EP3980524A4 - Lignées cellulaires pour la production de haut niveau de produits pharmaceutiques à base de protéines - Google Patents

Lignées cellulaires pour la production de haut niveau de produits pharmaceutiques à base de protéines Download PDF

Info

Publication number: EP3980524A4
Authority: EP; European Patent Office
Prior art keywords: production; cell lines; level protein; based pharmaceuticals; pharmaceuticals
Prior art date: 2019-06-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP19933147.1A

Other languages

German (de)

English (en)

Other versions

EP3980524A1 (fr

Inventor

Lawrence Forman

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

CHO Plus Inc

Original Assignee

CHO Plus Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2019-06-10

Filing date

2019-06-10

Publication date

2023-01-11

2019-06-10 Application filed by CHO Plus Inc filed Critical CHO Plus Inc

2022-04-13 Publication of EP3980524A1 publication Critical patent/EP3980524A1/fr

2023-01-11 Publication of EP3980524A4 publication Critical patent/EP3980524A4/fr

Status Pending legal-status Critical Current

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

EP19933147.1A 2019-06-10 2019-06-10 Lignées cellulaires pour la production de haut niveau de produits pharmaceutiques à base de protéines Pending EP3980524A4 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2019/036379 WO2020251537A1 (fr)	2019-06-10	2019-06-10	Lignées cellulaires pour la production de haut niveau de produits pharmaceutiques à base de protéines

Publications (2)

Publication Number	Publication Date
EP3980524A1 EP3980524A1 (fr)	2022-04-13
EP3980524A4 true EP3980524A4 (fr)	2023-01-11

Family

ID=73780999

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP19933147.1A Pending EP3980524A4 (fr)	2019-06-10	2019-06-10	Lignées cellulaires pour la production de haut niveau de produits pharmaceutiques à base de protéines

Country Status (9)

Country	Link
EP (1)	EP3980524A4 (fr)
JP (2)	JP2022543522A (fr)
KR (1)	KR102648479B1 (fr)
CN (1)	CN114096659A (fr)
AU (1)	AU2019450349B2 (fr)
BR (1)	BR112021024923A2 (fr)
IL (1)	IL288877B2 (fr)
WO (1)	WO2020251537A1 (fr)
ZA (1)	ZA202200397B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2023239928A1 (fr)	2022-06-09	2023-12-14	CHO Plus Inc.	Hybrides cellulaires comme cellules hôtes pour la production à haut rendement de vecteurs de thérapie génique et de vaccins viraux
WO2025128096A1 (fr) *	2023-12-13	2025-06-19	CHO Plus Inc.	Production élevée de protéines recombinées par la production d'hybrides cellulaires et l'enrichissement pour un phénotype mitochondrial préféré

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20120015841A1 (en) *	2009-02-02	2012-01-19	Chromocell Corporation	Novel cell lines and methods

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4912040A (en) *	1986-11-14	1990-03-27	Genetics Institute, Inc.	Eucaryotic expression system
US6136599A (en) *	1998-12-10	2000-10-24	Bayer Corporation	Human hybrid host cell for mammalian gene expression
DK1196566T3 (da) *	1999-07-12	2006-06-06	Genentech Inc	Ekspressionsvektorer og -metoder
US7033781B1 (en) *	1999-09-29	2006-04-25	Diversa Corporation	Whole cell engineering by mutagenizing a substantial portion of a starting genome, combining mutations, and optionally repeating
WO2006027202A1 (fr) *	2004-09-06	2006-03-16	Unite De Recherche En Biotherapie Et Oncologie (Rubio)	Generation d'hybrides de cellules a parents multiples
US7351582B2 (en) *	2005-06-17	2008-04-01	Avigenics, Inc.	Cell lines
WO2009103753A1 (fr) *	2008-02-20	2009-08-27	Ablynx Nv	Procédés d'identification et/ou de tri de cellules par molécule sécrétée et coffrets pour la mise en œuvre de tels procédés
SG176302A1 (en) *	2009-06-10	2012-01-30	Bts Res Internat Pty Ltd	Methods of generating hybrid/chimeric cells, and uses thereof
BR112016017606A2 (pt) *	2014-01-29	2017-10-10	Amgen Inc	superexpressão de reguladores de via de n-glicosilação para modular a glicosilação de proteínas recombinantes
US10329594B1 (en) *	2015-09-03	2019-06-25	CHO Plus, Inc.	Cell lines for high level production of protein-based pharmaceuticals
US12054733B2 (en) *	2017-06-16	2024-08-06	Lonza Ltd	Universal self-regulating mammalian cell line platform for the production of biologics

