EP4103168A4 - Verfahren zur herstellung von gamma-aminobuttersäuren und deren analogen - Google Patents
Verfahren zur herstellung von gamma-aminobuttersäuren und deren analogen Download PDFInfo
- Publication number
- EP4103168A4 EP4103168A4 EP21753915.4A EP21753915A EP4103168A4 EP 4103168 A4 EP4103168 A4 EP 4103168A4 EP 21753915 A EP21753915 A EP 21753915A EP 4103168 A4 EP4103168 A4 EP 4103168A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- aminobutry
- analogues
- gamma
- acids
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
- C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C67/347—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to unsaturated carbon-to-carbon bonds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN202011006475 | 2020-02-14 | ||
| PCT/IN2021/050141 WO2021161346A1 (en) | 2020-02-14 | 2021-02-13 | Process for the preparation of gamma amino butyric acids and analogs thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP4103168A1 EP4103168A1 (de) | 2022-12-21 |
| EP4103168A4 true EP4103168A4 (de) | 2024-04-24 |
Family
ID=77293016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP21753915.4A Pending EP4103168A4 (de) | 2020-02-14 | 2021-02-13 | Verfahren zur herstellung von gamma-aminobuttersäuren und deren analogen |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP4103168A4 (de) |
| JP (1) | JP7436689B2 (de) |
| WO (1) | WO2021161346A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116655482B (zh) * | 2023-06-05 | 2024-06-04 | 贵州大学 | 一类γ-氨基丁酸衍生物的制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5072023A (en) * | 1990-02-15 | 1991-12-10 | E. R. Squibb & Sons, Inc. | Process for preparing highly substituted phenyls |
| US6197819B1 (en) | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
| US5616793A (en) | 1995-06-02 | 1997-04-01 | Warner-Lambert Company | Methods of making (S)-3-(aminomethyl)-5-methylhexanoic acid |
| JP2002241358A (ja) | 2001-02-15 | 2002-08-28 | Nippon Soda Co Ltd | オキシム基を有する化合物及び殺虫・殺ダニ剤 |
| JP4250887B2 (ja) | 2001-10-22 | 2009-04-08 | 三菱化学株式会社 | アミド化合物の製造方法 |
| JP4562370B2 (ja) | 2003-10-02 | 2010-10-13 | 独立行政法人科学技術振興機構 | 転位不飽和化合物の製造方法 |
| AP2466A (en) | 2004-06-21 | 2012-09-17 | Warner Lambert Co | Preparation of pregabalin and related compounds |
| WO2006110783A2 (en) | 2005-04-11 | 2006-10-19 | Teva Pharmaceutical Industries Ltd. | Process for making (s)-pregabalin |
| US8293926B2 (en) | 2005-12-09 | 2012-10-23 | Sumitomo Chemical Company, Limited | Method of producing optically active 4-amino-3-substituted phenylbutanoic acid |
| WO2008062460A2 (en) * | 2006-10-06 | 2008-05-29 | Cadila Healthcare Limited | Crystalline forms of pregabalin |
| KR20090101462A (ko) | 2007-10-03 | 2009-09-28 | 테바 파마슈티컬 인더스트리즈 리미티드 | 프레가발린-4-엘리미네이트, 프레가발린 5-엘리미네이트, 기준 마커 및 표준물로서의 이들의 용도, 및 이들을 낮은 수준으로 함유하는 프레가발린의 제조 방법 |
| US20110144383A1 (en) | 2008-02-18 | 2011-06-16 | Matrix Laboratories Limited | Process for preparing (s)-3-(aminomethyl)-5-methylhexanoic acid |
| KR20110025917A (ko) * | 2008-05-21 | 2011-03-14 | 산도즈 아게 | ５－메틸－３－니트로메틸－헥산산 에스테르의 입체선택적 효소 가수분해 방법 |
| WO2010061403A2 (en) | 2008-11-26 | 2010-06-03 | Ind-Swift Laboratories Limited | Process to prepare highly pure (s)-pregabalin |
| WO2012093411A2 (en) | 2011-01-07 | 2012-07-12 | Dr Braja Sundar Pradhan | Process for the preparation of r-(-)-3- (carbamoylmethyl)-5-methylhexanoic acid and the intermediates |
| EP2916832B1 (de) * | 2012-11-07 | 2019-01-16 | Hikal Limited | Verfahren zur herstellung von pregabalin |
| WO2014181359A1 (en) | 2013-05-09 | 2014-11-13 | Council Of Scientific & Industrial Research | A process for the preparation of an anticonvulsant agent pregabalin hydrochloride |
| CN103833562B (zh) | 2013-12-04 | 2015-08-12 | 惠州市莱佛士制药技术有限公司 | 一种不对称合成普瑞巴林的制备方法 |
| JP6724283B2 (ja) | 2016-03-09 | 2020-07-15 | 国立大学法人 東京大学 | 光学活性の４−ニトロブタン酸エステル及びプレガバリンの製造方法 |
-
2021
