EP4189096A4 - Conception de virus artificiels à base de bactériophages pour remodelage du génome humain - Google Patents

Conception de virus artificiels à base de bactériophages pour remodelage du génome humain Download PDF

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Publication number: EP4189096A4
Authority: EP; European Patent Office
Prior art keywords: remodeling; design; human genome; based viruses; bacteriophage
Prior art date: 2020-07-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP21850710.1A

Other languages

German (de)

English (en)

Other versions

EP4189096A1 (fr

Inventor

Venigalla B. Rao

Jingen ZHU

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Catholic University of America

Original Assignee

Catholic University of America

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2020-07-29

Filing date

2021-07-21

Publication date

2024-10-09

2021-06-28 Priority claimed from US17/359,711 external-priority patent/US11401530B2/en

2021-07-21 Application filed by Catholic University of America filed Critical Catholic University of America

2021-07-21 Priority to EP24155130.8A priority Critical patent/EP4371564B1/fr

2023-06-07 Publication of EP4189096A1 publication Critical patent/EP4189096A1/fr

2024-10-09 Publication of EP4189096A4 publication Critical patent/EP4189096A4/fr

Status Pending legal-status Critical Current

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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/00041—Use of virus, viral particle or viral elements as a vector
- C12N2795/00043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/00051—Methods of production or purification of viral material
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10023—Virus like particles [VLP]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10041—Use of virus, viral particle or viral elements as a vector
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10111—Myoviridae
- C12N2795/10121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10111—Myoviridae
- C12N2795/10141—Use of virus, viral particle or viral elements as a vector
- C12N2795/10142—Use of virus, viral particle or viral elements as a vector virus or viral particle as vehicle, e.g. encapsulating small organic molecule
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10111—Myoviridae
- C12N2795/10141—Use of virus, viral particle or viral elements as a vector
- C12N2795/10143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Virology (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Plant Pathology (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Crystallography & Structural Chemistry (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EP21850710.1A 2020-07-29 2021-07-21 Conception de virus artificiels à base de bactériophages pour remodelage du génome humain Pending EP4189096A4 (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
EP24155130.8A EP4371564B1 (fr)	2020-07-29	2021-07-21	Conception de virus artificiels à base de bactériophages pour le remodelage du génome humain

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US202063058012P	2020-07-29	2020-07-29
US17/359,711 US11401530B2 (en)	2019-08-19	2021-06-28	Bacteriophage-based artificial viruses for human genome remodeling
PCT/IB2021/056248 WO2022023850A1 (fr)	2020-07-29	2021-07-21	Conception de virus artificiels à base de bactériophages pour remodelage du génome humain

Related Child Applications (2)

Application Number	Title	Priority Date	Filing Date
EP24155130.8A Division EP4371564B1 (fr)	2020-07-29	2021-07-21	Conception de virus artificiels à base de bactériophages pour le remodelage du génome humain
EP24155130.8A Division-Into EP4371564B1 (fr)	2020-07-29	2021-07-21	Conception de virus artificiels à base de bactériophages pour le remodelage du génome humain

Publications (2)

Publication Number	Publication Date
EP4189096A1 EP4189096A1 (fr)	2023-06-07
EP4189096A4 true EP4189096A4 (fr)	2024-10-09

Family

ID=80004157

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
EP21850710.1A Pending EP4189096A4 (fr)	2020-07-29	2021-07-21	Conception de virus artificiels à base de bactériophages pour remodelage du génome humain
EP24155130.8A Active EP4371564B1 (fr)	2020-07-29	2021-07-21	Conception de virus artificiels à base de bactériophages pour le remodelage du génome humain

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
EP24155130.8A Active EP4371564B1 (fr)	2020-07-29	2021-07-21	Conception de virus artificiels à base de bactériophages pour le remodelage du génome humain

Country Status (7)

