EP4234537A4 - Reagent for measuring skin sensitization, compound, and method for measuring skin sensitization - Google Patents

Reagent for measuring skin sensitization, compound, and method for measuring skin sensitization Download PDF

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Publication number
EP4234537A4
EP4234537A4 EP21882902.6A EP21882902A EP4234537A4 EP 4234537 A4 EP4234537 A4 EP 4234537A4 EP 21882902 A EP21882902 A EP 21882902A EP 4234537 A4 EP4234537 A4 EP 4234537A4
Authority
EP
European Patent Office
Prior art keywords
skin sensitization
measuring skin
reagent
compound
measuring
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP21882902.6A
Other languages
German (de)
French (fr)
Other versions
EP4234537A1 (en
Inventor
Takashi Tamura
Masaharu Fujita
Yusuke Yamamoto
Koji Takaku
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujifilm Corp
Original Assignee
Fujifilm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Corp filed Critical Fujifilm Corp
Publication of EP4234537A1 publication Critical patent/EP4234537A1/en
Publication of EP4234537A4 publication Critical patent/EP4234537A4/en
Pending legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
    • C07C323/41—Y being a hydrogen or an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7786—Fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G01N2030/067—Preparation by reaction, e.g. derivatising the sample

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
EP21882902.6A 2020-10-22 2021-10-21 Reagent for measuring skin sensitization, compound, and method for measuring skin sensitization Pending EP4234537A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2020177157 2020-10-22
PCT/JP2021/038929 WO2022085762A1 (en) 2020-10-22 2021-10-21 Reagent for measuring skin sensitization, compound, and method for measuring skin sensitization

Publications (2)

Publication Number Publication Date
EP4234537A1 EP4234537A1 (en) 2023-08-30
EP4234537A4 true EP4234537A4 (en) 2024-05-29

Family

ID=81290670

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21882902.6A Pending EP4234537A4 (en) 2020-10-22 2021-10-21 Reagent for measuring skin sensitization, compound, and method for measuring skin sensitization

Country Status (4)

Country Link
US (1) US20230258569A1 (en)
EP (1) EP4234537A4 (en)
JP (1) JP7750853B2 (en)
WO (1) WO2022085762A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP1711931S (en) * 2021-10-19 2022-04-06 Printer
USD1013032S1 (en) * 2022-05-20 2024-01-30 Kyocera Corporation Inkjet printer
USD1013031S1 (en) * 2022-05-20 2024-01-30 Kyocera Corporation Inkjet printer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0313873A1 (en) * 1987-10-30 1989-05-03 American Cyanamid Company Targeted forms of methyltrithio antitumor agents
EP2207030A1 (en) * 2007-10-05 2010-07-14 Hokkaido University Apparatus for auto-pretreating sugar chain
US20140227793A1 (en) * 2013-02-14 2014-08-14 California Institute Of Technology Compositions and methods for glycan sequencing
WO2020045621A1 (en) * 2018-08-31 2020-03-05 富士フイルム株式会社 Skin sensitization measuring method and skin sensitization measuring reagent

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5745458A (en) * 1980-09-02 1982-03-15 Fuji Photo Film Co Ltd Immunologic method for trace analysis
JP4595257B2 (en) 2001-06-29 2010-12-08 住友化学株式会社 Skin sensitization test method
JP2008139275A (en) 2006-11-02 2008-06-19 Sumitomo Chemical Co Ltd Skin sensitization test method
JP5223391B2 (en) 2008-03-14 2013-06-26 住友化学株式会社 Sensitization assay method using fluorescent cysteine derivative and fluorescent cysteine derivative
JP5466105B2 (en) 2009-08-13 2014-04-09 富士フイルム株式会社 Reagent for skin sensitization
JP5997543B2 (en) 2012-08-13 2016-09-28 富士フイルム株式会社 Reagent for skin sensitization
WO2021060477A1 (en) * 2019-09-26 2021-04-01 富士フイルム株式会社 Reagent for measuring skin sensitization, method for measuring skin sensitization, and compound

