EP4210819C0 - Systèmes et procédés de neuromodulation ciblée - Google Patents

Systèmes et procédés de neuromodulation ciblée

Info

Publication number
EP4210819C0
EP4210819C0 EP21880931.7A EP21880931A EP4210819C0 EP 4210819 C0 EP4210819 C0 EP 4210819C0 EP 21880931 A EP21880931 A EP 21880931A EP 4210819 C0 EP4210819 C0 EP 4210819C0
Authority
EP
European Patent Office
Prior art keywords
systems
methods
targeted neuromodulation
neuromodulation
targeted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
EP21880931.7A
Other languages
German (de)
English (en)
Other versions
EP4210819B1 (fr
EP4210819A1 (fr
EP4210819A4 (fr
Inventor
Nolan R Williams
Adi Maron-Katz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leland Stanford Junior University
Original Assignee
Leland Stanford Junior University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leland Stanford Junior University filed Critical Leland Stanford Junior University
Priority to EP25225294.5A priority Critical patent/EP4706535A3/fr
Publication of EP4210819A1 publication Critical patent/EP4210819A1/fr
Publication of EP4210819A4 publication Critical patent/EP4210819A4/fr
Application granted granted Critical
Publication of EP4210819C0 publication Critical patent/EP4210819C0/fr
Publication of EP4210819B1 publication Critical patent/EP4210819B1/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0004—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by the type of physiological signal transmitted
    • A61B5/0013—Medical image data
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A61B5/0022—Monitoring a patient using a global network, e.g. telephone networks, internet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/0036—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room including treatment, e.g., using an implantable medical device, ablating, ventilating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
    • A61B5/165—Evaluating the state of mind, e.g. depression, anxiety
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/72—Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7221—Determining signal validity, reliability or quality
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/74—Details of notification to user or communication with user or patient; User input means
    • A61B5/7475—User input or interface means, e.g. keyboard, pointing device, joystick
    • A61B5/748—Selection of a region of interest, e.g. using a graphics tablet
    • A61B5/7485—Automatic selection of region of interest
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
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    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A61N1/0534—Electrodes for deep brain stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36082—Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
    • A61N1/36096—Mood disorders, e.g. depression, anxiety or panic disorder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/004—Magnetotherapy specially adapted for a specific therapy
    • A61N2/006—Magnetotherapy specially adapted for a specific therapy for magnetic stimulation of nerve tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00—Magnetotherapy
    • A61N2/02—Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/4806—Functional imaging of brain activation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5608—Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/374—NMR or MRI
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/36—Image-producing devices or illumination devices not otherwise provided for
    • A61B90/37—Surgical systems with images on a monitor during operation
    • A61B2090/376—Surgical systems with images on a monitor during operation using X-rays, e.g. fluoroscopy
    • A61B2090/3762—Surgical systems with images on a monitor during operation using X-rays, e.g. fluoroscopy using computed tomography systems [CT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2576/00—Medical imaging apparatus involving image processing or analysis
    • A61B2576/02—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
    • A61B2576/026—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part for the brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Psychology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Developmental Disabilities (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Social Psychology (AREA)
  • Computer Networks & Wireless Communication (AREA)
  • Cardiology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Robotics (AREA)
  • Physiology (AREA)
  • Signal Processing (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Artificial Intelligence (AREA)
  • Educational Technology (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electrotherapy Devices (AREA)
EP21880931.7A 2020-10-12 2021-10-12 Systèmes et procédés de neuromodulation ciblée Active EP4210819B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP25225294.5A EP4706535A3 (fr) 2020-10-12 2021-10-12 Systèmes et procédés de neuromodulation ciblée

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063090680P 2020-10-12 2020-10-12
PCT/US2021/054633 WO2022081611A1 (fr) 2020-10-12 2021-10-12 Systèmes et procédés de neuromodulation ciblée

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP25225294.5A Division EP4706535A3 (fr) 2020-10-12 2021-10-12 Systèmes et procédés de neuromodulation ciblée

Publications (4)

Publication Number Publication Date
EP4210819A1 EP4210819A1 (fr) 2023-07-19
EP4210819A4 EP4210819A4 (fr) 2025-01-01
EP4210819C0 true EP4210819C0 (fr) 2025-12-24
EP4210819B1 EP4210819B1 (fr) 2025-12-24