Country	Link
EP (2)	EP4189096A4 (fr)
JP (2)	JP2023537296A (fr)
CN (1)	CN116323944B (fr)
CA (1)	CA3187240A1 (fr)
GB (2)	GB2628464B (fr)
MX (1)	MX2023001164A (fr)
WO (1)	WO2022023850A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2020252455A1 (fr)	2019-06-13	2020-12-17	The General Hospital Corporation	Pseudo-particules virales endogènes humaines génétiquement modifiées et leurs méthodes d'utilisation en vue d'une administration à des cellules
CA3189601A1 (fr)	2020-07-24	2022-01-27	The General Hospital Corporation	Pseudo-particules virales ameliorees et leurs methodes d'utilisation pour l'administration a des cellules
CN115209924A (zh) *	2021-02-07	2022-10-18	辉大(上海)生物科技有限公司	Rna腺相关病毒（raav）载体及其用途
CN114934059B (zh) *	2022-03-04	2023-02-21	深圳先进技术研究院	高通量简化噬菌体基因组骨架的方法
US20230355738A1 (en) *	2022-04-26	2023-11-09	The Catholic University Of America	Bacteriophage-based, needle and adjuvant-free, mucosal covid-19 vaccine

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20190330643A1 (en) *	2018-04-25	2019-10-31	The Catholic University Of America	Engineering of bacteriophages by genome editing using the crispr-cas9 system

Family Cites Families (5)

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Publication number	Priority date	Publication date	Assignee	Title
US9163262B2 (en) *	2003-12-17	2015-10-20	The Catholic University Of America	In vitro and in vivo delivery of genes and proteins using the bacteriophage T4 DNA packaging machine
CA2683063A1 (fr) *	2007-04-09	2008-10-16	Chimeros, Inc.	Systeme de relargage de medicaments par auto-assemblage de nanoparticules
WO2009129523A2 (fr) *	2008-04-18	2009-10-22	The General Hospital Corporation	Compositions et procédés d'administation d'acide nucléique
WO2018035387A1 (fr) *	2016-08-17	2018-02-22	The Broad Institute, Inc.	Nouveaux systèmes et enzymes crispr
WO2018191750A2 (fr) *	2017-04-14	2018-10-18	The Broad Institute Inc.	Nouvelle distribution de grandes charges utiles

2021
- 2021-07-21 JP JP2023506012A patent/JP2023537296A/ja active Pending
- 2021-07-21 CA CA3187240A patent/CA3187240A1/fr active Pending
- 2021-07-21 EP EP21850710.1A patent/EP4189096A4/fr active Pending
- 2021-07-21 CN CN202180065944.5A patent/CN116323944B/zh active Active
- 2021-07-21 WO PCT/IB2021/056248 patent/WO2022023850A1/fr not_active Ceased
- 2021-07-21 GB GB2400771.8A patent/GB2628464B/en active Active
- 2021-07-21 MX MX2023001164A patent/MX2023001164A/es unknown
- 2021-07-21 EP EP24155130.8A patent/EP4371564B1/fr active Active
- 2021-07-21 GB GB2301200.8A patent/GB2612491B/en active Active
2023
- 2023-12-19 JP JP2023214336A patent/JP2024037973A/ja active Pending

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20190330643A1 (en) *	2018-04-25	2019-10-31	The Catholic University Of America	Engineering of bacteriophages by genome editing using the crispr-cas9 system

Non-Patent Citations (7)

