EP4161548A4 - EXTRACTION OF PSYCHOACTIVE COMPOUNDS FROM PSYCHEDELIC MUSHROOMS - Google Patents

EXTRACTION OF PSYCHOACTIVE COMPOUNDS FROM PSYCHEDELIC MUSHROOMS Download PDF

Info

Publication number: EP4161548A4
Authority: EP; European Patent Office
Prior art keywords: psychedelic; mushrooms; extraction; psychoactive compounds; psychoactive
Prior art date: 2020-06-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP21827107.0A

Other languages

German (de)

French (fr)

Other versions

EP4161548A1 (en

Inventor

Benjamin Lightburn

Ryan Moss

Lisa Ranken

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Psilo Scientific Ltd

Original Assignee

Psilo Scientific Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2020-06-17

Filing date

2021-06-16

Publication date

2024-04-24

2021-06-16 Application filed by Psilo Scientific Ltd filed Critical Psilo Scientific Ltd

2021-06-16 Priority to EP24152237.4A priority Critical patent/EP4339200A3/en

2021-06-16 Priority to EP24165048.0A priority patent/EP4372094A3/en

2023-04-12 Publication of EP4161548A1 publication Critical patent/EP4161548A1/en

2024-04-24 Publication of EP4161548A4 publication Critical patent/EP4161548A4/en

Status Pending legal-status Critical Current

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/078—Psilocybe
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0215—Solid material in other stationary receptacles
- B01D11/0253—Fluidised bed of solid materials
- B01D11/0257—Fluidised bed of solid materials using mixing mechanisms, e.g. stirrers, jets
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/028—Flow sheets
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D11/00—Solvent extraction
- B01D11/02—Solvent extraction of solids
- B01D11/0288—Applications, solvents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Natural Medicines & Medicinal Plants (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Mycology (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Alternative & Traditional Medicine (AREA)
Zoology (AREA)
Botany (AREA)
Bioinformatics & Cheminformatics (AREA)
Medical Informatics (AREA)
Wood Science & Technology (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Medicines Containing Plant Substances (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

EP21827107.0A 2020-06-17 2021-06-16 EXTRACTION OF PSYCHOACTIVE COMPOUNDS FROM PSYCHEDELIC MUSHROOMS Pending EP4161548A4 (en)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
EP24152237.4A EP4339200A3 (en)	2020-06-17	2021-06-16	Ethanol extraction of psychoactive compounds from psilocybin fungus
EP24165048.0A EP4372094A3 (en)	2020-06-17	2021-06-16	Aqueous extraction of psychoactive compounds from psilocybin fungus

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US202063040317P	2020-06-17	2020-06-17
US202063046089P	2020-06-30	2020-06-30
CA3088384A CA3088384C (en)	2020-06-17	2020-07-29	Extraction of psychoactive compounds from psilocybin fungus
CA3089455A CA3089455C (en)	2020-06-17	2020-08-07	Methanol-based extraction of psychoactive compounds from fungus
PCT/CA2021/050822 WO2021253123A1 (en)	2020-06-17	2021-06-16	Extraction of psychoactive compounds from psychedelic fungus

Related Child Applications (3)

Application Number	Title	Priority Date	Filing Date
EP24165048.0A Division EP4372094A3 (en)	2020-06-17	2021-06-16	Aqueous extraction of psychoactive compounds from psilocybin fungus
EP24152237.4A Division EP4339200A3 (en)	2020-06-17	2021-06-16	Ethanol extraction of psychoactive compounds from psilocybin fungus
EP24152237.4A Division-Into EP4339200A3 (en)	2020-06-17	2021-06-16	Ethanol extraction of psychoactive compounds from psilocybin fungus

Publications (2)

Publication Number	Publication Date
EP4161548A1 EP4161548A1 (en)	2023-04-12
EP4161548A4 true EP4161548A4 (en)	2024-04-24

