EP4161548A4 - Extraktion psychoaktiver verbindungen aus psychedelischen pilzen - Google Patents

Extraktion psychoaktiver verbindungen aus psychedelischen pilzen Download PDF

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Publication number
EP4161548A4
EP4161548A4 EP21827107.0A EP21827107A EP4161548A4 EP 4161548 A4 EP4161548 A4 EP 4161548A4 EP 21827107 A EP21827107 A EP 21827107A EP 4161548 A4 EP4161548 A4 EP 4161548A4
Authority
EP
European Patent Office
Prior art keywords
psychedelic
mushrooms
extraction
psychoactive compounds
psychoactive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21827107.0A
Other languages
English (en)
French (fr)
Other versions
EP4161548A1 (de
Inventor
Benjamin Lightburn
Ryan Moss
Lisa Ranken
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Psilo Scientific Ltd
Original Assignee
Psilo Scientific Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Psilo Scientific Ltd filed Critical Psilo Scientific Ltd
Priority to EP24152237.4A priority Critical patent/EP4339200A3/de
Priority to EP24165048.0A priority patent/EP4372094A3/de
Publication of EP4161548A1 publication Critical patent/EP4161548A1/de
Publication of EP4161548A4 publication Critical patent/EP4161548A4/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/078—Psilocybe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0215—Solid material in other stationary receptacles
    • B01D11/0253—Fluidised bed of solid materials
    • B01D11/0257—Fluidised bed of solid materials using mixing mechanisms, e.g. stirrers, jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/028—Flow sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medical Informatics (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EP21827107.0A 2020-06-17 2021-06-16 Extraktion psychoaktiver verbindungen aus psychedelischen pilzen Pending EP4161548A4 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP24152237.4A EP4339200A3 (de) 2020-06-17 2021-06-16 Ethanolextraktion psychoaktiver verbindungen aus psilocybin-pilz
EP24165048.0A EP4372094A3 (de) 2020-06-17 2021-06-16 Wässrige extraktion psychoaktiver verbindungen aus psilocybin-pilz

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063040317P 2020-06-17 2020-06-17
US202063046089P 2020-06-30 2020-06-30
CA3088384A CA3088384C (en) 2020-06-17 2020-07-29 Extraction of psychoactive compounds from psilocybin fungus
CA3089455A CA3089455C (en) 2020-06-17 2020-08-07 Methanol-based extraction of psychoactive compounds from fungus
PCT/CA2021/050822 WO2021253123A1 (en) 2020-06-17 2021-06-16 Extraction of psychoactive compounds from psychedelic fungus

Related Child Applications (3)

Application Number Title Priority Date Filing Date
EP24165048.0A Division EP4372094A3 (de) 2020-06-17 2021-06-16 Wässrige extraktion psychoaktiver verbindungen aus psilocybin-pilz
EP24152237.4A Division EP4339200A3 (de) 2020-06-17 2021-06-16 Ethanolextraktion psychoaktiver verbindungen aus psilocybin-pilz
EP24152237.4A Division-Into EP4339200A3 (de) 2020-06-17 2021-06-16 Ethanolextraktion psychoaktiver verbindungen aus psilocybin-pilz

Publications (2)

Publication Number Publication Date
EP4161548A1 EP4161548A1 (de) 2023-04-12
EP4161548A4 true EP4161548A4 (de) 2024-04-24

Family

ID=72895839

Family Applications (3)

Application Number Title Priority Date Filing Date
EP24152237.4A Pending EP4339200A3 (de) 2020-06-17 2021-06-16 Ethanolextraktion psychoaktiver verbindungen aus psilocybin-pilz
EP21827107.0A Pending EP4161548A4 (de) 2020-06-17 2021-06-16 Extraktion psychoaktiver verbindungen aus psychedelischen pilzen
EP24165048.0A Withdrawn EP4372094A3 (de) 2020-06-17 2021-06-16 Wässrige extraktion psychoaktiver verbindungen aus psilocybin-pilz