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0313873A1 (en) * 1987-10-30 1989-05-03 American Cyanamid Company Targeted forms of methyltrithio antitumor agents
EP2207030A1 (en) * 2007-10-05 2010-07-14 Hokkaido University Apparatus for auto-pretreating sugar chain
US20140227793A1 (en) * 2013-02-14 2014-08-14 California Institute Of Technology Compositions and methods for glycan sequencing
WO2020045621A1 (en) * 2018-08-31 2020-03-05 富士フイルム株式会社 Skin sensitization measuring method and skin sensitization measuring reagent

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
A.Y. HASSAN, ET AL.: "Design, synthesis and anticancer activity of novel benzothiazole analogues", JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 56, no. 4, 28 February 2019 (2019-02-28), Wiley Periodicals, Hoboken, NJ, US, pages 1437 - 1457, XP093067519, ISSN: 0022-152X, DOI: 10.1002/jhet.3524 *
DATABASE CAPLUS [online] Chemical Abstracts Service, Columbus, OH, US; 1990, A.U. GRANIK, ET AL.: "Some derivatives of N-acyl derivatives of D-penicillamine: synthesis and antihypertensive effect", XP093305166, Database accession no. 1990:191617 *
E.D. MATVEEVA, ET AL.: "Synthesis of alpha-hydrazino phosphonates from-amino acid- and-glutathione-derived hydrazones", RUSSIAN CHEMICAL BULLETIN, INTERNATIONAL EDITION SERIYA KHIMICHESKAYA, vol. 60, no. 2, 11 August 2011 (2011-08-11), Springer Science+Business Media, New York, NY, US, pages 248 - 253, XP019937846, ISSN: 1573-9171, DOI: 10.1007/S11172-011-0041-Y *
KHIMIKO-FARMATSEVTICHESKII ZHURNAL, vol. 23, no. 11, 1989, pages 1320 - 1323 *
KYOUNG-SOON JANG, ET AL.: "A cationic cysteine-hydrazide as an enrichment tool for the mass spectrometric characterisation of bacterial free oligosaccharides", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, vol. 407, no. 20, 23 June 2015 (2015-06-23), Springer-Verlag, Berlin, DE, pages 6181 - 6190, XP035520263, ISSN: 1618-2642, DOI: 10.1007/s00216-015-8798-8 *
M. VON DELIUS, ET AL.: "Design, synthesis and operation of small molecules that walk along tracks", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 132, no. 45, 27 October 2010 (2010-10-27), American Chemical Society, Washington, DC, US, pages 16134 - 16145, XP055565232, ISSN: 0002-7863, DOI: 10.1021/ja106486b *
M.D. BARRATT, ET AL.: "Validation and subsequent development of the Derek skin sensitisation rulebase by analysis of the BgVV list of contact allergens", JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, vol. 39, no. 2, 6 January 1999 (1999-01-06), American Chemical Society, Washington, DC, US, pages 294 - 298, XP093150860, ISSN: 0095-2338, DOI: 10.1021/ci980204n *
See also references of WO2022085762A1 *
Y. SICAK, ET AL.: "Novel fluorine-containing chiral hydrazide-hydrazones: Design, synthesis, structural elucidation, antioxidant and anticholinesterase activity, and in silico studies", CHIRALITY, vol. 31, no. 8, 20 June 2019 (2019-06-20), Wiley Periodicals, Hoboken, NJ, US, pages 603 - 615, XP071748078, ISSN: 0899-0042, DOI: 10.1002/chir.23102 *

Also Published As

Publication number Publication date
US20230258569A1 (en) 2023-08-17
JP7750853B2 (en) 2025-10-07
WO2022085762A1 (en) 2022-04-28
JPWO2022085762A1 (en) 2022-04-28
EP4234537A1 (en) 2023-08-30

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