EP4164415A4 - Biodisponibilité rétinienne d'acides gras polyinsaturés à très longue chaîne synthétiques - Google Patents

Biodisponibilité rétinienne d'acides gras polyinsaturés à très longue chaîne synthétiques

Info

Publication number
EP4164415A4
EP4164415A4 EP21826542.9A EP21826542A EP4164415A4 EP 4164415 A4 EP4164415 A4 EP 4164415A4 EP 21826542 A EP21826542 A EP 21826542A EP 4164415 A4 EP4164415 A4 EP 4164415A4
Authority
EP
European Patent Office
Prior art keywords
retinal
bioavailability
synthetic
long
fatty acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21826542.9A
Other languages
German (de)
English (en)
Other versions
EP4164415A1 (fr
Inventor
Aruna GORUSUPUDI
Paul S. Bernstein
Jon D. RAINIER
Rameshu RALLABANDI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation Inc
Original Assignee
University of Utah Research Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Utah Research Foundation Inc filed Critical University of Utah Research Foundation Inc
Publication of EP4164415A1 publication Critical patent/EP4164415A1/fr
Publication of EP4164415A4 publication Critical patent/EP4164415A4/fr
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115Fatty acids or derivatives thereof; Fats or oils
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15Vitamins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355Tocopherols, e.g. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP21826542.9A 2020-06-15 2021-06-15 Biodisponibilité rétinienne d'acides gras polyinsaturés à très longue chaîne synthétiques Pending EP4164415A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063039331P 2020-06-15 2020-06-15
PCT/US2021/037524 WO2021257636A1 (fr) 2020-06-15 2021-06-15 Biodisponibilité rétinienne d'acides gras polyinsaturés à très longue chaîne synthétiques

Publications (2)

Publication Number Publication Date
EP4164415A1 EP4164415A1 (fr) 2023-04-19
EP4164415A4 true EP4164415A4 (fr) 2025-01-01

Family

ID=79268326

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21826542.9A Pending EP4164415A4 (fr) 2020-06-15 2021-06-15 Biodisponibilité rétinienne d'acides gras polyinsaturés à très longue chaîne synthétiques

Country Status (5)

Country Link
US (1) US20230226002A1 (fr)
EP (1) EP4164415A4 (fr)
CN (1) CN116194082A (fr)
CA (1) CA3182909A1 (fr)
WO (1) WO2021257636A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3175005A1 (fr) * 2020-03-11 2021-09-16 Bausch + Lomb Ireland Limited Compositions et procedes pour la sante oculaire comprenant des acides gras a tres longue chaine
CA3264559A1 (fr) * 2022-08-12 2024-02-15 University Of Utah Research Foundation Synthèse efficace d'acides gras polyinsaturés à très longue chaîne

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060210618A1 (en) * 2003-01-06 2006-09-21 Kazuhiro Kubo Phospholipid derivatives and process for the production there
US20200009100A1 (en) * 2017-03-20 2020-01-09 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Very-long-chain polyunsaturated fatty acids, elovanoid hydroxylated derivatives, and methods of use
WO2020102596A1 (fr) * 2018-11-15 2020-05-22 Retrotope, Inc. Composés deutérés, compositions et utilisations
WO2021181311A1 (fr) * 2020-03-11 2021-09-16 Bausch Health Ireland Limited Compositions et procédés pour la santé oculaire comprenant des acides gras à très longue chaîne

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2076244B1 (fr) * 2006-10-10 2016-12-07 Jina Pharmaceuticals Inc. Systèmes aqueux pour la préparation de composés pharmaceutiques à base lipidique et leurs compositions, procédés et utilisations
WO2011053892A1 (fr) * 2009-10-31 2011-05-05 Martek Biosciences Corporation Synthèse et utilisation d'acides gras polyinsaturés à très longue chaîne (vlc-pufa) oméga-3 et oméga-6
CA2792330C (fr) * 2010-03-23 2017-01-03 Virun, Inc Nanoemulsion comportant un derive peg de vitamine e et un sucrose ester d'acide gras
JP6137836B2 (ja) * 2011-01-27 2017-05-31 サンスター株式会社 多価不飽和脂肪酸含有組成物
EP2664329A1 (fr) * 2012-05-15 2013-11-20 F. Holzer GmbH Système de véhicule ophtalmologique
US20160279095A1 (en) * 2013-11-12 2016-09-29 Abbott Laboratories Use of nutritional compositions including natural vitamin e, and polyunsaturated fatty acid
AU2016219517B2 (en) * 2015-02-09 2020-02-06 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Compounds, compositions, and methods for the treatment of inflammatory, degenerative, and neurodegenerative diseases
JP2020514391A (ja) * 2017-03-20 2020-05-21 ボード オブ スーパーバイザーズ オブ ルイジアナ ステイト ユニバーシティ アンド アグリカルチュラル アンド メカニカル カレッジBoard Of Supervisors Of Louisiana State University And Agricultural And Mechanical College 超長鎖多価不飽和脂肪酸、エロバノイドヒドロキシル化誘導体、および使用方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060210618A1 (en) * 2003-01-06 2006-09-21 Kazuhiro Kubo Phospholipid derivatives and process for the production there
US20200009100A1 (en) * 2017-03-20 2020-01-09 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Very-long-chain polyunsaturated fatty acids, elovanoid hydroxylated derivatives, and methods of use
WO2020102596A1 (fr) * 2018-11-15 2020-05-22 Retrotope, Inc. Composés deutérés, compositions et utilisations
WO2021181311A1 (fr) * 2020-03-11 2021-09-16 Bausch Health Ireland Limited Compositions et procédés pour la santé oculaire comprenant des acides gras à très longue chaîne

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2021257636A1 *

Also Published As

Publication number Publication date
CA3182909A1 (fr) 2021-12-23
WO2021257636A1 (fr) 2021-12-23
CN116194082A (zh) 2023-05-30
US20230226002A1 (en) 2023-07-20
EP4164415A1 (fr) 2023-04-19

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Ipc: A61K 31/202 20060101ALI20241127BHEP

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