Family

ID=81079370

Family Applications (2)

Application Number Title Priority Date Filing Date
EP21880931.7A Active EP4210819B1 (fr) 2020-10-12 2021-10-12 Systèmes et procédés de neuromodulation ciblée
EP25225294.5A Pending EP4706535A3 (fr) 2020-10-12 2021-10-12 Systèmes et procédés de neuromodulation ciblée

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP25225294.5A Pending EP4706535A3 (fr) 2020-10-12 2021-10-12 Systèmes et procédés de neuromodulation ciblée

Country Status (10)

Country Link
US (3) US11857275B2 (fr)
EP (2) EP4210819B1 (fr)
JP (2) JP2023545136A (fr)
KR (1) KR20230107572A (fr)
AU (1) AU2021362169A1 (fr)
CA (1) CA3198621A1 (fr)
ES (1) ES3060848T3 (fr)
GB (2) GB2636959B (fr)
IL (1) IL302092A (fr)
WO (1) WO2022081611A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10595735B2 (en) 2018-01-12 2020-03-24 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for personalized clinical applications of accelerated theta-burst stimulation
AU2021362169A1 (en) 2020-10-12 2023-05-25 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for targeted neuromodulation
CN113367681B (zh) * 2021-07-05 2022-09-30 优脑银河(湖南)科技有限公司 靶点确定方法、装置、设备及存储介质
US20230110652A1 (en) * 2021-10-13 2023-04-13 Omniscient Neurotechnology Pty Limited Brain data visualization
JP2025528428A (ja) * 2022-08-25 2025-08-28 ウエスト バージニア ユニバーシティー ボード オブ ガバナーズ オン ビハーフ オブ ウエスト バージニア ユニバーシティー 神経精神機能を改善するための標的神経調節
WO2024097889A2 (fr) * 2022-11-02 2024-05-10 The Board Of Trustees Of The Leland Stanford Junior University Systèmes et procédés de vérification d'un traitement à base d'alcaloïde d'iboga à l'aide d'une connectivité spatio-temporelle
KR102931965B1 (ko) 2022-11-16 2026-03-04 포항공과대학교 산학협력단 순차적인 국소 전기 자극 방법
WO2024259443A1 (fr) * 2023-06-16 2024-12-19 The Regents Of The University Of California Systèmes et procédés de traitement automatisé de signaux de neuroimagerie
CN118398164B (zh) * 2024-06-20 2024-08-23 深圳中科华意科技有限公司 一种基于个性化大脑分割的电极定位系统
CN120804919B (zh) * 2025-09-10 2026-02-24 国家心血管病中心 基于磁共振参数的患者分类方法、装置、设备、介质