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Title
LIU JINNY L. ET AL: "Supporting information Viral nanoparticle-encapsidated enzyme and restructured DNA for cell delivery and gene expression", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 111, no. 37, 26 August 2014 (2014-08-26), pages 13319 - 13324, XP093184312, ISSN: 0027-8424, DOI: 10.1073/pnas.1321940111 *
LIU JINNY L. ET AL: "Viral nanoparticle-encapsidated enzyme and restructured DNA for cell delivery and gene expression", vol. 111, no. 37, 26 August 2014 (2014-08-26), pages 13319 - 13324, XP093184315, ISSN: 0027-8424, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169922/pdf/pnas.201321940.pdf> DOI: 10.1073/pnas.1321940111 *
MULLANEY J M ET AL: "CAPSID TARGETING SEQUENCE TARGETS FOREIGN PROTEINS INTO BACTERIOPHAGE T4 AND PERMITS PROTEOLYTIC PROCESSING", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 261, no. 3, 1 January 1996 (1996-01-01), pages 372 - 385, XP008048465, ISSN: 0022-2836, DOI: 10.1006/JMBI.1996.0470 *
MULLANEY JULIENNE M. ET AL: "Protocols for In Vitro Cultures and Secondary Metabolite Analysis of Aromatic and Medicinal Plants, Second Edition", vol. 1108, 30 October 2013 (2013-10-30), pages 69 - 85, XP093184314, ISSN: 1064-3745, Retrieved from the Internet <URL:https://link.springer.com/content/pdf/10.1007/978-1-62703-751-8_5> DOI: 10.1007/978-1-62703-751-8_5 *
See also references of WO2022023850A1 *
TAO PAN ET AL: "Engineering of Bacteriophage T4 Genome Using CRISPR-Cas9", vol. 6, no. 10, 20 October 2017 (2017-10-20), Washington DC ,USA, pages 1952 - 1961, XP055943284, ISSN: 2161-5063, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771229/pdf/nihms928175.pdf> DOI: 10.1021/acssynbio.7b00179 *
ZHU JINGEN ET AL: "Design of bacteriophage T4-based artificial viral vectors for human genome remodeling", vol. 14, no. 1, 30 May 2023 (2023-05-30), UK, XP093183195, ISSN: 2041-1723, Retrieved from the Internet <URL:https://www.nature.com/articles/s41467-023-38364-1.pdf> DOI: 10.1038/s41467-023-38364-1 *

Also Published As

Publication number	Publication date
EP4371564A2 (fr)	2024-05-22
CN116323944A (zh)	2023-06-23
EP4371564A3 (fr)	2024-08-21
GB2612491B (en)	2025-04-09
CN116323944B (zh)	2023-12-05
WO2022023850A1 (fr)	2022-02-03
EP4371564B1 (fr)	2026-03-18
MX2023001164A (es)	2023-09-15
GB2628464B (en)	2025-02-12
GB2628464A (en)	2024-09-25
GB202301200D0 (en)	2023-03-15
CA3187240A1 (fr)	2022-02-03
GB2612491A (en)	2023-05-03
JP2023537296A (ja)	2023-08-31
EP4189096A1 (fr)	2023-06-07
JP2024037973A (ja)	2024-03-19
GB202400771D0 (en)	2024-03-06

Legal Events

Date	Code	Title	Description
2022-02-04	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE
2023-05-05	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
2023-05-05	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE
2023-06-07	17P	Request for examination filed	Effective date: 20230129
2023-06-07	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR
2023-10-04	P01	Opt-out of the competence of the unified patent court (upc) registered	Effective date: 20230829
2023-11-08	DAV	Request for validation of the european patent (deleted)
2023-11-08	DAX	Request for extension of the european patent (deleted)
2024-10-09	A4	Supplementary search report drawn up and despatched	Effective date: 20240909
2024-10-09	RIC1	Information provided on ipc code assigned before grant	Ipc: C12N 7/00 20060101ALI20240903BHEP Ipc: A61K 31/7088 20060101ALI20240903BHEP Ipc: A61K 48/00 20060101ALI20240903BHEP Ipc: C12N 15/88 20060101ALI20240903BHEP Ipc: C12N 15/10 20060101ALI20240903BHEP Ipc: C12N 9/22 20060101ALI20240903BHEP Ipc: C12N 15/113 20100101ALI20240903BHEP Ipc: C12N 15/86 20060101AFI20240903BHEP
2026-05-01	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: EXAMINATION IS IN PROGRESS

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