Family

ID=72895839

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
EP24152237.4A Pending EP4339200A3 (en)	2020-06-17	2021-06-16	Ethanol extraction of psychoactive compounds from psilocybin fungus
EP21827107.0A Pending EP4161548A4 (en)	2020-06-17	2021-06-16	EXTRACTION OF PSYCHOACTIVE COMPOUNDS FROM PSYCHEDELIC MUSHROOMS
EP24165048.0A Withdrawn EP4372094A3 (en)	2020-06-17	2021-06-16	Aqueous extraction of psychoactive compounds from psilocybin fungus

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
EP24152237.4A Pending EP4339200A3 (en)	2020-06-17	2021-06-16	Ethanol extraction of psychoactive compounds from psilocybin fungus

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
EP24165048.0A Withdrawn EP4372094A3 (en)	2020-06-17	2021-06-16	Aqueous extraction of psychoactive compounds from psilocybin fungus

Country Status (6)

Country	Link
EP (3)	EP4339200A3 (en)
AU (1)	AU2021291583B2 (en)
BR (1)	BR112022025777A2 (en)
CA (6)	CA3124367C (en)
MX (1)	MX2022016531A (en)
WO (2)	WO2021253124A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN114787363A (en)	2019-10-01	2022-07-22	恩派瑞安神经科学公司	Genetic engineering of fungi to modulate tryptamine expression
KR20240096817A (en)	2020-05-19	2024-06-26	사이빈 아이알엘 리미티드	Deuterated tryptamine derivatives and methods of use
AU2021290454B2 (en)	2020-06-17	2024-01-11	Psilo Scientific Ltd	Process for Obtaining a Purified Psychoactive Alkaloid Solution
US12233355B2 (en)	2020-06-17	2025-02-25	Psilo Scientific Ltd.	Methanol-based extraction of psychoactive alkaloids from fungus
WO2022082320A1 (en) *	2020-10-23	2022-04-28	Psilo Scientific Ltd	Process for obtaining a purified psychoactive alkaloid solution
CA3113240C (en)	2020-12-28	2023-09-05	Psilo Scientific Ltd.	Transmucosal psychoactive alkaloid composition and preparation thereof
CA3127180C (en) *	2021-08-06	2024-03-05	Psilo Scientific Ltd.	Pre-evaporation standardization of extracted psychoactive compounds
GB2625237A (en) *	2021-09-17	2024-06-12	1242753 Ontario Inc	Psilocybin derived compositions and methods of using same
CA3232692A1 (en) *	2021-09-28	2023-04-06	Joseph Girardi	Chilled juice extraction processes and products using psychedelic and functional mushrooms
CA3133547C (en)	2021-10-07	2024-07-02	Psilo Scientific Ltd.	Liquid-liquid extraction of purified psychoactive alkaloid
EP4457336A4 (en)	2021-12-31	2026-01-14	Empyrean Neuroscience Inc	GENETICALLY MODIFIED ORGANISMS FOR THE PRODUCTION OF PSYCHOTROPIC ALKALOIDS
WO2023168023A1 (en)	2022-03-04	2023-09-07	Reset Pharmaceuticals, Inc.	Co-crystals or salts comprising psilocin
US12551519B2 (en)	2022-04-25	2026-02-17	VCENNA Technology & Labs Inc.	Extraction system and method for organic metabolites
WO2024159297A1 (en) *	2023-01-31	2024-08-08	Bluethera Biologics Inc.	Method of extracting a psychoactive compound from fungal biomass and formulations thereof
US12503713B1 (en)	2025-05-19	2025-12-23	Convergent Health Sciences LLC	Stabilization of tryptamines by denaturing enzymes, optimizing ionization states, and controlling confounding variables
US12497637B1 (en)	2025-05-19	2025-12-16	Convergent Health Sciences LLC	Stabilization of tryptamines by denaturing enzymes, optimizing ionization states, and controlling confounding variables

