EP4162030A4 - Souches atténuées vivantes de fièvre aphteuse modifiées par désoptimisation et leurs utilisations - Google Patents

Souches atténuées vivantes de fièvre aphteuse modifiées par désoptimisation et leurs utilisations Download PDF

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Publication number
EP4162030A4
EP4162030A4 EP21813459.1A EP21813459A EP4162030A4 EP 4162030 A4 EP4162030 A4 EP 4162030A4 EP 21813459 A EP21813459 A EP 21813459A EP 4162030 A4 EP4162030 A4 EP 4162030A4
Authority
EP
European Patent Office
Prior art keywords
deoptimisation
foot
mouth disease
live attenuated
attenuated strains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP21813459.1A
Other languages
German (de)
English (en)
Other versions
EP4162030A1 (fr
Inventor
Teresa B. De Los Santos
Aida E. Rieder
Fayna C. DIAZ-SAN SEGUNDO
Anna KLOC
John R. Coleman
Steffen Mueller
Gisselle N. MEDINA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Agriculture USDA
Codagenix Inc
Original Assignee
US Department of Agriculture USDA
Codagenix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Department of Agriculture USDA, Codagenix Inc filed Critical US Department of Agriculture USDA
Priority claimed from PCT/US2021/034282 external-priority patent/WO2021242879A1/fr
Publication of EP4162030A1 publication Critical patent/EP4162030A1/fr
Publication of EP4162030A4 publication Critical patent/EP4162030A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/125—Picornaviridae, e.g. calicivirus
    • A61K39/135—Foot- and mouth-disease virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32111—Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
EP21813459.1A 2020-05-27 2021-05-26 Souches atténuées vivantes de fièvre aphteuse modifiées par désoptimisation et leurs utilisations Withdrawn EP4162030A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063030431P 2020-05-27 2020-05-27
PCT/US2021/034282 WO2021242879A1 (fr) 2020-05-27 2021-05-26 Souches atténuées vivantes de fièvre aphteuse modifiées par désoptimisation et leurs utilisations

Publications (2)

Publication Number Publication Date
EP4162030A1 EP4162030A1 (fr) 2023-04-12
EP4162030A4 true EP4162030A4 (fr) 2024-07-24

Family

ID=85463132

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21813459.1A Withdrawn EP4162030A4 (fr) 2020-05-27 2021-05-26 Souches atténuées vivantes de fièvre aphteuse modifiées par désoptimisation et leurs utilisations

Country Status (2)

Country Link
EP (1) EP4162030A4 (fr)
CN (1) CN116249708A (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9180179B1 (en) * 2010-07-01 2015-11-10 The United States Of America, As Represented By The Secretary Of Agriculture Development of a marker foot and mouth disease virus vaccine candidate that is attenuated in the natural host
US20170067030A1 (en) * 2007-03-30 2017-03-09 The Research Foundation For The State University Of New York Attenuated viruses useful for vaccines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2587084C (fr) * 2004-10-08 2019-07-16 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Modulation de la valeur adaptative reproductive au moyen de codons synonymes employes moins frequemment
CN104826098B (zh) * 2015-05-14 2017-08-29 中国农业科学院兰州兽医研究所 一种a型口蹄疫标记疫苗及其构建方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170067030A1 (en) * 2007-03-30 2017-03-09 The Research Foundation For The State University Of New York Attenuated viruses useful for vaccines
US9180179B1 (en) * 2010-07-01 2015-11-10 The United States Of America, As Represented By The Secretary Of Agriculture Development of a marker foot and mouth disease virus vaccine candidate that is attenuated in the natural host

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
C. CARRILLO ET AL: "Comparative Genomics of Foot-and-Mouth Disease Virus", JOURNAL OF VIROLOGY, vol. 79, no. 10, 27 April 2005 (2005-04-27), pages 6487 - 6504, XP055120718, ISSN: 0022-538X, DOI: 10.1128/JVI.79.10.6487-6504.2005 *
DIAZ-SAN SEGUNDO FAYNA ET AL: "Foot-and-mouth disease vaccines", VETERINARY MICROBIOLOGY, ELSEVIER BV, NL, vol. 206, 19 December 2016 (2016-12-19), pages 102 - 112, XP085115673, ISSN: 0378-1135, DOI: 10.1016/J.VETMIC.2016.12.018 *
DIAZ-SAN SEGUNDO FAYNA ET AL: "Use of Synonymous Deoptimization to Derive Modified Live Attenuated Strains of Foot and Mouth Disease Virus", FRONTIERS IN MICROBIOLOGY, vol. 11, 21 January 2021 (2021-01-21), Lausanne, XP093174242, ISSN: 1664-302X, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861043/pdf/fmicb-11-610286.pdf> DOI: 10.3389/fmicb.2020.610286 *
LE NOUËN CYRIL ET AL: "Attenuation of Human Respiratory Viruses by Synonymous Genome Recoding", FRONTIERS IN IMMUNOLOGY, vol. 10, 4 June 2019 (2019-06-04), Lausanne, CH, XP093174278, ISSN: 1664-3224, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558635/pdf/fimmu-10-01250.pdf> DOI: 10.3389/fimmu.2019.01250 *
MARTIN D ET AL: "Rational Design of Attenuated FMDV Vaccines By Elevation of -CpG-and -UpA-Dinucleotide Frequencies", 1 January 2018 (2018-01-01), pages 1 - 22, XP093174293, Retrieved from the Internet <URL:https://www.fao.org/fileadmin/user_upload/eufmd_new/docs/Meeting_documents/Open_Session_2018/8.A.2_-_Ryan.pdf> *
See also references of WO2021242879A1 *

Also Published As

Publication number Publication date
CN116249708A (zh) 2023-06-09
EP4162030A1 (fr) 2023-04-12

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