EP4171609A4 - Conjugués de cytokine - Google Patents

Conjugués de cytokine Download PDF

Info

Publication number: EP4171609A4
Authority: EP; European Patent Office
Prior art keywords: cytokine conjugates; conjugates; cytokine
Prior art date: 2020-06-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP21828085.7A

Other languages

German (de)

English (en)

Other versions

EP4171609A1 (fr

Inventor

Volker Schellenberger

Eric Johansen

Angela HENKENSIEFKEN

Bryan Irving

Tracy Young

Vibha Chauhan

Valentine YEUNG

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Amunix Pharmaceuticals Inc

Original Assignee

Amunix Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2020-06-25

Filing date

2021-06-24

Publication date

2024-07-31

2021-06-24 Application filed by Amunix Pharmaceuticals Inc filed Critical Amunix Pharmaceuticals Inc

2023-05-03 Publication of EP4171609A1 publication Critical patent/EP4171609A1/fr

2024-07-31 Publication of EP4171609A4 publication Critical patent/EP4171609A4/fr

Status Pending legal-status Critical Current

Links

102000004127 Cytokines Human genes 0.000 title 1
108090000695 Cytokines Proteins 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/195—Chemokines, e.g. RANTES
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/208—IL-12
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5434—IL-12
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Toxicology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicinal Preparation (AREA)

EP21828085.7A 2020-06-25 2021-06-24 Conjugués de cytokine Pending EP4171609A4 (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US202063044335P	2020-06-25	2020-06-25
US202163197875P	2021-06-07	2021-06-07
US202163197944P	2021-06-07	2021-06-07
PCT/US2021/038909 WO2021262985A1 (fr)	2020-06-25	2021-06-24	Conjugués de cytokine

Publications (2)

Publication Number	Publication Date
EP4171609A1 EP4171609A1 (fr)	2023-05-03
EP4171609A4 true EP4171609A4 (fr)	2024-07-31

Family

ID=79281847

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP21828085.7A Pending EP4171609A4 (fr)	2020-06-25	2021-06-24	Conjugués de cytokine

Country Status (13)

Country	Link
US (1)	US20230265146A1 (fr)
EP (1)	EP4171609A4 (fr)
JP (1)	JP2023531496A (fr)
KR (1)	KR20230042014A (fr)
CN (1)	CN116096730A (fr)
AU (1)	AU2021296605A1 (fr)
BR (1)	BR112022026248A2 (fr)
CA (1)	CA3180251A1 (fr)
CO (1)	CO2023000048A2 (fr)
IL (1)	IL298626A (fr)
MX (1)	MX2022016389A (fr)
PH (1)	PH12022553408A1 (fr)
WO (1)	WO2021262985A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP4372000A3 (fr) *	2022-02-15	2024-07-17	Tagworks Pharmaceuticals B.V.	Proteine il12 masquee
AU2023363981A1 (en) *	2022-10-19	2025-05-01	Kalivir Immunotherapeutics, Inc.	Nucleic acids encoding tgf-beta inhibitor and il-12 and uses thereof
WO2025122957A1 (fr)	2023-12-08	2025-06-12	Amunix Pharmaceuticals, Inc.	Cytokines activables par une protéase et leurs méthodes de fabrication et d'utilisation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20190359672A1 (en) *	2018-03-28	2019-11-28	Bristol-Myers Squibb Company	Interleukin-2/interleukin-2 receptor alpha fusion proteins and methods of use
WO2020041636A1 (fr) *	2018-08-23	2020-02-27	Exalt Therapeutics, Llc	Polypeptides ifnl3 modifiés comprenant un fragment d'amélioration pharmacocinétique et leurs utilisations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20020077276A1 (en) *	1999-04-27	2002-06-20	Fredeking Terry M.	Compositions and methods for treating hemorrhagic virus infections and other disorders
CA2748314C (fr) *	2009-02-03	2018-10-02	Amunix Operating Inc.	Polypeptides recombinants etendus et compositions les comprenant
WO2011123830A2 (fr) *	2010-04-02	2011-10-06	Amunix Operating Inc.	Compositions d'alpha 1-antitrypsine, leurs procédés de préparation et d'utilisation
CN117462693A (zh) *	2012-02-27	2024-01-30	阿穆尼克斯运营公司	Xten缀合组合物和制造其的方法
IL319047A (en) *	2015-08-28	2025-04-01	Amunix Operating Inc	Chimeric polypeptide composition and methods for its preparation and use
JP7285220B2 (ja) *	2017-05-18	2023-06-01	モデルナティエックスインコーポレイテッド	連結したインターロイキン－１２（ｉｌ１２）ポリペプチドをコードするポリヌクレオチドを含む脂質ナノ粒子
EP3728326A4 (fr) *	2017-12-21	2021-12-15	Amunix Pharmaceuticals, Inc.	Segments de libération et compositions de liaison les comprenant
CA3100005A1 (fr) *	2018-05-14	2019-11-21	Werewolf Therapeutics, Inc.	Polypeptides de cytokine activables et leurs procedes d'utilisation