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB911946A (en) *	1958-02-21	1962-12-05	Sandoz Ltd	Psilocybin and psilocin and processes for their preparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
LU36879A1 (en)	1958-02-21
CN101292727A (en) *	2008-05-30	2008-10-29	曹晋忠	Powder preparing method for mushroom ethyl alcohol extract
GB2571696B (en) *	2017-10-09	2020-05-27	Compass Pathways Ltd	Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
WO2019099745A1 (en) *	2017-11-16	2019-05-23	CaaMTech, LLC	Compositions comprising a psilocybin derivative and a cannabinoid

2020
- 2020-07-29 CA CA3124367A patent/CA3124367C/en active Active
- 2020-07-29 CA CA3123908A patent/CA3123908C/en active Active
- 2020-07-29 CA CA3088384A patent/CA3088384C/en active Active
- 2020-08-07 CA CA3089455A patent/CA3089455C/en active Active
2021
- 2021-06-16 WO PCT/CA2021/050823 patent/WO2021253124A1/en not_active Ceased
- 2021-06-16 EP EP24152237.4A patent/EP4339200A3/en active Pending
- 2021-06-16 CA CA3161623A patent/CA3161623C/en active Active
- 2021-06-16 WO PCT/CA2021/050822 patent/WO2021253123A1/en not_active Ceased
- 2021-06-16 EP EP21827107.0A patent/EP4161548A4/en active Pending
- 2021-06-16 BR BR112022025777A patent/BR112022025777A2/en not_active Application Discontinuation
- 2021-06-16 EP EP24165048.0A patent/EP4372094A3/en not_active Withdrawn
- 2021-06-16 MX MX2022016531A patent/MX2022016531A/en unknown
- 2021-06-16 AU AU2021291583A patent/AU2021291583B2/en active Active
- 2021-06-16 CA CA3198238A patent/CA3198238C/en active Active

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB911946A (en) *	1958-02-21	1962-12-05	Sandoz Ltd	Psilocybin and psilocin and processes for their preparation

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
JANIS FRICKE ET AL: "Production Options for Psilocybin: Making of the Magic", CHEMISTRY - A EUROPEAN JOURNAL, vol. 25, no. 4, 18 January 2019 (2019-01-18), DE, pages 897 - 903, XP055766088, ISSN: 0947-6539, DOI: 10.1002/chem.201802758 *
OLUYEMISI FOLASHADE KUNLE ET AL: "Standardization of herbal medicines - A review", INTERNATIONAL JOURNAL OF BIODIVERSITY AND CONSERVATION, vol. 4, no. 3, 1 March 2012 (2012-03-01), pages 101 - 112, XP055435139, DOI: 10.5897/IJBC11.163 *
PELLEGRINI MANUELA ET AL: "Magic truffles or Philosopher's stones: a legal way to sell psilocybin?", vol. 5, no. 3, 28 February 2013 (2013-02-28), pages 182 - 185, XP009547892, ISSN: 1942-7611, Retrieved from the Internet <URL:https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fdta.1400> [retrieved on 20120809], DOI: 10.1002/DTA.1400 *
PIOTR PAWEL WIECZOREK ET AL: "Bioactive Alkaloids of Hallucinogenic Mushrooms", 30 November 2015 (2015-11-30), XP009545779, ISBN: 978-0-444-63462-7, Retrieved from the Internet <URL:https://ebookcentral.proquest.com/lib/epo-ebooks/reader.action?docID=2036175&ppg=148> [retrieved on 20150427] *
PSILOCYBIN EXERT: "Formulating New 'Magic Mushroom' compositions", INTERNET CITATION, 13 February 2018 (2018-02-13), pages 1 - 7, XP009542154, Retrieved from the Internet <URL:https://web.archive.org/web/20200704105500/https://psilocybintechnology.com/formulating-new-magic-mushroom-compositions/> [retrieved on 20230305] *
ROMAN KYSILKA ET AL: "A novel extraction procedure for psilocybin and psilocin determination in mushroom samples", PLANTA MEDICA, THIEME VERLAG, DE, vol. 56, no. 3, 30 November 1989 (1989-11-30), pages 327 - 328, XP009536241, ISSN: 0032-0943, DOI: 10.1055/S-2006-960970 *
See also references of WO2021253123A1 *
TSUJIKAWA KENJI ET AL: "Morphological and chemical analysis of magic mushrooms in Japan", vol. 138, no. 1-3, 30 November 2003 (2003-11-30), pages 85 - 90, XP009547895, ISSN: 0379-0738, Retrieved from the Internet <URL:https://api.elsevier.com/content/article/PII:S0379073803003785?httpAccept=text/plain> [retrieved on 20230919], DOI: 10.1016/J.FORSCIINT.2003.08.009 *

