 2022-04-13

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Ipc: C12N 15/85 20060101ALI20221207BHEP

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