2021
- 2021-06-24 CN CN202180045253.9A patent/CN116096730A/zh active Pending
- 2021-06-24 BR BR112022026248A patent/BR112022026248A2/pt unknown
- 2021-06-24 KR KR1020237002104A patent/KR20230042014A/ko active Pending
- 2021-06-24 JP JP2022579000A patent/JP2023531496A/ja active Pending
- 2021-06-24 AU AU2021296605A patent/AU2021296605A1/en active Pending
- 2021-06-24 EP EP21828085.7A patent/EP4171609A4/fr active Pending
- 2021-06-24 CA CA3180251A patent/CA3180251A1/fr active Pending
- 2021-06-24 WO PCT/US2021/038909 patent/WO2021262985A1/fr not_active Ceased
- 2021-06-24 PH PH1/2022/553408A patent/PH12022553408A1/en unknown
- 2021-06-24 MX MX2022016389A patent/MX2022016389A/es unknown
- 2021-06-24 IL IL298626A patent/IL298626A/en unknown
2022
- 2022-12-02 US US18/073,935 patent/US20230265146A1/en active Pending
2023
- 2023-01-04 CO CONC2023/0000048A patent/CO2023000048A2/es unknown

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20190359672A1 (en) *	2018-03-28	2019-11-28	Bristol-Myers Squibb Company	Interleukin-2/interleukin-2 receptor alpha fusion proteins and methods of use
WO2020041636A1 (fr) *	2018-08-23	2020-02-27	Exalt Therapeutics, Llc	Polypeptides ifnl3 modifiés comprenant un fragment d'amélioration pharmacocinétique et leurs utilisations

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
FU YONG ET AL: "Engineering cytokines for cancer immunotherapy: a systematic review", FRONTIERS IN IMMUNOLOGY, vol. 14, 6 July 2023 (2023-07-06), Lausanne, CH, XP093172564, ISSN: 1664-3224, DOI: 10.3389/fimmu.2023.1218082 *
See also references of WO2021262985A1 *

Also Published As

Publication number	Publication date
WO2021262985A1 (fr)	2021-12-30
KR20230042014A (ko)	2023-03-27
AU2021296605A9 (en)	2023-03-09
AU2021296605A1 (en)	2023-02-23
CN116096730A (zh)	2023-05-09
EP4171609A1 (fr)	2023-05-03
CA3180251A1 (fr)	2021-12-30
US20230265146A1 (en)	2023-08-24
PH12022553408A1 (en)	2024-04-22
MX2022016389A (es)	2023-04-11
IL298626A (en)	2023-01-01
CO2023000048A2 (es)	2023-03-27
BR112022026248A2 (pt)	2023-01-17
JP2023531496A (ja)	2023-07-24

Legal Events

Date	Code	Title	Description
2021-12-31	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2023-03-31	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2023-03-31	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2023-05-03	17P	Request for examination filed	Effective date: 20230113
2023-05-03	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2023-12-29	REG	Reference to a national code	Ref country code: HK Ref legal event code: DE Ref document number: 40092983 Country of ref document: HK
2024-07-31	A4	Supplementary search report drawn up and despatched	Effective date: 20240702
2024-07-31	RIC1	Information provided on ipc code assigned before grant	Ipc: A61P 35/00 20060101ALI20240626BHEP Ipc: A61K 49/00 20060101ALI20240626BHEP Ipc: A61K 47/64 20170101ALI20240626BHEP Ipc: A61K 47/50 20170101ALI20240626BHEP Ipc: C07K 1/12 20060101ALI20240626BHEP Ipc: A61K 38/17 20060101AFI20240626BHEP

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