2019
- 2019-06-10 KR KR1020227000886A patent/KR102648479B1/ko active Active
- 2019-06-10 EP EP19933147.1A patent/EP3980524A4/fr active Pending
- 2019-06-10 WO PCT/US2019/036379 patent/WO2020251537A1/fr not_active Ceased
- 2019-06-10 CN CN201980097383.XA patent/CN114096659A/zh active Pending
- 2019-06-10 JP JP2021573362A patent/JP2022543522A/ja active Pending
- 2019-06-10 BR BR112021024923A patent/BR112021024923A2/pt unknown
- 2019-06-10 IL IL288877A patent/IL288877B2/en unknown
- 2019-06-10 AU AU2019450349A patent/AU2019450349B2/en active Active
2022
- 2022-01-07 ZA ZA2022/00397A patent/ZA202200397B/en unknown
2024
- 2024-04-05 JP JP2024061743A patent/JP2024091682A/ja active Pending

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20120015841A1 (en) *	2009-02-02	2012-01-19	Chromocell Corporation	Novel cell lines and methods

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DORNER ANDREW J. ET AL: "The Levels of Endoplasmic Reticulum Proteins and ATP Affect Folding and Secretion of Selective Proteins", BIOLOGICALS, 1 January 1994 (1994-01-01), pages 103 - 112, XP093003660, Retrieved from the Internet <URL:https://reader.elsevier.com/reader/sd/pii/S1045105684710165?token=069F25DB2642E2D12088208A58559271B0E6DB7AA135D27F0D1CEB4132C546674B48627BE3FB27EA3E8A11B57B75D245&originRegion=eu-west-1&originCreation=20221130141652> [retrieved on 20221130] *
KRISTINE SCHAUER ET AL: "Probabilistic density maps to study global endomembrane organization", NATURE METHODS, vol. 7, no. 7, 1 July 2010 (2010-07-01), pages 560 - 566, XP055011171, ISSN: 1548-7091, DOI: 10.1038/nmeth.1462 *
See also references of WO2020251537A1 *

Also Published As

Publication number	Publication date
ZA202200397B (en)	2025-06-25
IL288877A (en)	2022-07-01
JP2024091682A (ja)	2024-07-05
KR102648479B1 (ko)	2024-03-15
KR20220024478A (ko)	2022-03-03
IL288877B1 (en)	2024-01-01
JP2022543522A (ja)	2022-10-13
CA3143154A1 (fr)	2020-12-17
CN114096659A (zh)	2022-02-25
AU2019450349A1 (en)	2022-01-27
IL288877B2 (en)	2024-05-01
WO2020251537A1 (fr)	2020-12-17
BR112021024923A2 (pt)	2022-02-15
AU2019450349B2 (en)	2022-05-26
EP3980524A1 (fr)	2022-04-13

Legal Events

Date	Code	Title	Description
2020-12-18	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2022-03-11	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2022-03-11	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2022-04-13	17P	Request for examination filed	Effective date: 20220110
2022-04-13	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2022-09-14	DAV	Request for validation of the european patent (deleted)
2022-09-14	DAX	Request for extension of the european patent (deleted)
2023-01-11	A4	Supplementary search report drawn up and despatched	Effective date: 20221213
2023-01-11	RIC1	Information provided on ipc code assigned before grant	Ipc: C12N 15/85 20060101ALI20221207BHEP Ipc: C12N 5/16 20060101ALI20221207BHEP Ipc: C12N 5/00 20060101AFI20221207BHEP

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