Also Published As

Publication number	Publication date
EP4372094A2 (en)	2024-05-22
CA3161623C (en)	2023-04-04
MX2022016531A (en)	2023-09-12
CA3198238C (en)	2025-06-10
CA3089455A1 (en)	2021-09-14
EP4339200A2 (en)	2024-03-20
WO2021253123A1 (en)	2021-12-23
CA3124367A1 (en)	2020-10-07
EP4339200A3 (en)	2024-03-27
CA3088384A1 (en)	2020-10-07
CA3123908A1 (en)	2020-10-07
EP4372094A3 (en)	2024-08-07
CA3161623A1 (en)	2021-12-23
CA3123908C (en)	2022-03-22
CA3088384C (en)	2021-08-03
AU2021291583B2 (en)	2023-12-07
BR112022025777A2 (en)	2023-01-10
WO2021253124A1 (en)	2021-12-23
CA3198238A1 (en)	2021-12-23
AU2021291583A1 (en)	2023-02-02
CA3124367C (en)	2022-04-26
CA3089455C (en)	2022-07-05
EP4161548A1 (en)	2023-04-12

Legal Events

Date	Code	Title	Description
2021-12-24	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2023-03-10	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2023-03-10	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2023-04-12	17P	Request for examination filed	Effective date: 20230106
2023-04-12	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2023-04-19	RAP3	Party data changed (applicant data changed or rights of an application transferred)	Owner name: PSILO SCIENTIFIC LTD
2023-09-20	DAV	Request for validation of the european patent (deleted)
2023-09-20	DAX	Request for extension of the european patent (deleted)
2024-04-24	A4	Supplementary search report drawn up and despatched	Effective date: 20240326
2024-04-24	RIC1	Information provided on ipc code assigned before grant	Ipc: C12P 17/10 20060101ALI20240320BHEP Ipc: A61P 25/00 20060101ALI20240320BHEP Ipc: A61K 45/06 20060101ALI20240320BHEP Ipc: C12P 17/00 20060101ALI20240320BHEP Ipc: C07F 9/572 20060101ALI20240320BHEP Ipc: C07D 209/16 20060101ALI20240320BHEP Ipc: B01D 11/02 20060101ALI20240320BHEP Ipc: A61K 31/675 20060101ALI20240320BHEP Ipc: A61K 31/4045 20060101ALI20240320BHEP Ipc: A23L 31/00 20160101ALI20240320BHEP Ipc: A61K 36/07 20060101AFI20240320BHEP
2024-11-15	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: EXAMINATION IS IN PROGRESS
2024-12-18	17Q	First examination report despatched	Effective date: 20241118

Publication	Publication Date	Title
EP4161548A4 (en)	2024-04-24	EXTRACTION OF PSYCHOACTIVE COMPOUNDS FROM PSYCHEDELIC MUSHROOMS
JP1728903S (en)	2022-11-01	Mules
EP4366831A4 (en)	2025-06-11	ANTIVIRAL COMPOUNDS
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