EP4161549A4 - METHOD FOR OBTAINING A PURIFIED PSYCHOACTIVE ALKALOID SOLUTION - Google Patents

METHOD FOR OBTAINING A PURIFIED PSYCHOACTIVE ALKALOID SOLUTION Download PDF

Info

Publication number
EP4161549A4
EP4161549A4 EP21881426.7A EP21881426A EP4161549A4 EP 4161549 A4 EP4161549 A4 EP 4161549A4 EP 21881426 A EP21881426 A EP 21881426A EP 4161549 A4 EP4161549 A4 EP 4161549A4
Authority
EP
European Patent Office
Prior art keywords
purified
obtaining
alkaloid solution
psychoactive
psychoactive alkaloid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21881426.7A
Other languages
German (de)
French (fr)
Other versions
EP4161549A1 (en
Inventor
Ryan Moss
Benjamin Lightburn
Lisa Ranken
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Psilo Scientific Ltd
Original Assignee
Psilo Scientific Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA3097246A external-priority patent/CA3097246C/en
Priority claimed from PCT/CA2021/050813 external-priority patent/WO2021253116A1/en
Application filed by Psilo Scientific Ltd filed Critical Psilo Scientific Ltd
Publication of EP4161549A1 publication Critical patent/EP4161549A1/en
Publication of EP4161549A4 publication Critical patent/EP4161549A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/078—Psilocybe
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP21881426.7A 2020-10-23 2021-10-23 METHOD FOR OBTAINING A PURIFIED PSYCHOACTIVE ALKALOID SOLUTION Pending EP4161549A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CA3097246A CA3097246C (en) 2020-10-23 2020-10-23 Process for obtaining a purified psychoactive alkaloid solution
PCT/CA2021/050813 WO2021253116A1 (en) 2020-06-17 2021-06-14 Compositions comprising psychoactive compounds from psychoactive organisms
PCT/CA2021/051495 WO2022082320A1 (en) 2020-10-23 2021-10-23 Process for obtaining a purified psychoactive alkaloid solution

Publications (2)

Publication Number Publication Date
EP4161549A1 EP4161549A1 (en) 2023-04-12
EP4161549A4 true EP4161549A4 (en) 2023-11-29

Family

ID=81291112

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21881426.7A Pending EP4161549A4 (en) 2020-10-23 2021-10-23 METHOD FOR OBTAINING A PURIFIED PSYCHOACTIVE ALKALOID SOLUTION

Country Status (4)

Country Link
EP (1) EP4161549A4 (en)
BR (1) BR112022025782A2 (en)
MX (1) MX2023004350A (en)
WO (1) WO2022082320A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220370413A1 (en) 2021-03-06 2022-11-24 Mind Medicine, Inc. Formulations of psilocin that have enhanced stability
CN119656653B (en) * 2025-02-18 2025-06-13 浙江工业大学 Application of cyanamide waste residue charcoal in lotus alkaloid extraction, a solid phase extraction adsorbent and its application

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101491647A (en) * 2007-04-18 2009-07-29 北京和润创新医药科技发展有限公司 Method for separating ergot total alkaloids in ergot stem extract
CA3123908A1 (en) * 2020-06-17 2020-10-07 Psilo Scientific Ltd. Ethanol extraction of psychoactive compounds from psilocybin fungus

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4169535A1 (en) * 2019-04-26 2023-04-26 The University of North Carolina at Chapel Hill Methods and compositions for dual glycan binding aav2.5 vector

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101491647A (en) * 2007-04-18 2009-07-29 北京和润创新医药科技发展有限公司 Method for separating ergot total alkaloids in ergot stem extract
CA3123908A1 (en) * 2020-06-17 2020-10-07 Psilo Scientific Ltd. Ethanol extraction of psychoactive compounds from psilocybin fungus

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 200961, Derwent World Patents Index; AN 2009-M36108, XP002810227 *
FAKHARI ALI REZA ET AL: "Optimized ultrasound-assisted extractionprocedure for the analysis of opium alkaloids in papaver plants by cyclodextrin-modified capillary electrophoresis", JOURNAL OF SEPARATION SCIENCE, WILEY, DE, vol. 33, no. 14, 30 June 2010 (2010-06-30), pages 2153 - 2159, XP009548440, ISSN: 1615-9306, DOI: 10.1002/JSSC.201000135 *
PELLEGRINI MANUELA ET AL: "Magic truffles or Philosopher's stones: a legal way to sell psilocybin?", vol. 5, no. 3, 28 February 2013 (2013-02-28), pages 182 - 185, XP009547892, ISSN: 1942-7611, Retrieved from the Internet <URL:https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fdta.1400> [retrieved on 20120809], DOI: 10.1002/DTA.1400 *
See also references of WO2022082320A1 *

Also Published As

Publication number Publication date
BR112022025782A2 (en) 2024-01-30
MX2023004350A (en) 2023-09-12
WO2022082320A1 (en) 2022-04-28
EP4161549A1 (en) 2023-04-12

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Owner name: PSILO SCIENTIFIC LTD

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Effective date: 20231102

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Ipc: B01D 15/42 20060101ALI20231025BHEP

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