EP4256404A4 - ELECTROHOLOGRAPHIC MICROSCOPE SYSTEM WITH THE ABILITY TO DISTINGUISH CELLS AND MICROORGANISMS BASED ON LIGHT TRANSMITTANCE - Google Patents

ELECTROHOLOGRAPHIC MICROSCOPE SYSTEM WITH THE ABILITY TO DISTINGUISH CELLS AND MICROORGANISMS BASED ON LIGHT TRANSMITTANCE Download PDF

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Publication number
EP4256404A4
EP4256404A4 EP21901159.0A EP21901159A EP4256404A4 EP 4256404 A4 EP4256404 A4 EP 4256404A4 EP 21901159 A EP21901159 A EP 21901159A EP 4256404 A4 EP4256404 A4 EP 4256404A4
Authority
EP
European Patent Office
Prior art keywords
electroholographic
ability
light transmittance
microscope system
microorganisms based
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP21901159.0A
Other languages
German (de)
French (fr)
Other versions
EP4256404A1 (en
Inventor
Rahmetullah VAROL
Abdurrahim YILMAZ
Huseyin UVET
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yildiz Teknik Universitesi
Original Assignee
Yildiz Teknik Universitesi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yildiz Teknik Universitesi filed Critical Yildiz Teknik Universitesi
Publication of EP4256404A1 publication Critical patent/EP4256404A1/en
Publication of EP4256404A4 publication Critical patent/EP4256404A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/04—Processes or apparatus for producing holograms
    • G03H1/0443—Digital holography, i.e. recording holograms with digital recording means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/04—Processes or apparatus for producing holograms
    • G03H1/08—Synthesising holograms, i.e. holograms synthesized from objects or objects from holograms
    • G03H1/0866—Digital holographic imaging, i.e. synthesizing holobjects from holograms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/1454—Optical arrangements using phase shift or interference, e.g. for improving contrast
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/1717—Systems in which incident light is modified in accordance with the properties of the material investigated with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
    • G01N2021/1721—Electromodulation
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/0005—Adaptation of holography to specific applications
    • G03H2001/0033—Adaptation of holography to specific applications in hologrammetry for measuring or analysing
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/0005—Adaptation of holography to specific applications
    • G03H2001/0033—Adaptation of holography to specific applications in hologrammetry for measuring or analysing
    • G03H2001/0044—Adaptation of holography to specific applications in hologrammetry for measuring or analysing holographic fringes deformations; holographic sensors
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/0005—Adaptation of holography to specific applications
    • G03H2001/005—Adaptation of holography to specific applications in microscopy, e.g. digital holographic microscope [DHM]
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/04—Processes or apparatus for producing holograms
    • G03H1/0443—Digital holography, i.e. recording holograms with digital recording means
    • G03H2001/0454—Arrangement for recovering hologram complex amplitude
    • G03H2001/0458—Temporal or spatial phase shifting, e.g. parallel phase shifting method
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H2227/00—Mechanical components or mechanical aspects not otherwise provided for
    • G03H2227/03—Means for moving one component

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Theoretical Computer Science (AREA)
  • Computing Systems (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
EP21901159.0A 2020-12-02 2021-06-14 ELECTROHOLOGRAPHIC MICROSCOPE SYSTEM WITH THE ABILITY TO DISTINGUISH CELLS AND MICROORGANISMS BASED ON LIGHT TRANSMITTANCE Withdrawn EP4256404A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2020/19536A TR202019536A2 (en) 2020-12-02 2020-12-02 Electro-holographic microscope system that can separate cells and micro-organisms according to their light transmittance.
PCT/TR2021/050597 WO2022119521A1 (en) 2020-12-02 2021-06-14 Electro-holographic microscope system capable of distinguishing cells and microorganisms based on the light transmittance

Publications (2)

Publication Number Publication Date
EP4256404A1 EP4256404A1 (en) 2023-10-11
EP4256404A4 true EP4256404A4 (en) 2024-06-12

Family

ID=81855023

Family Applications (1)

Application Number Title Priority Date Filing Date
EP21901159.0A Withdrawn EP4256404A4 (en) 2020-12-02 2021-06-14 ELECTROHOLOGRAPHIC MICROSCOPE SYSTEM WITH THE ABILITY TO DISTINGUISH CELLS AND MICROORGANISMS BASED ON LIGHT TRANSMITTANCE

Country Status (3)

Country Link
EP (1) EP4256404A4 (en)
TR (1) TR202019536A2 (en)
WO (1) WO2022119521A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050036181A1 (en) * 2001-12-04 2005-02-17 Pierre Marquet Apparatus and method for digital holographic imaging

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7924432B2 (en) * 2006-12-21 2011-04-12 Howard Hughes Medical Institute Three-dimensional interferometric microscopy
US8896840B2 (en) * 2012-04-25 2014-11-25 Canon Kabushiki Kaisha Interferometric method and digital holographic microscope
JP7244829B2 (en) * 2019-02-22 2023-03-23 株式会社日立製作所 interference electron microscope

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050036181A1 (en) * 2001-12-04 2005-02-17 Pierre Marquet Apparatus and method for digital holographic imaging

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MOR HABAZA ET AL: "Rapid 3D Refractive-Index Imaging of Live Cells in Suspension without Labeling Using Dielectrophoretic Cell Rotation", ADVANCED SCIENCE, vol. 4, no. 2, 21 October 2016 (2016-10-21), pages 1600205, XP055563982, ISSN: 2198-3844, DOI: 10.1002/advs.201600205 *
QIANG YUHAO ET AL: "Mechanical fatigue of human red blood cells", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 116, no. 40, 16 September 2019 (2019-09-16), pages 19828 - 19834, XP093145439, ISSN: 0027-8424, DOI: 10.1073/pnas.1910336116 *
See also references of WO2022119521A1 *
TENG YAO ET AL: "Electrodeformation-Based Biomechanical Chip for Quantifying Global Viscoelasticity of Cancer Cells Regulated by Cell Cycle", ANALYTICAL CHEMISTRY, vol. 90, no. 14, 13 June 2018 (2018-06-13), US, pages 8370 - 8378, XP093145288, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.8b00584 *

Also Published As

Publication number Publication date
TR202019536A2 (en) 2022-06-21
EP4256404A1 (en) 2023-10-11
WO2022119521A1 (en) 2022-06-09

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