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001039664A1 (fr) * 1999-12-02 2001-06-07 The General Hospital Corporation Procede et appareil permettant de mesurer des indices d'activite cerebrale
US20090105521A1 (en) 2004-09-13 2009-04-23 Jonathan Bentwich Systems and methods for assessing and treating medical conditions related to the central nervous system and for enhancing cognitive functions
US7894903B2 (en) 2005-03-24 2011-02-22 Michael Sasha John Systems and methods for treating disorders of the central nervous system by modulation of brain networks
US7606622B2 (en) 2006-01-24 2009-10-20 Cardiac Pacemakers, Inc. Method and device for detecting and treating depression
CN101888875A (zh) * 2007-10-04 2010-11-17 纽若尼克斯有限公司 用于治疗与中枢神经系统有关的医学疾病以及用于提高认知功能的系统和方法
US20110224571A1 (en) 2009-11-16 2011-09-15 Alvaro Pascual-Leone Non-invasive methods for evaluating cortical plasticity impairments
US20110245633A1 (en) 2010-03-04 2011-10-06 Neumitra LLC Devices and methods for treating psychological disorders
ES2563781T3 (es) 2011-02-24 2016-03-16 Takasago International Corporation Método de IRMf para identificar estímulos olfativos del sistema de recompensa dopaminérgico
JP5492247B2 (ja) 2012-05-08 2014-05-14 株式会社Ｇｍ３ 心拍変動指標を用いた精神症状及び精神疾患発病リスク評価のための指標生成装置及びそれを用いた指標生成方法
WO2013172981A1 (fr) * 2012-05-16 2013-11-21 Beth Israel Deaconess Medical Center, Inc. Identification de sites cibles individuels pour des applications de stimulation magnétique transcrânienne
US10220211B2 (en) 2013-01-22 2019-03-05 Livanova Usa, Inc. Methods and systems to diagnose depression
JP6445548B2 (ja) * 2013-06-26 2018-12-26 コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． マルチモード組織分類のためのシステム
WO2015079439A1 (fr) 2013-11-26 2015-06-04 Technion Research And Development Foundation Limited Modulation neuronale
US11412975B2 (en) 2014-03-28 2022-08-16 The General Hospital Corporation System and method for measuring functional brain specialization
CA2857555A1 (fr) 2014-04-01 2015-10-01 William F. Stubbeman Methode et systeme de stimulation cerebrale therapeutique a l'aide d'impulsions electromagnetiques
US9773308B2 (en) 2014-07-15 2017-09-26 The Brigham And Women's Hospital Systems and methods for generating biomarkers based on multivariate classification of functional imaging and associated data
DK3277178T3 (da) * 2015-03-31 2020-04-27 Cortechs Labs Inc Kovariat-modulatlas
US10543367B2 (en) 2015-06-18 2020-01-28 Taipei Medical University Transcranial burst electrostimulation apparatus and its applications
US11164596B2 (en) 2016-02-25 2021-11-02 Samsung Electronics Co., Ltd. Sensor assisted evaluation of health and rehabilitation
US20190083805A1 (en) 2016-03-28 2019-03-21 The Board Of Trustees Of The Leland Stanford Junior University Detecting or treating post-traumatic stress syndrome
US11324963B2 (en) 2016-04-28 2022-05-10 The Board Of Trustees Of The Leland Stanford Junior University Brain stimulation treatment in depression
US11704790B2 (en) * 2017-09-26 2023-07-18 Washington University Supervised classifier for optimizing target for neuromodulation, implant localization, and ablation
JP6722845B2 (ja) * 2017-10-03 2020-07-15 株式会社国際電気通信基礎技術研究所 判別装置、うつ症状の判別方法、うつ症状のレベルの判定方法、うつ病患者の層別化方法、うつ症状の治療効果の判定方法及び脳活動訓練装置
US10595735B2 (en) * 2018-01-12 2020-03-24 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for personalized clinical applications of accelerated theta-burst stimulation
US12383196B2 (en) 2018-10-15 2025-08-12 The Board Of Trustees Of The Leland Stanford Junior University Treatment of depression using machine learning
US11395920B2 (en) * 2019-01-22 2022-07-26 General Electric Company Brain connectivity atlas for personalized functional neurosurgery targeting and brain stimulation programming
US10905882B2 (en) * 2019-01-22 2021-02-02 General Electric Company Systems and methods for predicting optimal deep brain stimulation parameters
EP3963544A4 (fr) * 2019-05-01 2023-01-04 Blackthorn Therapeutics, Inc. Systèmes et procédés pour traiter des données d'imagerie par résonance magnétique (irm)
AU2021362169A1 (en) 2020-10-12 2023-05-25 The Board Of Trustees Of The Leland Stanford Junior University Systems and methods for targeted neuromodulation

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JP2023545136A (ja) 2023-10-26
US20250318879A1 (en) 2025-10-16
KR20230107572A (ko) 2023-07-17
GB2636959A (en) 2025-07-02
CA3198621A1 (fr) 2022-04-21
EP4706535A3 (fr) 2026-03-25
US12285222B2 (en) 2025-04-29
GB2614504A (en) 2023-07-05
JP2026012376A (ja) 2026-01-23
GB2636959B (en) 2025-12-24
EP4210819B1 (fr) 2025-12-24
GB202305377D0 (en) 2023-05-24
AU2021362169A1 (en) 2023-05-25
WO2022081611A1 (fr) 2022-04-21
ES3060848T3 (en) 2026-03-30
GB2614504B (en) 2025-05-28
IL302092A (en) 2023-06-01
GB202505545D0 (en) 2025-05-28
EP4210819A1 (fr) 2023-07-19
EP4706535A2 (fr) 2026-03-11
EP4210819A4 (fr) 2025-01-01
US20240081920A1 (en) 2024-03-14

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