- 2021-02-13 EP EP21753915.4A patent/EP4103168A4/de active Pending
- 2021-02-13 WO PCT/IN2021/050141 patent/WO2021161346A1/en not_active Ceased
- 2021-02-13 JP JP2022548730A patent/JP7436689B2/ja active Active
Non-Patent Citations (1)
| Title |
|---|
| H. ISHITANI, ET AL.: "Synthesis of (+/- )-pregabalin by utilising a three-step sequential-flow system with heterogeneous catalysts", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2017, no. 44, 10 October 2017 (2017-10-10), Wiley-VCH Verlag, Weinheim, DE, pages 6491 - 6494, XP072119280, ISSN: 1434-193X, DOI: 10.1002/ejoc.201700998 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP7436689B2 (ja) | 2024-02-22 |
| EP4103168A1 (de) | 2022-12-21 |
| JP2023513330A (ja) | 2023-03-30 |
| WO2021161346A1 (en) | 2021-08-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP4146249A4 (de) | Verbessertes verfahren zur herstellung von semaglutid | |
| EP4139250A4 (de) | Verfahren zur herstellung von iodosilanen und zusammensetzungen daraus | |
| EP4200311A4 (de) | Verfahren zur herstellung von cholsäurederivaten und ausgangsprodukte dafür | |
| EP4526302A4 (de) | Verfahren zur herstellung von feinenon und zwischenprodukten davon | |
| EP4380932C0 (de) | Verfahren zur herstellung von aficampten | |
| EP4328221A4 (de) | Verfahren zur herstellung von l-nikotin | |
| EP4230634C0 (de) | Verfahren zur herstellung von glufosinat-ammonium | |
| EP4433058A4 (de) | Verbessertes verfahren zur herstellung von lorbinectedin und dessen morphs | |
| EP4370491A4 (de) | Integriertes verfahren zur herstellung von trifluoriodmethan | |
| EP4387961A4 (de) | Verfahren zur herstellung von histondemethylasehemmern | |
| EP4134381A4 (de) | Verfahren zur herstellung von düngemitteln | |
| EP4365223A4 (de) | Verfahren zur herstellung von polytetrafluorethylenpartikeln | |
| EP4239070A4 (de) | Verfahren zur herstellung von l-aminosäure | |
| EP4249459A4 (de) | Verfahren zur herstellung von ungesättigtem chlorfluorkohlenwasserstoff und zusammensetzung | |
| EP4217503A4 (de) | Verfahren zur herstellung von semaglutid und semapeptid | |
| EP4257661C0 (de) | Verfahren zur herstellung von aktivkohle | |
| EP4323362C0 (de) | Verfahren zur herstellung von carbanukleosiden mit amiden | |
| EP4140992C0 (de) | Verfahren zur herstellung von s-nikotin | |
| EP4110747C0 (de) | Verfahren zur effizienten herstellung von (bio)-alkandiolen | |
| EP4241841A4 (de) | Verfahren zur herstellung von polyethylenglykolmodifizierter uratoxidase | |
| EP4514392A4 (de) | Verfahren zur herstellung von imeglimin und salzen davon | |
| EP4410562A4 (de) | Verfahren zur herstellung von drucksachen | |
| EP4439589A4 (de) | System zur herstellung von radionukliden und verfahren zur herstellung von radionukliden | |
| EP4455079A4 (de) | Ammoxidationsreaktor und verfahren zur herstellung von salpetersäure | |
| EP4175937A4 (de) | Verfahren zur herstellung von vanillin und anderen substituierten phenylaldehyden |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
| 17P | Request for examination filed |
Effective date: 20220801 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
| DAV | Request for validation of the european patent (deleted) | ||
| DAX | Request for extension of the european patent (deleted) | ||
| P01 | Opt-out of the competence of the unified patent court (upc) registered |
Effective date: 20230626 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R079 Free format text: PREVIOUS MAIN CLASS: A61K0031197000 Ipc: C07C0227200000 |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20240321 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07C 251/38 20060101ALI20240315BHEP Ipc: C07C 249/08 20060101ALI20240315BHEP Ipc: C07C 233/47 20060101ALI20240315BHEP Ipc: C07C 231/00 20060101ALI20240315BHEP Ipc: C07C 69/716 20060101ALI20240315BHEP Ipc: C07C 67/347 20060101ALI20240315BHEP Ipc: C07C 229/08 20060101ALI20240315BHEP Ipc: C07C 227/20 20060101AFI20240315BHEP |