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP24152237.4A Pending EP4339200A3 (de) 2020-06-17 2021-06-16 Ethanolextraktion psychoaktiver verbindungen aus psilocybin-pilz

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP24165048.0A Withdrawn EP4372094A3 (de) 2020-06-17 2021-06-16 Wässrige extraktion psychoaktiver verbindungen aus psilocybin-pilz

Country Status (6)

Country Link
EP (3) EP4339200A3 (de)
AU (1) AU2021291583B2 (de)
BR (1) BR112022025777A2 (de)
CA (6) CA3124367C (de)
MX (1) MX2022016531A (de)
WO (2) WO2021253124A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114787363A (zh) 2019-10-01 2022-07-22 恩派瑞安神经科学公司 对真菌进行遗传工程化以调节色胺表达
KR20240096817A (ko) 2020-05-19 2024-06-26 사이빈 아이알엘 리미티드 중수소화된 트립타민 유도체 및 사용 방법
AU2021290454B2 (en) 2020-06-17 2024-01-11 Psilo Scientific Ltd Process for Obtaining a Purified Psychoactive Alkaloid Solution
US12233355B2 (en) 2020-06-17 2025-02-25 Psilo Scientific Ltd. Methanol-based extraction of psychoactive alkaloids from fungus
WO2022082320A1 (en) * 2020-10-23 2022-04-28 Psilo Scientific Ltd Process for obtaining a purified psychoactive alkaloid solution
CA3113240C (en) 2020-12-28 2023-09-05 Psilo Scientific Ltd. Transmucosal psychoactive alkaloid composition and preparation thereof
CA3127180C (en) * 2021-08-06 2024-03-05 Psilo Scientific Ltd. Pre-evaporation standardization of extracted psychoactive compounds
GB2625237A (en) * 2021-09-17 2024-06-12 1242753 Ontario Inc Psilocybin derived compositions and methods of using same
CA3232692A1 (en) * 2021-09-28 2023-04-06 Joseph Girardi Chilled juice extraction processes and products using psychedelic and functional mushrooms
CA3133547C (en) 2021-10-07 2024-07-02 Psilo Scientific Ltd. LIQUID-LIQUID EXTRACTION OF PURIFIED PSYCHOACTIVE ALKALOIDS
EP4457336A4 (de) 2021-12-31 2026-01-14 Empyrean Neuroscience Inc Genetisch modifizierte organismen zur herstellung psychotroper alkaloide
WO2023168023A1 (en) 2022-03-04 2023-09-07 Reset Pharmaceuticals, Inc. Co-crystals or salts comprising psilocin
US12551519B2 (en) 2022-04-25 2026-02-17 VCENNA Technology & Labs Inc. Extraction system and method for organic metabolites
WO2024159297A1 (en) * 2023-01-31 2024-08-08 Bluethera Biologics Inc. Method of extracting a psychoactive compound from fungal biomass and formulations thereof
US12503713B1 (en) 2025-05-19 2025-12-23 Convergent Health Sciences LLC Stabilization of tryptamines by denaturing enzymes, optimizing ionization states, and controlling confounding variables
US12497637B1 (en) 2025-05-19 2025-12-16 Convergent Health Sciences LLC Stabilization of tryptamines by denaturing enzymes, optimizing ionization states, and controlling confounding variables

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB911946A (en) * 1958-02-21 1962-12-05 Sandoz Ltd Psilocybin and psilocin and processes for their preparation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU36879A1 (de) 1958-02-21
CN101292727A (zh) * 2008-05-30 2008-10-29 曹晋忠 菌类乙醇提取物的粉体制备方法
GB2571696B (en) * 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
WO2019099745A1 (en) * 2017-11-16 2019-05-23 CaaMTech, LLC Compositions comprising a psilocybin derivative and a cannabinoid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB911946A (en) * 1958-02-21 1962-12-05 Sandoz Ltd Psilocybin and psilocin and processes for their preparation

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
JANIS FRICKE ET AL: "Production Options for Psilocybin: Making of the Magic", CHEMISTRY - A EUROPEAN JOURNAL, vol. 25, no. 4, 18 January 2019 (2019-01-18), DE, pages 897 - 903, XP055766088, ISSN: 0947-6539, DOI: 10.1002/chem.201802758 *
OLUYEMISI FOLASHADE KUNLE ET AL: "Standardization of herbal medicines - A review", INTERNATIONAL JOURNAL OF BIODIVERSITY AND CONSERVATION, vol. 4, no. 3, 1 March 2012 (2012-03-01), pages 101 - 112, XP055435139, DOI: 10.5897/IJBC11.163 *
PELLEGRINI MANUELA ET AL: "Magic truffles or Philosopher's stones: a legal way to sell psilocybin?", vol. 5, no. 3, 28 February 2013 (2013-02-28), pages 182 - 185, XP009547892, ISSN: 1942-7611, Retrieved from the Internet <URL:https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fdta.1400> [retrieved on 20120809], DOI: 10.1002/DTA.1400 *
PIOTR PAWEL WIECZOREK ET AL: "Bioactive Alkaloids of Hallucinogenic Mushrooms", 30 November 2015 (2015-11-30), XP009545779, ISBN: 978-0-444-63462-7, Retrieved from the Internet <URL:https://ebookcentral.proquest.com/lib/epo-ebooks/reader.action?docID=2036175&ppg=148> [retrieved on 20150427] *
PSILOCYBIN EXERT: "Formulating New 'Magic Mushroom' compositions", INTERNET CITATION, 13 February 2018 (2018-02-13), pages 1 - 7, XP009542154, Retrieved from the Internet <URL:https://web.archive.org/web/20200704105500/https://psilocybintechnology.com/formulating-new-magic-mushroom-compositions/> [retrieved on 20230305] *
ROMAN KYSILKA ET AL: "A novel extraction procedure for psilocybin and psilocin determination in mushroom samples", PLANTA MEDICA, THIEME VERLAG, DE, vol. 56, no. 3, 30 November 1989 (1989-11-30), pages 327 - 328, XP009536241, ISSN: 0032-0943, DOI: 10.1055/S-2006-960970 *
See also references of WO2021253123A1 *
TSUJIKAWA KENJI ET AL: "Morphological and chemical analysis of magic mushrooms in Japan", vol. 138, no. 1-3, 30 November 2003 (2003-11-30), pages 85 - 90, XP009547895, ISSN: 0379-0738, Retrieved from the Internet <URL:https://api.elsevier.com/content/article/PII:S0379073803003785?httpAccept=text/plain> [retrieved on 20230919], DOI: 10.1016/J.FORSCIINT.2003.08.009 *

Also Published As

Publication number Publication date
EP4372094A2 (de) 2024-05-22
CA3161623C (en) 2023-04-04
MX2022016531A (es) 2023-09-12
CA3198238C (en) 2025-06-10
CA3089455A1 (en) 2021-09-14
EP4339200A2 (de) 2024-03-20
WO2021253123A1 (en) 2021-12-23
CA3124367A1 (en) 2020-10-07
EP4339200A3 (de) 2024-03-27
CA3088384A1 (en) 2020-10-07
CA3123908A1 (en) 2020-10-07
EP4372094A3 (de) 2024-08-07
CA3161623A1 (en) 2021-12-23
CA3123908C (en) 2022-03-22
CA3088384C (en) 2021-08-03
AU2021291583B2 (en) 2023-12-07
BR112022025777A2 (pt) 2023-01-10
WO2021253124A1 (en) 2021-12-23
CA3198238A1 (en) 2021-12-23
AU2021291583A1 (en) 2023-02-02
CA3124367C (en) 2022-04-26
CA3089455C (en) 2022-07-05
EP4161548A1 (de) 2023-04-12

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